Fig. 3

GFAP immunohistochemistry to study astroglial activation due to QA striatal lesion. In the non-lesioned side GFAP-immunopositive astroglial cells were few in number, not activated and easily detectable at high magnification both in control (a) and PLP-α-syn mice (b). There was intense astroglia activation following QA injection on the lesioned side in both controls (c) and PLP-α-syn mice (d). Statistical analysis with two-way ANOVA showed comparable astroglial activation in control and PLP-α-syn mice as measured by GFAP optical density (e). Data are presented as mean ± SEM. ***p < 0.001. OD optical density