Fig. 7
Effect of DEX on L-type Ca2+ current (I Ca,L) in untreated and SGX-treated cells. In these experiments, cells were bathed in normal Tyrode’s solution containing 1.8 mM CaCl2 and the recording pipette was filled with Cs+-containing solution. In the upper parts of a and b, superimposed I Ca,L traces were obtained in untreated cells respectively. I Ca,L traces labeled a in each panel are controls (i.e., in the absence of DEX) and those labeled b were obtained after addition of 30 μM DEX. Inset in the upper part of each panel indicates the voltage protocol used. Bar graphs shown in each panel indicate the summary of data showing inhibitory effect of DEX on the peak amplitude of I Ca,L in untreated (A) and SGX-treated (B) cells (mean ± SEM; n = 11 for each bar). *Significantly different from control (P < 0.05). DEX: 30 μM dexamethasone