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Figure 5 | BMC Neuroscience

Figure 5

From: Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons

Figure 5

Treatment with CP2 and other TP compounds prevents cholesterol accumulation in HD neurons. A. Intracellular cholesterol levels in striatal neurons from control (C) and HD72 (HD) mice with and without CP2 treatment at different days in culture. Control neurons do not accumulate cholesterol; HD neurons without CP2 treatment accumulate cholesterol to high extent than control neurons (13 DIC). Treatment with CP2 prevented cholesterol accumulation in HD neuron at 13 DIC. At least 15 cells were taken into analysis for each data point. *, p < 0.001. B. Different TP compounds prevent cholesterol accumulation in HD neurons with similar efficiency. Data represent intracellular cholesterol levels in untreated control and HD neurons and neurons treated with 2 μM of different TP compounds on day 13 in culture. Numbers represent relative fluorescence units of filipin staining. At least 10 cells in each experiment were taken into analysis.

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BMC Neuroscience

ISSN: 1471-2202

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