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Sensory systems

Section edited by Jiu-Lin Du

This section deals with sensory functions and sensory processing. Topics of interest include, but are not limited to, gustatory and olfactory signal transduction, chemosensory circuits, phototransduction and auditory neurophysiology.

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  1. Content type: Research article

    Electrical stimulation is widely used in experimental pain research but it lacks selectivity towards small nociceptive fibers. When using standard surface patch electrodes and rectangular pulses, large fibers ...

    Authors: Rosa Hugosdottir, Carsten Dahl Mørch, Ole Kæseler Andersen, Thordur Helgason and Lars Arendt-Nielsen

    Citation: BMC Neuroscience 2019 20:48

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  2. Content type: Research article

    There is a need for new approaches to increase the knowledge of the membrane excitability of small nerve fibers both in healthy subjects, as well as during pathological conditions. Our research group has previ...

    Authors: Rosa Hugosdottir, Carsten Dahl Mørch, Cecilia Klitgaard Jørgensen, Camilla Winther Nielsen, Mathias Vassard Olsen, Mads Jozwiak Pedersen and Jenny Tigerholm

    Citation: BMC Neuroscience 2019 20:47

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  3. Content type: Research article

    Postoperative pain (POP) is a severe acute pain encountered in patients suffering from an operation, and is less than adequately controlled by the currently available analgesics. Phosphatidylinositol 3-kinase ...

    Authors: Bing Xu, Cheng Mo, Chengmei Lv, Susu Liu, Jun Li, Jieying Chen, Yanhong Wei, Hongwei An, Li Ma and Xuehai Guan

    Citation: BMC Neuroscience 2019 20:36

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  4. Content type: Research article

    The mosquito Aedes aegypti has a wide variety of sensory pathways that have supported its success as a species as well as a highly competent vector of numerous debilitating infectious pathogens. Investigations in...

    Authors: Michelle Bui, Jennifer Shyong, Eleanor K. Lutz, Ting Yang, Ming Li, Kenneth Truong, Ryan Arvidson, Anna Buchman, Jeffrey A. Riffell and Omar S. Akbari

    Citation: BMC Neuroscience 2019 20:27

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  5. Content type: Research article

    Despite increasing evidence that lipopolysaccharide (LPS) affects the biological active substances of dorsal root ganglia (DRG) we have limited knowledge of the influence of a single low dose of LPS, which doe...

    Authors: Anita Mikołajczyk and Dagmara Złotkowska

    Citation: BMC Neuroscience 2019 20:18

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  6. Content type: Research article

    Reports show that stressful events before injury exacerbates post-injury pain. The mechanism underlying stress-induced heightened thermal pain is unclear. Here, we examined the effects of chronic intermittent ...

    Authors: Natasha M. Sosanya, Thomas H. Garza, Winfred Stacey, Stephen L. Crimmins, Robert J. Christy and Bopaiah P. Cheppudira

    Citation: BMC Neuroscience 2019 20:17

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  7. Content type: Research article

    Peripheral diabetic neuropathy can be painful and its symptoms include hyperalgesia, allodynia and spontaneous pain. Hydrogen sulfide (H2S) is involved in diabetes-induced hyperalgesia and allodynia. However, the...

    Authors: José Eduardo Roa-Coria, Jorge Baruch Pineda-Farias, Paulino Barragán-Iglesias, Geovanna Nallely Quiñonez-Bastidas, Ángel Zúñiga-Romero, Juan Carlos Huerta-Cruz, Juan Gerardo Reyes-García, Francisco Javier Flores-Murrieta, Vinicio Granados-Soto and Héctor Isaac Rocha-González

    Citation: BMC Neuroscience 2019 20:1

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  8. Content type: Research article

    Glycine receptors (GlyRs) are involved in the development of spinal pain sensitization. The GlyRα3 subunit has recently emerged as a key factor in inflammatory pain pathways in the spinal cord dorsal horn (DH)...

    Authors: Hung-Chen Wang, Kuang-I Cheng, Pei-Ru Chen, Kuang-Yi Tseng, Aij-Lie Kwan and Lin-Li Chang

    Citation: BMC Neuroscience 2018 19:72

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  9. Content type: Research article

    Auditory function and cochlear morphology have previously been described in a porcine model with spontaneous WS2-like phenotype. In the present study, cochlear histopathology was further investigated in the in...

    Authors: Wei Chen, Qing-Qing Hao, Li–Li Ren, Wei Ren, Hui-sang Lin, Wei-Wei Guo and Shi-Ming Yang

    Citation: BMC Neuroscience 2018 19:28

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  10. Content type: Research article

    In the mammalian superior olivary complex (SOC), synaptic inhibition contributes to the processing of binaural sound cues important for sound localization. Previous analyses demonstrated a tonotopic gradient f...

    Authors: Lena Ebbers, Maren Weber and Hans Gerd Nothwang

    Citation: BMC Neuroscience 2017 18:75

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  11. Content type: Research article

    Systemic inflammation is known to induce sickness behaviors, including decreased social interaction and pain. We have reported increased serum inflammatory cytokines in a rat model of repetitive strain injury ...

    Authors: D. L. Xin, J. Hadrévi, M. E. Elliott, M. Amin, M. Y. Harris, A. E. Barr-Gillespie and M. F. Barbe

    Citation: BMC Neuroscience 2017 18:36

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  12. Content type: Research article

    Oddball paradigms are frequently used to study auditory discrimination by comparing event-related potential (ERP) responses from a standard, high probability sound and to a deviant, low probability sound. Prev...

    Authors: Phillip M. Gilley, Kristin Uhler, Kaylee Watson and Christine Yoshinaga-Itano

    Citation: BMC Neuroscience 2017 18:34

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  13. Content type: Research article

    Primary open angle glaucoma is a heterogeneous group of optic neuropathies that results in optic nerve degeneration and a loss of retinal ganglion cells (RGCs) ultimately causing blindness if allowed to progre...

    Authors: Nolan R. McGrady, Alena Z. Minton, Dorota L. Stankowska, Shaoqing He, Hayden B. Jefferies and Raghu R. Krishnamoorthy

    Citation: BMC Neuroscience 2017 18:27

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  14. Content type: Research article

    The role of the piriform cortex (PC) in olfactory information processing remains largely unknown. The anterior part of the piriform cortex (APC) has been the focus of cortical-level studies of olfactory codin...

    Authors: Junli Yang, Gerhard Litscher, Zhongren Sun, Qiang Tang, Kiyoshi Kishi, Satoko Oda, Masaaki Takayanagi, Zemin Sheng, Yang Liu, Wenhai Guo, Ting Zhang, Lu Wang, Ingrid Gaischek, Daniela Litscher, Irmgard Th. Lippe and Masaru Kuroda

    Citation: BMC Neuroscience 2017 18:25

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  15. Content type: Research article

    Previous studies compared evoked potentials (EPs) between several sleep stages but only one uniform wake state. However, using electroencephalography (EEG), several arousal states can be distinguished before s...

    Authors: Jue Huang, Tilman Hensch, Christine Ulke, Christian Sander, Janek Spada, Philippe Jawinski and Ulrich Hegerl

    Citation: BMC Neuroscience 2017 18:21

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  16. Content type: Research article

    Patients with medication-overuse headache suffer not only from chronic headache, but often from psychiatric comorbidities, such as anxiety and depression. The mechanisms underlying these comorbidities are uncl...

    Authors: Aree Wanasuntronwong, Ukkrit Jansri and Anan Srikiatkhachorn

    Citation: BMC Neuroscience 2017 18:1

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  17. Content type: Research article

    Transcranial focused ultrasound (FUS) is gaining momentum as a novel non-invasive brain stimulation method, with promising potential for superior spatial resolution and depth penetration compared to transcrani...

    Authors: Wonhye Lee, Yong An Chung, Yujin Jung, In-Uk Song and Seung-Schik Yoo

    Citation: BMC Neuroscience 2016 17:68

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  18. Content type: Research article

    Larval zebrafish, with a simple and transparent vertebrate brain composed of ~100 K neurons, is well suited for deciphering entire neural circuit activity underlying behavior. Moreover, their small body size (...

    Authors: Yiming Bai, Harrison Liu, Bo Huang, Mahendra Wagle and Su Guo

    Citation: BMC Neuroscience 2016 17:63

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  19. Content type: Research article

    Mechanosensitive afferents innervating the bladder increase their firing rate as the bladder fills and pressure rises. However, the relationship between afferent firing rates and intravesical pressure is not a...

    Authors: Shani E. Ross, Zachariah J. Sperry, Colin M. Mahar and Tim M. Bruns

    Citation: BMC Neuroscience 2016 17:57

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  20. Content type: Methodology article

    In many functional magnetic resonance imaging (fMRI) studies, experimental design often depends on the eye state (i.e., whether the participants had their eyes open or closed). Closed eyes during an fMRI is th...

    Authors: Stefan Brodoehl, Otto W. Witte and Carsten M. Klingner

    Citation: BMC Neuroscience 2016 17:48

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  21. Content type: Research article

    Anticipatory and compensatory balance responses are used by the central nervous system (CNS) to preserve balance, hence they significantly contribute to the understanding of physiological mechanisms of postura...

    Authors: Andresa M. C. Germano, Daniel Schmidt and Thomas L. Milani

    Citation: BMC Neuroscience 2016 17:41

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  22. Content type: Research article

    Resiniferatoxin (RTX) is a potent analog of capsaicin and activates transient receptor potential (TRP) vanilloid type (TRPV) 1. In the current study, we investigated the preventive effect of perineural RTX on ...

    Authors: Won Uk Koh, Seong-Soo Choi, Ji Hyun Kim, Hye Joo Yoon, Ho-Soo Ahn, Sun Kyung Lee, Jeong Gil Leem, Jun Gol Song and Jin Woo Shin

    Citation: BMC Neuroscience 2016 17:38

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  23. Content type: Research article

    Retinal inflammation can cause retinal neural disorders. In particular, functional disorder in the cone photoreceptor system influences visual acuity. However, the underlying mechanism is not yet fully underst...

    Authors: Mamoru Kamoshita, Kaoru Fujinami, Eriko Toda, Kazuo Tsubota and Yoko Ozawa

    Citation: BMC Neuroscience 2016 17:32

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  24. Content type: Research article

    The magnitude of multimodal enhancement in the brain is believed to depend on the stimulus intensity and timing. Such an effect has been found in many species, but has not been previously investigated in insects.

    Authors: Anna Balkenius and Christian Balkenius

    Citation: BMC Neuroscience 2016 17:29

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  25. Content type: Research article

    Steady-state visual evoked potentials have been utilized widely in basic and applied research in recent years. These oscillatory responses of the visual cortex are elicited by flickering stimuli. They have th...

    Authors: Søren K. Andersen and Matthias M. Müller

    Citation: BMC Neuroscience 2015 16:95

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  26. Content type: Research article

    The vomeronasal organ (VNO) is specialized in detecting pheromone and heterospecific cues in the environment. Recent studies demonstrate the involvement of multiple ion channels in VNO signal transduction, inc...

    Authors: SangSeong Kim, Limei Ma, Jay Unruh, Sean McKinney and C. Ron Yu

    Citation: BMC Neuroscience 2015 16:90

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  27. Content type: Research article

    Emotional scenes and faces have shown to capture and bind visual resources at early sensory processing stages, i.e. in early visual cortex. However, emotional words have led to mixed results. In the current st...

    Authors: Sophie M. Trauer, Sonja A. Kotz and Matthias M. Müller

    Citation: BMC Neuroscience 2015 16:89

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  28. Content type: Software

    To study the mapping from the retina to the brain, typically a small region of the retina is injected with a dye, which then propagates to the retina’s target structures. To determine the location of the inje...

    Authors: J. J. Johannes Hjorth, Elise Savier, David C. Sterratt, Michaël Reber and Stephen J. Eglen

    Citation: BMC Neuroscience 2015 16:80

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  29. Content type: Research article

    Tactile adaptation is a phenomenon of the sensory system that results in temporal desensitization after an exposure to sustained or repetitive tactile stimuli. Previous studies reported psychophysical and phys...

    Authors: Yoon Gi Chung, Sang Woo Han, Hyung-Sik Kim, Soon-Cheol Chung, Jang-Yeon Park, Christian Wallraven and Sung-Phil Kim

    Citation: BMC Neuroscience 2015 16:71

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  30. Content type: Research article

    A myriad of studies have argued that tactile sensibility is underpinned exclusively by large myelinated mechanoreceptors. However, the functional significance of their slow-conducting counterparts, termed C-lo...

    Authors: Saad S. Nagi, James S. Dunn, Ingvars Birznieks, Richard M. Vickery and David A. Mahns

    Citation: BMC Neuroscience 2015 16:52

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  31. Content type: Research article

    Hair cells are important for maintaining our sense of hearing and balance. However, they are difficult to regenerate in mammals once they are lost. Clarification of the molecular mechanisms underlying inner ea...

    Authors: Akiko Taura, Hiroe Ohnishi, Shohei Ochi, Fumi Ebisu, Takayuki Nakagawa and Juichi Ito

    Citation: BMC Neuroscience 2014 15:121

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  32. Content type: Research article

    Notch signaling plays a crucial role in the fate determination of cochlear progenitor cells, hair cells, and supporting cells in the developing cochlea. Recent studies have demonstrated the temporal activation...

    Authors: Yosuke Tona, Kiyomi Hamaguchi, Masaaki Ishikawa, Takushi Miyoshi, Norio Yamamoto, Kohei Yamahara, Juichi Ito and Takayuki Nakagawa

    Citation: BMC Neuroscience 2014 15:66

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  33. Content type: Research article

    Slow-adapting type I (SA-I) afferents deliver sensory signals to the somatosensory cortex during low-frequency (or static) mechanical stimulation. It has been reported that the somatosensory projection from SA...

    Authors: Yoon Gi Chung, Sang Woo Han, Hyung-Sik Kim, Soon-Cheol Chung, Jang-Yeon Park, Christian Wallraven and Sung-Phil Kim

    Citation: BMC Neuroscience 2014 15:43

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  34. Content type: Research article

    The main olfactory epithelium (MOE) in mammals is a specialized organ to detect odorous molecules in the external environment. The MOE consists of four types of cells: olfactory sensory neurons, supporting cel...

    Authors: Tatsuya Yamaguchi, Junpei Yamashita, Makoto Ohmoto, Imad Aoudé, Tatsuya Ogura, Wangmei Luo, Alexander A Bachmanov, Weihong Lin, Ichiro Matsumoto and Junji Hirota

    Citation: BMC Neuroscience 2014 15:13

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  35. Content type: Research article

    To survive dynamic environments, it is essential for all animals to appropriately modulate their behavior in response to various stimulus intensities. For instance, the nematode Caenorhabditis elegans suppresses ...

    Authors: Jarred Sanders, Stanislav Nagy, Graham Fetterman, Charles Wright, Millet Treinin and David Biron

    Citation: BMC Neuroscience 2013 14:156

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  36. Content type: Research article

    Humans are able to extract regularities from complex auditory scenes in order to form perceptually meaningful elements. It has been shown previously that this process depends critically on both the temporal in...

    Authors: Ivan Chakalov, Rossitza Draganova, Andreas Wollbrink, Hubert Preissl and Christo Pantev

    Citation: BMC Neuroscience 2013 14:120

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  37. Content type: Research article

    Human nociceptive withdrawal reflexes (NWR) can be evoked by electrical stimulation applied to the sole of the foot. However, elicitation of NWRs is highly site dependent, and NWRs are especially difficult to ...

    Authors: Ken Steffen Frahm, Carsten Dahl Mørch, Warren M Grill, Nathan B Lubock, Kristian Hennings and Ole Kæseler Andersen

    Citation: BMC Neuroscience 2013 14:116

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  38. Content type: Research article

    The nociceptive withdrawal reflex (NWR) has been proven to be a valuable tool in the objective assessment of central hyperexcitability in the nociceptive system at spinal level that is present in some chronic ...

    Authors: José A Biurrun Manresa, Giang P Nguyen, Michele Curatolo, Thomas B Moeslund and Ole K Andersen

    Citation: BMC Neuroscience 2013 14:110

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  39. Content type: Research article

    Mice produce ultrasonic vocalizations in various inter-individual encounters and with high call rates. However, it is so far virtually unknown how these vocal patterns are generated. On the one hand, these voc...

    Authors: Steffen R Hage, Natalja Gavrilov, Ferdinand Salomon and Anna M Stein

    Citation: BMC Neuroscience 2013 14:99

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  40. Content type: Research article

    Sleep restriction alters pain perception in animals and humans, and many studies have indicated that paradoxical sleep deprivation (PSD) promotes hyperalgesia. The hyperalgesia observed after mechanical nocice...

    Authors: Fabio Damasceno, Gabriela O Skinner, Paulo C Araújo, Marcia MD Ferraz, Frank Tenório and Olga MMS de Almeida

    Citation: BMC Neuroscience 2013 14:92

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  41. Content type: Research article

    Temporal order judgement (TOJ) is the ability to detect the order of occurrence of two sequentially delivered stimuli. Previous research has shown that TOJ in the presence of synchronized periodic conditioning...

    Authors: Kevin GH Lee, Mark F Jacobs, Michael J Asmussen, Christopher M Zapallow, Mark Tommerdahl and Aimee J Nelson

    Citation: BMC Neuroscience 2013 14:89

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  42. Content type: Research article

    Phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac Exchanger 2 (P-Rex2) is a guanine nucleotide exchange factor (GEF) that specifically activates Rac GTPases, important regulators of actin cytoskeleton r...

    Authors: David M Sherry and Bradley A Blackburn

    Citation: BMC Neuroscience 2013 14:70

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  43. Content type: Research article

    The basal forebrain (BF) regulates cortical activity by the action of cholinergic projections to the cortex. At the same time, it also sends substantial GABAergic projections to both cortex and thalamus, whose...

    Authors: Anwesha Bhattacharyya, Julia Veit, Robert Kretz, Igor Bondar and Gregor Rainer

    Citation: BMC Neuroscience 2013 14:55

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