Figure 4From: Hippocampal CA1/subiculum-prefrontal cortical pathways induce plastic changes of nociceptive responses in cingulate and prelimbic areasHFS/LFS induced LTE and LTD of nociceptive responses in the PFC A: HFS (100 Hz, 20 μA, 15 s) delivered to CA1/SB induced LTE (solid circles) or LTD (open circles) of nociceptive responses in the PFC. B: LFS (1 Hz, 5 pulses, 600 bursts) induced LTD of nociceptive responses (solid squares). The means of three successive trials before HFS (or LFS) served as the control value (100%). Statistical analysis: ** p < 0.01, ***p < 0.001Back to article page