Voltage-gated sodium channel expression and action potential generation in differentiated NG108-15 cells

BMC Neuroscience

Table 1 Differentiation-induced changes in membrane properties of NG108-15 cells

		RMP	V_max	Depolarization amplitude	Current threshold
	n	(mv)	(mV/ms)	(mV)	(pA)
Day 0	22	−34.9 ± 1.4	20.1 ± 0.9	32.1 ± 1.6	n/a
Day 9	15	−43.2 ± 1.5*	23.2 ± 1.2	45.0 ± 2.9*	n/a
Day 21
Without AP	30	−45.4 ± 2.1*	28.5 ± 3.5*	46.1 ± 4.7*	n/a
Day 21
with AP	25	−56.1 ± 1.6*^#$	136.1 ± 13.7*^#$	79.4 ± 7.4*^#$	48.2 ± 2.7

RMP resting membrane potential; V_max maximum rate of depolarization of action potential (AP). Data are means ± SEM, n is the number of cells studied. *P < 0.05 vs. 0 day of differentiation (day 0, undifferentiated cells); ^#P < 0.05 vs. cells after 9 days of differentiation (day 9); ^$P < 0.05 vs. cells after 21 days of differentiation (day 21) without AP.

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