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  1. Rodent brain slices—particularly hippocampal slices—are widely used in experimental investigations of epileptiform activity. Oxygenated artificial cerebrospinal fluid (ACSF) is used to maintain slices in vitro...

    Authors: Haiyu Liu, Sai Zhang and Liang Zhang

    Citation: BMC Neuroscience 2021 22:46

    Content type: Methodology article

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  2. During infection and inflammation, a reduced oxygen level clearly affects cellular functions. Oxygen levels during CNS infections are unknown. Here we established and evaluated an in vivo measurement system to...

    Authors: Nicole de Buhr, Alexander Martens, Marita Meurer, Marta C. Bonilla, Franz Söbbeler, Lara Twele, Stephan Neudeck, Michael Wendt, Andreas Beineke, Sabine Kästner and Maren von Köckritz-Blickwede

    Citation: BMC Neuroscience 2021 22:45

    Content type: Research

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  3. The aim of this study was to investigate whether AMN082 exerts its neuroprotective effect by attenuating glutamate receptor-associated neuronal apoptosis and improving functional outcomes after traumatic brain...

    Authors: Chung-Che Lu, Tee-Tau Eric Nyam, Jinn-Rung Kuo, Yao-Lin Lee, Chung-Ching Chio and Che-Chuan Wang

    Citation: BMC Neuroscience 2021 22:44

    Content type: Research

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  4. Autism, a childhood behavioral disorder, belongs to a large suite of diseases, collectively referred to as autism spectrum disorders (ASD). Though multifactorial in etiology, approximately 10% of ASD are assoc...

    Authors: Kyong-Oh Shin, Debra A. Crumrine, Sungeun Kim, Yerin Lee, Bogyeong Kim, Katrina Abuabara, Chaehyeong Park, Yoshikazu Uchida, Joan S. Wakefield, Jason M. Meyer, Sekyoo Jeong, Byeong Deog Park, Kyungho Park and Peter M. Elias

    Citation: BMC Neuroscience 2021 22:43

    Content type: Research article

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  5. ETB has been reported to regulate neurogenesis and vasoregulation in foetal development. Its dysfunction was known to cause HSCR, an aganglionic colonic disorder with syndromic forms reported to associate with bo...

    Authors: Ko-Chin Chen, Zan-Min Song and Geoffrey D. Croaker

    Citation: BMC Neuroscience 2021 22:42

    Content type: Research article

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  6. Memantine, a low- to moderate-affinity uncompetitive N-methyl-D-aspartate receptor antagonist, has been shown to improve cognitive functions in animal models of Alzheimer’s disease (AD). Here we treated APP/PS...

    Authors: Peng Li, Jin Xu, Huanhuan Gu, Hua Peng, You Yin and Jianhua Zhuang

    Citation: BMC Neuroscience 2021 22:41

    Content type: Research

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  7. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12868-021-00644-1

    Authors: Sabine Wislet-Gendebien, Naomi P. Visanji, Shawn N. Whitehead, Diana Marsilio, Weimin Hou, Daniel Figeys, Paul E. Fraser, Steffany A. L. Bennett and Anurag Tandon

    Citation: BMC Neuroscience 2021 22:40

    Content type: Retraction Note

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    The original article was published in BMC Neuroscience 2008 9:92

  8. Matrix metallopeptidase 9 (MMP9) has been implicated in a variety of neurological disorders, including Alzheimer’s disease (AD), where MMP9 levels are elevated in the brain and cerebrovasculature. Previously o...

    Authors: Charis Ringland, Jonas Elias Schweig, Maxwell Eisenbaum, Daniel Paris, Ghania Ait-Ghezala, Michael Mullan, Fiona Crawford, Laila Abdullah and Corbin Bachmeier

    Citation: BMC Neuroscience 2021 22:39

    Content type: Research

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  9. The receptor for advanced glycation end-products (RAGE) is involved in neuroinflammation. This study investigated the changes in RAGE expression following noise-induced hearing loss.

    Authors: Chang Ho Lee, Kyung Woon Kim, Da-hye Lee, So Min Lee and So Young Kim

    Citation: BMC Neuroscience 2021 22:38

    Content type: Research article

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  10. Pathophysiological evidence from temporal lobe epilepsy models highlights the hippocampus as the most affected structure due to its high degree of neuroplasticity and control of the dynamics of limbic structur...

    Authors: Miguel A. Núñez-Ochoa, Gustavo A. Chiprés-Tinajero, Nadia P. González-Domínguez and Laura Medina-Ceja

    Citation: BMC Neuroscience 2021 22:37

    Content type: Research article

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  11. The neural networks underpinning language control and domain-general executive functions overlap in bilinguals, but existing evidence is mainly correlative. Here, we present the first neurofunctional evidence ...

    Authors: Yan Jing Wu, Mo Chen, Guillaume Thierry, Yongben Fu, Junjie Wu and Taomei Guo

    Citation: BMC Neuroscience 2021 22:36

    Content type: Research article

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  12. Asymptomatic Moyamoya disease (MMD) impairs hemodynamic and cognitive function. The relationship between these changes, cerebral blood flow (CBF), and network connectivity remains largely unknown. The aim of t...

    Authors: Shihao He, Ziqi Liu, Yanchang Wei, Ran Duan, Zongsheng Xu, Cai Zhang, Li Yuan, Tian Li, Ning Ma, Xin Lou, Xiaoyuan Liu and Rong Wang

    Citation: BMC Neuroscience 2021 22:35

    Content type: Research

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  13. The Grooved Pegboard Test (GPT) is widely adopted to evaluate manual dexterity, it presents normative data but the test is influenced by different factors. The influence of time spent on smartphones has not be...

    Authors: Luca Petrigna, Milda Treigienė, Ewan Thomas, Diba Mani, Simona Pajaujiene, Patrik Drid, Gioacchino Lavanco, Antonio Palma and Antonino Bianco

    Citation: BMC Neuroscience 2021 22:34

    Content type: Research article

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  14. Autism spectrum disorder (ASD) is characterized by the core symptoms of impaired social interactions. Increasing evidence suggests that ASD has a strong genetic link with mutations in chromodomain helicase DNA...

    Authors: Stanislav M. Cherepanov, Maria Gerasimenko, Teruko Yuhi, Kazumi Furuhara, Chiharu Tsuji, Shigeru Yokoyama, Keiichi I. Nakayama, Masaaki Nishiyama and Haruhiro Higashida

    Citation: BMC Neuroscience 2021 22:32

    Content type: Research article

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  15. Protective ventilation with lower tidal volumes reduces systemic and organ-specific inflammation. In sepsis-induced encephalopathy or acute brain injury the use of protective ventilation has not been widely in...

    Authors: Axel Nyberg, Erik Gremo, Jonas Blixt, Jesper Sperber, Anders Larsson, Miklós Lipcsey, Andreas Pikwer and Markus Castegren

    Citation: BMC Neuroscience 2021 22:31

    Content type: Research article

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  16. In everyday life, negative emotions can be implicitly regulated by positive stimuli, without any conscious cognitive engagement; however, the effects of such implicit regulation on mood and related neuro-mecha...

    Authors: M. Berthold-Losleben, S. Papalini, U. Habel, K. Losleben, F. Schneider, K. Amunts and N. Kohn

    Citation: BMC Neuroscience 2021 22:30

    Content type: Research

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  17. The implication of the steroids estradiol, progesterone and testosterone in cerebral vasospasm after aneurysmal subarachnoid hemorrhage (aSAH) has not been comprehensively assessed. In rodents, studies suggest...

    Authors: Jan Martin, Eva Plank, Bernhard Ulm, Jens Gempt, Maria Wostrack, Bettina Jungwirth and Simone M. Kagerbauer

    Citation: BMC Neuroscience 2021 22:29

    Content type: Research article

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  18. Brain radiation exposure, in particular, radiotherapy, can induce cognitive impairment in patients, with significant effects persisting for the rest of their life. However, the main mechanisms leading to this ...

    Authors: Bo Xu Ren, Isaac Huen, Zi Jun Wu, Hong Wang, Meng Yun Duan, Ilonka Guenther, K. N. Bhanu Prakash and Feng Ru Tang

    Citation: BMC Neuroscience 2021 22:28

    Content type: Research article

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  19. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Mara A. Guzmán-Ruiz, Amor Herrera-González, Adriana Jiménez, Alan Candelas-Juárez, Crystal Quiroga-Lozano, Claudia Castillo-Díaz, Erika Orta-Salazar, Diana Organista-Juárez, Sofía Díaz-Cintra and Rosalinda Guevara-Guzmán

    Citation: BMC Neuroscience 2021 22:27

    Content type: Correction

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    The original article was published in BMC Neuroscience 2021 22:14

  20. Nociceptin/orphanin FQ (N/OFQ) has been revealed to play bidirectional roles in orofacial pain modulation. Calcitonin gene-related peptide (CGRP) is a well-known pro-nociceptive molecule that participates in t...

    Authors: Xinyu Yan, Han Han, Shizhen Zhang, Yanzhu Lu, Linghuan Ren, Yufei Tang, Xiaolong Li, Fan Jian, Yan Wang, Hu Long and Wenli Lai

    Citation: BMC Neuroscience 2021 22:25

    Content type: Research article

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  21. Methamphetamine (METH) is one of the most widely abused illicit substances worldwide; unfortunately, its addiction mechanism remains unclear. Based on accumulating evidence, changes in gene expression and chro...

    Authors: Hui Li, Jing-An Chen, Qian-Zhi Ding, Guan-Yi Lu, Ning Wu, Rui-Bin Su, Fei Li and Jin Li

    Citation: BMC Neuroscience 2021 22:24

    Content type: Research article

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  22. Tau theory explains how both intrinsically and perceptually guided movements are controlled by the brain. According to general tau theory, voluntary, self-paced human movements are controlled by coupling the t...

    Authors: Mehrdad Bahadori, Paola Cesari, Cathy Craig and Mehran Emadi Andani

    Citation: BMC Neuroscience 2021 22:23

    Content type: Research article

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  23. Differences of genotypes between male and female have been studied in Parkinson’s disease (PD), but limited research has focused on the comparison between sexes with LRRK2 G2385 variant.

    Authors: Shi-Shuang Cui, Rao Fu, Juan-Juan Du, Yi-Qi Lin, Pei Huang, Chao Gao, Hai-Yan Zhou and Sheng-Di Chen

    Citation: BMC Neuroscience 2021 22:22

    Content type: Research article

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  24. Hepatic encephalopathy (HE) is a neurological complication resulting from acute or chronic liver disease. Hyperammonemia leading to astrocyte swelling and cerebral edema in combination with neuroinflammation i...

    Authors: Fatme Seval Ismail, Timo Jendrik Faustmann, Franco Corvace, Anamariya Tsvetanova, Zahra Moinfar and Pedro M. Faustmann

    Citation: BMC Neuroscience 2021 22:21

    Content type: Research article

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  25. Atherosclerotic plaques are often present in regions of arteries with complicated flow patterns. Vascular morphology plays important role in hemodynamics. In this study, we investigated the relationship betwee...

    Authors: Jinmei Zheng, Bin Sun, Ruolan Lin, Yongqi Teng, Xihai Zhao and Yunjing Xue

    Citation: BMC Neuroscience 2021 22:20

    Content type: Research article

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  26. The SCN11A gene, encoded Nav1.9 TTX resistant sodium channels, is a main effector in peripheral inflammation related pain in nociceptive neurons. The role of SCN11A gene in the auditory system has not been well c...

    Authors: Mian Zu, Wei-Wei Guo, Tao Cong, Fei Ji, Shi-Li Zhang, Yue Zhang, Xin Song, Wei Sun, David Z. Z. He, Wei-Guo Shi and Shi-Ming Yang

    Citation: BMC Neuroscience 2021 22:18

    Content type: Research article

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  27. Several studies have shown that glutamate neurotransmission in the nucleus accumbens (NAc) is required for the development of morphine-induced conditional place preference (CPP). In addition, metabotropic glut...

    Authors: Zahra Ebrahimi, Nazanin Kahvandi, Alireza Komaki, Seyed Asaad Karimi, Marzieh Naderishahab and Abdolrahman Sarihi

    Citation: BMC Neuroscience 2021 22:17

    Content type: Research article

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  28. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Laszlo Szpisjak, Gabor Szaraz, Andras Salamon, Viola L. Nemeth, Noemi Szepfalusi, Gabor Veres, Balint Kincses, Zoltan Maroti, Tibor Kalmar, Malgorzata Rydzanicz, Rafal Ploski, Peter Klivenyi and Denes Zadori

    Citation: BMC Neuroscience 2021 22:16

    Content type: Correction

    Published on:

    The original article was published in BMC Neuroscience 2021 22:7

  29. Rupture of intracranial aneurysm (IA) is the main cause of devastating subarachnoid hemorrhage, which urges our understanding of the pathogenesis and regulatory mechanisms of IA. However, the regulatory roles ...

    Authors: Yuan-Bo Pan, Jianan Lu, Biao Yang, Cameron Lenahan, Jianmin Zhang and Anwen Shao

    Citation: BMC Neuroscience 2021 22:15

    Content type: Research article

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  30. Alzheimer’s disease (AD) is characterized by cognitive impairment that eventually develops into dementia. Amyloid-beta (Aβ) accumulation is a widely described hallmark in AD, and has been reported to cause olf...

    Authors: Mara A. Guzmán-Ruiz, Amor Herrera-González, Adriana Jiménez, Alan Candelas-Juárez, Crystal Quiroga-Lozano, Claudia Castillo-Díaz, Erika Orta-Salazar, Diana Organista-Juárez, Sofía Díaz-Cintra and Rosalinda Guevara-Guzmán

    Citation: BMC Neuroscience 2021 22:14

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Neuroscience 2021 22:27

  31. Aside from the homeostatic and circadian components, light has itself an important, direct as well as indirect role in sleep regulation. Light exerts indirect sleep effect by modulating the circadian rhythms. ...

    Authors: Örs Szalontai, Attila Tóth, Máté Pethő, Dóra Keserű, Tünde Hajnik and László Détári

    Citation: BMC Neuroscience 2021 22:13

    Content type: Research article

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  32. Men and women show differences in sensitivity to reward and punishment, which may impact behavior in health and disease. However, the neural bases of these sex differences remain under-investigated. Here, by c...

    Authors: Isha Dhingra, Sheng Zhang, Simon Zhornitsky, Wuyi Wang, Thang M. Le and Chiang-Shan R. Li

    Citation: BMC Neuroscience 2021 22:12

    Content type: Research article

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  33. Attachment theory demonstrates that early attachment experience shapes internal working models with mental representations of self and close relationships, which affects personality traits and interpersonal re...

    Authors: Min Deng, Xing Zhang, Xiaoyan Bi and Chunhai Gao

    Citation: BMC Neuroscience 2021 22:11

    Content type: Research article

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  34. There is growing evidence for a positive correlation between measures of muscular strength and cognitive abilities. However, the neurophysiological correlates of this relationship are not well understood so fa...

    Authors: Fabian Herold, Tom Behrendt, Alexander Törpel, Dennis Hamacher, Notger G. Müller and Lutz Schega

    Citation: BMC Neuroscience 2021 22:10

    Content type: Research article

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  35. We previously reported that heat shock protein 27 (HSP27) phosphorylation plays an important role in the activation of glucose-6-phosphate dehydrogenase (G6PD), resulting in the upregulation of the pentose pho...

    Authors: Kazuya Matsuo, Kohkichi Hosoda, Jun Tanaka, Yusuke Yamamoto, Taichiro Imahori, Tomoaki Nakai, Yasuhiro Irino, Masakazu Shinohara, Takashi Sasayama and Eiji Kohmura

    Citation: BMC Neuroscience 2021 22:9

    Content type: Research article

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  36. It has been shown that eosinophils are decreased and monocytes are elevated in patients with acute ischemic stroke (AIS), but the impact of eosinophil-to-monocyte ratio (EMR) on clinical outcomes among AIS pat...

    Authors: Shuhong Yu, Yi Luo, Tan Zhang, Chenrong Huang, Yu Fu, Qiang Zhang, Fangyue Zeng, Hao Huang, Chunyuan Zhang and Zhiliang Guo

    Citation: BMC Neuroscience 2021 22:8

    Content type: Research article

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  37. SYNE1 ataxia is an autosomal recessive hereditary condition, the main characteristic features of which are gait and limb ataxia and cerebellar dysarthria. Reports have revealed that the clinical phenotype of SYNE...

    Authors: Laszlo Szpisjak, Gabor Szaraz, Andras Salamon, Viola L. Nemeth, Noemi Szepfalusi, Gabor Veres, Balint Kincses, Zoltan Maroti, Tibor Kalmar, Malgorzata Rydzanicz, Rafal Ploski, Peter Klivenyi and Denes Zadori

    Citation: BMC Neuroscience 2021 22:7

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Neuroscience 2021 22:16

  38. Neuropathic pain (NeuP) is a complex, debilitating condition of the somatosensory system, where dysregulation between pro- and anti-inflammatory cytokines and chemokines are believed to play a pivotal role. As...

    Authors: Mika Jönsson, Björn Gerdle, Bijar Ghafouri and Emmanuel Bäckryd

    Citation: BMC Neuroscience 2021 22:6

    Content type: Research article

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  39. The Period Circadian Regulator 2 (Per2) gene is important for the modulation of circadian rhythms that influence biological processes. Circadian control of the hypothalamus-pituitary-adrenal (HPA) axis is critica...

    Authors: Ashley L. Russell, Lauren Miller, Hannah Yi, Rita Keil, Robert J. Handa and T. John Wu

    Citation: BMC Neuroscience 2021 22:5

    Content type: Research article

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  40. Astrocytes are responsible for a broad range of functions that maintain homeostasis in the brain. However, their response to the pro-inflammatory cytokines released by activated microglia in various neurologic...

    Authors: Emilia Zgórzyńska, Dawid Stulczewski, Barbara Dziedzic, Kuan-Pin Su and Anna Walczewska

    Citation: BMC Neuroscience 2021 22:4

    Content type: Research article

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  41. Status epilepticus (SE) is a life-threatening neurological disorder. The hippocampus, as an important area of the brain that regulates cognitive function, is usually damaged after SE, and cognitive deficits of...

    Authors: Xin-Ming Luo, Jing Zhao, Wen-Yue Wu, Jie Fu, Zheng-Yu Li, Ming Zhang and Jie Lu

    Citation: BMC Neuroscience 2021 22:2

    Content type: Research article

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  42. A common problem in neurophysiological signal processing is the extraction of meaningful information from high dimension, low sample size data (HDLSS). We present RoLDSIS (regression on low-dimension spanned i...

    Authors: Adrielle C. Santana, Adriano V. Barbosa, Hani C. Yehia and Rafael Laboissière

    Citation: BMC Neuroscience 2021 22:1

    Content type: Methodology article

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  43. Conditioned pain modulation (CPM) evaluates the effect of a painful conditioning stimulus (CS) on a painful test stimulus (TS). Using painful cutaneous electrical stimulation (PCES) as TS and painful cold wate...

    Authors: A. T. L. Do, E. K. Enax-Krumova, Ö. Özgül, L. B. Eitner, S. Heba, M. Tegenthoff, C. Maier and O. Höffken

    Citation: BMC Neuroscience 2020 21:53

    Content type: Research article

    Published on:

  44. Ventromedial hypothalamic nucleus (VMN) gluco-regulatory transmission is subject to sex-specific control by estradiol. The VMN is characterized by high levels of aromatase expression.

    Authors: Md. Main Uddin, Mostafa M. H. Ibrahim and Karen P. Briski

    Citation: BMC Neuroscience 2020 21:51

    Content type: Research article

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