Fig. 1

Temporal expression profile of il1b in the brain of zebrafish after pentylenetetrazole-evoked seizures. Relative quantification of the interleukin-1 beta (il1b) transcript 0.05, 1, 6, 12, 24, and 48 h after pentylenetetrazole (PTZ)-induced seizures in the brain of zebrafish at 7 days post fertilization. Each time-point seizure group was exposed to 15 mM PTZ for 20 min, and their time-matched control groups were handled identically, but included exposure to water (n = 5 per group). Data obtained from each seizure group was compared with their respective time-point matched control group. Data are presented as mean ± SEM. Statistical analyses were performed using the Mann–Whitney test, and differences were considered significant if p < 0.05. Asterisk (*) indicates p ≤ 0.05. CG control group, SG seizure group