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Neurobiology of disease

Section edited by Karsten Ruscher

This section covers the neurobiological aspects of diseases that can affect the brain. Topics of interest include, but are not limited to, neuroinflammation, neurodegenerative pathophysiology, neurogenesis and experimental brain research. Diseases range across neurodegeneration, demyelinating conditions, addiction, psychiatric conditions, stroke and spinal cord conditions.

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  1. Content type: Research article

    Recent evidence has suggested that Alzheimer’s disease (AD)-associated neuronal loss may occur via the caspase-independent route of programmed cell death (PCD) in addition to caspase-dependent mechanisms. Howe...

    Authors: Wenfeng Yu, Mathilde Bonnet, Mark Farso, Keran Ma, Jean-Guy Chabot, Elisabeth Martin, Alicia Torriglia, Zhizhong Guan, JoAnne McLaurin, Rémi Quirion and Slavica Krantic

    Citation: BMC Neuroscience 2014 15:73

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  2. Content type: Research article

    α-Synuclein (α-syn) plays a central role in the pathogenesis of synucleinopathies, a group of neurodegenerative disorders that includes Parkinson disease, dementia with Lewy bodies and multiple system atrophy....

    Authors: Suzana Aulić, Tran Thanh Nhat Le, Fabio Moda, Saïda Abounit, Stefania Corvaglia, Loredana Casalis, Stefano Gustincich, Chiara Zurzolo, Fabrizio Tagliavini and Giuseppe Legname

    Citation: BMC Neuroscience 2014 15:69

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  3. Content type: Research article

    Genomic reprogramming is thought to be, at least in part, responsible for the protective effect of brain preconditioning. Unraveling mechanisms of this endogenous neuroprotection, activated by preconditioning,...

    Authors: Kimberly EM Cox-Limpens, Johan SH Vles, Daniel LA van den Hove, Luc JI Zimmermann and Antonio WD Gavilanes

    Citation: BMC Neuroscience 2014 15:67

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  4. Content type: Research article

    Glucocorticoid released by stressful stimuli elicits various stress responses. Acute treatment with a single dose of corticosterone (CORT; predominant glucocorticoid of rats) alone has previously been shown to...

    Authors: Hyejin Kim, Jee Hyun Yi, Kyuhyun Choi, Seokheon Hong, Ki Soon Shin and Shin Jung Kang

    Citation: BMC Neuroscience 2014 15:65

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  5. Content type: Research article

    RIP3 (Receptor-interacting protein 3) pathway was mainly described as the molecular mechanism of necroptosis (programmed necrosis). But recently, non-RIP3 pathways were found to mediate necroptosis. We deliber...

    Authors: Lei Shang, Ju-Fang Huang, Wei Ding, Shuang Chen, Li-Xiang Xue, Ruo-Fei Ma and Kun Xiong

    Citation: BMC Neuroscience 2014 15:63

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  6. Content type: Research article

    Adolescence is a developmental stage vulnerable to alcohol drinking-related problems and the onset of alcoholism. Hypothalamus is a key brain region for food and water intake regulation, and is one of the alco...

    Authors: Hong Zou, Ke Wang, Yang Gao, Huaiguang Song, Qinglian Xie, Meilei Jin, Guoping Zhao, Huasheng Xiao and Lei Yu

    Citation: BMC Neuroscience 2014 15:61

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  7. Content type: Research article

    Following the onset of focal ischemic stroke, the brain experiences a series of alterations including infarct evolvement, cellular proliferation in the penumbra, and behavioral deficits. However, systematic st...

    Authors: Hailong Li, Nannan Zhang, Hsin-Yun Lin, Yang Yu, Quan-Yu Cai, Lixin Ma and Shinghua Ding

    Citation: BMC Neuroscience 2014 15:58

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  8. Content type: Research article

    Reactive oxygen species (ROS) are essential for normal physiological functioning of the brain. However, uncompensated increase in ROS levels may results in oxidative stress. Phospholipase A2 (PLA2) is one of the ...

    Authors: Emily Beaulieu, Julie Ioffe, Shawn N Watson, Petra M Hermann and Willem C Wildering

    Citation: BMC Neuroscience 2014 15:56

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  9. Content type: Research article

    Both active and passive tobacco smoke (TS) potentially impair the vascular endothelial function in a causative and dose-dependent manner, largely related to the content of reactive oxygen species (ROS), nicoti...

    Authors: Pooja Naik, Neel Fofaria, Shikha Prasad, Ravi K Sajja, Babette Weksler, Pierre-Olivier Couraud, Ignacio A Romero and Luca Cucullo

    Citation: BMC Neuroscience 2014 15:51

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  10. Content type: Research article

    Microglia are resident mononuclear phagocytes of the brain that become activated in response to insults including neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and prion disease. ...

    Authors: Julia Grizenkova, Shaheen Akhtar, Sebastian Brandner, John Collinge and Sarah E Lloyd

    Citation: BMC Neuroscience 2014 15:44

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  11. Content type: Research article

    Bone morphogenic proteins (BMPs) promote the survival of neurons, suggesting a therapeutic application of BMPs in the treatment of acute and chronic neurodegenerative disorders. However, the application of rec...

    Authors: Ann-Marie Heinonen, Mahbubur Rahman, Godwin Dogbevia, Hannah Jakobi, Stefan Wölfl, Rolf Sprengel and Markus Schwaninger

    Citation: BMC Neuroscience 2014 15:38

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  12. Content type: Research article

    Extraneuronal levels of the neurotransmitter glutamate in brain rise during aging. This is thought to lead to synaptic dysfunction and neuronal injury or death. To study the effects of glutamate hyperactivity ...

    Authors: Xinkun Wang, Nilam D Patel, Dongwei Hui, Ranu Pal, Mohamed M Hafez, Mohamed M Sayed-Ahmed, Abdulaziz A Al-Yahya and Elias K Michaelis

    Citation: BMC Neuroscience 2014 15:37

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  13. Content type: Research article

    Nicotine is rapidly absorbed from cigarette smoke and therefore induces a number of chronic illnesses with the widespread use of tobacco products. Studies have shown a few cerebral metabolites modified by nico...

    Authors: Hongyu Li, Bo Chen, Xue Shao, Zhengtao Hu, Yi Deng, Ruiming Zhu, Yan Li, Baolai Zhang, Jing Hou, Changman Du, Qian Zhao, Dengqi Fu, Qian Bu, Yinglan Zhao and Xiaobo Cen

    Citation: BMC Neuroscience 2014 15:32

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  14. Content type: Research article

    To explore the neuroprotective effect and optimize the therapeutic dose and time window of picroside II by orthogonal test and the expression of myelin basic protein (MBP) in cerebral ischemic injury in rats. ...

    Authors: Li Zhao, Yunliang Guo, Xiaojun Ji and Meizeng Zhang

    Citation: BMC Neuroscience 2014 15:25

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  15. Content type: Research article

    Age is considered a primary risk factor for neurodegenerative diseases including Alzheimer’s disease (AD). It is also now well understood that mitochondrial function declines with age. Mitochondrial deficits h...

    Authors: Rosemary A Schuh, Kathryn C Jackson, Anna E Schlappal, Espen E Spangenburg, Christopher W Ward, Ji H Park, Natalie Dugger, Guo Li Shi and Paul S Fishman

    Citation: BMC Neuroscience 2014 15:24

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  16. Content type: Research article

    Paraquat, still used as an herbicide in some parts of the world, is now regarded as a dangerous environmental neurotoxin and is linked to the development Parkinson’s disease (PD). Paraquat interacts with cellu...

    Authors: Krithika Muthukumaran, Samantha Leahy, Kate Harrison, Marianna Sikorska, Jagdeep K Sandhu, Jerome Cohen, Corrine Keshan, Daniel Lopatin, Harvey Miller, Henryk Borowy-Borowski, Patricia Lanthier, Shelly Weinstock and Siyaram Pandey

    Citation: BMC Neuroscience 2014 15:21

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  17. Content type: Research article

    Although cerebral palsy (CP) is usually defined as a group of permanent motor disorders due to non-progressive disturbances in the developing fetal or infant brain, recent research has shown that CP individual...

    Authors: Inmaculada Riquelme, Iván Padrón, Ignasi Cifre, Ana M González-Roldán and Pedro Montoya

    Citation: BMC Neuroscience 2014 15:10

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  18. Content type: Research article

    Mitochondrial dysfunction has been linked to neuronal death and a wide array of neurodegenerative diseases. Previously, we have shown sex differences in mitochondria-mediated cell death pathways following hypo...

    Authors: Jaswinder Sharma, Michael V Johnston and Mir Ahamed Hossain

    Citation: BMC Neuroscience 2014 15:9

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  19. Content type: Research article

    Bacterial superantigens are potent T cell activators that can activate T cells with specificity for antigens of the central nervous system (CNS). In this study, we compared the effect of two S. aureus strains on ...

    Authors: Thais Graziela Donegá França, Fernanda Chiuso-Minicucci, Sofia Fernanda Gonçalves Zorzella-Pezavento, Larissa Lumi Watanabe Ishikawa, Larissa Camargo da Rosa, Priscila Maria Colavite, Camila Marques, Maura Rosane Valério Ikoma, Maria de Lourdes Ribeiro de Souza da Cunha and Alexandrina Sartori

    Citation: BMC Neuroscience 2014 15:8

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  20. Content type: Research article

    Despite strong evidence that the pathophysiology of Tourette syndrome (TS) involves structural and functional disturbances of the basal ganglia and cortical frontal areas, findings from in vivo imaging studies...

    Authors: Kirsten R Müller-Vahl, Julian Grosskreutz, Tino Prell, Jörn Kaufmann, Nils Bodammer and Thomas Peschel

    Citation: BMC Neuroscience 2014 15:6

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  21. Content type: Research article

    Despite the evidence that renal hemodynamics is impaired in experimental diabetes, associated with glomeruli structural alterations, renal nerves were not yet investigated in experimental models of diabetes an...

    Authors: Karina Laurenti Sato, Luciana Sayuri Sanada, Renata da Silva Ferreira, Maria Carolina del Bem de Barros Oliveti de Marco, Jaci Airton Castania, Helio Cesar Salgado, Randy Alan Nessler and Valeria Paula Sassoli Fazan

    Citation: BMC Neuroscience 2014 15:5

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  22. Content type: Research article

    Ischemic brain injury due to stroke and/or cardiac arrest is a major health issue in modern society requiring urgent development of new effective therapies. The aim of this study was to evaluate mitochondrial,...

    Authors: Olga Suchadolskiene, Andrius Pranskunas, Giedre Baliutyte, Vincentas Veikutis, Zilvinas Dambrauskas, Dinas Vaitkaitis and Vilmante Borutaite

    Citation: BMC Neuroscience 2014 15:2

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  23. Content type: Research article

    Cortical neurons display network-level dynamics with unique spatiotemporal patterns that construct the backbone of processing information signals and contribute to higher functions. Recent years have seen a we...

    Authors: José Jiun-Shian Wu, Wei-Pang Chang, Hsi-Chien Shih, Chen-Tung Yen and Bai Chuang Shyu

    Citation: BMC Neuroscience 2014 15:3

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  24. Content type: Research article

    Insulin-like growth factor binding protein-2 (IGFBP-2) regulates the bioavailability, transportation, and localization of insulin-like growth factor-I (IGF-I), an effective neuroprotectant in animal stroke mod...

    Authors: Lauren Fletcher, Elif Isgor, Shane Sprague, Lindsey H Williams, Betty B Alajajian, David F Jimenez and Murat Digicaylioglu

    Citation: BMC Neuroscience 2013 14:158

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  25. Content type: Research article

    It has been suggested that glutamatergic system hyperactivity may be related to the pathogenesis of Parkinson’s disease (PD). Vesicular glutamate transporters (VGLUT1-3) import glutamate into synaptic vesicles...

    Authors: Mathieu Favier, Carole Carcenac, Guillaume Drui, Sabrina Boulet, Salah El Mestikawy and Marc Savasta

    Citation: BMC Neuroscience 2013 14:152

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  26. Content type: Software

    A recent study of lateral septum (LS) suggested a large number of autism-related genes with altered expression in the postpartum state. However, formally testing the findings for enrichment of autism-associate...

    Authors: Brian E Eisinger, Michael C Saul, Terri M Driessen and Stephen C Gammie

    Citation: BMC Neuroscience 2013 14:147

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  27. Content type: Research article

    Traumatic spinal cord injury (SCI)-induced overproduction of endogenous deleterious substances triggers secondary cell death to spread damage beyond the initial injury site. Substantial experimental evidence s...

    Authors: Xiang Ling, Feng Bao, Hao Qian and Danxia Liu

    Citation: BMC Neuroscience 2013 14:146

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  28. Content type: Research article

    Parkinson’s disease is an age-related disease whose pathogenesis is not completely known. Animal models exist for investigating the disease but not all results can be easily transferred to humans. Therefore, m...

    Authors: Finja Büchel, Sandra Saliger, Andreas Dräger, Stephanie Hoffmann, Clemens Wrzodek, Andreas Zell and Philipp J Kahle

    Citation: BMC Neuroscience 2013 14:136

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  29. Content type: Research article

    Mutations of the gene encoding the major component of Lewy bodies (LB), α-synuclein (α-syn), cause autosomal dominant forms of Parkinson’s disease (PD), whereas loss-of-function mutations of the gene encoding ...

    Authors: Margot Fournier, Amandine Roux, Jérôme Garrigue, Marie-Paule Muriel, Paul Blanche, Hilal A Lashuel, John P Anderson, Robin Barbour, Jiping Huang, Sophie Tezenas du Montcel, Alexis Brice and Olga Corti

    Citation: BMC Neuroscience 2013 14:135

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  30. Content type: Research article

    Endothelin-1 (ET-1) is a potent vasoconstrictor, and astrocytic ET-1 is reported to play a role in the pathogenesis of cerebral ischemic injury and cytotoxic edema. However, it is still unknown whether astrocy...

    Authors: Patrick KK Yeung, Jiangang Shen, Stephen SM Chung and Sookja K Chung

    Citation: BMC Neuroscience 2013 14:131

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  31. Content type: Research article

    Serotonin (5-HT) is a well-known modulator of eating behavior. However, the molecular mechanisms linking its action to body weight balance have been only partially elucidated. Since platelets are a suitable pe...

    Authors: Gino Giannaccini, Laura Betti, Lionella Palego, Alessandro Marsili, Ferruccio Santini, Caterina Pelosini, Laura Fabbrini, Lara Schmid, Laura Giusti, Margherita Maffei, Mario Lanza, Mario Cristofaro, Stefano Baroni, Mauro Mauri, Paolo Vitti, Paola Fierabracci…

    Citation: BMC Neuroscience 2013 14:128

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  32. Content type: Research article

    The developmental morphogen sonic hedgehog (Shh) may continue to play a trophic role in the support of terminally-differentiated motor neurons, of potential relevance to motor neuron disease. In addition, it m...

    Authors: Xiaoxing Ma, Patrick Turnbull, Randy Peterson and John Turnbull

    Citation: BMC Neuroscience 2013 14:119

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  33. Content type: Research article

    Mice generated by a Cre/LoxP transgenic paradigm were used to model neurodegenerative basal ganglia disease of which Huntington disease (HD) is the prototypical example. In HD, death occurs in striatal project...

    Authors: Arthur Smardencas, Kerelos Rizkalla, Hyun Ah Kim, Jim Massalas, Claire O’Leary, Michelle E Ehrlich, Günter Schütz, Andrew J Lawrence and John Drago

    Citation: BMC Neuroscience 2013 14:111

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  34. Content type: Research article

    Posttranslational modifications of beta amyloid (Aβ) have been shown to affect its biophysical and neurophysiological properties. One of these modifications is N-terminal pyroglutamate (pE) formation. Enzymati...

    Authors: Andreas Becker, Stephanie Kohlmann, Anca Alexandru, Wolfgang Jagla, Fabio Canneva, Christoph Bäuscher, Holger Cynis, Reinhard Sedlmeier, Sigrid Graubner, Stephan Schilling, Hans-Ulrich Demuth and Stephan von Hörsten

    Citation: BMC Neuroscience 2013 14:108

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  35. Content type: Research article

    It has been shown that olfactory ensheathing glia (OEG) and Schwann cell (SCs) transplantation are beneficial as cellular treatments for spinal cord injury (SCI), especially acute and sub-acute time points. In...

    Authors: Helen R Barbour, Christine D Plant, Alan R Harvey and Giles W Plant

    Citation: BMC Neuroscience 2013 14:106

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  36. Content type: Research article

    Gene expression profiling of the postmortem human brain is part of the effort to understand the neuropathological underpinnings of schizophrenia. Existing microarray studies have identified a large number of g...

    Authors: Meeta Mistry, Jesse Gillis and Paul Pavlidis

    Citation: BMC Neuroscience 2013 14:105

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  37. Content type: Research article

    Traumatic injury to the central nervous system results in damage to tissue beyond the primary injury, termed secondary degeneration. Key events thought to be associated with secondary degeneration involve aspe...

    Authors: Nadia Cummins, Carole A Bartlett, Michael Archer, Elora Bartlett, Jan M Hemmi, Alan R Harvey, Sarah A Dunlop and Melinda Fitzgerald

    Citation: BMC Neuroscience 2013 14:98

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  38. Content type: Research article

    Bone marrow is an accessible source of progenitor cells, which have been investigated as treatment for neurological diseases in a number of clinical trials. Here we evaluated the potential benefit of bone marr...

    Authors: Enéas Galdini Ferrazoli, Miriam Marcela Blanco, Simone Bittencourt, André Luis Lacerda Bachi, Luciana Bahia, Milena Botelho Pereira Soares, Ricardo Ribeiro-dos-Santos, Luiz Eugênio Mello and Beatriz Monteiro Longo

    Citation: BMC Neuroscience 2013 14:97

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  39. Content type: Research article

    The severity of angiographically assessed coronary artery disease may be the factor that influences the degree of brain damage during on-pump surgery. Modern technology such as computed electroencephalography ...

    Authors: Irina V Tarasova, Roman S Tarasov, Olga A Trubnikova, Olga L Barbarash and Leonid S Barbarash

    Citation: BMC Neuroscience 2013 14:95

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  40. Content type: Research article

    Glutamate is one of the major neurotransmitters in the central nervous system. It is a potent neurotoxin capable of neuronal destruction through numerous signal pathways when present in high concentration. Glu...

    Authors: Nailya S Gliyazova, Eun Y Huh and Gordon C Ibeanu

    Citation: BMC Neuroscience 2013 14:93

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  41. Content type: Research article

    SV2A, SV2B and SV2C are synaptic vesicle proteins that are structurally related to members of the major facilitator superfamily (MFS). The function and transported substrate of the SV2 proteins is not clearly ...

    Authors: Julie Crèvecœur, Patrik Foerch, Melissa Doupagne, Caroline Thielen, Catherine Vandenplas, Gustave Moonen, Manuel Deprez and Bernard Rogister

    Citation: BMC Neuroscience 2013 14:87

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  42. Content type: Research article

    The afferent projections from the auricular branch of the vagus nerve (ABVN) to the nucleus tractus solitaries (NTS) have been proposed as the anatomical basis for the increased parasympathetic tone seen in au...

    Authors: Wei He, Xiang-Hong Jing, Bing Zhu, Xin-Long Zhu, Liang Li, Wan-Zhu Bai and Hui Ben

    Citation: BMC Neuroscience 2013 14:85

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  43. Content type: Methodology article

    Electrical stimulation of brain structures has been widely used in rodent models for kindling or modeling deep brain stimulation used clinically. This requires surgical implantation of intracranial electrodes ...

    Authors: Melanie Jeffrey, Min Lang, Jonathan Gane, Chiping Wu, W McIntyre Burnham and Liang Zhang

    Citation: BMC Neuroscience 2013 14:82

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  44. Content type: Research article

    The olfactory ensheathing cells (OECs) derived from olfactory bulb (OB) may improve motor function after transplantation in injured spinal cord. However, the effects of OEC transplantation on sensory function ...

    Authors: Bing-Chen Lang, Zhuo Zhang, Long-Yun Lv, Jin Liu, Ting-Yong Wang, Ling-Hui Yang, Da-Qing Liao, Wen-Sheng Zhang and Ting-Hua Wang

    Citation: BMC Neuroscience 2013 14:80

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  45. Content type: Research article

    Abnormal processing of esophageal sensation at the level of the central nervous system has been proven to be involved in gastroesophageal reflux disease (GERD). However, most studies were focused on the possib...

    Authors: Huihui Sun, Ying Chen, Xiaohu Zhao, Xiangbin Wang, Yuanxi Jiang, Ping Wu, Yinhan Tang, Qingwei Meng and Shuchang Xu

    Citation: BMC Neuroscience 2013 14:69

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  46. Content type: Research article

    The plasma protein hemopexin (HPX) exhibits the highest binding affinity to free heme. In vitro experiments and gene-knock out technique have suggested that HPX may have a neuroprotective effect. However, the ...

    Authors: Beibei Dong, Min Cai, Zongping Fang, Haidong Wei, Fangyun Zhu, Guochao Li, Hailong Dong and Lize Xiong

    Citation: BMC Neuroscience 2013 14:58

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  47. Content type: Research article

    Alzheimer disease is a multifactorial disorder characterized by the progressive deterioration of neuronal networks. The pathological hallmarks includes extracellular amyloid plaques and intraneuronal neurofibr...

    Authors: Sandra Sivilia, Luca Lorenzini, Alessandro Giuliani, Marco Gusciglio, Mercedes Fernandez, Vito Antonio Baldassarro, Chiara Mangano, Luca Ferraro, Vladimiro Pietrini, Maria Francesca Baroc, Arturo R Viscomi, Simone Ottonello, Gino Villetti, Bruno P Imbimbo, Laura Calzà and Luciana Giardino

    Citation: BMC Neuroscience 2013 14:44

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  48. Content type: Methodology article

    Even though more than 600 stroke treatments have been shown effective in preclinical studies, clinically proven treatment alternatives for cerebral infarction remain scarce. Amongst the reasons for the discrep...

    Authors: Jakob O Ström, Edvin Ingberg, Annette Theodorsson and Elvar Theodorsson

    Citation: BMC Neuroscience 2013 14:41

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