Figure 4
From: Amyloid-like aggregates of neuronal tau induced by formaldehyde promote apoptosis of neuronal cells
Tau deposits were imaged by transmission electron microscopy and atomic force microscopy. Tau deposits were formed by incubation of tau with formaldehyde in 100 mM sodium phosphate, pH 7.2, for one day. (A) Formaldehyde-treated tau deposits stained with uranyl acetate were observed under the electron microscope (Bar: 100 nm); (B) Tau (40 μM) was incubated with heparin (1 mg/ml) under the same conditions (Bar: 50 nm). (C) Formaldehyde-treated tau deposits observed by AFM (Bar: 125 nm). (D) Tau alone as a control was observed by AFM (Bar: 125 nm).