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Systems Neuroscience

Section edited by Tianzi Jiang and Jiu-Lin Du

Topics of interest include, but are not limited to, the understanding of structure and function of neural circuits, systems and networks from microscale to macroscale, sensory functions and sensory processing, how high-level cognitive functions such as emotion, memory, attention language, and self-awareness manifest on neural circuits and brain networks, and the related neurotechniques,. This section also covers computational and theoretical neuromodeling.

  1. Pyridoxine (PDX; vitamin B6), is an essential vitamin. PDX deficiency induces various symptoms, and when PDX is misused it acts as a neurotoxicant, inducing severe sensory neuropathy.

    Authors: Sumin Yun, Woosuk Kim, Min Soo Kang, Tae Hyeong Kim, Yoonhwan Kim, Jin-Ok Ahn, Jung Hoon Choi, In Koo Hwang and Jin-Young Chung

    Citation: BMC Neuroscience 2020 21:11

    Content type: Research article

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  2. Non-motor symptoms are common aspects of Parkinson’s disease (PD) occurring even at the prodromal stage of the disease and greatly affecting the quality of life. Here, we investigated whether non-motor symptom...

    Authors: Flavia Niccolini, Heather Wilson, Beniamino Giordano, Konstantinos Diamantopoulos, Gennaro Pagano, Kallol Ray Chaudhuri and Marios Politis

    Citation: BMC Neuroscience 2019 20:55

    Content type: Research article

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  3. Movement performance depends on the synaptic interactions generated by coherent parallel sensorimotor cortical outputs to different downstream targets. The major outputs of the neocortex to subcortical structu...

    Authors: Rafael Olivares-Moreno, Mónica López-Hidalgo, Alain Altamirano-Espinoza, Adriana González-Gallardo, Anaid Antaramian, Verónica Lopez-Virgen and Gerardo Rojas-Piloni

    Citation: BMC Neuroscience 2019 20:50

    Content type: Research article

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  5. Neuropathic pain (NP) is a prevalent disease, which badly impairs the life quality of patients. The underlying mechanism of NP is still not fully understood. It has been reported that spinal Annexin A10 (ANXA1...

    Authors: LiHong Sun, Qi Xu, WenXin Zhang, CuiCui Jiao, Hui Wu and XinZhong Chen

    Citation: BMC Neuroscience 2019 20:28

    Content type: Research article

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  6. Prepulse inhibition (PPI) of the acoustic startle response, a measurement of sensorimotor gaiting, is modulated by monoaminergic, presumably dopaminergic neurotransmission. Disturbances of the dopaminergic sys...

    Authors: Patricia Panther, Maria Kuehne, Jürgen Voges, Sven Nullmeier, Jörn Kaufmann, Janet Hausmann, Daniel Bittner, Imke Galazky, Hans-Jochen Heinze, Andreas Kupsch and Tino Zaehle

    Citation: BMC Neuroscience 2019 20:20

    Content type: Research article

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  7. Previous data show that serotonin 2C (5-HT2C) and cannabinoid 1 (CB1) receptors have a role in the modulation of sleep–wake cycle. Namely, antagonists on these receptors promoted wakefulness and inhibited rapid e...

    Authors: Emese Bogáthy, Noémi Papp, Laszló Tóthfalusi, Szilvia Vas and György Bagdy

    Citation: BMC Neuroscience 2019 20:14

    Content type: Research article

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  8. The recovery of neurophysiological parameters at various time intervals following fatiguing exercise has been investigated previously. However, the repetition of neuromuscular assessments during the recovery p...

    Authors: Saied Jalal Aboodarda, Selina Fan, Kyla Coates and Guillaume Y. Millet

    Citation: BMC Neuroscience 2019 20:9

    Content type: Research article

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  9. Social behavior and interactions pervasively shape and influence our lives and relationships. Competition, in particular, has become a core topic in social neuroscience since it stresses the relevance and sali...

    Authors: Michela Balconi and Maria Elide Vanutelli

    Citation: BMC Neuroscience 2018 19:63

    Content type: Research article

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  10. Transcranial focused ultrasound (tFUS) is a new non-invasive neuromodulation technique that uses mechanical energy to modulate neuronal excitability with high spatial precision. tFUS has been shown to be capab...

    Authors: Leo Ai, Priya Bansal, Jerel K. Mueller and Wynn Legon

    Citation: BMC Neuroscience 2018 19:56

    Content type: Research article

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  11. Given the reported inverse association between light and depressive mood, ambient light may also be associated with some of the brain regions in healthy subjects. The present study aims to investigate the effe...

    Authors: Hirofumi Hirakawa, Takeshi Terao, Koji Hatano, Kentaro Kohno and Nobuyoshi Ishii

    Citation: BMC Neuroscience 2018 19:44

    Content type: Research article

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  12. The functional connectivity of the default mode network (DMN) decreases in patients with Alzheimer’s disease (AD) as well as in patients with type 2 diabetes mellitus (T2DM). Altered functional connectivity of...

    Authors: Kenji Ishibashi, Keita Sakurai, Keigo Shimoji, Aya M. Tokumaru and Kenji Ishii

    Citation: BMC Neuroscience 2018 19:33

    Content type: Research article

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  13. Autonomic nervous system (ANS) activity has been shown to vary with the state of brain arousal. In a previous study, this association of ANS activity with distinct states of brain arousal was demonstrated usin...

    Authors: Jue Huang, Christine Ulke, Christian Sander, Philippe Jawinski, Janek Spada, Ulrich Hegerl and Tilman Hensch

    Citation: BMC Neuroscience 2018 19:18

    Content type: Research article

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  14. Binocular disparity provides a powerful cue for depth perception in a stereoscopic environment. Despite increasing knowledge of the cortical areas that process disparity from neuroimaging studies, the neural m...

    Authors: Yuan Li, Chuncheng Zhang, Chunping Hou, Li Yao, Jiacai Zhang and Zhiying Long

    Citation: BMC Neuroscience 2017 18:80

    Content type: Research article

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  17. Recording of motor evoked potentials (MEPs) is used during navigated transcranial magnetic stimulation (nTMS) motor mapping to locate motor function in the human brain. However, factors potentially underlying ...

    Authors: Nico Sollmann, Lucia Bulubas, Noriko Tanigawa, Claus Zimmer, Bernhard Meyer and Sandro M. Krieg

    Citation: BMC Neuroscience 2017 18:5

    Content type: Research Article

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  18. Sensori-perceptual processing of emotional stimuli under attentive conditions effectively prevents response disinhibition. This is observed saliently in low-impulsive people, because of their high sensitivity ...

    Authors: Takahiro Soshi, Takamasa Noda, Kumiko Ando, Kanako Nakazawa, Hideki Tsumura and Takayuki Okada

    Citation: BMC Neuroscience 2015 16:87

    Content type: Research article

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  19. Under experimental conditions, virtually all behaviors of Caenorhabditis elegans are achieved by combinations of simple locomotion, including forward, reversal movement, turning by deep body bending, and gradual ...

    Authors: Tokumitsu Wakabayashi, Kazumi Sakata, Takuya Togashi, Hiroaki Itoi, Sayaka Shinohe, Miwa Watanabe and Ryuzo Shingai

    Citation: BMC Neuroscience 2015 16:79

    Content type: Research article

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  1. The pathogenesis of medication overuse headache (MOH) involves hyperexcitability of cortical and trigeminal neurons. Derangement of the brainstem modulating system, especially raphe nuclei may contribute to th...

    Authors: Prangtip Potewiratnanond, Supang Maneesri le Grand, Anan Srikiatkhachorn and Weera Supronsinchai

    Citation: BMC Neuroscience 2019 20:54

    Content type: Research article

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  2. Electrical stimulation is widely used in experimental pain research but it lacks selectivity towards small nociceptive fibers. When using standard surface patch electrodes and rectangular pulses, large fibers ...

    Authors: Rosa Hugosdottir, Carsten Dahl Mørch, Ole Kæseler Andersen, Thordur Helgason and Lars Arendt-Nielsen

    Citation: BMC Neuroscience 2019 20:48

    Content type: Research article

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  3. There is a need for new approaches to increase the knowledge of the membrane excitability of small nerve fibers both in healthy subjects, as well as during pathological conditions. Our research group has previ...

    Authors: Rosa Hugosdottir, Carsten Dahl Mørch, Cecilia Klitgaard Jørgensen, Camilla Winther Nielsen, Mathias Vassard Olsen, Mads Jozwiak Pedersen and Jenny Tigerholm

    Citation: BMC Neuroscience 2019 20:47

    Content type: Research article

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  4. Postoperative pain (POP) is a severe acute pain encountered in patients suffering from an operation, and is less than adequately controlled by the currently available analgesics. Phosphatidylinositol 3-kinase ...

    Authors: Bing Xu, Cheng Mo, Chengmei Lv, Susu Liu, Jun Li, Jieying Chen, Yanhong Wei, Hongwei An, Li Ma and Xuehai Guan

    Citation: BMC Neuroscience 2019 20:36

    Content type: Research article

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  5. The mosquito Aedes aegypti has a wide variety of sensory pathways that have supported its success as a species as well as a highly competent vector of numerous debilitating infectious pathogens. Investigations in...

    Authors: Michelle Bui, Jennifer Shyong, Eleanor K. Lutz, Ting Yang, Ming Li, Kenneth Truong, Ryan Arvidson, Anna Buchman, Jeffrey A. Riffell and Omar S. Akbari

    Citation: BMC Neuroscience 2019 20:27

    Content type: Research article

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  7. Despite increasing evidence that lipopolysaccharide (LPS) affects the biological active substances of dorsal root ganglia (DRG) we have limited knowledge of the influence of a single low dose of LPS, which doe...

    Authors: Anita Mikołajczyk and Dagmara Złotkowska

    Citation: BMC Neuroscience 2019 20:18

    Content type: Research article

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  8. Reports show that stressful events before injury exacerbates post-injury pain. The mechanism underlying stress-induced heightened thermal pain is unclear. Here, we examined the effects of chronic intermittent ...

    Authors: Natasha M. Sosanya, Thomas H. Garza, Winfred Stacey, Stephen L. Crimmins, Robert J. Christy and Bopaiah P. Cheppudira

    Citation: BMC Neuroscience 2019 20:17

    Content type: Research article

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  9. Peripheral diabetic neuropathy can be painful and its symptoms include hyperalgesia, allodynia and spontaneous pain. Hydrogen sulfide (H2S) is involved in diabetes-induced hyperalgesia and allodynia. However, the...

    Authors: José Eduardo Roa-Coria, Jorge Baruch Pineda-Farias, Paulino Barragán-Iglesias, Geovanna Nallely Quiñonez-Bastidas, Ángel Zúñiga-Romero, Juan Carlos Huerta-Cruz, Juan Gerardo Reyes-García, Francisco Javier Flores-Murrieta, Vinicio Granados-Soto and Héctor Isaac Rocha-González

    Citation: BMC Neuroscience 2019 20:1

    Content type: Research article

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  10. Glycine receptors (GlyRs) are involved in the development of spinal pain sensitization. The GlyRα3 subunit has recently emerged as a key factor in inflammatory pain pathways in the spinal cord dorsal horn (DH)...

    Authors: Hung-Chen Wang, Kuang-I Cheng, Pei-Ru Chen, Kuang-Yi Tseng, Aij-Lie Kwan and Lin-Li Chang

    Citation: BMC Neuroscience 2018 19:72

    Content type: Research article

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  11. Auditory function and cochlear morphology have previously been described in a porcine model with spontaneous WS2-like phenotype. In the present study, cochlear histopathology was further investigated in the in...

    Authors: Wei Chen, Qing-Qing Hao, Li–Li Ren, Wei Ren, Hui-sang Lin, Wei-Wei Guo and Shi-Ming Yang

    Citation: BMC Neuroscience 2018 19:28

    Content type: Research article

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  12. In the mammalian superior olivary complex (SOC), synaptic inhibition contributes to the processing of binaural sound cues important for sound localization. Previous analyses demonstrated a tonotopic gradient f...

    Authors: Lena Ebbers, Maren Weber and Hans Gerd Nothwang

    Citation: BMC Neuroscience 2017 18:75

    Content type: Research article

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  13. Systemic inflammation is known to induce sickness behaviors, including decreased social interaction and pain. We have reported increased serum inflammatory cytokines in a rat model of repetitive strain injury ...

    Authors: D. L. Xin, J. Hadrévi, M. E. Elliott, M. Amin, M. Y. Harris, A. E. Barr-Gillespie and M. F. Barbe

    Citation: BMC Neuroscience 2017 18:36

    Content type: Research article

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  14. Oddball paradigms are frequently used to study auditory discrimination by comparing event-related potential (ERP) responses from a standard, high probability sound and to a deviant, low probability sound. Prev...

    Authors: Phillip M. Gilley, Kristin Uhler, Kaylee Watson and Christine Yoshinaga-Itano

    Citation: BMC Neuroscience 2017 18:34

    Content type: Research article

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  15. Primary open angle glaucoma is a heterogeneous group of optic neuropathies that results in optic nerve degeneration and a loss of retinal ganglion cells (RGCs) ultimately causing blindness if allowed to progre...

    Authors: Nolan R. McGrady, Alena Z. Minton, Dorota L. Stankowska, Shaoqing He, Hayden B. Jefferies and Raghu R. Krishnamoorthy

    Citation: BMC Neuroscience 2017 18:27

    Content type: Research article

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  16. The role of the piriform cortex (PC) in olfactory information processing remains largely unknown. The anterior part of the piriform cortex (APC) has been the focus of cortical-level studies of olfactory codin...

    Authors: Junli Yang, Gerhard Litscher, Zhongren Sun, Qiang Tang, Kiyoshi Kishi, Satoko Oda, Masaaki Takayanagi, Zemin Sheng, Yang Liu, Wenhai Guo, Ting Zhang, Lu Wang, Ingrid Gaischek, Daniela Litscher, Irmgard Th. Lippe and Masaru Kuroda

    Citation: BMC Neuroscience 2017 18:25

    Content type: Research article

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  17. Previous studies compared evoked potentials (EPs) between several sleep stages but only one uniform wake state. However, using electroencephalography (EEG), several arousal states can be distinguished before s...

    Authors: Jue Huang, Tilman Hensch, Christine Ulke, Christian Sander, Janek Spada, Philippe Jawinski and Ulrich Hegerl

    Citation: BMC Neuroscience 2017 18:21

    Content type: Research article

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  19. Patients with medication-overuse headache suffer not only from chronic headache, but often from psychiatric comorbidities, such as anxiety and depression. The mechanisms underlying these comorbidities are uncl...

    Authors: Aree Wanasuntronwong, Ukkrit Jansri and Anan Srikiatkhachorn

    Citation: BMC Neuroscience 2017 18:1

    Content type: Research article

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  20. Transcranial focused ultrasound (FUS) is gaining momentum as a novel non-invasive brain stimulation method, with promising potential for superior spatial resolution and depth penetration compared to transcrani...

    Authors: Wonhye Lee, Yong An Chung, Yujin Jung, In-Uk Song and Seung-Schik Yoo

    Citation: BMC Neuroscience 2016 17:68

    Content type: Research article

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  21. Larval zebrafish, with a simple and transparent vertebrate brain composed of ~100 K neurons, is well suited for deciphering entire neural circuit activity underlying behavior. Moreover, their small body size (...

    Authors: Yiming Bai, Harrison Liu, Bo Huang, Mahendra Wagle and Su Guo

    Citation: BMC Neuroscience 2016 17:63

    Content type: Research article

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  22. Mechanosensitive afferents innervating the bladder increase their firing rate as the bladder fills and pressure rises. However, the relationship between afferent firing rates and intravesical pressure is not a...

    Authors: Shani E. Ross, Zachariah J. Sperry, Colin M. Mahar and Tim M. Bruns

    Citation: BMC Neuroscience 2016 17:57

    Content type: Research article

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  23. In many functional magnetic resonance imaging (fMRI) studies, experimental design often depends on the eye state (i.e., whether the participants had their eyes open or closed). Closed eyes during an fMRI is th...

    Authors: Stefan Brodoehl, Otto W. Witte and Carsten M. Klingner

    Citation: BMC Neuroscience 2016 17:48

    Content type: Methodology article

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  24. Anticipatory and compensatory balance responses are used by the central nervous system (CNS) to preserve balance, hence they significantly contribute to the understanding of physiological mechanisms of postura...

    Authors: Andresa M. C. Germano, Daniel Schmidt and Thomas L. Milani

    Citation: BMC Neuroscience 2016 17:41

    Content type: Research article

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  25. Resiniferatoxin (RTX) is a potent analog of capsaicin and activates transient receptor potential (TRP) vanilloid type (TRPV) 1. In the current study, we investigated the preventive effect of perineural RTX on ...

    Authors: Won Uk Koh, Seong-Soo Choi, Ji Hyun Kim, Hye Joo Yoon, Ho-Soo Ahn, Sun Kyung Lee, Jeong Gil Leem, Jun Gol Song and Jin Woo Shin

    Citation: BMC Neuroscience 2016 17:38

    Content type: Research article

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  26. Retinal inflammation can cause retinal neural disorders. In particular, functional disorder in the cone photoreceptor system influences visual acuity. However, the underlying mechanism is not yet fully underst...

    Authors: Mamoru Kamoshita, Kaoru Fujinami, Eriko Toda, Kazuo Tsubota and Yoko Ozawa

    Citation: BMC Neuroscience 2016 17:32

    Content type: Research article

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  27. The magnitude of multimodal enhancement in the brain is believed to depend on the stimulus intensity and timing. Such an effect has been found in many species, but has not been previously investigated in insects.

    Authors: Anna Balkenius and Christian Balkenius

    Citation: BMC Neuroscience 2016 17:29

    Content type: Research article

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  28. Steady-state visual evoked potentials have been utilized widely in basic and applied research in recent years. These oscillatory responses of the visual cortex are elicited by flickering stimuli. They have th...

    Authors: Søren K. Andersen and Matthias M. Müller

    Citation: BMC Neuroscience 2015 16:95

    Content type: Research article

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  29. The vomeronasal organ (VNO) is specialized in detecting pheromone and heterospecific cues in the environment. Recent studies demonstrate the involvement of multiple ion channels in VNO signal transduction, inc...

    Authors: SangSeong Kim, Limei Ma, Jay Unruh, Sean McKinney and C. Ron Yu

    Citation: BMC Neuroscience 2015 16:90

    Content type: Research article

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  30. Emotional scenes and faces have shown to capture and bind visual resources at early sensory processing stages, i.e. in early visual cortex. However, emotional words have led to mixed results. In the current st...

    Authors: Sophie M. Trauer, Sonja A. Kotz and Matthias M. Müller

    Citation: BMC Neuroscience 2015 16:89

    Content type: Research article

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  31. To study the mapping from the retina to the brain, typically a small region of the retina is injected with a dye, which then propagates to the retina’s target structures. To determine the location of the inje...

    Authors: J. J. Johannes Hjorth, Elise Savier, David C. Sterratt, Michaël Reber and Stephen J. Eglen

    Citation: BMC Neuroscience 2015 16:80

    Content type: Software

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  32. Tactile adaptation is a phenomenon of the sensory system that results in temporal desensitization after an exposure to sustained or repetitive tactile stimuli. Previous studies reported psychophysical and phys...

    Authors: Yoon Gi Chung, Sang Woo Han, Hyung-Sik Kim, Soon-Cheol Chung, Jang-Yeon Park, Christian Wallraven and Sung-Phil Kim

    Citation: BMC Neuroscience 2015 16:71

    Content type: Research article

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  33. A myriad of studies have argued that tactile sensibility is underpinned exclusively by large myelinated mechanoreceptors. However, the functional significance of their slow-conducting counterparts, termed C-lo...

    Authors: Saad S. Nagi, James S. Dunn, Ingvars Birznieks, Richard M. Vickery and David A. Mahns

    Citation: BMC Neuroscience 2015 16:52

    Content type: Research article

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  34. Hair cells are important for maintaining our sense of hearing and balance. However, they are difficult to regenerate in mammals once they are lost. Clarification of the molecular mechanisms underlying inner ea...

    Authors: Akiko Taura, Hiroe Ohnishi, Shohei Ochi, Fumi Ebisu, Takayuki Nakagawa and Juichi Ito

    Citation: BMC Neuroscience 2014 15:121

    Content type: Research article

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  35. Notch signaling plays a crucial role in the fate determination of cochlear progenitor cells, hair cells, and supporting cells in the developing cochlea. Recent studies have demonstrated the temporal activation...

    Authors: Yosuke Tona, Kiyomi Hamaguchi, Masaaki Ishikawa, Takushi Miyoshi, Norio Yamamoto, Kohei Yamahara, Juichi Ito and Takayuki Nakagawa

    Citation: BMC Neuroscience 2014 15:66

    Content type: Research article

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  36. Slow-adapting type I (SA-I) afferents deliver sensory signals to the somatosensory cortex during low-frequency (or static) mechanical stimulation. It has been reported that the somatosensory projection from SA...

    Authors: Yoon Gi Chung, Sang Woo Han, Hyung-Sik Kim, Soon-Cheol Chung, Jang-Yeon Park, Christian Wallraven and Sung-Phil Kim

    Citation: BMC Neuroscience 2014 15:43

    Content type: Research article

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  38. The main olfactory epithelium (MOE) in mammals is a specialized organ to detect odorous molecules in the external environment. The MOE consists of four types of cells: olfactory sensory neurons, supporting cel...

    Authors: Tatsuya Yamaguchi, Junpei Yamashita, Makoto Ohmoto, Imad Aoudé, Tatsuya Ogura, Wangmei Luo, Alexander A Bachmanov, Weihong Lin, Ichiro Matsumoto and Junji Hirota

    Citation: BMC Neuroscience 2014 15:13

    Content type: Research article

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  39. To survive dynamic environments, it is essential for all animals to appropriately modulate their behavior in response to various stimulus intensities. For instance, the nematode Caenorhabditis elegans suppresses ...

    Authors: Jarred Sanders, Stanislav Nagy, Graham Fetterman, Charles Wright, Millet Treinin and David Biron

    Citation: BMC Neuroscience 2013 14:156

    Content type: Research article

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  41. Humans are able to extract regularities from complex auditory scenes in order to form perceptually meaningful elements. It has been shown previously that this process depends critically on both the temporal in...

    Authors: Ivan Chakalov, Rossitza Draganova, Andreas Wollbrink, Hubert Preissl and Christo Pantev

    Citation: BMC Neuroscience 2013 14:120

    Content type: Research article

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  42. Human nociceptive withdrawal reflexes (NWR) can be evoked by electrical stimulation applied to the sole of the foot. However, elicitation of NWRs is highly site dependent, and NWRs are especially difficult to ...

    Authors: Ken Steffen Frahm, Carsten Dahl Mørch, Warren M Grill, Nathan B Lubock, Kristian Hennings and Ole Kæseler Andersen

    Citation: BMC Neuroscience 2013 14:116

    Content type: Research article

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  43. The nociceptive withdrawal reflex (NWR) has been proven to be a valuable tool in the objective assessment of central hyperexcitability in the nociceptive system at spinal level that is present in some chronic ...

    Authors: José A Biurrun Manresa, Giang P Nguyen, Michele Curatolo, Thomas B Moeslund and Ole K Andersen

    Citation: BMC Neuroscience 2013 14:110

    Content type: Research article

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  44. Mice produce ultrasonic vocalizations in various inter-individual encounters and with high call rates. However, it is so far virtually unknown how these vocal patterns are generated. On the one hand, these voc...

    Authors: Steffen R Hage, Natalja Gavrilov, Ferdinand Salomon and Anna M Stein

    Citation: BMC Neuroscience 2013 14:99

    Content type: Research article

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  45. Sleep restriction alters pain perception in animals and humans, and many studies have indicated that paradoxical sleep deprivation (PSD) promotes hyperalgesia. The hyperalgesia observed after mechanical nocice...

    Authors: Fabio Damasceno, Gabriela O Skinner, Paulo C Araújo, Marcia MD Ferraz, Frank Tenório and Olga MMS de Almeida

    Citation: BMC Neuroscience 2013 14:92

    Content type: Research article

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  46. Temporal order judgement (TOJ) is the ability to detect the order of occurrence of two sequentially delivered stimuli. Previous research has shown that TOJ in the presence of synchronized periodic conditioning...

    Authors: Kevin GH Lee, Mark F Jacobs, Michael J Asmussen, Christopher M Zapallow, Mark Tommerdahl and Aimee J Nelson

    Citation: BMC Neuroscience 2013 14:89

    Content type: Research article

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  47. Phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac Exchanger 2 (P-Rex2) is a guanine nucleotide exchange factor (GEF) that specifically activates Rac GTPases, important regulators of actin cytoskeleton r...

    Authors: David M Sherry and Bradley A Blackburn

    Citation: BMC Neuroscience 2013 14:70

    Content type: Research article

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  49. The basal forebrain (BF) regulates cortical activity by the action of cholinergic projections to the cortex. At the same time, it also sends substantial GABAergic projections to both cortex and thalamus, whose...

    Authors: Anwesha Bhattacharyya, Julia Veit, Robert Kretz, Igor Bondar and Gregor Rainer

    Citation: BMC Neuroscience 2013 14:55

    Content type: Research article

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  1. It is a crucial task of brain science researches to explore functional connective maps of Biological Neural Networks (BNN). The maps help to deeply study the dominant relationship between the structures of the...

    Authors: Mei-jia Zhu, Chao-yi Dong, Xiao-yan Chen, Jing-wen Ren and Xiao-yi Zhao

    Citation: BMC Neuroscience 2020 21:7

    Content type: Methodology article

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  2. Three-dimensional (3D) reconstruction of human peripheral nerves, as a useful tool to understand the nerve internal information and functional basis, has become an important area of research in the peripheral ...

    Authors: Peng Luo, Jianghui Dong, Jian Qi, Yi Zhang, Xiaolin Liu, Yingchun Zhong, Cory J. Xian and Liping Wang

    Citation: BMC Neuroscience 2019 20:32

    Content type: Research article

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  4. Alzheimer’s disease (AD) is a primary cause of dementia in ageing population affecting more than 35 million people around the globe. It is a chronic neurodegenerative disease caused by defected folding and agg...

    Authors: Sidra Khalid, Muhammad Ammar Zahid, Hussain Ali, Yeong S. Kim and Salman Khan

    Citation: BMC Neuroscience 2018 19:74

    Content type: Research article

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  6. Learning algorithms come in three orders of complexity: zeroth-order (perturbation), first-order (gradient descent), and second-order (e.g., quasi-Newton). But which of these are used in the brain? We trained ...

    Authors: John Kim, Fariya Mostafa and Douglas Blair Tweed

    Citation: BMC Neuroscience 2017 18:50

    Content type: Research article

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  7. Various strategies have been used for inferring brain functions from stroke lesions. We explored a new mathematical approach based on game theory, the so-called multi-perturbation Shapley value analysis (MSA),...

    Authors: Melissa Zavaglia, Nils D. Forkert, Bastian Cheng, Christian Gerloff, Götz Thomalla and Claus C. Hilgetag

    Citation: BMC Neuroscience 2016 17:40

    Content type: Methodology article

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  8. Functional connectivity analyses of multiple neurons provide a powerful bottom-up approach to reveal functions of local neuronal circuits by using simultaneous recording of neuronal activity. A statistical met...

    Authors: Shigeyuki Oba, Ken Nakae, Yuji Ikegaya, Shunsuke Aki, Junichiro Yoshimoto and Shin Ishii

    Citation: BMC Neuroscience 2016 17:27

    Content type: Methodology article

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  11. In neuroscience, experimental designs in which multiple measurements are collected in the same research object or treatment facility are common. Such designs result in clustered or nested data. When clusters i...

    Authors: Emmeke Aarts, Conor V. Dolan, Matthijs Verhage and Sophie van der Sluis

    Citation: BMC Neuroscience 2015 16:94

    Content type: Research article

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  12. The topological structure of the wiring of the mammalian brain cortex plays an important role in shaping the functional dynamics of large-scale neural activity. Due to their central embedding in the network, h...

    Authors: Ruben Schmidt, Karl J. R. LaFleur, Marcel A. de Reus, Leonard H. van den Berg and Martijn P. van den Heuvel

    Citation: BMC Neuroscience 2015 16:54

    Content type: Research article

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  13. Symptoms of schizophrenia are related to deficits in self-monitoring function, which may be a consequence of irregularity in aspects of the default mode network (DMN). Schizophrenia can also be characterized b...

    Authors: June Sic Kim, Kyung Soon Shin, Wi Hoon Jung, Sung Nyun Kim, Jun Soo Kwon and Chun Kee Chung

    Citation: BMC Neuroscience 2014 15:104

    Content type: Research article

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  14. Pairwise association between neurons is a key feature in understanding neural coding. Statistical neuroscience provides tools to estimate and assess these associations. In the mammalian brain, activating ascen...

    Authors: Aldana M González Montoro, Ricardo Cao, Nelson Espinosa, Javier Cudeiro and Jorge Mariño

    Citation: BMC Neuroscience 2014 15:96

    Content type: Research article

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  15. Graph-based analysis of fMRI data has recently emerged as a promising approach to study brain networks. Based on the assessment of synchronous fMRI activity at separate brain sites, functional connectivity gra...

    Authors: Kristian Loewe, Marcus Grueschow, Christian M Stoppel, Rudolf Kruse and Christian Borgelt

    Citation: BMC Neuroscience 2014 15:78

    Content type: Methodology article

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  16. How it is possible to “faithfully” represent a three-dimensional stereoscopic scene using Cartesian coordinates on a plane, and how three-dimensional perceptions differ between an actual scene and an image of ...

    Authors: Zhao Songnian, Zou Qi, Liu Chang, Liu Xuemin, Sun Shousi and Qiu Jun

    Citation: BMC Neuroscience 2014 15:50

    Content type: Research article

    Published on:

  17. Micro-Electrode Array (MEA) technology allows researchers to perform long-term non-invasive neuronal recordings in-vitro while actively interacting with the cultured neurons. Despite numerous studies carried o...

    Authors: Alessandro Napoli, Jichun Xie and Iyad Obeid

    Citation: BMC Neuroscience 2014 15:17

    Content type: Methodology article

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  19. In concurrent EEG/fMRI recordings, EEG data are impaired by the fMRI gradient artifacts which exceed the EEG signal by several orders of magnitude. While several algorithms exist to correct the EEG data, these...

    Authors: Johann Glaser, Roland Beisteiner, Herbert Bauer and Florian Ph S Fischmeister

    Citation: BMC Neuroscience 2013 14:138

    Content type: Software

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  20. A major cue for the position of a high-frequency sound source in azimuth is the difference in sound pressure levels in the two ears, Interaural Level Differences (ILDs), as a sound is presented from different ...

    Authors: Balemir Uragun and Ramesh Rajan

    Citation: BMC Neuroscience 2013 14:114

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