Figure 5From: Enhancement of L-3-hydroxybutyryl-CoA dehydrogenase activity and circulating ketone body levels by pantethine. Relevance to dopaminergic injuryIn vitro improvement of mitochondrial functions by pantetheine. Mitochondria were isolated from control mice and incubated with increasing concentrations of MPP+ for 5 min; 0, 0.5 or 1 mM pantetheine was then added and (A) complex I activity, (B) oxygen consumption and (C) ATP levels were determined. Values are means ± SD; n = 4 mice per assay. Significant difference between assays in the presence of the absence of pantetheine, **p < 0.01.Back to article page