Figure 4
From: Schwann cells migrate along axons in the absence of GDNF signaling
Early inhibition of SC proliferation also prevents axonal SC colonization. A: Scheme showing the experimental setup (Expl. = Explantation, Aph. = Aphidicolin Analy. = Analysis, DIV = Day In Vitro). B,D,F and H show brightfield images of axonal growth of control (B and D) and aphidicolin treated samples (F and H). In both conditions axonal growth could be observed. C, E, G and I show DAPI stainings of controls (C and E) and aphidicolin treated samples (G and I). Where in the control condition a multitude of SC could be observed, in the aphidicolin treated sample only rarely cells could be observed outside the ganglion (arrows). Nuclear detritus was observed in both conditions (arrowheads). (Scale bars = 100 μm).