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  1. The cryptochrome 1 and 2 genes (cry1 and cry2) are necessary for the generation of circadian rhythms, as mice lacking both of these genes (cry1,2-/-) lack circadian rhythms. We studied sleep in cry1,2-/- mice und...

    Authors: Jonathan P Wisor, Bruce F O'Hara, Akira Terao, Chris P Selby, Thomas S Kilduff, Aziz Sancar, Dale M Edgar and Paul Franken
    Citation: BMC Neuroscience 2002 3:20
  2. Several lines of evidence strongly suggest that agouti-related peptide (AGRP) plays a key role in the regulation of metabolic function but ablation of the AGRP gene has no apparent effect on metabolic function...

    Authors: Hideo Makimura, Tooru M Mizuno, Jason W Mastaitis, Reuven Agami and Charles V Mobbs
    Citation: BMC Neuroscience 2002 3:18
  3. Rat oligonucleotide microarrays were used to detect changes in gene expression in the dorsal root ganglion (DRG) 3 days following sciatic nerve transection (axotomy). Two comparisons were made using two sets o...

    Authors: Michael Costigan, Katia Befort, Laurie Karchewski, Robert S Griffin, Donatella D'Urso, Andrew Allchorne, Joanne Sitarski, James W Mannion, Richard E Pratt and Clifford J Woolf
    Citation: BMC Neuroscience 2002 3:16
  4. Huntington's disease (HD) pathogenesis is due to an expanded polyglutamine tract in huntingtin, but the specificity of neuronal loss compared with other polyglutamine disorders also implies a role for the prot...

    Authors: Hiroki Takano and James F Gusella
    Citation: BMC Neuroscience 2002 3:15
  5. Current efforts to study the genetic underpinnings of higher brain functions have been lacking appropriate phenotypes to describe cognition. One of the problems is that many cognitive concepts for which there ...

    Authors: John Fossella, Tobias Sommer, Jin Fan, Yanhong Wu, James M Swanson, Donald W Pfaff and Michael I Posner
    Citation: BMC Neuroscience 2002 3:14
  6. Oxidative stress has shown to contribute in the mechanisms underlying apoptotic cell death occuring in AIDS-dementia complex. Here we investigated the role of peroxynitrite in apoptosis occurring in astroglial...

    Authors: Carolina Muscoli, Daniela Salvemini, Donatella Paolino, Michelangelo Iannone, Ernesto Palma, Antonio Cufari, Domenicantonio Rotiroti, Carlo Federico Perno, Stefano Aquaro and Vincenzo Mollace
    Citation: BMC Neuroscience 2002 3:13
  7. Neurons in the dorsal spinal cord play important roles in nociception and pain. These neurons receive input from peripheral sensory neurons and then transmit the signals to the brain, as well as receive and in...

    Authors: Hong Sun, Jian Xu, Kimberly B Della Penna, Robert J Benz, Fumi Kinose, Daniel J Holder, Kenneth S Koblan, David L Gerhold and Hao Wang
    Citation: BMC Neuroscience 2002 3:11
  8. Starting from Benzer's initiative, the approach of forward genetics has been widely used to isolate mutations affecting learning and memory. For this aim, mainly the odor-shock conditioning was employed. We ha...

    Authors: Nikolai G Kamyshev, Konstantin G Iliadi, Julia V Bragina, Elena A Kamysheva, Elena V Tokmatcheva, Thomas Preat and Elena V Savvateeva-Popova
    Citation: BMC Neuroscience 2002 3:9
  9. This work examines the central nervous system distribution of virus-labeled neurons from the rat urinary bladder and the prostate simultaneously within the same tissue sections. Two immunohistochemically disti...

    Authors: Irving Nadelhaft, Alejandro J Miranda-Sousa and Pedro L Vera
    Citation: BMC Neuroscience 2002 3:8
  10. The jellyfish green fluorescent protein (GFP) can be inserted into the middle of another protein to produce a functional, fluorescent fusion protein. Finding permissive sites for insertion, however, can be dif...

    Authors: Douglas L Sheridan, Catherine H Berlot, Antoine Robert, Fiona M Inglis, Klara B Jakobsdottir, James R Howe and Thomas E Hughes
    Citation: BMC Neuroscience 2002 3:7
  11. Previously, we reported effects of the cry b mutation on circadian rhythms in period and timeless gene expression within isolated peripheral Drosophila tissues. We relied on...

    Authors: Joel D Levine, Pablo Funes, Harold B Dowse and Jeffrey C Hall
    Citation: BMC Neuroscience 2002 3:5
  12. Previous studies have demonstrated that centrally administered natriuretic peptides and pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) have hyperthermic properties. Isatin (indole-2, 3-dione)...

    Authors: Imre Pataki, Ágnes Adamik, Vivette Glover, Gábor Tóth and Gyula Telegdy
    Citation: BMC Neuroscience 2002 3:2
  13. Circadian clocks are biological oscillators that regulate molecular, physiological, and behavioral rhythms in a wide variety of organisms. While behavioral rhythms are typically monitored over many cycles, a s...

    Authors: Joel D Levine, Pablo Funes, Harold B Dowse and Jeffrey C Hall
    Citation: BMC Neuroscience 2002 3:1
  14. In learning and memory tasks, requiring visual spatial memory (VSM), males exhibit higher performance levels compared to females (a difference attributed to sex steroid hormonal influences). Based upon the res...

    Authors: Trent D Lund and Edwin D Lephart
    Citation: BMC Neuroscience 2001 2:21
  15. In learning and memory tasks, requiring visual spatial memory (VSM), males exhibit superior performance to females (a difference attributed to the hormonal influence of estrogen). This study examined the influ...

    Authors: Trent D Lund, Timothy W West, Lilyan Y Tian, Lihong H Bu, Daniel L Simmons, Kenneth DR Setchell, Herman Adlercreutz and Edwin D Lephart
    Citation: BMC Neuroscience 2001 2:20
  16. Recently a hyperthermic rat hippocampal slice model system has been used to investigate febrile seizure pathophysiology. Our previous data indicates that heating immature rat hippocampal slices from 34 to 41°C...

    Authors: Jie Wu, Sam P Javedan, Kevin Ellsworth, Kris Smith and Robert S Fisher
    Citation: BMC Neuroscience 2001 2:18
  17. One mechanism that directs the action of the second messengers, cAMP and diacylglycerol, is the compartmentalization of protein kinase A (PKA) and protein kinase C (PKC). A-kinase anchoring proteins (AKAPs) ca...

    Authors: Guy A Perkins, Lin Wang, Lily Jun-shen Huang, Kenneth Humphries, Virginia J Yao, Maryann Martone, Thomas J Deerinck, David M Barraclough, Jonathan D Violin, Donelson Smith, Alexandra Newton, John D Scott, Susan S Taylor and Mark H Ellisman
    Citation: BMC Neuroscience 2001 2:17
  18. Current efforts to study the genetics of higher functions have been lacking appropriate phenotypes to describe cognition. One of the problems is that many cognitive concepts for which there is a single word (e...

    Authors: Jin Fan, Yanhong Wu, John A Fossella and Michael I Posner
    Citation: BMC Neuroscience 2001 2:14
  19. Predictions from conduction velocity data for primate retinal ganglion cell axons indicate that the conduction time to the lateral geniculate nucleus for stimulation of peripheral retina should be no longer th...

    Authors: Jennifer H Darrien, Katrina Herd, Lisa-Jo Starling, Jay R Rosenberg and James D Morrison
    Citation: BMC Neuroscience 2001 2:13
  20. BMP-5 is expressed in the nervous system throughout development and into adulthood. However its effects on neural tissues are not well defined. BMP-5 is a member of the 60A subgroup of BMPs, other members of w...

    Authors: Hiroko N Beck, Karen Drahushuk, David B Jacoby, Dennis Higgins and Pamela J Lein
    Citation: BMC Neuroscience 2001 2:12
  21. Alterations in arginine vasopressin regulation and secretion have been proposed as one possible biochemical abnormality in patients with obsessive-compulsive disorder. In golden hamsters, arginine vasopressin ...

    Authors: Craig F Ferris, Mads F Rasmussen, Tara Messenger and Gary Koppel
    Citation: BMC Neuroscience 2001 2:10
  22. Axons within the mature mammalian central nervous system fail to regenerate following injury, usually resulting in long-lasting motor and sensory deficits. Studies involving transplantation of adult neurons in...

    Authors: David B Pettigrew, Kristina P Shockley and Keith A Crutcher
    Citation: BMC Neuroscience 2001 2:8
  23. Taste receptor cells are responsible for transducing chemical stimuli into electrical signals that lead to the sense of taste. An important second messenger in taste transduction is IP3, which is involved in both...

    Authors: Tod R Clapp, Leslie M Stone, Robert F Margolskee and Sue C Kinnamon
    Citation: BMC Neuroscience 2001 2:6
  24. A previous report showed that the open field behavior of rats sensitized to the dopamine agonist quinpirole satisfies 5 performance criteria for compulsive checking behavior. In an effort to extend the paralle...

    Authors: Henry Szechtman, Michael J Eckert, Wai S Tse, Jonathan T Boersma, Carlo A Bonura, Jessica Z McClelland, Kirsten E Culver and David Eilam
    Citation: BMC Neuroscience 2001 2:4
  25. Human immunodeficiency virus (HIV) infection continues to increase at alarming rates in drug abusers, especially in women. Drugs of abuse can cause long-lasting damage to the brain and HIV infection frequently...

    Authors: Jadwiga Turchan, Caroline Anderson, Kurt F Hauser, Qinmiao Sun, Jiayou Zhang, Ying Liu, Phyllis M Wise, Inna Kruman, William Maragos, Mark P Mattson, Rosemarie Booze and Avindra Nath
    Citation: BMC Neuroscience 2001 2:3
  26. Chemical methods of transfection that have proven successful with cell lines often do not work with primary cultures of neurons. Recent data, however, suggest that linear polymers of the cation polyethyleneimi...

    Authors: Craig Horbinski, Michal K Stachowiak, Dennis Higgins and Sarah G Finnegan
    Citation: BMC Neuroscience 2001 2:2
  27. The fly visual system is a highly ordered brain structure with well-established physiological and behavioral functions. A large number of interneurons in the posterior part of the third visual neuropil, the lo...

    Authors: Tilmann M Brotz, Eckart D Gundelfinger and Alexander Borst
    Citation: BMC Neuroscience 2001 2:1

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