Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration

Table 1 Cocaine intake data for samples.

	Arrays				qPCR Confirmation
	Group	N	Average Total Intake	Average Injections Per Session	N	Average Total Intake	Average Injections Per Session
mPFC	Naïve	6	-*	-	11	-	-
	1-day Abstinence	6	934 ± 108 mg/kg	62 ± 7	6	934 ± 108 mg/kg	62 ± 7
	10-days Abstinence				7	950 ± 105 mg/kg	63 ± 7
	100-days Abstinence	6	856 ± 42 mg/kg	57 ± 3	8	855 ± 39 mg/kg	57 ± 3
NAc	Naïve	5	-*	-	11	-	-
	1-day Abstinence	5	932 ± 118 mg/kg	57 ± 28	6	934 ± 108 mg/kg	62 ± 7
	10-days Abstinence	5	951 ± 116 mg/kg	63 ± 8	7	950 ± 105 mg/kg	63 ± 7
	100-days Abstinence				8	855 ± 39 mg/kg	57 ± 3

* Naïve animals were not exposed to cocaine, and therefore have zero intake. There were no significant differences in cocaine intake or number of injections per session between groups. "Arrays" indicates animals used for microarray analysis and "qPCR Confirmation indicates animals used for confirmatory qPCR analysis. All of the samples from the array analysis were included in the qPCR confirmation. Data is presented as Mean ± S.D.

ISSN: 1471-2202