|  |  | Biphasic curve | Sigmoidal curve | ||||
---|---|---|---|---|---|---|---|---|
 | N | K+ mean ± s.e.m | Emax 1(%) ± s.e.m | Emax 2(%) ± s.e.m | pEC50(1) ± s.e.m | pEC50(2) ± s.e.m | Emax (%) ± s.e.m | pEC50 ± s.e.m |
ET-1 MCA | Â | Â | Â | Â | Â | Â | Â | Â |
Sham | 6 | 1.76 ± 0.57 |  |  |  |  | 152 ± 11 | 8.59 ± 0.14 |
SAH | 7 | 1.95 ± 0.34 | 28 ± 8a, b | 148 ± 5 | 12.62 ± 0.23a, b | 9.35 ± 0.22 |  |  |
SAH+SB386023-b at 0 h | 5 | 2.22 ± 0, 35 |  |  |  |  | 133 ± 5 | 8.87 ± 0, 15 |
SAH+SB386023-b after 6 h | 9 | 1.81 ± 0, 27 |  |  |  |  | 176 ± 6 | 8.92 ± 0.13 |
SAH+SB386023-b after 12 h | 5 | 1.45 ± 0.27 | 27 ± 7a, b | 149 ± 17 | 12.02 ± 0.39a, b | 9.13 ± 0.17 |  |  |
ET-1 BA | Â | Â | Â | Â | Â | Â | Â | Â |
Sham | 6 | 4.00 ± 0.58 |  |  |  |  | 119 ± 9 | 9.37 ± 0.10 |
SAH | 6 | 3.70 ± 0.47 | 34 ± 5a, b | 126 ± 8 | 12.21 ± 0.15a, b | 9.67 ± 0.02 |  |  |
SAH+SB386023-b at 0 h | 6 | 3.92 ± 0.45 |  |  |  |  | 124 ± 5 | 9.23 ± 0.16 |
SAH+SB386023-b after 6 h | 6 | 4.23 ± 0.41 |  |  |  |  | 155 ± 10 | 8.80 ± 0.13 |
SAH+SB386023-b after 12 h | 6 | 3.75 ± 0.32 | 29 ± 5 | 125 ± 5 | 12.41 ± 0.18 | 9.75 ± 0.23 |  |  |
5-CT MCA | Â | Â | Â | Â | Â | Â | Â | Â |
Sham | 6 | 1.67 ± 0.54 | 17 ± 6a | 42 ± 9a | 8.40 ± 0.14 | 6.08 ± 0.64a |  |  |
SAH | 6 | 2.35 ± 0.40 | 35 ± 2a, b | 60 ± 3a, b | 8.47 ± 0.17 | 7.11 ± 0.01a, b |  |  |
SAH+SB386023-b at 0 h | 5 | 2.45 ± 0.25 | 16 ± 5b | 43 ± 8 | 8.48 ± 0.13 | 6.39 ± 0.33 |  |  |
SAH+SB386023-b after 6 h | 6 | 1.81 ± 0.27 | 21 ± 5b | 45 ± 17 | 8.43 ± 0, 11 | 6.33 ± 0.51 |  |  |
SAH+SB386023-b after 12 h | 6 | 2.09 ± 0.35 | 50 ± 6 | 92 ± 9 | 8.37 ± 0.10 | 6.47 ± 0.02 |  |  |
5-CT BA | Â | Â | Â | Â | Â | Â | Â | Â |
Sham | 6 | 3.90 ± 0.62 | 18 ± 6a | 56 ± 9 | 8.00 ± 0.11a | 6.25 ± 0.15 |  |  |
SAH | 8 | 4.00 ± 0.26 | 43 ± 6a, b | 64 ± 5 | 8.46 ± 0.21a, b | 6.68 ± 0.01 |  |  |
SAH+SB386023-b at 0 h | 6 | 3, 89 ± 0.22 | 20 ± 4b | 47 ± 4 | 8.09 ± 0.21a | 6.12 ± 0.12 |  |  |
SAH+SB386023-b after 6 h | 6 | 4.23 ± 0.41 | 12 ± 3b | 47 ± 9 | 7.92 ± 0.23b | 6.05 ± 0.44 |  |  |
SAH+SB386023-b after 12 h | 6 | 3.75 ± 0.43 | 38 ± 5b | 55 ± 4 | 8.30 ± 0.19a, b | 6.48 ± 0.10 |  |  |