Figure 4

Striatal (co-)localizations of Aβ, pE3-Aβ, QC and astroglia in lateral striatum. Double immunofluorescent labeling of total Aβ (red) and pE3-Aβ (green) revealed intraneuronal colocalization of tg product and pE-modified Aβ in the lateral striatum of hom E8 animals (A). Double immunofluorescent labeling of the lateral striatum showed mQC-specific immunoreactivity (red), which is colocalized with pE3-Aβ (green) in hom E8 animals (B). Double immunofluorescent labeling revealed increased GFAP reactivity (green) of activated astroglia in the vicinity of pE3-Aβ positive cells (red) in the lateral striatum of hom E8 animals (C).