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Fig. 3 | BMC Neuroscience

Fig. 3

From: Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPARα-dependent manner

Fig. 3

Treatment with 2% H2 related to PPARα improved the spontaneous alternation test in the Y-maze and fear conditioning memory of CLP-induced septic mice from days 1 to 7. (A) Cognition function 3, 5 and 7 days after the operation was assessed using the Y-maze test (n = 3). The percentage of alternation was determined with the spontaneous alternation test, and (B) the number of line crossings was unchanged. (C). The acquisition of memory during the training phase before the operation was similar among all groups in the fear conditioning test (n = 5). (D). Fear conditioning memory was quantified by the percentage of freezing time that was improved in the CLP + H2 group at days 1 to 7 after CLP operation versus the CLP and CLP + H2 + GW6471 groups. CLP, caecal ligation and puncture; SD, standard deviation. Values are expressed as the mean ± SD. *P < 0.05 versus the sham group; #P < 0.05 versus the CLP group; &P < 0.05 versus the CLP + H2 group

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BMC Neuroscience

ISSN: 1471-2202

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