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  1. Gamma-aminobutyric acid type A receptors (GABAA-Rs) are the major inhibitory receptors in the mammalian brain and are modulated by a number of sedative/hypnotic drugs including benzodiazepines and anesthetics. Th...

    Authors: Dev Chandra, Esa R Korpi, Celia P Miralles, Angel L De Blas and Gregg E Homanics
    Citation: BMC Neuroscience 2005 6:30
  2. While SII cortex is considered to be the first cortical stage of the pathway that integrates tactile information arising from both sides of the body, SI cortex is generally not considered as a region in which ...

    Authors: Mark Tommerdahl, Stephen B Simons, Joannellyn S Chiu, Oleg Favorov and Barry Whitsel
    Citation: BMC Neuroscience 2005 6:29
  3. Neural stem cells (NSCs) can be isolated from the adult mammalian brain and expanded in culture, in the form of cellular aggregates called neurospheres. Neurospheres provide an in vitro model for studying NSC beh...

    Authors: Maria Sievertzon, Valtteri Wirta, Alex Mercer, Konstantinos Meletis, Rikard Erlandsson, Lilian Wikström, Jonas Frisén and Joakim Lundeberg
    Citation: BMC Neuroscience 2005 6:28
  4. The neuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative disorders characterized by accumulation of autofluorescent material in many tissues, especially in neurons. Mutations in the CL...

    Authors: Liina Lonka, Antti Aalto, Outi Kopra, Mervi Kuronen, Zaal Kokaia, Mart Saarma and Anna-Elina Lehesjoki
    Citation: BMC Neuroscience 2005 6:27
  5. The forebrain subventricular zone (SVZ)-olfactory bulb pathway and hippocampal subgranular zone (SGZ) generate neurons into adulthood in the mammalian brain. Neurogenesis increases after injury to the adult br...

    Authors: Maryam Faiz, Laia Acarin, Bernardo Castellano and Berta Gonzalez
    Citation: BMC Neuroscience 2005 6:26
  6. Annexin A7 is a member of the annexin protein family, which is characterized by its ability to interact with phospholipids in the presence of Ca2+-ions and which is thought to function in Ca2+-homeostasis. Result...

    Authors: Michaela Rick, Soraya I Ramos Garrido, Claudia Herr, Dietmar R Thal, Angelika A Noegel and Christoph S Clemen
    Citation: BMC Neuroscience 2005 6:25
  7. Neurite growth can be elicited by growth factors and interactions with extracellular matrix molecules like laminin. Among the targets of the signalling pathways activated by these stimuli are cytoskeletal elem...

    Authors: Kristy L Williams, Masuma Rahimtula and Karen M Mearow
    Citation: BMC Neuroscience 2005 6:24
  8. The sweet taste inhibitor lactisole acts on the human sweet taste receptor heteromer TAS1R2-TAS1R3 but not on its rodent counterpart. Recently, it was shown that the lactisole sensitivity of the human sweet ta...

    Authors: Marcel Winnig, Bernd Bufe and Wolfgang Meyerhof
    Citation: BMC Neuroscience 2005 6:22
  9. In mammals, the CNS vasculature is established during the postnatal period via active angiogenesis, providing different brain regions with capillary networks of various densities that locally supply adapted me...

    Authors: Gérard Alonso, Evelyne Galibert, Anne Duvoid-Guillou and Anne Vincent
    Citation: BMC Neuroscience 2005 6:20
  10. When spinal motor axons are injured, the nucleolus, nucleus and cell body of the injured cell transiently increase in size, the nucleus becomes more eccentrically placed, and the organization of polyribosomes ...

    Authors: David L McIlwain and Victoria B Hoke
    Citation: BMC Neuroscience 2005 6:19
  11. Recent discoveries suggest that arealization of the mammalian cortical sheet develops in a manner consonant with principles established for embryonic patterning of the body. Signaling centers release morphogen...

    Authors: David C Airey, Alicia I Robbins, Katherine M Enzinger, Fangbai Wu and Christine E Collins
    Citation: BMC Neuroscience 2005 6:18
  12. Mechanisms that affect recovery from fetal and neonatal hypoxic-ischemic (H-I) brain injury have not been fully elucidated. The incidence of intrapartum asphyxia is approximately 2.5%, but the occurrence of ad...

    Authors: John Bartley, Thomas Soltau, Hereward Wimborne, Sunjun Kim, Angeline Martin-Studdard, David Hess, William Hill, Jennifer Waller and James Carroll
    Citation: BMC Neuroscience 2005 6:15
  13. Physiological and morphological evidence suggests that activation of the ventromedial preoptic area of the hypothalamus (VMPO) is an essential component of an intravenous LPS-dependent fever. In response to th...

    Authors: Heather J Ranels and John D Griffin
    Citation: BMC Neuroscience 2005 6:14
  14. Apoptosis plays a key role in cell death observed in neurodegenerative diseases marked by a progressive loss of neurons as seen in Alzheimer's disease. Although the exact cause of apoptosis is not known, a num...

    Authors: YueMei Zhang and Bhagu R Bhavnani
    Citation: BMC Neuroscience 2005 6:13
  15. A distinctive property of SII is that it is the first cortical stage of the somatosensory projection pathway that integrates information arising from both sides of the body. However, there is very little known...

    Authors: Mark Tommerdahl, Stephen B Simons, Joannellyn S Chiu, Vinay Tannan, Oleg Favorov and Barry Whitsel
    Citation: BMC Neuroscience 2005 6:11
  16. The blood brain barrier (BBB) is the first line of defence of the central nervous system (CNS) against circulating pathogens, such as HIV. The cytotoxic HIV protein, gp120, damages endothelial cells of the BBB...

    Authors: Dianne Langford, Rosemary Hurford, Makoto Hashimoto, Murat Digicaylioglu and Eliezer Masliah
    Citation: BMC Neuroscience 2005 6:8
  17. The pathology of Alzheimer's disease (AD) is comprised of extracellular amyloid plaques, intracellular tau tangles, dystrophic neurites and neurodegeneration. The mechanisms by which these various pathological...

    Authors: Chad A Dickey, Marcia N Gordon, Donna M Wilcock, Donna L Herber, Melissa J Freeman and Dave Morgan
    Citation: BMC Neuroscience 2005 6:7
  18. The progressive nature of Wallerian degeneration has long been controversial. Conflicting reports that distal stumps of injured axons degenerate anterogradely, retrogradely, or simultaneously are based on stat...

    Authors: Bogdan Beirowski, Robert Adalbert, Diana Wagner, Daniela S Grumme, Klaus Addicks, Richard R Ribchester and Michael P Coleman
    Citation: BMC Neuroscience 2005 6:6
  19. In Leber's congenital amaurosis (LCA), affected individuals are blind, or nearly so, from birth. This early onset suggests abnormal development of the neural retina. Mutations in genes that affect the developm...

    Authors: Eric M Morrow, Takahisa Furukawa, Elio Raviola and Constance L Cepko
    Citation: BMC Neuroscience 2005 6:5
  20. Nerve growth factor (NGF), glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) all play important roles in the development of the peripheral sensory nervous system. ...

    Authors: Theodore J Price, Michael D Louria, Damaries Candelario-Soto, Gregory O Dussor, Nathanial A Jeske, Amol M Patwardhan, Anibal Diogenes, Amanda A Trott, Kenneth M Hargreaves and Christopher M Flores
    Citation: BMC Neuroscience 2005 6:4
  21. Iron is necessary for neuronal function but in excess generates neurodegeneration. Although most of the components of the iron homeostasis machinery have been described in neurons, little is known about the pa...

    Authors: Pabla Aguirre, Natalia Mena, Victoria Tapia, Miguel Arredondo and Marco T Núñez
    Citation: BMC Neuroscience 2005 6:3
  22. Nicotinic acetylcholine receptors (nAChRs) are pentameric proteins that are important drug targets for a variety of diseases including Alzheimer's, schizophrenia and various forms of epilepsy. One of the most ...

    Authors: Steven D Buckingham, Luanda Pym, Andrew K Jones, Laurence Brown, Mark SP Sansom, David B Sattelle and Philip C Biggin
    Citation: BMC Neuroscience 2005 6:2
  23. Huntington's disease (HD) is an inherited neurodegenerative disorder triggered by an expanded polyglutamine tract in huntingtin that is thought to confer a new conformational property on this large protein. Th...

    Authors: Jin Wang, Silvia Gines, Marcy E MacDonald and James F Gusella
    Citation: BMC Neuroscience 2005 6:1
  24. Define covariates of cerebrospinal corticotropin-releasing hormone (CRH) levels in normal humans. CRHCSF was measured in 9 normal subjects as part of an intensive study of physiological responses stressors in chr...

    Authors: James N Baraniuk, Hilda Maibach, Gail Whalen and Daniel J Clauw
    Citation: BMC Neuroscience 2004 5:58
  25. JNCL is a recessively inherited, childhood-onset neurodegenerative disease most-commonly caused by a ~1 kb CLN3 mutation. The resulting loss of battenin activity leads to deposition of mitochondrial ATP synthase,...

    Authors: Elisa Fossale, Pavlina Wolf, Janice A Espinola, Tanya Lubicz-Nawrocka, Allison M Teed, Hanlin Gao, Dorotea Rigamonti, Elena Cattaneo, Marcy E MacDonald and Susan L Cotman
    Citation: BMC Neuroscience 2004 5:57
  26. Sign-language comprehension activates the auditory cortex in deaf subjects. It is not known whether this functional plasticity in the temporal cortex is age dependent. We conducted functional magnetic-resonanc...

    Authors: Norihiro Sadato, Hiroki Yamada, Tomohisa Okada, Masaki Yoshida, Takehiro Hasegawa, Ken-Ichi Matsuki, Yoshiharu Yonekura and Harumi Itoh
    Citation: BMC Neuroscience 2004 5:56
  27. The neuroprotective effect of xenon has been demonstrated for glutamatergic neurons. In the present study it is investigated if dopaminergic neurons, i.e. nerve-growth-factor differentiated PC-12 cells, are pr...

    Authors: Christian Petzelt, Per Blom, Wolfgang Schmehl, Jana Müller and Wolfgang J Kox
    Citation: BMC Neuroscience 2004 5:55
  28. Leptin and insulin are long-term regulators of body weight. They act in hypothalamic centres to modulate the function of specific neuronal subtypes, by altering transcriptional control of releasable peptides a...

    Authors: Shirin Mirshamsi, Hilary A Laidlaw, Ke Ning, Erin Anderson, Laura A Burgess, Alexander Gray, Calum Sutherland and Michael LJ Ashford
    Citation: BMC Neuroscience 2004 5:54
  29. GABAergic inhibition and effects of intracellular chloride ions on calcium channel activity have been proposed to regulate neurotransmission from photoreceptors. To assess the impact of these and other chlorid...

    Authors: Wallace B Thoreson and Eric J Bryson
    Citation: BMC Neuroscience 2004 5:53
  30. Ischemia within the optic nerve head (ONH) may contribute to retinal ganglion cell (RGC) loss in primary open angle glaucoma (POAG). Ischemia has been reported to increase neurotrophin and high affinity Trk re...

    Authors: Wendi S Lambert, Abbot F Clark and Robert J Wordinger
    Citation: BMC Neuroscience 2004 5:51
  31. Chronic food restriction augments the rewarding effect of centrally administered psychostimulant drugs and this effect may involve a previously documented upregulation of D-1 dopamine receptor-mediated MAP kin...

    Authors: Yan Pan, Yemiliya Berman and Kenneth D Carr
    Citation: BMC Neuroscience 2004 5:50
  32. There is great interest in appropriate phenotypes that serve as indicator of genetically transmitted frontal (dys)function, such as ADHD. Here we investigate the ability to deal with response conflict, and we ...

    Authors: John F Stins, G Caroline M van Baal, Tinca JC Polderman, Frank C Verhulst and Dorret I Boomsma
    Citation: BMC Neuroscience 2004 5:49
  33. Behavior results from the integration of ongoing sensory signals and contextual information in various forms, such as past experience, expectations, current goals, etc. Thus, the response to a specific stimulu...

    Authors: Emilio Salinas
    Citation: BMC Neuroscience 2004 5:47
  34. During the preovulatory surge of gonadotropin-releasing hormone (GnRH), a very large amount of the peptide is released in the hypothalamo-hypophyseal portal blood for 24-36H00. To study whether this release is...

    Authors: Martine Batailler, Alain Caraty, Benoît Malpaux and Yves Tillet
    Citation: BMC Neuroscience 2004 5:46
  35. Human faces provide important signals in social interactions by inferring two main types of information, individual identity and emotional expression. The ability to readily assess both, the variability and co...

    Authors: Jan Gläscher, Oliver Tüscher, Cornelius Weiller and Christian Büchel
    Citation: BMC Neuroscience 2004 5:45
  36. Knowledge of how synapses alter their efficiency of communication is central to the understanding of learning and memory. The most extensively studied forms of synaptic plasticity are long-term potentiation (L...

    Authors: Andreas Lüthi, Martin A Wikström, Mary J Palmer, Paul Matthews, Tim A Benke, John TR Isaac and Graham L Collingridge
    Citation: BMC Neuroscience 2004 5:44
  37. Topographic reorganization of central maps following peripheral nerve injury has been well characterized. Despite extensive documentation of these physiological changes, the underlying anatomical correlates ha...

    Authors: James D Churchill, Jason A Tharp, Cara L Wellman, Dale R Sengelaub and Preston E Garraghty
    Citation: BMC Neuroscience 2004 5:43
  38. Consciousness poses two main problems. The first is understanding the conditions that determine to what extent a system has conscious experience. For instance, why is our consciousness generated by certain par...

    Authors: Giulio Tononi
    Citation: BMC Neuroscience 2004 5:42
  39. In order to optimize the potential benefits of neural stem cell (NSC) transplantation for the treatment of neurodegenerative disorders, it is necessary to understand their biological characteristics. Although ...

    Authors: Lennard P Niles, Kristen J Armstrong, Lyda M Rincón Castro, Chung V Dao, Rohita Sharma, Catherine R McMillan, Laurie C Doering and David L Kirkham
    Citation: BMC Neuroscience 2004 5:41
  40. How does the brain convert sounds and phonemes into comprehensible speech? In the present magnetoencephalographic study we examined the hypothesis that the coherence of electromagnetic oscillatory activity wit...

    Authors: Markus Härle, Brigitte S Rockstroh, Andreas Keil, Christian Wienbruch and Thomas R Elbert
    Citation: BMC Neuroscience 2004 5:40
  41. Tasks involving conflict are widely used to study executive attention. In the flanker task, a target stimulus is surrounded by distracting information that can be congruent or incongruent with the correct resp...

    Authors: M Rosario Rueda, Michael I Posner, Mary K Rothbart and Clintin P Davis-Stober
    Citation: BMC Neuroscience 2004 5:39

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