Table 2 Clinical data for all children with PHIV (N = 75)

Sample size (N)

39

36

Clinical data at baseline (age 6–8 weeks)

 CD4 count (cells/mm³)

1827 ± 955

1739 ± 833

 CD4%

33 ± 10

33 ± 10

 CD4/CD8 ratio

1.4 ± 0.9 [0.2–4.4]^a

1.2 ± 0.7 [0.2–3.4]^a

 CD8 count (cells/mm³)

1660 ± 1218

1686 ± 871

 Viral load at enrolment

  High (>750,000 copies/mL): n (%)

21 (53.8%)

23 (63.9%)

  Low (400–750,000 copies/mL): n (%)

18 (46.2%)

13 (36.1%)

  Suppressed (< 400 copies/mL): n (%)

0 (0%)

0 (0%)

Other clinical / treatment measures

 Age at ART initiation (weeks)

8.3 [7.4, 9.7] [6.6–12.0]^a

18.9 [7.7, 27.2] [6.0–75.7]^a

 Age at ART interruption (weeks)

51.7 [47.3, 72.6]

-

 Age of first viral load suppression (weeks)

33.9 [31.5, 49.8] [30.6–213.3]^a

47.6 [33.5, 79.2] [29.1–285.6]^a

 Duration of ART interruption (weeks)

34.4 [20.4, 52.3] [5.7–299.4]^a

0.00 (not interrupted)

 Nadir CD4%

19 ± 6

20 ± 6

 Age at nadir CD4% (weeks)

91.0 [55.9, 125.7]

27.9 [18.8, 51.0]

 CDC classification

  A: n (%)

8 (20%)

1 (3%)

 B: n (%)

9 (23%)

7 (19%)

 Severe B: n (%)

2 (5%)

7 (19%)

 C: n (%)

20 (51%)

19 (53%)

 Unknown: n (%)

0 (0%)

2 (6%)

 HIV encephalopathy diagnosis: n (%)

7 (18%)

5 (14%)