Skip to content


Neurobiology of disease

Section edited by Karsten Ruscher

This section covers the neurobiological aspects of diseases that can affect the brain. Topics of interest include, but are not limited to, neuroinflammation, neurodegenerative pathophysiology, neurogenesis and experimental brain research. Diseases range across neurodegeneration, demyelinating conditions, addiction, psychiatric conditions, stroke and spinal cord conditions.

Page 3 of 10
  1. Content type: Research article

    Sleep disruptions are common in epilepsy patients. Our previous study demonstrates that homeostatic factors and circadian rhythm may mediate epilepsy-induced sleep disturbances when epilepsy occurs at differen...

    Authors: Tzu-Rung Huang, Shuo-Bin Jou, Yu-Ju Chou, Pei-Lu Yi, Chun-Jen Chen and Fang-Chia Chang

    Citation: BMC Neuroscience 2016 17:74

    Published on:

  2. Content type: Review

    Epilepsy is one of the most common neurological diseases characterized by excessive hyperexcitability of neurons. Molecular mechanisms of epilepsy are diverse and not really understood. All in common is the mi...

    Authors: Helena F. Pernice, Rico Schieweck, Michael A. Kiebler and Bastian Popper

    Citation: BMC Neuroscience 2016 17:73

    Published on:

  3. Content type: Methodology article

    Cone photoreceptors are specialised sensory retinal neurons responsible for photopic vision, colour perception and visual acuity. Retinal degenerative diseases are a heterogeneous group of eye diseases in whic...

    Authors: Antonino Glaviano, Andrew J. Smith, Alfonso Blanco, Sarah McLoughlin, Maria L. Cederlund, Theresa Heffernan, Beata Sapetto-Rebow, Yolanda Alvarez, Jun Yin and Breandán N. Kennedy

    Citation: BMC Neuroscience 2016 17:71

    Published on:

  4. Content type: Research article

    Fused in sarcoma (FUS) is an RNA-binding protein associated with the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. ALS manifests in patients as a progres...

    Authors: Kasey L. Jackson, Hemangini A. Dhaibar, Robert D. Dayton, Sergio G. Cananzi, William G. Mayhan, Edward Glasscock and Ronald L. Klein

    Citation: BMC Neuroscience 2016 17:69

    Published on:

  5. Content type: Research article

    There is evidence that experimentally elicited auditory illusions in the general population index risk for psychotic symptoms. As little is known about underlying cortical mechanisms of auditory illusions, an ...

    Authors: E. Schepers, L. Bodar, J. van Os and R. Lousberg

    Citation: BMC Neuroscience 2016 17:65

    Published on:

  6. Content type: Research article

    Bilateral adrenalectomy has been shown to damage the hippocampal neurons. Although the effects of long-term adrenalectomy have been studied extensively there are few publications on the effects of short-term a...

    Authors: Naserddine Hamadi, Azimullah Sheikh, Nather Madjid, Loai Lubbad, Naheed Amir, Safa Al-Deen Saudi Shehab, Fatima Khelifi-Touhami and Abdu Adem

    Citation: BMC Neuroscience 2016 17:61

    Published on:

  7. Content type: Research article

    Astaxanthin is a carotenoid pigment that possesses potent antioxidative, anti-inflammatory, antitumor, and immunomodulatory activities. Previous studies have demonstrated that astaxanthin displays potential ne...

    Authors: Mingkun Zhang, Zhenwen Cui, Hua Cui, Yang Cao, Yong Wang and Chunlong Zhong

    Citation: BMC Neuroscience 2016 17:60

    Published on:

  8. Content type: Research article

    Parkinson disease (PD) is a movement disorder affecting 1 % of people over the age of 60. The etiology of the disease is unknown; however, accumulating evidence suggests that mitochondrial defects, oxidative s...

    Authors: Hayate Javed, Sheikh Azimullah, Salema B. Abul Khair, Shreesh Ojha and M. Emdadul Haque

    Citation: BMC Neuroscience 2016 17:58

    Published on:

  9. Content type: Research article

    Recurrent convulsions can cause irreversible astrocyte death, impede neuron regeneration, and further aggravate brain damage. MicroRNAs have been revealed as players in the progression of numerous diseases inc...

    Authors: Liqun Liu, Lingjuan Liu, Jiayun Shi, Menglin Tan, Jie Xiong, Xingfang Li, Qingpeng Hu, Zhuwen Yi and Ding’an Mao

    Citation: BMC Neuroscience 2016 17:56

    Published on:

  10. Content type: Research article

    Amyloid-beta (Aβ) accumulation is a hallmark of Alzheimer’s disease (AD) that can lead to neuronal dysfunction and apoptosis. Tumor necrosis factor, alpha-induced protein 1 (TNFAIP1) is an apoptotic protein th...

    Authors: Ning Liu, Zhanyang Yu, Yu Xun, Miaomiao Li, Xiaoning Peng, Ye Xiao, Xiang Hu, Yi Sun, Manjun Yang, Shiquan Gan, Shishan Yuan, Xiaoying Wang, Shuanglin Xiang and Jian Zhang

    Citation: BMC Neuroscience 2016 17:51

    Published on:

  11. Content type: Research article

    Peripheral neuropathy is a common and dose-limiting side effect of many cancer chemotherapies. The taxane agents, including paclitaxel (Taxol®), are effective chemotherapeutic drugs but cause degeneration of pred...

    Authors: Aniqa Tasnim, Zoe Rammelkamp, Amy B. Slusher, Krystyna Wozniak, Barbara S. Slusher and Mohamed H. Farah

    Citation: BMC Neuroscience 2016 17:47

    Published on:

  12. Content type: Research article

    We previously reported the production of transgenic rats (APP21 line) that over-express human amyloid precursor protein (APP) containing Swedish and Indiana mutations. In order to generate a better model for A...

    Authors: Cansu Agca, Diana Klakotskaia, Todd R. Schachtman, Anthony W. Chan, James J. Lah and Yuksel Agca

    Citation: BMC Neuroscience 2016 17:46

    Published on:

  13. Content type: Research article

    Murine models of Alzheimer’s disease (AD) are mainly based on overexpression of pathologic amyloid precursor protein and/or presenilins. Those genes resemble underlying cause of early onset type of AD while ab...

    Authors: Kristina Endres, Sven Reinhardt, Anastasia Geladaris, Julia Knies, Marcus Grimm, Tobias Hartmann and Ulrich Schmitt

    Citation: BMC Neuroscience 2016 17:44

    Published on:

  14. Content type: Research article

    After spinal cord (SC)-injury, a non-modulated immune response contributes to the damage of neural tissue. Protective autoimmunity (PA) is a T cell mediated, neuroprotective response induced after SC-injury. ...

    Authors: Susana Martiñón, Elisa García-Vences, Diana Toscano-Tejeida, Adrian Flores-Romero, Roxana Rodriguez-Barrera, Manuel Ferrusquia, Rolando E. Hernández-Muñoz and Antonio Ibarra

    Citation: BMC Neuroscience 2016 17:42

    Published on:

  15. Content type: Research article

    Canine intervertebral disc πherniation causes a naturally-occurring spinal cord injury (SCI) that bears critical similarities to human SCI with respect to both injury pathomechanisms and treatment. As such, it...

    Authors: Rae L. Russell, Jonathan M. Levine, Nick D. Jeffery, Colin Young, Armando Mondragon, Bryan Lee, C. Elizabeth Boudreau, C. Jane Welsh and Gwendolyn J. Levine

    Citation: BMC Neuroscience 2016 17:31

    Published on:

  16. Content type: Research article

    Kainic acid (KA)-induced excitotoxicity promotes cytoplasmic calcium accumulation, oxidative stress, and apoptotic signaling, leading to hippocampal neuronal death. Mitochondria play a critical role in neuroin...

    Authors: Hwajin Kim, Jong Youl Lee, Keon Jae Park, Won-Ho Kim and Gu Seob Roh

    Citation: BMC Neuroscience 2016 17:33

    Published on:

    The Erratum to this article has been published in BMC Neuroscience 2017 18:16

  17. Content type: Research article

    In the current study, a transient cerebral ischemia producing selective cell death was designated a mild ischemic insult. A comparable insult in humans is a transient ischemic attack (TIA) that is associated with...

    Authors: Ursula I. Tuor, Zonghang Zhao, Philip A. Barber and Min Qiao

    Citation: BMC Neuroscience 2016 17:28

    Published on:

  18. Content type: Research article

    Anorexia can occur as a serious complication of disease. Increasing evidence suggests that inflammation plays a major role, along with a hypothalamic dysregulation characterized by locally elevated serotonin l...

    Authors: J. T. Dwarkasing, R. F. Witkamp, M. V. Boekschoten, M. C. Ter Laak, M. S. Heins and K. van Norren

    Citation: BMC Neuroscience 2016 17:26

    Published on:

  19. Content type: Research article

    Red/near-infrared light therapy (R/NIR-LT) has been developed as a treatment for a range of conditions, including injury to the central nervous system (CNS). However, clinical trials have reported variable or ...

    Authors: Bethany Eve Ashworth, Emma Stephens, Carole A. Bartlett, Stylianos Serghiou, Marcus K. Giacci, Anna Williams, Nathan S. Hart and Melinda Fitzgerald

    Citation: BMC Neuroscience 2016 17:21

    Published on:

Page 3 of 10