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BMC Neuroscience

Neurobiology of disease

Section edited by Karsten Ruscher

This section covers the neurobiological aspects of diseases that can affect the brain. Topics of interest include, but are not limited to, neuroinflammation, neurodegenerative pathophysiology, neurogenesis and experimental brain research. Diseases range across neurodegeneration, demyelinating conditions, addiction, psychiatric conditions, stroke and spinal cord conditions.

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  1. Content type: Research article

    Anorexia can occur as a serious complication of disease. Increasing evidence suggests that inflammation plays a major role, along with a hypothalamic dysregulation characterized by locally elevated serotonin l...

    Authors: J. T. Dwarkasing, R. F. Witkamp, M. V. Boekschoten, M. C. Ter Laak, M. S. Heins and K. van Norren

    Citation: BMC Neuroscience 2016 17:26

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  2. Content type: Research article

    Red/near-infrared light therapy (R/NIR-LT) has been developed as a treatment for a range of conditions, including injury to the central nervous system (CNS). However, clinical trials have reported variable or ...

    Authors: Bethany Eve Ashworth, Emma Stephens, Carole A. Bartlett, Stylianos Serghiou, Marcus K. Giacci, Anna Williams, Nathan S. Hart and Melinda Fitzgerald

    Citation: BMC Neuroscience 2016 17:21

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  3. Content type: Research article

    We recently reported that poly-arginine peptides have neuroprotective properties both in vitro and in vivo. In cultured cortical neurons exposed to glutamic acid excitotoxicity, we demonstrated that neuroprote...

    Authors: Diego Milani, Vince W. Clark, Jane L. Cross, Ryan S. Anderton, Neville W. Knuckey and Bruno P. Meloni

    Citation: BMC Neuroscience 2016 17:19

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  4. Content type: Methodology article

    Regeneration of new myelin is impaired in persistent multiple sclerosis (MS) lesions, leaving neurons unable to function properly and subject to further degeneration. Current MS therapies attempt to ameliorate...

    Authors: Karen D. Lariosa-Willingham, Elen S. Rosler, Jay S. Tung, Jason C. Dugas, Tassie L. Collins and Dmitri Leonoudakis

    Citation: BMC Neuroscience 2016 17:16

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  5. Content type: Research article

    Glutamate carboxypeptidase II (GCPII) inactivates the peptide co-transmitter N-acetylaspartylglutamate following synaptic release. Inhibition of GCPII elevates extracellular levels of the peptide, inhibits glutam...

    Authors: Yang Cao, Yang Gao, Siyi Xu, Jingang Bao, Yingying Lin, Xingguang Luo, Yong Wang, Qizhong Luo, Jiyao Jiang, Joseph H. Neale and Chunlong Zhong

    Citation: BMC Neuroscience 2016 17:15

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  6. Content type: Research article

    It has been demonstrated that the zebrafish model of pentylenetetrazole (PTZ)-evoked seizures and the well-established rodent models of epilepsy are similar pertaining to behavior, electrographic features, and c-

    Authors: Patrícia Gonçalves Barbalho, Iscia Lopes-Cendes and Claudia Vianna Maurer-Morelli

    Citation: BMC Neuroscience 2016 17:12

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  7. Content type: Research article

    Spinal cord edema is a serious complication and pathophysiological change after ischemia reperfusion (IR) injury. It has been demonstrated closely associated with bimodal disruption of blood–spinal cord barrie...

    Authors: Xiao-Qian Li, Bo Fang, Wen-Fei Tan, Zhi-Lin Wang, Xi-Jia Sun, Zai-Li Zhang and Hong Ma

    Citation: BMC Neuroscience 2016 17:10

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  8. Content type: Research article

    Bilateral subthalamic nucleus deep brain stimulation (STN-DBS) of parkinson’s disease (PD) patients has demonstrated to improve motor performance and to reduce dopa-induced dyskinesia. An association between t...

    Authors: Massiva Sayad, Mohamed Zouambia, Malika Chaouch, Farida Ferrat, Mustapha Nebbal, Mohamed Bendini, Suzanne Lesage, Alexis Brice, Mohamed Brahim Errahmani and Boualem Asselah

    Citation: BMC Neuroscience 2016 17:6

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  9. Content type: Research article

    Limb remote ischemic postconditioning (LRIP) can ameliorate cerebral ischemia–reperfusion injury (IRI), while the underlying mechanism remains elusive. Hypoxia-inducible factor 1α (HIF-1α) is an important tran...

    Authors: Yonghua Zong, Ling Jiang, Mingxiao Zhang, Fangfang Zhou, Wenqian Qi, Shuai Li, Huijun Yang, Yu Zou, Qingjie Xia, Xue Zhou, Xiaosong Hu and Tinghua Wang

    Citation: BMC Neuroscience 2015 16:97

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  10. Content type: Research article

    Multiple system atrophy (MSA) is a fatal adult-onset neurodegenerative disease characterized by α-synuclein (α-syn) positive oligodendroglial cytoplasmic inclusions. The latter are associated with a neuronal m...

    Authors: Daniela Kuzdas-Wood, Lisa Fellner, Melanie Premstaller, Carlijn Borm, Bastiaan Bloem, Deniz Kirik, Gregor K. Wenning and Nadia Stefanova

    Citation: BMC Neuroscience 2015 16:86

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  11. Content type: Research article

    Tauopathies are a group of neurodegenerative disorders with accumulation of three-repeat (3R) or four-repeat (4R) Tau. While 3R tau is found in Pick’s disease and Alzheimer’s disease (AD), 4R tau is more abund...

    Authors: Edward Rockenstein, Kiren Ubhi, Michael Mante, Jazmin Florio, Anthony Adame, Stefan Winter, Hemma Brandstaetter, Dieter Meier and Eliezer Masliah

    Citation: BMC Neuroscience 2015 16:85

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  12. Content type: Research article

    T cells undergo autoimmunization following spinal cord injury (SCI) and play both protective and destructive roles during the recovery process. T cell-deficient athymic nude (AN) rats exhibit improved function...

    Authors: David Satzer, Catherine Miller, Jacob Maxon, Joseph Voth, Christina DiBartolomeo, Rebecca Mahoney, James R. Dutton, Walter C. Low and Ann M. Parr

    Citation: BMC Neuroscience 2015 16:74

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  13. Content type: Research article

    Necroptosis is a newly identified type of programmed cell death that differs from apoptosis. Recent studies have demonstrated that necroptosis is involved in multiple pathologies of various human diseases. Rec...

    Authors: Haruo Kanno, Hiroshi Ozawa, Satoshi Tateda, Kenichiro Yahata and Eiji Itoi

    Citation: BMC Neuroscience 2015 16:62

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  14. Content type: Research article

    The pathological hallmarks of Parkinson’s disease are intracellular inclusions composed mainly of misfolded α-synuclein (αSYN). Under physiological conditions αSYN is mostly localized in synapses. In addition,...

    Authors: Emmy H. Rannikko, Stephanie S. Weber and Philipp J. Kahle

    Citation: BMC Neuroscience 2015 16:57

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  15. Content type: Research article

    There is currently a lack of reliable, minimally invasive biomarkers that could predict the extent of alcoholism-induced CNS damage. Developing such biomarkers may prove useful in reducing the prevalence of al...

    Authors: Cherry Ignacio, Steven D. Hicks, Patrick Burke, Lambert Lewis, Zsuzsa Szombathyne-Meszaros and Frank A. Middleton

    Citation: BMC Neuroscience 2015 16:55

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  16. Content type: Research article

    The elevated body swing test (EBST) is a behavioral test used to evaluate experimental stroke in rodents. The basic idea is that when the animal is suspended vertically by the tail, it will swing its head late...

    Authors: Edvin Ingberg, Johanna Gudjonsdottir, Elvar Theodorsson, Annette Theodorsson and Jakob O Ström

    Citation: BMC Neuroscience 2015 16:50

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  17. Content type: Research article

    Inflammation following intracerebral hemorrhage (ICH) significantly contributes to secondary brain damage and poor outcomes. Prostaglandin E2 (PGE2) is known to modulate neuroinflammatory responses and is upregul...

    Authors: Jenna L Leclerc, Abdullah S Ahmad, Nilendra Singh, Luke Soshnik-Schierling, Ellis Greene, Alex Dang and Sylvain Doré

    Citation: BMC Neuroscience 2015 16:48

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  18. Content type: Research article

    Lipids play different important roles in central nervous system so that dysregulation of lipid pathways has been implicated in a growing number of neurodegenerative disorders including multiple sclerosis (MS)...

    Authors: Daniele Vergara, Michele D’Alessandro, Antonia Rizzello, Lidia De Riccardis, Paola Lunetti, Piero Del Boccio, Francesca De Robertis, Giorgio Trianni, Michele Maffia and Anna M Giudetti

    Citation: BMC Neuroscience 2015 16:46

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