Figure 1
Competition curves of [3H] Ro 15-1788 in the Sch of HIB and NHIB hamsters. Displacement curves of [3H] Ro 15-1788 (mean % of total binding ± s.e.m) showing the differing binding capacities in the suprachiasmatic nucleus (Sch) of a) HIB and b) NHIB hamsters. Competition study was carried out in the presence of different concentration (500 nM-1 nM) of α1 (zolpidem, white square) and α2 (flunitrazepam, black triangle) agonists plus α4 antagonist (Ro 15-4513, black square) and α5 inverse agonist, (Ry 080, white circle) as described in "Materials and Methods". Each point represents the mean of five separate tests.