Volume 8 Supplement 2

Sixteenth Annual Computational Neuroscience Meeting: CNS*2007

Open Access

Supralinear reliability of cortical spiking from synchronous thalamic inputs

  • Wang Hsi-Ping1Email author,
  • Jean-Marc Fellous1, 2,
  • Don Spencer1 and
  • Terrence Sejnowski1
BMC Neuroscience20078(Suppl 2):P130

DOI: 10.1186/1471-2202-8-S2-P130

Published: 6 July 2007

Thalamic and cortical V1 layer 4 neurons are capable of firing highly reliably and precisely upon repeated presentations of the same visual stimulus to the retina. To compare candidate causal mechanisms of spike-time reliability, a reconstructed multicompartment spiny stellate cell model with dynamic stochastic synapses was given varying synaptic inputs. We found reliability was primarily influenced by the number of synapses that fired synchronously during events (synchrony magnitude), which exhibits a supralinear relation; rather than by the rate of synchronous firing events (event rate) or synaptic strength, which exhibits comparatively more linear relations, even in the absence of voltage dependent conductances. Supralinear reliability highlights the efficacy of synchronous but weak synapses in driving output spiking, and may have implications for neural synchronicity within and between cortical areas.

Authors’ Affiliations

Salk Institute, La Jolla, CA and University of California at San Diego
University of Arizona


© Hsi-Ping et al; licensee BioMed Central Ltd. 2007

This article is published under license to BioMed Central Ltd.