Figure 2From: Intravitreal NGF administration counteracts retina degeneration after permanent carotid artery occlusion in ratMorphometric analysis of the retina and optic nerve in the experimental groups. In the retina, the OPL layer almost disappears in 2VO animal 8 days after surgery (A; Student-t test: ***p < 0.0001). A reduction in the number of ganglion cells 75 days after surgery was also found (B, Student's t test: *p < 0.05). The atrophic effect of ligation is shown as reduction of the optic nerve diameter (C; one-way ANOVA and post hoc Tukey's test: ##p < 0.001). The semiquantitative analysis of relative immunoreactive area for the betaIII-Tubulin (D) shows a strong reduction at 8, 30 and 75 days after ligation (one-way ANOVA and post hoc Tukey's test: #p < 0.05, ##p < 0.001), such as the analysis of MBP (E, one-way ANOVA and post hoc Tukey's test: #p < 0.05; ##p < 0.001). Abbreviations: ONL: outer nuclear layer; OPL: outer plexiform layer; INL: inner nuclear layer; IPL: inner plexiform layer;GCL: ganglion cell layer.Back to article page