Table 1 Proteomic identification of dysregulated proteins in SMN-deficient ES cells
From: Proteomic assessment of a cell model of spinal muscular atrophy
Protein Name | Gene Symbol | Fold Change | Function |
|---|---|---|---|
Undifferentiated | Â | Â | Â |
   Chaperonin 6a | Cct6a | +2.6 | Protein folding |
   FK506 binding protein 4 | Fkbp4 | +1.75 | Protein folding and trafficking |
   Peroxiredoxin 6 | Prdx1 | +1.6 | Redox regulation |
   Stress-induced-phosphoprotein 1 | Stip1 | -1.75 | Adaptor protein for Hsp70 and Hsp90 |
Differentiated | Â | Â | Â |
   Lactate dehydrogenase B | Ldhb | +3.6 | Glycolysis |
   Brain creatine kinase | Ckb | +1.8 | Cellular energy homeostasis |
   Glyoxalase 1 | Glo1 | +1.75 | Detoxification of glucose degradation products |
   Tropomyosin 3 | Tpm3 | +1.75 | Stabilization of actin filaments |
   Annexin A5 | Anxa5 | +1.7 | Cell signaling, Inflammation; Growth/differentiation |
   Ubiquitin carboxy-terminal hydrolase L1 | Uchl1 | +1.7 | De-ubiquitination; Ubiquitin ligation; Mono-ubiquitin stabilizer |
   Alpha-tubulin | Tuba1a | +1.5 | Cytoskeletal protein |
   Aldehyde dehydrogenase | Aldh5a1 | -1.7 | Aldehyde oxidation |
   14-3-3 gamma | Ywhag | -1.7 | Cell signaling; Check point control; Apoptosis |
   Heat shock protein 90B | Hsp90b1 | -1.8 | Chaperone protein |
   Heat shock protein 70K | Hspa9 | -2.2 | Chaperone protein; Cell proliferation |