White matter damage and systemic inflammation in Parkinson’s disease

BMC Neuroscience

Table 3 Linear regression analysis results for correlations between diffusion tensor abnormalities and inflammatory parameters

WM tract	Granu LFA-1		Granu APO2.7 (%)		Lymph APO2.7 (%)		Total APO2.7 (%)		P-selectin
WM tract	Beta (Stand.)	P	Beta (Stand.)	P	Beta (Stand.)	P	Beta (Stand.)	P	Beta (Stand.)	P
Regression of systemic inflammatory variables
FA
Left inferior longitudinal fasciculus	−0.259	0.002	−0.218	0.008
Right superior longitudinal fasciculus	−0.291	0.001					−0.216	0.008
Right inferior longitudinal fasciculus					−0.184	0.040
Left superior longitudinal fasciculus	−0.292	0.001
Left cerebellum			−0.201	0.017
Left inferior fronto-occipital fasciculus	−0.205	0.010	−0.199	0.010
MD
Left inferior longitudinal fasciculus									0.249	0.004
Right superior longitudinal fasciculus	0.204	0.018							0.188	0.026
Left cerebellum							0.263	0.002
Left inferior fronto-occipital fasciculus	0.151	0.039	0.264	0.000
RD
Left inferior longitudinal fasciculus	0.182	0.033	0.178	0.034
Right superior longitudinal fasciculus	0.281	0.001	0.201	0.013
Right inferior longitudinal fasciculus	0.251	0.005
Left cerebellum							0.265	0.001
Left inferior fronto-occipital fasciculus	0.163	0.023	0.262	0.000

Linear regression between DTI indices and inflammatory parameters was performed after controlling for age and sex as predictors
APO apoptosis, Granu granulocyte, Lymph lymphocyte, Total total leukocyte, LFA-1 leukocyte function associated antigen-1, FA fractional anisotropy, MD mean diffusivity, RD radial diffusivity, WM white matter

ISSN: 1471-2202