Table 2 Bio-functions of down- or up-regulated genes in Glud1 Tg compared with wt hippocampus at various ages

10 days post birth

Ion binding and transport, transmembrane transport, extracellular space, neuronal development, metabolism and energy generation

4.5 months

Neuron projection, axonal guidance, synaptic transmission, ion binding, cytoskeleton, protein ubiquitination, intracellular transport, cell adhesion, synaptic vesicle

9 months

Signal transduction, nervous system development, cell adhesion, synaptic transmission, ion homeostasis

Nervous system development, signal transduction, cytoskeleton, focal adhesion, ion transport, synaptic transmission, protein folding and degradation

14.5 months

Extracellular region, cell adhesion, and ion transport

20 months

Voltage-gated channel

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