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Neurobiology of disease

Section edited by Karsten Ruscher

This section covers the neurobiological aspects of diseases that can affect the brain. Topics of interest include, but are not limited to, neuroinflammation, neurodegenerative pathophysiology, neurogenesis and experimental brain research. Diseases range across neurodegeneration, demyelinating conditions, addiction, psychiatric conditions, stroke and spinal cord conditions.

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  1. Mitochondrial dysfunction has been linked to neuronal death and a wide array of neurodegenerative diseases. Previously, we have shown sex differences in mitochondria-mediated cell death pathways following hypo...

    Authors: Jaswinder Sharma, Michael V Johnston and Mir Ahamed Hossain

    Citation: BMC Neuroscience 2014 15:9

    Content type: Research article

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  2. Bacterial superantigens are potent T cell activators that can activate T cells with specificity for antigens of the central nervous system (CNS). In this study, we compared the effect of two S. aureus strains on ...

    Authors: Thais Graziela Donegá França, Fernanda Chiuso-Minicucci, Sofia Fernanda Gonçalves Zorzella-Pezavento, Larissa Lumi Watanabe Ishikawa, Larissa Camargo da Rosa, Priscila Maria Colavite, Camila Marques, Maura Rosane Valério Ikoma, Maria de Lourdes Ribeiro de Souza da Cunha and Alexandrina Sartori

    Citation: BMC Neuroscience 2014 15:8

    Content type: Research article

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  3. Despite strong evidence that the pathophysiology of Tourette syndrome (TS) involves structural and functional disturbances of the basal ganglia and cortical frontal areas, findings from in vivo imaging studies...

    Authors: Kirsten R Müller-Vahl, Julian Grosskreutz, Tino Prell, Jörn Kaufmann, Nils Bodammer and Thomas Peschel

    Citation: BMC Neuroscience 2014 15:6

    Content type: Research article

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  4. Despite the evidence that renal hemodynamics is impaired in experimental diabetes, associated with glomeruli structural alterations, renal nerves were not yet investigated in experimental models of diabetes an...

    Authors: Karina Laurenti Sato, Luciana Sayuri Sanada, Renata da Silva Ferreira, Maria Carolina del Bem de Barros Oliveti de Marco, Jaci Airton Castania, Helio Cesar Salgado, Randy Alan Nessler and Valeria Paula Sassoli Fazan

    Citation: BMC Neuroscience 2014 15:5

    Content type: Research article

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  5. Cortical neurons display network-level dynamics with unique spatiotemporal patterns that construct the backbone of processing information signals and contribute to higher functions. Recent years have seen a we...

    Authors: José Jiun-Shian Wu, Wei-Pang Chang, Hsi-Chien Shih, Chen-Tung Yen and Bai Chuang Shyu

    Citation: BMC Neuroscience 2014 15:3

    Content type: Research article

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  6. Ischemic brain injury due to stroke and/or cardiac arrest is a major health issue in modern society requiring urgent development of new effective therapies. The aim of this study was to evaluate mitochondrial,...

    Authors: Olga Suchadolskiene, Andrius Pranskunas, Giedre Baliutyte, Vincentas Veikutis, Zilvinas Dambrauskas, Dinas Vaitkaitis and Vilmante Borutaite

    Citation: BMC Neuroscience 2014 15:2

    Content type: Research article

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  7. Insulin-like growth factor binding protein-2 (IGFBP-2) regulates the bioavailability, transportation, and localization of insulin-like growth factor-I (IGF-I), an effective neuroprotectant in animal stroke mod...

    Authors: Lauren Fletcher, Elif Isgor, Shane Sprague, Lindsey H Williams, Betty B Alajajian, David F Jimenez and Murat Digicaylioglu

    Citation: BMC Neuroscience 2013 14:158

    Content type: Research article

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  8. It has been suggested that glutamatergic system hyperactivity may be related to the pathogenesis of Parkinson’s disease (PD). Vesicular glutamate transporters (VGLUT1-3) import glutamate into synaptic vesicles...

    Authors: Mathieu Favier, Carole Carcenac, Guillaume Drui, Sabrina Boulet, Salah El Mestikawy and Marc Savasta

    Citation: BMC Neuroscience 2013 14:152

    Content type: Research article

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  9. A recent study of lateral septum (LS) suggested a large number of autism-related genes with altered expression in the postpartum state. However, formally testing the findings for enrichment of autism-associate...

    Authors: Brian E Eisinger, Michael C Saul, Terri M Driessen and Stephen C Gammie

    Citation: BMC Neuroscience 2013 14:147

    Content type: Software

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  10. Traumatic spinal cord injury (SCI)-induced overproduction of endogenous deleterious substances triggers secondary cell death to spread damage beyond the initial injury site. Substantial experimental evidence s...

    Authors: Xiang Ling, Feng Bao, Hao Qian and Danxia Liu

    Citation: BMC Neuroscience 2013 14:146

    Content type: Research article

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  11. Parkinson’s disease is an age-related disease whose pathogenesis is not completely known. Animal models exist for investigating the disease but not all results can be easily transferred to humans. Therefore, m...

    Authors: Finja Büchel, Sandra Saliger, Andreas Dräger, Stephanie Hoffmann, Clemens Wrzodek, Andreas Zell and Philipp J Kahle

    Citation: BMC Neuroscience 2013 14:136

    Content type: Research article

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  12. Mutations of the gene encoding the major component of Lewy bodies (LB), α-synuclein (α-syn), cause autosomal dominant forms of Parkinson’s disease (PD), whereas loss-of-function mutations of the gene encoding ...

    Authors: Margot Fournier, Amandine Roux, Jérôme Garrigue, Marie-Paule Muriel, Paul Blanche, Hilal A Lashuel, John P Anderson, Robin Barbour, Jiping Huang, Sophie Tezenas du Montcel, Alexis Brice and Olga Corti

    Citation: BMC Neuroscience 2013 14:135

    Content type: Research article

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  13. Endothelin-1 (ET-1) is a potent vasoconstrictor, and astrocytic ET-1 is reported to play a role in the pathogenesis of cerebral ischemic injury and cytotoxic edema. However, it is still unknown whether astrocy...

    Authors: Patrick KK Yeung, Jiangang Shen, Stephen SM Chung and Sookja K Chung

    Citation: BMC Neuroscience 2013 14:131

    Content type: Research article

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  14. Serotonin (5-HT) is a well-known modulator of eating behavior. However, the molecular mechanisms linking its action to body weight balance have been only partially elucidated. Since platelets are a suitable pe...

    Authors: Gino Giannaccini, Laura Betti, Lionella Palego, Alessandro Marsili, Ferruccio Santini, Caterina Pelosini, Laura Fabbrini, Lara Schmid, Laura Giusti, Margherita Maffei, Mario Lanza, Mario Cristofaro, Stefano Baroni, Mauro Mauri, Paolo Vitti, Paola Fierabracci…

    Citation: BMC Neuroscience 2013 14:128

    Content type: Research article

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  15. The developmental morphogen sonic hedgehog (Shh) may continue to play a trophic role in the support of terminally-differentiated motor neurons, of potential relevance to motor neuron disease. In addition, it m...

    Authors: Xiaoxing Ma, Patrick Turnbull, Randy Peterson and John Turnbull

    Citation: BMC Neuroscience 2013 14:119

    Content type: Research article

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  16. Mice generated by a Cre/LoxP transgenic paradigm were used to model neurodegenerative basal ganglia disease of which Huntington disease (HD) is the prototypical example. In HD, death occurs in striatal project...

    Authors: Arthur Smardencas, Kerelos Rizkalla, Hyun Ah Kim, Jim Massalas, Claire O’Leary, Michelle E Ehrlich, Günter Schütz, Andrew J Lawrence and John Drago

    Citation: BMC Neuroscience 2013 14:111

    Content type: Research article

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  17. Posttranslational modifications of beta amyloid (Aβ) have been shown to affect its biophysical and neurophysiological properties. One of these modifications is N-terminal pyroglutamate (pE) formation. Enzymati...

    Authors: Andreas Becker, Stephanie Kohlmann, Anca Alexandru, Wolfgang Jagla, Fabio Canneva, Christoph Bäuscher, Holger Cynis, Reinhard Sedlmeier, Sigrid Graubner, Stephan Schilling, Hans-Ulrich Demuth and Stephan von Hörsten

    Citation: BMC Neuroscience 2013 14:108

    Content type: Research article

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  18. It has been shown that olfactory ensheathing glia (OEG) and Schwann cell (SCs) transplantation are beneficial as cellular treatments for spinal cord injury (SCI), especially acute and sub-acute time points. In...

    Authors: Helen R Barbour, Christine D Plant, Alan R Harvey and Giles W Plant

    Citation: BMC Neuroscience 2013 14:106

    Content type: Research article

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  19. Gene expression profiling of the postmortem human brain is part of the effort to understand the neuropathological underpinnings of schizophrenia. Existing microarray studies have identified a large number of g...

    Authors: Meeta Mistry, Jesse Gillis and Paul Pavlidis

    Citation: BMC Neuroscience 2013 14:105

    Content type: Research article

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  20. Traumatic injury to the central nervous system results in damage to tissue beyond the primary injury, termed secondary degeneration. Key events thought to be associated with secondary degeneration involve aspe...

    Authors: Nadia Cummins, Carole A Bartlett, Michael Archer, Elora Bartlett, Jan M Hemmi, Alan R Harvey, Sarah A Dunlop and Melinda Fitzgerald

    Citation: BMC Neuroscience 2013 14:98

    Content type: Research article

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  21. Bone marrow is an accessible source of progenitor cells, which have been investigated as treatment for neurological diseases in a number of clinical trials. Here we evaluated the potential benefit of bone marr...

    Authors: Enéas Galdini Ferrazoli, Miriam Marcela Blanco, Simone Bittencourt, André Luis Lacerda Bachi, Luciana Bahia, Milena Botelho Pereira Soares, Ricardo Ribeiro-dos-Santos, Luiz Eugênio Mello and Beatriz Monteiro Longo

    Citation: BMC Neuroscience 2013 14:97

    Content type: Research article

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  22. The severity of angiographically assessed coronary artery disease may be the factor that influences the degree of brain damage during on-pump surgery. Modern technology such as computed electroencephalography ...

    Authors: Irina V Tarasova, Roman S Tarasov, Olga A Trubnikova, Olga L Barbarash and Leonid S Barbarash

    Citation: BMC Neuroscience 2013 14:95

    Content type: Research article

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  23. Glutamate is one of the major neurotransmitters in the central nervous system. It is a potent neurotoxin capable of neuronal destruction through numerous signal pathways when present in high concentration. Glu...

    Authors: Nailya S Gliyazova, Eun Y Huh and Gordon C Ibeanu

    Citation: BMC Neuroscience 2013 14:93

    Content type: Research article

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  24. SV2A, SV2B and SV2C are synaptic vesicle proteins that are structurally related to members of the major facilitator superfamily (MFS). The function and transported substrate of the SV2 proteins is not clearly ...

    Authors: Julie Crèvecœur, Patrik Foerch, Melissa Doupagne, Caroline Thielen, Catherine Vandenplas, Gustave Moonen, Manuel Deprez and Bernard Rogister

    Citation: BMC Neuroscience 2013 14:87

    Content type: Research article

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  25. The afferent projections from the auricular branch of the vagus nerve (ABVN) to the nucleus tractus solitaries (NTS) have been proposed as the anatomical basis for the increased parasympathetic tone seen in au...

    Authors: Wei He, Xiang-Hong Jing, Bing Zhu, Xin-Long Zhu, Liang Li, Wan-Zhu Bai and Hui Ben

    Citation: BMC Neuroscience 2013 14:85

    Content type: Research article

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  26. Electrical stimulation of brain structures has been widely used in rodent models for kindling or modeling deep brain stimulation used clinically. This requires surgical implantation of intracranial electrodes ...

    Authors: Melanie Jeffrey, Min Lang, Jonathan Gane, Chiping Wu, W McIntyre Burnham and Liang Zhang

    Citation: BMC Neuroscience 2013 14:82

    Content type: Methodology article

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  27. The olfactory ensheathing cells (OECs) derived from olfactory bulb (OB) may improve motor function after transplantation in injured spinal cord. However, the effects of OEC transplantation on sensory function ...

    Authors: Bing-Chen Lang, Zhuo Zhang, Long-Yun Lv, Jin Liu, Ting-Yong Wang, Ling-Hui Yang, Da-Qing Liao, Wen-Sheng Zhang and Ting-Hua Wang

    Citation: BMC Neuroscience 2013 14:80

    Content type: Research article

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  28. Abnormal processing of esophageal sensation at the level of the central nervous system has been proven to be involved in gastroesophageal reflux disease (GERD). However, most studies were focused on the possib...

    Authors: Huihui Sun, Ying Chen, Xiaohu Zhao, Xiangbin Wang, Yuanxi Jiang, Ping Wu, Yinhan Tang, Qingwei Meng and Shuchang Xu

    Citation: BMC Neuroscience 2013 14:69

    Content type: Research article

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  29. The plasma protein hemopexin (HPX) exhibits the highest binding affinity to free heme. In vitro experiments and gene-knock out technique have suggested that HPX may have a neuroprotective effect. However, the ...

    Authors: Beibei Dong, Min Cai, Zongping Fang, Haidong Wei, Fangyun Zhu, Guochao Li, Hailong Dong and Lize Xiong

    Citation: BMC Neuroscience 2013 14:58

    Content type: Research article

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  30. Alzheimer disease is a multifactorial disorder characterized by the progressive deterioration of neuronal networks. The pathological hallmarks includes extracellular amyloid plaques and intraneuronal neurofibr...

    Authors: Sandra Sivilia, Luca Lorenzini, Alessandro Giuliani, Marco Gusciglio, Mercedes Fernandez, Vito Antonio Baldassarro, Chiara Mangano, Luca Ferraro, Vladimiro Pietrini, Maria Francesca Baroc, Arturo R Viscomi, Simone Ottonello, Gino Villetti, Bruno P Imbimbo, Laura Calzà and Luciana Giardino

    Citation: BMC Neuroscience 2013 14:44

    Content type: Research article

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  31. Even though more than 600 stroke treatments have been shown effective in preclinical studies, clinically proven treatment alternatives for cerebral infarction remain scarce. Amongst the reasons for the discrep...

    Authors: Jakob O Ström, Edvin Ingberg, Annette Theodorsson and Elvar Theodorsson

    Citation: BMC Neuroscience 2013 14:41

    Content type: Methodology article

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  32. We have shown previously that near-infrared light (NIr) treatment or photobiomodulation neuroprotects dopaminergic cells in substantia nigra pars compacta (SNc) from degeneration induced by 1-methyl-4-phenyl-1...

    Authors: Cécile Moro, Napoleon Torres, Nabil El Massri, David Ratel, Daniel M Johnstone, Jonathan Stone, John Mitrofanis and Alim-Louis Benabid

    Citation: BMC Neuroscience 2013 14:40

    Content type: Research article

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  33. Upregulation of vasoconstrictor receptors in cerebral arteries, including endothelin B (ETB) and 5-hydroxytryptamine 1B (5-HT1B) receptors, has been suggested to contribute to delayed cerebral ischemia, a feared ...

    Authors: Gro Klitgaard Povlsen, Sara Ellinor Johansson, Carl Christian Larsen, Ajoy Kumar Samraj and Lars Edvinsson

    Citation: BMC Neuroscience 2013 14:34

    Content type: Research article

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  34. Erythropoietin (EPO) and its covalently modified analogs are neuroprotective in various models of brain damage and disease. We investigated the effect on brain damage and memory performance, of a continuous 3-...

    Authors: Johan Undén, Carin Sjölund, John-Kalle Länsberg, Tadeusz Wieloch, Karsten Ruscher and Bertil Romner

    Citation: BMC Neuroscience 2013 14:27

    Content type: Research article

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  35. Post-stroke hyperglycemia appears to be associated with poor outcome from stroke, greater mortality, and reduced functional recovery. Focal cerebral ischemia data support that neural stem cells (NSCs) play an ...

    Authors: Jian Chen, Yang Guo, Wei Cheng, Ruiqing Chen, Tianzhu Liu, Zhenzhou Chen and Sheng Tan

    Citation: BMC Neuroscience 2013 14:24

    Content type: Research article

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  36. Substantial experimental evidence supports that reactive species mediate secondary damage after traumatic spinal cord injury (SCI) by inducing oxidative stress. Removal of reactive species may reduce secondary...

    Authors: Danxia Liu, Yichu Shan, Lokanatha Valluru and Feng Bao

    Citation: BMC Neuroscience 2013 14:23

    Content type: Research article

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  37. Anti-NMDA-encephalitis is caused by antibodies against the N-methyl-D-aspartate receptor (NMDAR) and characterized by a severe encephalopathy with psychosis, epileptic seizures and autonomic disturbances. It p...

    Authors: Sabine U Jantzen, Stefano Ferrea, Claudia Wach, Kim Quasthoff, Sebastian Illes, Dag Scherfeld, Hans-Peter Hartung, Rüdiger J Seitz and Marcel Dihné

    Citation: BMC Neuroscience 2013 14:17

    Content type: Research article

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  38. Receptor-interacting protein 3 (RIP3), a member of RIP family proteins, has been shown to participate in programmed necrosis or necroptosis in cell biology studies. Evidence suggests that necroptosis may be a ...

    Authors: Ju-Fang Huang, Lei Shang, Meng-Qi Zhang, Hui Wang, Dan Chen, Jian-Bin Tong, He Huang, Xiao-Xin Yan, Le-Ping Zeng and Kun Xiong

    Citation: BMC Neuroscience 2013 14:16

    Content type: Research article

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  39. Cerebral ischemia results in enhanced expression of contractile cerebrovascular receptors, such as endothelin type B (ETB), 5-hydroxytryptamine type 1B (5-HT1B), angiotensin II type 1 (AT1) and thromboxane (TP) r...

    Authors: Saema Ansar, Sajedeh Eftekhari, Roya Waldsee, Elisabeth Nilsson, Ola Nilsson, Hans Säveland and Lars Edvinsson

    Citation: BMC Neuroscience 2013 14:12

    Content type: Research article

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  40. Progressive accumulation of α-synuclein (α-Syn) protein in different brain regions is a hallmark of synucleinopathic diseases, such as Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy...

    Authors: David Amschl, Jörg Neddens, Daniel Havas, Stefanie Flunkert, Roland Rabl, Heinrich Römer, Edward Rockenstein, Eliezer Masliah, Manfred Windisch and Birgit Hutter-Paier

    Citation: BMC Neuroscience 2013 14:6

    Content type: Research article

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  41. Domoic acid (DA) is an excitatory amino acid analogue of kainic acid (KA) that acts via activation of glutamate receptors to elicit a rapid and potent excitotoxic response, resulting in neuronal cell death. Re...

    Authors: Koji Tsunekawa, Fumio Kondo, Teruhiko Okada, Guo-Gang Feng, Lei Huang, Naohisa Ishikawa and Shoshiro Okada

    Citation: BMC Neuroscience 2013 14:4

    Content type: Research article

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  42. Genetic networks control cellular functions. Aberrations in normal cellular function are caused by mutations in genes that disrupt the fine tuning of genetic networks and cause disease or disorder. However, th...

    Authors: Suhas V Vasaikar, Aditya K Padhi, Bhyravabhotla Jayaram and James Gomes

    Citation: BMC Neuroscience 2013 14:3

    Content type: Database

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  43. Although the etiology of PD remains unclear, increasing evidence has shown that oxidative stress plays an important role in its pathogenesis and that of other neurodegenerative disorders. NOX2, a cytochrome su...

    Authors: Qinyong Ye, Bixia Huang, Xiaodong Zhang, Yuangui Zhu and Xiaochun Chen

    Citation: BMC Neuroscience 2012 13:156

    Content type: Research article

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  44. Leukotrienes are potent inflammatory mediators, which in a number of studies have been found to be associated with ischemic stroke pathology: gene variants affecting leukotriene synthesis, including the FLAP (...

    Authors: Jakob O Ström, Tobias Strid and Sven Hammarström

    Citation: BMC Neuroscience 2012 13:146

    Content type: Research article

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  45. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, caused by progressive loss of motor neurons. Changes are widespread in the subcortical white matter in ALS. Diffusion tensor imaging (...

    Authors: Carsten Keil, Tino Prell, Thomas Peschel, Viktor Hartung, Reinhard Dengler and Julian Grosskreutz

    Citation: BMC Neuroscience 2012 13:141

    Content type: Research article

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  46. Prepulse inhibition (PPI) of the startle response is an important tool to investigate the biology of schizophrenia. PPI is usually observed by use of a startle reflex such as blinking following an intense soun...

    Authors: Koji Inui, Aki Tsuruhara, Minori Kodaira, Eishi Motomura, Hisashi Tanii, Makoto Nishihara, Sumru Keceli and Ryusuke Kakigi

    Citation: BMC Neuroscience 2012 13:135

    Content type: Research article

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  47. In animal models, the metabolic syndrome elicits a cerebral response characterized by altered phospholipid and unesterified fatty acid concentrations and increases in pro-apoptotic inflammatory mediators that ...

    Authors: Ameer Y Taha, Fei Gao, Epolia Ramadan, Yewon Cheon, Stanley I Rapoport and Hyung-Wook Kim

    Citation: BMC Neuroscience 2012 13:131

    Content type: Research article

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  48. Alcohol use disorders (AUDs) lead to alterations in central nervous system (CNS) architecture along with impaired learning and memory. Previous work from our group and that of others suggests that one mechanis...

    Authors: Steven D Hicks, Lambert Lewis, Julie Ritchie, Patrick Burke, Ynesse Abdul-Malak, Nyssa Adackapara, Kelly Canfield, Erik Shwarts, Karen Gentile, Zsuzsa Szombathyne Meszaros and Frank A Middleton

    Citation: BMC Neuroscience 2012 13:128

    Content type: Research article

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  49. Complete recovery of motor function after stroke is rare with deficits persisting into the chronic phase of recovery. Diffusion tensor imaging (DTI) can evaluate relationships between white matter microstructu...

    Authors: Michael R Borich, Cameron Mang and Lara A Boyd

    Citation: BMC Neuroscience 2012 13:107

    Content type: Research article

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