Fig. 82

The phase of post-synaptic firing in response to frequency-modulated inhomogenous Poisson pre-synaptic spike trains depends on the configuration of input synapses. A The connectivity involves M independent pre-synaptic neurons each with NM synaptic release sites at a post-synaptic neuron. Vesicles are released probabilistically when activated by a pre-synaptic action-potential, if one is available at that site. The post-synaptic neuron depolarizes and produces action potentials after arrival of neurotransmitter according to standard models. B The phase lead of output spiking relative to periodic modulation at frequency f, for M active-zones is both frequency-dependent and configuration-dependent. The figure is from simulations but we also derived the same result mathematically