From: Imaging the neural circuitry and chemical control of aggressive motivation
 | Volume of Activation | % Change in BOLD Signal | ||
---|---|---|---|---|
Brain Area | Novel Female SRX251 | Novel Female Fluoxetine | Novel Female SRX251 | Novel Female Fluoxetine |
retrosplenial cortex (130) | 23 (3, 67) ** | 6 (1, 7) | 6.6 ± 0.3 | 3.9 ± 0.2 |
orbital cortex (45) | 12 (2, 45)** | 4 (0, 8) | 2.7 ± 0.1 | 2.7 ± 0.2 |
auditory cortex (98) | 14 (5, 75)** | 6 (1, 13) | 3.3 ± 0.3 | 3.4 ± 0.2 |
somatosensory cortex (599) | 79 (23, 292) | 40 (15, 94) | 3.2 ± 0.2 | 3.6 ± 0.2 |
motor cortex (386) | 72 (18, 230)** | 16 (6, 33) | 3.1 ± 0.2 | 3.2 ± 0.3 |
visual cortex (212) | 26 (3, 67) | 22 (4, 63) | 5.8 ± 0.5 | 4.2 ± 0.2 |
insular cortex (128) | 17 (6, 62)** | 6 (0, 11) | 4.4 ± 0.3 | 3.8 ± 0.3 |
prelimbic cortex (32) | 6 (1, 19)* | 3 (0, 5) | 2.9 ± 0.2 | 2.5 ± 0.2 |
infralimbic cortex (17) | 2 (0, 13) | 0 (0, 3) | 2.2 ± 0.1 | 2.2 ± 0.1 |
anterior cingulate ctx (73) | 15 (1, 40)** | 3 (0, 10) | 3.0 ± 0.2 | 1.9 ± 0.2 |
CA1 hippocampus (154) | 20 (8, 79)** | 8 (3, 15) | 3.2 ± 0.2 | 3.4 ± 0.2 |
dentate gyrus (100) | 19 (2, 47)** | 4 (0, 7) | 3.2 ± 0.1 | 2.8 ± 0.2 |
cortical n. amygdala (69) | 6 (3, 26) | 5 (2, 7) | 4.0 ± 0.3 | 4.4 ± 0.3 |
basal n. amygdala (24) | 1 (0, 6) | 1 (0, 2) | 2.1 ± 0.2 | 1.9 ± 0.3 |
central n. amygdala (13) | 1 (0, 4) | 0 (0, 0) | 1.5 ± 0.1 | 1.8 ± 0.1 |
medial n. amygdala (14) | 1 (0, 2) | 0 (0, 1) | 1.2 ± 0.3 | 1.4 ± 0.2 |
bed n. stria terminalis (15) | 2 (0, 7) | 1 (0, 14) | 2.2 ± 0.2 | 2.0 ± 0.1 |
lateral post. n. thalamus (18) | 2 (0, 8) | 1 (0, 2) | 2.5 ± 0.2 | 1.9 ± 0.2 |
anterior n. thalamus (12) | 2 (0, 13) | 0 (0, 7) | 1.8 ± 0.2 | 0.6 ± 0.1 |
substantia nigra (28) | 3 (1, 11) | 1 (0, 2) | 5.6 ± 0.4 | 4.6 ± 0.6 |
ventral tegmentum (16) | 1 (0, 8) | 1 (0, 2) | 2.7 ± 0.2 | 2.4 ± 0.2 |
dorsal striatum (305) | 26 (16, 158)** | 6 (1, 15) | 2.5 ± 0.1 | 2.7 ± 0.2 |
ventral pallidum (41) | 2 (1, 9) | 1 (0, 4) | 2.1 ± 0.2 | 2.5 ± 0.1 |
lateral hypothalamus (64) | 7 (1,24) | 4 (1, 11) | 3.4 ± 0.3 | 3.9 ± 0.3 |
periaquedutcal gray (42) | 5 (1, 15) ** | 1 (0, 3) | 2.9 ± 0.2 | 3.3 ± 0.2 |
raphe nuclei (15) | 2 (0, 7) | 0 (0, 1) | 4.1 ± 0.4* | 0.8 ± 0.3 |
accumbens (45) | 5 (0, 19) | 2 (0, 4) | 2.2 ± 0.2 | 2.6 ± 0.2 |
PVN hypothalamus (3) | 2 (0,6) | 0 (0, 2) | 1.8 ± 0.1 | 2.2 ± 0.1 |