Fig. 8

Western blot analysis of effects of CBL on levels of Akt/GSK3β in the 3R Tau transgenic mice. a Representative immunoblots of samples from the 6–9 month group analyzed with antibodies against p-GSK3β (Y216), t-GSK3β, t-Akt and p-Akt (Ser473). b, c Image analysis of the ration between p-GSK3β (Y216) and total and p-Akt (Ser473) and total respectively. For analysis, N = 10 non-tg and N = 10 3R Tau tg mice from each age and treatment group. *P < 0.05 when compared to non-tg control using one way ANOVA with Dunnet’s post hoc test. ^# P < 0.05 when compared to tg control using one way ANOVA with Tukey post hoc test