Figure 5
From: Viable mouse gene ablations that robustly alter brain Aβ levels are rare
Effect of GPR3 KO on brain Aβ levels in aged mice. Aβ40 and Aβ42 were determined in one year aged mice for 13 GPR3 wild type (G3+/+) and 13 homozygous GPR3 KO (G3-/-) mice. For comparison, Aβ40 and Aβ42 for five young wild type (B1/2+/+) and four young BACE1, BACE2 homozygous double KO (B1/2 dKO) are shown. Values are expressed as percentage of mean value in the GPR3 wild type mice. One individual GPR3 wild type mouse with a value of 624% was excluded from the analysis.