Table 5 Regression formula for hypotheses 3B
From: Method parameters’ impact on mortality and variability in rat stroke experiments: a meta-analysis
Regression formula for the effect of Occluding filament type on Mortality rate (hypothesis 3B) | |||||
|---|---|---|---|---|---|
Variable (reference category) | Variable categories | Regression coefficient | 0.95 confidence interval for regression coefficient | p-value | |
Constant | NA | 16.8 | 13.2 | 20.4 | 0.000 |
Occluding filament type (Uncoated) | Silicon coated | −1.2 | −4.7 | 2.4 | 0.516 |
Poly-L-Lysine coated | 3.0 | −1.3 | 7.4 | 0.171 | |
Other coatings | −3.6 | −9.0 | 1.8 | 0.188 | |
Type of anesthetic (Inhalation anesthetic) | Chloral Hydrate | 5.0 | 0.57 | 9.4 | 0.027 |
Ketamine | 3.1 | −1.6 | 7.8 | 0.198 | |
Barbiturates and bensodiazepines | 6.6 | −0.91 | 14.1 | 0.085 | |
Other anesthetic | 5.6 | −0.04 | 11.2 | 0.052 | |
Awakening of rats during occlusion (No) | [Yes] | 9.7 | 4.5 | 14.8 | 0.000 |
Heart rate monitoring (No) | [Yes] | −6.5 | −10.8 | −2.2 | 0.003 |
Type of infarct size evaluation (TTC) | Radiology | 13.3 | 6.5 | 20.1 | 0.000 |
Acidic/Basic stain or silver stain histology | −1.2 | −5.2 | 2.9 | 0.576 | |
Immunohistology | 10.8 | 1.6 | 20.0 | 0.022 | |
Criteria for excluding rats (None) | Observed absence of cerebral blood flow reduction | −5.5 | −8.6 | −2.4 | 0.001 |
Lack of functional deficit | .39 | −3.5 | 4.2 | 0.843 | |
Too small infarct | −7.4 | −14.2 | -.56 | 0.034 | |
Other pathology in animal | −1.2 | −5.3 | 2.9 | 0.577 | |