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Neurobiology of disease

Topics of interest include, but are not limited to, neuroinflammation, neurodegenerative pathophysiology, neurodevelopmental disorders, neuropsychiatric disorders, addiction, stroke, ischemia, spinal cord injury, traumatic brain injury (TBI), demyelination and genetic and genomic analysis of diseases of the nervous system.

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  1. Even though more than 600 stroke treatments have been shown effective in preclinical studies, clinically proven treatment alternatives for cerebral infarction remain scarce. Amongst the reasons for the discrep...

    Authors: Jakob O Ström, Edvin Ingberg, Annette Theodorsson and Elvar Theodorsson

    Citation: BMC Neuroscience 2013 14:41

    Content type: Methodology article

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  2. We have shown previously that near-infrared light (NIr) treatment or photobiomodulation neuroprotects dopaminergic cells in substantia nigra pars compacta (SNc) from degeneration induced by 1-methyl-4-phenyl-1...

    Authors: Cécile Moro, Napoleon Torres, Nabil El Massri, David Ratel, Daniel M Johnstone, Jonathan Stone, John Mitrofanis and Alim-Louis Benabid

    Citation: BMC Neuroscience 2013 14:40

    Content type: Research article

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  3. Upregulation of vasoconstrictor receptors in cerebral arteries, including endothelin B (ETB) and 5-hydroxytryptamine 1B (5-HT1B) receptors, has been suggested to contribute to delayed cerebral ischemia, a feared ...

    Authors: Gro Klitgaard Povlsen, Sara Ellinor Johansson, Carl Christian Larsen, Ajoy Kumar Samraj and Lars Edvinsson

    Citation: BMC Neuroscience 2013 14:34

    Content type: Research article

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  4. Erythropoietin (EPO) and its covalently modified analogs are neuroprotective in various models of brain damage and disease. We investigated the effect on brain damage and memory performance, of a continuous 3-...

    Authors: Johan Undén, Carin Sjölund, John-Kalle Länsberg, Tadeusz Wieloch, Karsten Ruscher and Bertil Romner

    Citation: BMC Neuroscience 2013 14:27

    Content type: Research article

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  5. Post-stroke hyperglycemia appears to be associated with poor outcome from stroke, greater mortality, and reduced functional recovery. Focal cerebral ischemia data support that neural stem cells (NSCs) play an ...

    Authors: Jian Chen, Yang Guo, Wei Cheng, Ruiqing Chen, Tianzhu Liu, Zhenzhou Chen and Sheng Tan

    Citation: BMC Neuroscience 2013 14:24

    Content type: Research article

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  6. Substantial experimental evidence supports that reactive species mediate secondary damage after traumatic spinal cord injury (SCI) by inducing oxidative stress. Removal of reactive species may reduce secondary...

    Authors: Danxia Liu, Yichu Shan, Lokanatha Valluru and Feng Bao

    Citation: BMC Neuroscience 2013 14:23

    Content type: Research article

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  7. Anti-NMDA-encephalitis is caused by antibodies against the N-methyl-D-aspartate receptor (NMDAR) and characterized by a severe encephalopathy with psychosis, epileptic seizures and autonomic disturbances. It p...

    Authors: Sabine U Jantzen, Stefano Ferrea, Claudia Wach, Kim Quasthoff, Sebastian Illes, Dag Scherfeld, Hans-Peter Hartung, Rüdiger J Seitz and Marcel Dihné

    Citation: BMC Neuroscience 2013 14:17

    Content type: Research article

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  8. Receptor-interacting protein 3 (RIP3), a member of RIP family proteins, has been shown to participate in programmed necrosis or necroptosis in cell biology studies. Evidence suggests that necroptosis may be a ...

    Authors: Ju-Fang Huang, Lei Shang, Meng-Qi Zhang, Hui Wang, Dan Chen, Jian-Bin Tong, He Huang, Xiao-Xin Yan, Le-Ping Zeng and Kun Xiong

    Citation: BMC Neuroscience 2013 14:16

    Content type: Research article

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  9. Cerebral ischemia results in enhanced expression of contractile cerebrovascular receptors, such as endothelin type B (ETB), 5-hydroxytryptamine type 1B (5-HT1B), angiotensin II type 1 (AT1) and thromboxane (TP) r...

    Authors: Saema Ansar, Sajedeh Eftekhari, Roya Waldsee, Elisabeth Nilsson, Ola Nilsson, Hans Säveland and Lars Edvinsson

    Citation: BMC Neuroscience 2013 14:12

    Content type: Research article

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  10. Progressive accumulation of α-synuclein (α-Syn) protein in different brain regions is a hallmark of synucleinopathic diseases, such as Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy...

    Authors: David Amschl, Jörg Neddens, Daniel Havas, Stefanie Flunkert, Roland Rabl, Heinrich Römer, Edward Rockenstein, Eliezer Masliah, Manfred Windisch and Birgit Hutter-Paier

    Citation: BMC Neuroscience 2013 14:6

    Content type: Research article

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  11. Domoic acid (DA) is an excitatory amino acid analogue of kainic acid (KA) that acts via activation of glutamate receptors to elicit a rapid and potent excitotoxic response, resulting in neuronal cell death. Re...

    Authors: Koji Tsunekawa, Fumio Kondo, Teruhiko Okada, Guo-Gang Feng, Lei Huang, Naohisa Ishikawa and Shoshiro Okada

    Citation: BMC Neuroscience 2013 14:4

    Content type: Research article

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  12. Genetic networks control cellular functions. Aberrations in normal cellular function are caused by mutations in genes that disrupt the fine tuning of genetic networks and cause disease or disorder. However, th...

    Authors: Suhas V Vasaikar, Aditya K Padhi, Bhyravabhotla Jayaram and James Gomes

    Citation: BMC Neuroscience 2013 14:3

    Content type: Database

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  13. Although the etiology of PD remains unclear, increasing evidence has shown that oxidative stress plays an important role in its pathogenesis and that of other neurodegenerative disorders. NOX2, a cytochrome su...

    Authors: Qinyong Ye, Bixia Huang, Xiaodong Zhang, Yuangui Zhu and Xiaochun Chen

    Citation: BMC Neuroscience 2012 13:156

    Content type: Research article

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  14. Leukotrienes are potent inflammatory mediators, which in a number of studies have been found to be associated with ischemic stroke pathology: gene variants affecting leukotriene synthesis, including the FLAP (...

    Authors: Jakob O Ström, Tobias Strid and Sven Hammarström

    Citation: BMC Neuroscience 2012 13:146

    Content type: Research article

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  15. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, caused by progressive loss of motor neurons. Changes are widespread in the subcortical white matter in ALS. Diffusion tensor imaging (...

    Authors: Carsten Keil, Tino Prell, Thomas Peschel, Viktor Hartung, Reinhard Dengler and Julian Grosskreutz

    Citation: BMC Neuroscience 2012 13:141

    Content type: Research article

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  16. Prepulse inhibition (PPI) of the startle response is an important tool to investigate the biology of schizophrenia. PPI is usually observed by use of a startle reflex such as blinking following an intense soun...

    Authors: Koji Inui, Aki Tsuruhara, Minori Kodaira, Eishi Motomura, Hisashi Tanii, Makoto Nishihara, Sumru Keceli and Ryusuke Kakigi

    Citation: BMC Neuroscience 2012 13:135

    Content type: Research article

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  17. In animal models, the metabolic syndrome elicits a cerebral response characterized by altered phospholipid and unesterified fatty acid concentrations and increases in pro-apoptotic inflammatory mediators that ...

    Authors: Ameer Y Taha, Fei Gao, Epolia Ramadan, Yewon Cheon, Stanley I Rapoport and Hyung-Wook Kim

    Citation: BMC Neuroscience 2012 13:131

    Content type: Research article

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  18. Alcohol use disorders (AUDs) lead to alterations in central nervous system (CNS) architecture along with impaired learning and memory. Previous work from our group and that of others suggests that one mechanis...

    Authors: Steven D Hicks, Lambert Lewis, Julie Ritchie, Patrick Burke, Ynesse Abdul-Malak, Nyssa Adackapara, Kelly Canfield, Erik Shwarts, Karen Gentile, Zsuzsa Szombathyne Meszaros and Frank A Middleton

    Citation: BMC Neuroscience 2012 13:128

    Content type: Research article

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  19. Complete recovery of motor function after stroke is rare with deficits persisting into the chronic phase of recovery. Diffusion tensor imaging (DTI) can evaluate relationships between white matter microstructu...

    Authors: Michael R Borich, Cameron Mang and Lara A Boyd

    Citation: BMC Neuroscience 2012 13:107

    Content type: Research article

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  20. Cell therapy is a potential therapeutic approach for several neurodegenetative disease, including Huntington Disease (HD). To evaluate the putative efficacy of cell therapy in HD, most studies have used excito...

    Authors: Gehan El-Akabawy, Ivan Rattray, Saga M Johansson, Richard Gale, Gillian Bates and Michel Modo

    Citation: BMC Neuroscience 2012 13:97

    Content type: Research article

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  21. Amyloid precursor protein (APP), a key molecule in Alzheimer’s disease (AD), is metabolized in two alternative cleavages, generating either the amyloidogenic peptides involved in AD pathology or the soluble fo...

    Authors: Christiane Rose, Katell Peoc’h, Stéphanie Chasseigneaux, Claire Paquet, Julien Dumurgier, Fanchon Bourasset, Frédéric Calon, Jean-Louis Laplanche, Jacques Hugon and Bernadette Allinquant

    Citation: BMC Neuroscience 2012 13:84

    Content type: Methodology article

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  22. The discovery of the inherited disorders of creatine (Cr) synthesis and transport in the last few years disclosed the importance of blood Cr supply for the normal functioning of the brain. These putatively rar...

    Authors: Claudia Carducci, Carla Carducci, Silvia Santagata, Enrico Adriano, Cristiana Artiola, Stefano Thellung, Elena Gatta, Mauro Robello, Tullio Florio, Italo Antonozzi, Vincenzo Leuzzi and Maurizio Balestrino

    Citation: BMC Neuroscience 2012 13:41

    Content type: Research article

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  23. Multiple sclerosis (MS) varies considerably in its incidence and progression in females and males. In spite of clinical evidence, relatively few studies have explored molecular mechanisms possibly involved in ...

    Authors: Alessandro Massella, Giulia D'Intino, Mercedes Fernández, Sandra Sivilia, Luca Lorenzini, Silvia Giatti, Roberto C Melcangi, Laura Calzà and Luciana Giardino

    Citation: BMC Neuroscience 2012 13:12

    Content type: Research article

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  24. Berberine (BER), the major alkaloidal component of Rhizoma coptidis, has multiple pharmacological effects including inhibition of acetylcholinesterase, reduction of cholesterol and glucose levels, anti-inflammato...

    Authors: Feiqi Zhu, Fujun Wu, Ying Ma, Guangjian Liu, Zhong Li, Yong'an Sun and Zhong Pei

    Citation: BMC Neuroscience 2011 12:125

    Content type: Research article

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  25. Parkinson's disease (PD) is characterized at the cellular level by a destruction of neuromelanin (NM)-containing dopaminergic cells and a profound reduction in striatal dopamine. It has been shown recently tha...

    Authors: Uwe Oberländer, Katrien Pletinckx, Anja Döhler, Nora Müller, Manfred B Lutz, Thomas Arzberger, Peter Riederer, Manfred Gerlach, Eleni Koutsilieri and Carsten Scheller

    Citation: BMC Neuroscience 2011 12:116

    Content type: Research article

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  26. Evidence suggests that rheumatoid arthritis (RA) may enhance or reduce the progression of Alzheimer's disease (AD). The present study was performed to directly explore the effects of collagen-induced rheumatoi...

    Authors: Sun Mi Park, Jin Hee Shin, Gyeong Joon Moon, Sung Ig Cho, Yong Beom Lee and Byoung Joo Gwag

    Citation: BMC Neuroscience 2011 12:106

    Content type: Research article

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  27. Hirano bodies are actin-rich cytoplasmic inclusions found predominantly in the brain in association with a variety of conditions including aging and Alzheimer's disease. The function of Hirano bodies in normal...

    Authors: Sangdeuk Ha, Ruth Furukawa, Michael Stramiello, John J Wagner and Marcus Fechheimer

    Citation: BMC Neuroscience 2011 12:97

    Content type: Research article

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  28. Overexpression of mutant copper/zinc superoxide dismutase (SOD1) in rodents has provided useful models for studying the pathogenesis of amyotrophic lateral sclerosis (ALS). Microglia have been shown to contribute...

    Authors: Siranush A Sargsyan, Daniel J Blackburn, Siân C Barber, Julian Grosskreutz, Kurt J De Vos, Peter N Monk and Pamela J Shaw

    Citation: BMC Neuroscience 2011 12:91

    Content type: Research article

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  29. Rett syndrome is a neurodevelopmental and autistic disease caused by mutations of Methyl-CpG-binding protein 2 (MECP2) gene. MeCP2 protein is mainly expressed in neurons and binds to methylated gene promoters to ...

    Authors: Kunio Miyake, Takae Hirasawa, Masaki Soutome, Masayuki Itoh, Yu-ichi Goto, Kazushi Endoh, Kenichiro Takahashi, Shinichi Kudo, Takayuki Nakagawa, Sana Yokoi, Takahiro Taira, Johji Inazawa and Takeo Kubota

    Citation: BMC Neuroscience 2011 12:81

    Content type: Research article

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  30. α-synuclein [α-Syn]-mediated activation of GSK-3β leading to increases in hyperphosphorylated Tau has been shown by us to occur in striata of Parkinson's diseased [PD] patients and in animal models of PD. In A...

    Authors: Tiffany Kaul, Joel Credle, Thomas Haggerty, Adam W Oaks, Eliezer Masliah and Anita Sidhu

    Citation: BMC Neuroscience 2011 12:79

    Content type: Research article

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  31. Proanthocyanidin is a polyphenolic bioflavonoid with known antioxidant activity. Some flavonoids have a modulatory effect on [Ca2+]i. Although proanthocyanidin extract from blueberries reportedly affects Ca2+ buf...

    Authors: Seo-Hee Ahn, Hee Jung Kim, Imju Jeong, Yi Jae Hong, Myung-Jun Kim, Duck-Joo Rhie, Yang-Hyeok Jo, Sang June Hahn and Shin Hee Yoon

    Citation: BMC Neuroscience 2011 12:78

    Content type: Research article

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  32. The primary cilium is a solitary organelle important in cellular signaling, that projects from the cell surface of most growth-arrested or post-mitotic cells including neurons in the central nervous system. We...

    Authors: Xiaoxing Ma, Randy Peterson and John Turnbull

    Citation: BMC Neuroscience 2011 12:71

    Content type: Research article

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  33. To cope with the limitations faced by autograft acquisitions particularly for multiple nerve injuries, artificial nerve conduit has been introduced by researchers as a substitute for autologous nerve graft for...

    Authors: Wenwen Yu, Wen Zhao, Chao Zhu, Xiuli Zhang, Dongxia Ye, Wenjie Zhang, Yong Zhou, Xinquan Jiang and Zhiyuan Zhang

    Citation: BMC Neuroscience 2011 12:68

    Content type: Research article

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  34. Perivenular inflammation is a common early pathological feature in multiple sclerosis (MS). A recent hypothesis stated that CNS inflammation is induced by perivenular iron deposits that occur in response to al...

    Authors: Rachel Williams, Aaron M Rohr, Wen-Tung Wang, In-Young Choi, Phil Lee, Nancy EJ Berman, Sharon G Lynch and Steven M LeVine

    Citation: BMC Neuroscience 2011 12:59

    Content type: Research article

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  35. Rett syndrome (RTT, MIM #312750) is a severe neurological disorder caused by mutations in the X-linked methyl-CpG binding protein 2 (MECP2) gene. Female patients are affected with an incidence of 1/15000 live bir...

    Authors: Nicolas Panayotis, Adeline Ghata, Laurent Villard and Jean-Christophe Roux

    Citation: BMC Neuroscience 2011 12:47

    Content type: Research article

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  36. The appearance of Aβ42 peptide deposits is admitted to be a key event in the pathogenesis of Alzheimer's disease, although amyloid deposits also occur in aged non-demented subjects. Aβ42 is a degradation produ...

    Authors: Jean-Marie Serot, Johann Peltier, Antony Fichten, Nelly Ledeme, Anne-Marie Bourgeois, Pierre Jouanny, Patrick Toussaint, Daniel Legars, Olivier Godefroy and Jean-Claude Mazière

    Citation: BMC Neuroscience 2011 12:42

    Content type: Research article

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  37. Long-term primary neuronal cultures are a useful tool for the investigation of biochemical processes associated with neuronal senescence. Improvements in available technology make it possible to observe matura...

    Authors: Sarah J Bertrand, Marina V Aksenova, Micheal Y Aksenov, Charles F Mactutus and Rosemarie M Booze

    Citation: BMC Neuroscience 2011 12:38

    Content type: Research article

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  38. The cause of sporadic amyotrophic lateral sclerosis (ALS) is largely unknown but hypotheses about disease mechanisms include oxidative stress, defective axonal transport, mitochondrial dysfunction and disrupte...

    Authors: Ralf Palmisano, Panagiota Golfi, Peter Heimann, Christopher Shaw, Claire Troakes, Thomas Schmitt-John and Jörg W Bartsch

    Citation: BMC Neuroscience 2011 12:24

    Content type: Research article

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  39. The exact cause of schizophrenia is not known, although several aetiological theories have been proposed for the disease, including developmental or neurodegenerative processes, neurotransmitter abnormalities,...

    Authors: Marcella Reale, Antonia Patruno, Maria A De Lutiis, Mirko Pesce, Mario Felaco, Massimo Di Giannantonio, Marta Di Nicola and Alfredo Grilli

    Citation: BMC Neuroscience 2011 12:13

    Content type: Research article

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  40. Injury to the peripheral branch of dorsal root ganglia (DRG) neurons prior to injury to the central nervous system (CNS) DRG branch results in the regeneration of the central branch. The exact mechanism mediat...

    Authors: Ernesto A Aguilar Salegio, Anthony N Pollard, Malcolm Smith and Xin-Fu Zhou

    Citation: BMC Neuroscience 2011 12:11

    Content type: Research article

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  41. Protein aggregates containing alpha-synuclein, beta-amyloid and hyperphosphorylated tau are commonly found during neurodegenerative processes which is often accompanied by the impairment of mitochondrial compl...

    Authors: Rodrigo S Chaves, Thaiany Q Melo, Stephanie A Martins and Merari FR Ferrari

    Citation: BMC Neuroscience 2010 11:144

    Content type: Research article

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  42. Accumulation of amyloid-β (Aβ) peptide in the brain is thought to play a key pathological role in Alzheimer's disease. Many pharmacological targets have therefore been proposed based upon the biochemistry of A...

    Authors: Jeremy H Toyn, Xu-Alan Lin, Mark W Thompson, Valerie Guss, Jere E Meredith Jr, Sethu Sankaranarayanan, Nestor Barrezueta, John Corradi, Antara Majumdar, Daniel L Small, Melissa Hansard, Thomas Lanthorn, Ryan S Westphal and Charles F Albright

    Citation: BMC Neuroscience 2010 11:143

    Content type: Research article

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  43. Neuron-derived neurotrophic factor (NDNF) is evolutionarily well conserved, being present in invertebrate animals such as the nematode, Caenorhabditis elegans, as well as in the fruit fly, Drosophila melanogaster

    Authors: Xiu-Li Kuang, Xiao-Mei Zhao, Hai-Fang Xu, Yuan-Yuan Shi, Jin-Bo Deng and Guo-Tao Sun

    Citation: BMC Neuroscience 2010 11:137

    Content type: Research article

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  44. The ability to respond to changes in the extra-intracellular environment is prerequisite for cell survival. Cellular responses to the environment include elevating defense systems, such as the antioxidant defe...

    Authors: Rajkumar Tulsawani, Lorena S Kelly, Nigar Fatma, Bhavanaben Chhunchha, Eri Kubo, Anil Kumar and Dhirendra P Singh

    Citation: BMC Neuroscience 2010 11:125

    Content type: Research article

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  45. Protein aggregation plays important roles in several neurodegenerative disorders. For instance, insoluble aggregates of phosphorylated tau and of Aβ peptides are cornerstones in the pathology of Alzheimer's di...

    Authors: Masood Kamali-Moghaddam, Frida Ekholm Pettersson, Di Wu, Hillevi Englund, Spyros Darmanis, Anna Lord, Gholamreza Tavoosidana, Dag Sehlin, Sigrun Gustafsdottir, Lars NG Nilsson, Lars Lannfelt and Ulf Landegren

    Citation: BMC Neuroscience 2010 11:124

    Content type: Methodology article

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  46. Sporadic late-onset Alzheimer's disease (AD) appears to evolve from an interplay between genetic and environmental factors. One environmental factor that continues to be of great interest is that of Chlamydia pne...

    Authors: Christine J Hammond, Loretta R Hallock, Raymond J Howanski, Denah M Appelt, C Scott Little and Brian J Balin

    Citation: BMC Neuroscience 2010 11:121

    Content type: Methodology article

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  47. Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder linked to expanded CAG-triplet nucleotide repeats within the huntingtin gene. Intracellular huntingtin aggregates are present in neuro...

    Authors: Zacharias Kohl, Martin Regensburger, Robert Aigner, Mahesh Kandasamy, Beate Winner, Ludwig Aigner and Jürgen Winkler

    Citation: BMC Neuroscience 2010 11:114

    Content type: Research article

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  48. The zebrafish has been suggested as a model system for studying human diseases that affect nervous system function and motor output. However, few of the ion channels that control neuronal activity in zebrafish...

    Authors: Allan F Mock, Jessica L Richardson, Jui-Yi Hsieh, Gina Rinetti and Diane M Papazian

    Citation: BMC Neuroscience 2010 11:99

    Content type: Research article

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