Hirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain

Table 1 Additive versus synergistic cell death induced by co-expression of AICD and tau

Tau	% Cell death (Additive) = GFP/AICD + GFP/tau	% Cell death ± SD (Actual) = GFP/AICD/tau	p value
352tauWT	22.3% ± 1.46	24.6% ± 1.74	N.S.
441tauWT	20.9% ± 2.78	22.0% ± 2.36	N.S.
352tauPHP	21.7% ± 1.98	38.1% ± 4.35	p < 0.05
R5H	21.3% ± 2.49	42.9% ± 4.09	p < 0.01
K18	22.0% ± 4.24	39.0% ± 6.98	p < 0.05
K18ΔK280	42.5% ± 4.28	42.3% ± 4.61	N.S.
P301L	21.4% ± 2.97	30.2% ± 3.79	p < 0.05
G272V	21.9% ± 2.73	40.2% ± 1.40	p < 0.01
R406W	20.4% ± 3.93	31.7% ± 2.70	p < 0.05

Values of cell death obtained when GFP/AICD or GFP/tau transiently expressed were added together and compared to the actual values of cell death obtained when GFP/AICD/tau were co-expressed. Synergistic cell death (bold entries) was observed when AICD was co-expressed with 352PHP, R5H, K18, P301L, G272V, or R406W. N.S. = not significant.

ISSN: 1471-2202