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Neurobiology of disease

Section edited by Karsten Ruscher

This section covers the neurobiological aspects of diseases that can affect the brain. Topics of interest include, but are not limited to, neuroinflammation, neurodegenerative pathophysiology, neurogenesis and experimental brain research. Diseases range across neurodegeneration, demyelinating conditions, addiction, psychiatric conditions, stroke and spinal cord conditions.

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  1. Content type: Research article

    The current standard of care for insomnia includes gamma-aminobutyric acid receptor A (GABAA) activators, which promote sleep as well as general central nervous system depression. Dual orexin receptor antagonists...

    Authors: Anthony L Gotter, Susan L Garson, Joanne Stevens, Regina L Munden, Steven V Fox, Pamela L Tannenbaum, Lihang Yao, Scott D Kuduk, Terrence McDonald, Jason M Uslaner, Spencer J Tye, Paul J Coleman, Christopher J Winrow and John J Renger

    Citation: BMC Neuroscience 2014 15:109

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  2. Content type: Research article

    Cell-derived microparticles are secreted in response to cell damage or dysfunction. Endothelial and platelet dysfunction are thought to contribute to the development of multiple sclerosis (MS). Our aim here is...

    Authors: Beatriz Marcos-Ramiro, Pedro Oliva Nacarino, Esther Serrano-Pertierra, Miguel Ángel Blanco-Gelaz, Babette B Weksler, Ignacio A Romero, Pierre O Couraud, Alberto Tuñón, Carlos López-Larrea, Jaime Millán and Eva Cernuda-Morollón

    Citation: BMC Neuroscience 2014 15:110

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  3. Content type: Methodology article

    Previous studies have demonstrated that white matter (WM) lesions bias automated brain tissue classifications and cerebral volume measurements. However, filling WM lesions using the intensity of neighbouring n...

    Authors: Stefano Magon, Laura Gaetano, M Mallar Chakravarty, Jason P Lerch, Yvonne Naegelin, Christoph Stippich, Ludwig Kappos, Ernst-Wilhelm Radue and Till Sprenger

    Citation: BMC Neuroscience 2014 15:106

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  4. Content type: Research article

    The causes of dural arteriovenous fistula have not been clearly defined. The aim of this study was to investigate the mechanism of dural arteriovenous fistula formation induced by high intracranial venous pres...

    Authors: Shou-Sen Wang, Chang-Hua Li, Xiao-Jun Zhang and Ru-Mi Wang

    Citation: BMC Neuroscience 2014 15:101

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  5. Content type: Research article

    Neuropsychiatric affection involving extrapyramidal symptoms is a frequent component of Wilson’s disease (WD). WD is caused by a genetic defect of the copper (Cu) efflux pump ATPase7B. Mouse strains with natur...

    Authors: Sorina Georgiana Boaru, Uta Merle, Ricarda Uerlings, Astrid Zimmermann, Sabine Weiskirchen, Andreas Matusch, Wolfgang Stremmel and Ralf Weiskirchen

    Citation: BMC Neuroscience 2014 15:98

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  6. Content type: Research article

    Alzheimer’s Disease (AD) and Fronto temporal lobar dementia (FTLD) are common causes of dementia in the aging population for which limited therapeutical options are available. These disorders are associated wi...

    Authors: Edward Rockenstein, Kiren Ubhi, Margarita Trejo, Michael Mante, Christina Patrick, Anthony Adame, Philipp Novak, Marion Jech, Edith Doppler, Herbert Moessler and Eliezer Masliah

    Citation: BMC Neuroscience 2014 15:90

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  7. Content type: Research article

    The neuronal cytoplasmic localization of SET, an inhibitor of the phosphatase 2A (PP2A), results in tau hyperphosphorylation in the brains of Alzheimer patients through mechanisms that are still not well defined.

    Authors: Stéphanie Chasseigneaux, Christine Clamagirand, Léa Huguet, Lucie Gorisse-Hussonnois, Christiane Rose and Bernadette Allinquant

    Citation: BMC Neuroscience 2014 15:82

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  8. Content type: Research article

    Hirano bodies are actin-rich paracrystalline inclusions found in brains of patients with Alzheimer’s disease (AD), frontotemporal dementia (FTD), and in normal aged individuals. Although studies of post-mortem...

    Authors: William Spears, Matthew Furgerson, John Michael Sweetnam, Parker Evans, Marla Gearing, Marcus Fechheimer and Ruth Furukawa

    Citation: BMC Neuroscience 2014 15:74

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  9. Content type: Research article

    Recent evidence has suggested that Alzheimer’s disease (AD)-associated neuronal loss may occur via the caspase-independent route of programmed cell death (PCD) in addition to caspase-dependent mechanisms. Howe...

    Authors: Wenfeng Yu, Mathilde Bonnet, Mark Farso, Keran Ma, Jean-Guy Chabot, Elisabeth Martin, Alicia Torriglia, Zhizhong Guan, JoAnne McLaurin, Rémi Quirion and Slavica Krantic

    Citation: BMC Neuroscience 2014 15:73

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  10. Content type: Research article

    α-Synuclein (α-syn) plays a central role in the pathogenesis of synucleinopathies, a group of neurodegenerative disorders that includes Parkinson disease, dementia with Lewy bodies and multiple system atrophy....

    Authors: Suzana Aulić, Tran Thanh Nhat Le, Fabio Moda, Saïda Abounit, Stefania Corvaglia, Loredana Casalis, Stefano Gustincich, Chiara Zurzolo, Fabrizio Tagliavini and Giuseppe Legname

    Citation: BMC Neuroscience 2014 15:69

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  11. Content type: Research article

    Genomic reprogramming is thought to be, at least in part, responsible for the protective effect of brain preconditioning. Unraveling mechanisms of this endogenous neuroprotection, activated by preconditioning,...

    Authors: Kimberly EM Cox-Limpens, Johan SH Vles, Daniel LA van den Hove, Luc JI Zimmermann and Antonio WD Gavilanes

    Citation: BMC Neuroscience 2014 15:67

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  12. Content type: Research article

    Glucocorticoid released by stressful stimuli elicits various stress responses. Acute treatment with a single dose of corticosterone (CORT; predominant glucocorticoid of rats) alone has previously been shown to...

    Authors: Hyejin Kim, Jee Hyun Yi, Kyuhyun Choi, Seokheon Hong, Ki Soon Shin and Shin Jung Kang

    Citation: BMC Neuroscience 2014 15:65

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  13. Content type: Research article

    RIP3 (Receptor-interacting protein 3) pathway was mainly described as the molecular mechanism of necroptosis (programmed necrosis). But recently, non-RIP3 pathways were found to mediate necroptosis. We deliber...

    Authors: Lei Shang, Ju-Fang Huang, Wei Ding, Shuang Chen, Li-Xiang Xue, Ruo-Fei Ma and Kun Xiong

    Citation: BMC Neuroscience 2014 15:63

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  14. Content type: Research article

    Adolescence is a developmental stage vulnerable to alcohol drinking-related problems and the onset of alcoholism. Hypothalamus is a key brain region for food and water intake regulation, and is one of the alco...

    Authors: Hong Zou, Ke Wang, Yang Gao, Huaiguang Song, Qinglian Xie, Meilei Jin, Guoping Zhao, Huasheng Xiao and Lei Yu

    Citation: BMC Neuroscience 2014 15:61

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  15. Content type: Research article

    Following the onset of focal ischemic stroke, the brain experiences a series of alterations including infarct evolvement, cellular proliferation in the penumbra, and behavioral deficits. However, systematic st...

    Authors: Hailong Li, Nannan Zhang, Hsin-Yun Lin, Yang Yu, Quan-Yu Cai, Lixin Ma and Shinghua Ding

    Citation: BMC Neuroscience 2014 15:58

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  16. Content type: Research article

    Reactive oxygen species (ROS) are essential for normal physiological functioning of the brain. However, uncompensated increase in ROS levels may results in oxidative stress. Phospholipase A2 (PLA2) is one of the ...

    Authors: Emily Beaulieu, Julie Ioffe, Shawn N Watson, Petra M Hermann and Willem C Wildering

    Citation: BMC Neuroscience 2014 15:56

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  17. Content type: Research article

    Both active and passive tobacco smoke (TS) potentially impair the vascular endothelial function in a causative and dose-dependent manner, largely related to the content of reactive oxygen species (ROS), nicoti...

    Authors: Pooja Naik, Neel Fofaria, Shikha Prasad, Ravi K Sajja, Babette Weksler, Pierre-Olivier Couraud, Ignacio A Romero and Luca Cucullo

    Citation: BMC Neuroscience 2014 15:51

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  18. Content type: Research article

    Microglia are resident mononuclear phagocytes of the brain that become activated in response to insults including neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and prion disease. ...

    Authors: Julia Grizenkova, Shaheen Akhtar, Sebastian Brandner, John Collinge and Sarah E Lloyd

    Citation: BMC Neuroscience 2014 15:44

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  19. Content type: Research article

    Bone morphogenic proteins (BMPs) promote the survival of neurons, suggesting a therapeutic application of BMPs in the treatment of acute and chronic neurodegenerative disorders. However, the application of rec...

    Authors: Ann-Marie Heinonen, Mahbubur Rahman, Godwin Dogbevia, Hannah Jakobi, Stefan Wölfl, Rolf Sprengel and Markus Schwaninger

    Citation: BMC Neuroscience 2014 15:38

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  20. Content type: Research article

    Extraneuronal levels of the neurotransmitter glutamate in brain rise during aging. This is thought to lead to synaptic dysfunction and neuronal injury or death. To study the effects of glutamate hyperactivity ...

    Authors: Xinkun Wang, Nilam D Patel, Dongwei Hui, Ranu Pal, Mohamed M Hafez, Mohamed M Sayed-Ahmed, Abdulaziz A Al-Yahya and Elias K Michaelis

    Citation: BMC Neuroscience 2014 15:37

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  21. Content type: Research article

    Nicotine is rapidly absorbed from cigarette smoke and therefore induces a number of chronic illnesses with the widespread use of tobacco products. Studies have shown a few cerebral metabolites modified by nico...

    Authors: Hongyu Li, Bo Chen, Xue Shao, Zhengtao Hu, Yi Deng, Ruiming Zhu, Yan Li, Baolai Zhang, Jing Hou, Changman Du, Qian Zhao, Dengqi Fu, Qian Bu, Yinglan Zhao and Xiaobo Cen

    Citation: BMC Neuroscience 2014 15:32

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  22. Content type: Research article

    To explore the neuroprotective effect and optimize the therapeutic dose and time window of picroside II by orthogonal test and the expression of myelin basic protein (MBP) in cerebral ischemic injury in rats. ...

    Authors: Li Zhao, Yunliang Guo, Xiaojun Ji and Meizeng Zhang

    Citation: BMC Neuroscience 2014 15:25

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  23. Content type: Research article

    Age is considered a primary risk factor for neurodegenerative diseases including Alzheimer’s disease (AD). It is also now well understood that mitochondrial function declines with age. Mitochondrial deficits h...

    Authors: Rosemary A Schuh, Kathryn C Jackson, Anna E Schlappal, Espen E Spangenburg, Christopher W Ward, Ji H Park, Natalie Dugger, Guo Li Shi and Paul S Fishman

    Citation: BMC Neuroscience 2014 15:24

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  24. Content type: Research article

    Paraquat, still used as an herbicide in some parts of the world, is now regarded as a dangerous environmental neurotoxin and is linked to the development Parkinson’s disease (PD). Paraquat interacts with cellu...

    Authors: Krithika Muthukumaran, Samantha Leahy, Kate Harrison, Marianna Sikorska, Jagdeep K Sandhu, Jerome Cohen, Corrine Keshan, Daniel Lopatin, Harvey Miller, Henryk Borowy-Borowski, Patricia Lanthier, Shelly Weinstock and Siyaram Pandey

    Citation: BMC Neuroscience 2014 15:21

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  25. Content type: Research article

    Although cerebral palsy (CP) is usually defined as a group of permanent motor disorders due to non-progressive disturbances in the developing fetal or infant brain, recent research has shown that CP individual...

    Authors: Inmaculada Riquelme, Iván Padrón, Ignasi Cifre, Ana M González-Roldán and Pedro Montoya

    Citation: BMC Neuroscience 2014 15:10

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  26. Content type: Research article

    Mitochondrial dysfunction has been linked to neuronal death and a wide array of neurodegenerative diseases. Previously, we have shown sex differences in mitochondria-mediated cell death pathways following hypo...

    Authors: Jaswinder Sharma, Michael V Johnston and Mir Ahamed Hossain

    Citation: BMC Neuroscience 2014 15:9

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  27. Content type: Research article

    Bacterial superantigens are potent T cell activators that can activate T cells with specificity for antigens of the central nervous system (CNS). In this study, we compared the effect of two S. aureus strains on ...

    Authors: Thais Graziela Donegá França, Fernanda Chiuso-Minicucci, Sofia Fernanda Gonçalves Zorzella-Pezavento, Larissa Lumi Watanabe Ishikawa, Larissa Camargo da Rosa, Priscila Maria Colavite, Camila Marques, Maura Rosane Valério Ikoma, Maria de Lourdes Ribeiro de Souza da Cunha and Alexandrina Sartori

    Citation: BMC Neuroscience 2014 15:8

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  28. Content type: Research article

    Despite strong evidence that the pathophysiology of Tourette syndrome (TS) involves structural and functional disturbances of the basal ganglia and cortical frontal areas, findings from in vivo imaging studies...

    Authors: Kirsten R Müller-Vahl, Julian Grosskreutz, Tino Prell, Jörn Kaufmann, Nils Bodammer and Thomas Peschel

    Citation: BMC Neuroscience 2014 15:6

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  29. Content type: Research article

    Despite the evidence that renal hemodynamics is impaired in experimental diabetes, associated with glomeruli structural alterations, renal nerves were not yet investigated in experimental models of diabetes an...

    Authors: Karina Laurenti Sato, Luciana Sayuri Sanada, Renata da Silva Ferreira, Maria Carolina del Bem de Barros Oliveti de Marco, Jaci Airton Castania, Helio Cesar Salgado, Randy Alan Nessler and Valeria Paula Sassoli Fazan

    Citation: BMC Neuroscience 2014 15:5

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  30. Content type: Research article

    Ischemic brain injury due to stroke and/or cardiac arrest is a major health issue in modern society requiring urgent development of new effective therapies. The aim of this study was to evaluate mitochondrial,...

    Authors: Olga Suchadolskiene, Andrius Pranskunas, Giedre Baliutyte, Vincentas Veikutis, Zilvinas Dambrauskas, Dinas Vaitkaitis and Vilmante Borutaite

    Citation: BMC Neuroscience 2014 15:2

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  31. Content type: Research article

    Cortical neurons display network-level dynamics with unique spatiotemporal patterns that construct the backbone of processing information signals and contribute to higher functions. Recent years have seen a we...

    Authors: José Jiun-Shian Wu, Wei-Pang Chang, Hsi-Chien Shih, Chen-Tung Yen and Bai Chuang Shyu

    Citation: BMC Neuroscience 2014 15:3

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  32. Content type: Research article

    Insulin-like growth factor binding protein-2 (IGFBP-2) regulates the bioavailability, transportation, and localization of insulin-like growth factor-I (IGF-I), an effective neuroprotectant in animal stroke mod...

    Authors: Lauren Fletcher, Elif Isgor, Shane Sprague, Lindsey H Williams, Betty B Alajajian, David F Jimenez and Murat Digicaylioglu

    Citation: BMC Neuroscience 2013 14:158

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  33. Content type: Research article

    It has been suggested that glutamatergic system hyperactivity may be related to the pathogenesis of Parkinson’s disease (PD). Vesicular glutamate transporters (VGLUT1-3) import glutamate into synaptic vesicles...

    Authors: Mathieu Favier, Carole Carcenac, Guillaume Drui, Sabrina Boulet, Salah El Mestikawy and Marc Savasta

    Citation: BMC Neuroscience 2013 14:152

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  34. Content type: Software

    A recent study of lateral septum (LS) suggested a large number of autism-related genes with altered expression in the postpartum state. However, formally testing the findings for enrichment of autism-associate...

    Authors: Brian E Eisinger, Michael C Saul, Terri M Driessen and Stephen C Gammie

    Citation: BMC Neuroscience 2013 14:147

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  35. Content type: Research article

    Traumatic spinal cord injury (SCI)-induced overproduction of endogenous deleterious substances triggers secondary cell death to spread damage beyond the initial injury site. Substantial experimental evidence s...

    Authors: Xiang Ling, Feng Bao, Hao Qian and Danxia Liu

    Citation: BMC Neuroscience 2013 14:146

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  36. Content type: Research article

    Parkinson’s disease is an age-related disease whose pathogenesis is not completely known. Animal models exist for investigating the disease but not all results can be easily transferred to humans. Therefore, m...

    Authors: Finja Büchel, Sandra Saliger, Andreas Dräger, Stephanie Hoffmann, Clemens Wrzodek, Andreas Zell and Philipp J Kahle

    Citation: BMC Neuroscience 2013 14:136

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  37. Content type: Research article

    Mutations of the gene encoding the major component of Lewy bodies (LB), α-synuclein (α-syn), cause autosomal dominant forms of Parkinson’s disease (PD), whereas loss-of-function mutations of the gene encoding ...

    Authors: Margot Fournier, Amandine Roux, Jérôme Garrigue, Marie-Paule Muriel, Paul Blanche, Hilal A Lashuel, John P Anderson, Robin Barbour, Jiping Huang, Sophie Tezenas du Montcel, Alexis Brice and Olga Corti

    Citation: BMC Neuroscience 2013 14:135

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  38. Content type: Research article

    Endothelin-1 (ET-1) is a potent vasoconstrictor, and astrocytic ET-1 is reported to play a role in the pathogenesis of cerebral ischemic injury and cytotoxic edema. However, it is still unknown whether astrocy...

    Authors: Patrick KK Yeung, Jiangang Shen, Stephen SM Chung and Sookja K Chung

    Citation: BMC Neuroscience 2013 14:131

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  39. Content type: Research article

    Serotonin (5-HT) is a well-known modulator of eating behavior. However, the molecular mechanisms linking its action to body weight balance have been only partially elucidated. Since platelets are a suitable pe...

    Authors: Gino Giannaccini, Laura Betti, Lionella Palego, Alessandro Marsili, Ferruccio Santini, Caterina Pelosini, Laura Fabbrini, Lara Schmid, Laura Giusti, Margherita Maffei, Mario Lanza, Mario Cristofaro, Stefano Baroni, Mauro Mauri, Paolo Vitti, Paola Fierabracci…

    Citation: BMC Neuroscience 2013 14:128

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  40. Content type: Research article

    The developmental morphogen sonic hedgehog (Shh) may continue to play a trophic role in the support of terminally-differentiated motor neurons, of potential relevance to motor neuron disease. In addition, it m...

    Authors: Xiaoxing Ma, Patrick Turnbull, Randy Peterson and John Turnbull

    Citation: BMC Neuroscience 2013 14:119

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  41. Content type: Research article

    Mice generated by a Cre/LoxP transgenic paradigm were used to model neurodegenerative basal ganglia disease of which Huntington disease (HD) is the prototypical example. In HD, death occurs in striatal project...

    Authors: Arthur Smardencas, Kerelos Rizkalla, Hyun Ah Kim, Jim Massalas, Claire O’Leary, Michelle E Ehrlich, Günter Schütz, Andrew J Lawrence and John Drago

    Citation: BMC Neuroscience 2013 14:111

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  42. Content type: Research article

    Posttranslational modifications of beta amyloid (Aβ) have been shown to affect its biophysical and neurophysiological properties. One of these modifications is N-terminal pyroglutamate (pE) formation. Enzymati...

    Authors: Andreas Becker, Stephanie Kohlmann, Anca Alexandru, Wolfgang Jagla, Fabio Canneva, Christoph Bäuscher, Holger Cynis, Reinhard Sedlmeier, Sigrid Graubner, Stephan Schilling, Hans-Ulrich Demuth and Stephan von Hörsten

    Citation: BMC Neuroscience 2013 14:108

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  43. Content type: Research article

    It has been shown that olfactory ensheathing glia (OEG) and Schwann cell (SCs) transplantation are beneficial as cellular treatments for spinal cord injury (SCI), especially acute and sub-acute time points. In...

    Authors: Helen R Barbour, Christine D Plant, Alan R Harvey and Giles W Plant

    Citation: BMC Neuroscience 2013 14:106

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  44. Content type: Research article

    Gene expression profiling of the postmortem human brain is part of the effort to understand the neuropathological underpinnings of schizophrenia. Existing microarray studies have identified a large number of g...

    Authors: Meeta Mistry, Jesse Gillis and Paul Pavlidis

    Citation: BMC Neuroscience 2013 14:105

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  45. Content type: Research article

    Traumatic injury to the central nervous system results in damage to tissue beyond the primary injury, termed secondary degeneration. Key events thought to be associated with secondary degeneration involve aspe...

    Authors: Nadia Cummins, Carole A Bartlett, Michael Archer, Elora Bartlett, Jan M Hemmi, Alan R Harvey, Sarah A Dunlop and Melinda Fitzgerald

    Citation: BMC Neuroscience 2013 14:98

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  46. Content type: Research article

    Bone marrow is an accessible source of progenitor cells, which have been investigated as treatment for neurological diseases in a number of clinical trials. Here we evaluated the potential benefit of bone marr...

    Authors: Enéas Galdini Ferrazoli, Miriam Marcela Blanco, Simone Bittencourt, André Luis Lacerda Bachi, Luciana Bahia, Milena Botelho Pereira Soares, Ricardo Ribeiro-dos-Santos, Luiz Eugênio Mello and Beatriz Monteiro Longo

    Citation: BMC Neuroscience 2013 14:97

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  47. Content type: Research article

    The severity of angiographically assessed coronary artery disease may be the factor that influences the degree of brain damage during on-pump surgery. Modern technology such as computed electroencephalography ...

    Authors: Irina V Tarasova, Roman S Tarasov, Olga A Trubnikova, Olga L Barbarash and Leonid S Barbarash

    Citation: BMC Neuroscience 2013 14:95

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  48. Content type: Research article

    Glutamate is one of the major neurotransmitters in the central nervous system. It is a potent neurotoxin capable of neuronal destruction through numerous signal pathways when present in high concentration. Glu...

    Authors: Nailya S Gliyazova, Eun Y Huh and Gordon C Ibeanu

    Citation: BMC Neuroscience 2013 14:93

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