Figure 3From: Neuropeptide delivery to the brain: a von Willebrand factor signal peptide to direct neuropeptide secretionIn vivo effects of AAV-VWF_AgRP 83-132 on energy balance. In situ hybridization showing unilateral transduction of the PVN by 1 μl, containing 1 x 109 g.c., of AAV-VWF-AgRP83-132 (A). AAV-VWF-AgRP83-132 increased food intake (B) and BW gain (C) compared to AAV-GFP. Data at 28 days post injection (N = 3).Back to article page