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Neurobiology of disease

Topics of interest include, but are not limited to, neuroinflammation, neurodegenerative pathophysiology, neurodevelopmental disorders, neuropsychiatric disorders, addiction, stroke, ischemia, spinal cord injury, traumatic brain injury (TBI), demyelination and genetic and genomic analysis of diseases of the nervous system.

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  1. Glutamate carboxypeptidase II (GCPII) inactivates the peptide co-transmitter N-acetylaspartylglutamate following synaptic release. Inhibition of GCPII elevates extracellular levels of the peptide, inhibits glutam...

    Authors: Yang Cao, Yang Gao, Siyi Xu, Jingang Bao, Yingying Lin, Xingguang Luo, Yong Wang, Qizhong Luo, Jiyao Jiang, Joseph H. Neale and Chunlong Zhong

    Citation: BMC Neuroscience 2016 17:15

    Content type: Research article

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  2. It has been demonstrated that the zebrafish model of pentylenetetrazole (PTZ)-evoked seizures and the well-established rodent models of epilepsy are similar pertaining to behavior, electrographic features, and c-

    Authors: Patrícia Gonçalves Barbalho, Iscia Lopes-Cendes and Claudia Vianna Maurer-Morelli

    Citation: BMC Neuroscience 2016 17:12

    Content type: Research article

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  3. Spinal cord edema is a serious complication and pathophysiological change after ischemia reperfusion (IR) injury. It has been demonstrated closely associated with bimodal disruption of blood–spinal cord barrie...

    Authors: Xiao-Qian Li, Bo Fang, Wen-Fei Tan, Zhi-Lin Wang, Xi-Jia Sun, Zai-Li Zhang and Hong Ma

    Citation: BMC Neuroscience 2016 17:10

    Content type: Research article

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  4. Bilateral subthalamic nucleus deep brain stimulation (STN-DBS) of parkinson’s disease (PD) patients has demonstrated to improve motor performance and to reduce dopa-induced dyskinesia. An association between t...

    Authors: Massiva Sayad, Mohamed Zouambia, Malika Chaouch, Farida Ferrat, Mustapha Nebbal, Mohamed Bendini, Suzanne Lesage, Alexis Brice, Mohamed Brahim Errahmani and Boualem Asselah

    Citation: BMC Neuroscience 2016 17:6

    Content type: Research article

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  5. Limb remote ischemic postconditioning (LRIP) can ameliorate cerebral ischemia–reperfusion injury (IRI), while the underlying mechanism remains elusive. Hypoxia-inducible factor 1α (HIF-1α) is an important tran...

    Authors: Yonghua Zong, Ling Jiang, Mingxiao Zhang, Fangfang Zhou, Wenqian Qi, Shuai Li, Huijun Yang, Yu Zou, Qingjie Xia, Xue Zhou, Xiaosong Hu and Tinghua Wang

    Citation: BMC Neuroscience 2015 16:97

    Content type: Research article

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  6. Multiple system atrophy (MSA) is a fatal adult-onset neurodegenerative disease characterized by α-synuclein (α-syn) positive oligodendroglial cytoplasmic inclusions. The latter are associated with a neuronal m...

    Authors: Daniela Kuzdas-Wood, Lisa Fellner, Melanie Premstaller, Carlijn Borm, Bastiaan Bloem, Deniz Kirik, Gregor K. Wenning and Nadia Stefanova

    Citation: BMC Neuroscience 2015 16:86

    Content type: Research article

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  7. Tauopathies are a group of neurodegenerative disorders with accumulation of three-repeat (3R) or four-repeat (4R) Tau. While 3R tau is found in Pick’s disease and Alzheimer’s disease (AD), 4R tau is more abund...

    Authors: Edward Rockenstein, Kiren Ubhi, Michael Mante, Jazmin Florio, Anthony Adame, Stefan Winter, Hemma Brandstaetter, Dieter Meier and Eliezer Masliah

    Citation: BMC Neuroscience 2015 16:85

    Content type: Research article

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  8. T cells undergo autoimmunization following spinal cord injury (SCI) and play both protective and destructive roles during the recovery process. T cell-deficient athymic nude (AN) rats exhibit improved function...

    Authors: David Satzer, Catherine Miller, Jacob Maxon, Joseph Voth, Christina DiBartolomeo, Rebecca Mahoney, James R. Dutton, Walter C. Low and Ann M. Parr

    Citation: BMC Neuroscience 2015 16:74

    Content type: Research article

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  9. Necroptosis is a newly identified type of programmed cell death that differs from apoptosis. Recent studies have demonstrated that necroptosis is involved in multiple pathologies of various human diseases. Rec...

    Authors: Haruo Kanno, Hiroshi Ozawa, Satoshi Tateda, Kenichiro Yahata and Eiji Itoi

    Citation: BMC Neuroscience 2015 16:62

    Content type: Research article

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  10. The pathological hallmarks of Parkinson’s disease are intracellular inclusions composed mainly of misfolded α-synuclein (αSYN). Under physiological conditions αSYN is mostly localized in synapses. In addition,...

    Authors: Emmy H. Rannikko, Stephanie S. Weber and Philipp J. Kahle

    Citation: BMC Neuroscience 2015 16:57

    Content type: Research article

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  11. There is currently a lack of reliable, minimally invasive biomarkers that could predict the extent of alcoholism-induced CNS damage. Developing such biomarkers may prove useful in reducing the prevalence of al...

    Authors: Cherry Ignacio, Steven D. Hicks, Patrick Burke, Lambert Lewis, Zsuzsa Szombathyne-Meszaros and Frank A. Middleton

    Citation: BMC Neuroscience 2015 16:55

    Content type: Research article

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  12. The elevated body swing test (EBST) is a behavioral test used to evaluate experimental stroke in rodents. The basic idea is that when the animal is suspended vertically by the tail, it will swing its head late...

    Authors: Edvin Ingberg, Johanna Gudjonsdottir, Elvar Theodorsson, Annette Theodorsson and Jakob O Ström

    Citation: BMC Neuroscience 2015 16:50

    Content type: Research article

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  13. Inflammation following intracerebral hemorrhage (ICH) significantly contributes to secondary brain damage and poor outcomes. Prostaglandin E2 (PGE2) is known to modulate neuroinflammatory responses and is upregul...

    Authors: Jenna L Leclerc, Abdullah S Ahmad, Nilendra Singh, Luke Soshnik-Schierling, Ellis Greene, Alex Dang and Sylvain Doré

    Citation: BMC Neuroscience 2015 16:48

    Content type: Research article

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  14. Lipids play different important roles in central nervous system so that dysregulation of lipid pathways has been implicated in a growing number of neurodegenerative disorders including multiple sclerosis (MS)...

    Authors: Daniele Vergara, Michele D’Alessandro, Antonia Rizzello, Lidia De Riccardis, Paola Lunetti, Piero Del Boccio, Francesca De Robertis, Giorgio Trianni, Michele Maffia and Anna M Giudetti

    Citation: BMC Neuroscience 2015 16:46

    Content type: Research article

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  15. Stroke immediately sets into motion sustained excitotoxicity and calcium dysregulation, causing aberrant activity in neuronal nitric oxide synthase (nNOS) and an imbalance in the levels of nitric oxide (NO). D...

    Authors: Mushfiquddin Khan, Tajinder S Dhammu, Fumiyo Matsuda, Avtar K Singh and Inderjit Singh

    Citation: BMC Neuroscience 2015 16:42

    Content type: Research article

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  16. Plasma membrane localization can play a significant role in the ultimate function of certain proteins. Specific membrane domains like lipid rafts have been shown to be inhibitory domains to a number of signali...

    Authors: Robert J Donati, Jeffrey Schappi, Andrew H Czysz, Alexander Jackson and Mark M Rasenick

    Citation: BMC Neuroscience 2015 16:40

    Content type: Research article

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  17. Mitochondrial dysregulation is important in axonal damage and demyelination in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). There is however, no evidence in the literature of an...

    Authors: Mariam Al-Shamsi, Allen Shahin, Marwa F Ibrahim, Saeed Tareq, Abdul-Kader Souid and Eric P K Mensah-Brown

    Citation: BMC Neuroscience 2015 16:37

    Content type: Research article

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  18. Systemic infections can influence the course of multiple sclerosis (MS), especially by driving recurrent acute episodes. The question whether the infection enhances tissue damage is of great clinical importanc...

    Authors: Prateek Kumar, Katharina Friebe, Rieka Schallhorn, Zahra Moinfar, Roland Nau, Mathias Bähr, Sandra Schütze and Katharina Hein

    Citation: BMC Neuroscience 2015 16:36

    Content type: Research article

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  19. Noise exposure (NE) is a severe modern health hazard that induces hearing impairment. However, the noise-induced ultrastructural changes of blood-labyrinth barrier (BLB) and the potential involvements of tight...

    Authors: Yong-Xiang Wu, Guo-Xia Zhu, Xin-Qin Liu, Fei Sun, Ke Zhou, Shuang Wang, Chun-Mei Wang, Jin-Wen Jia, Jian-Tao Song and Lian-Jun Lu

    Citation: BMC Neuroscience 2014 15:136

    Content type: Research article

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  20. The roles of iron in epilepsy and its pathophysiological significance are poorly understood, especially whether iron levels are abnormal in subcortcal structures. This study aims to demonstrate whole-brain iro...

    Authors: Zhiqiang Zhang, Wei Liao, Boris Bernhardt, Zhengge Wang, Kangjian Sun, Fang Yang, Yijun Liu and Guangming Lu

    Citation: BMC Neuroscience 2014 15:117

    Content type: Research article

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  21. Stroke is the primary cause of long-term disability in the United States. Interestingly, mounting evidence has suggested potential sex differences in the response to stroke treatment in patients as, at least i...

    Authors: Lin Liu, Louise McCullough and Jun Li

    Citation: BMC Neuroscience 2014 15:118

    Content type: Research article

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  22. In our previous researches, we have found that apoptosis was induced in the medial prefrontal cortex (mPFC) of post-traumatic stress disorder (PTSD) rats. Endoplasmic reticulum (ER) stress-induced apoptosis ha...

    Authors: Bo Yu, Lili Wen, Bing Xiao, Fang Han and Yuxiu Shi

    Citation: BMC Neuroscience 2014 15:115

    Content type: Research article

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  23. The complex aetiology of most mental disorders involves gene-environment interactions that may operate using epigenetic mechanisms particularly DNA methylation. It may explain many of the features seen in ment...

    Authors: Melkaye G Melka, Christina A Castellani, Nagalingam Rajakumar, Richard O’Reilly and Shiva M Singh

    Citation: BMC Neuroscience 2014 15:112

    Content type: Research article

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  24. Insulin signaling and Tau protein phosphorylation in the hippocampi of young and old obese Zucker fa/fa rats and their lean controls were assessed to determine whether obesity-induced peripheral insulin resist...

    Authors: Andrea Špolcová, Barbora Mikulášková, Katarína Kršková, Lucia Gajdošechová, Štefan Zórad, Rafał Olszanecki, Maciej Suski, Beata Bujak-Giżycka, Blanka Železná and Lenka Maletínská

    Citation: BMC Neuroscience 2014 15:111

    Content type: Research article

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  25. Cell-derived microparticles are secreted in response to cell damage or dysfunction. Endothelial and platelet dysfunction are thought to contribute to the development of multiple sclerosis (MS). Our aim here is...

    Authors: Beatriz Marcos-Ramiro, Pedro Oliva Nacarino, Esther Serrano-Pertierra, Miguel Ángel Blanco-Gelaz, Babette B Weksler, Ignacio A Romero, Pierre O Couraud, Alberto Tuñón, Carlos López-Larrea, Jaime Millán and Eva Cernuda-Morollón

    Citation: BMC Neuroscience 2014 15:110

    Content type: Research article

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  26. The current standard of care for insomnia includes gamma-aminobutyric acid receptor A (GABAA) activators, which promote sleep as well as general central nervous system depression. Dual orexin receptor antagonists...

    Authors: Anthony L Gotter, Susan L Garson, Joanne Stevens, Regina L Munden, Steven V Fox, Pamela L Tannenbaum, Lihang Yao, Scott D Kuduk, Terrence McDonald, Jason M Uslaner, Spencer J Tye, Paul J Coleman, Christopher J Winrow and John J Renger

    Citation: BMC Neuroscience 2014 15:109

    Content type: Research article

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  27. Previous studies have demonstrated that white matter (WM) lesions bias automated brain tissue classifications and cerebral volume measurements. However, filling WM lesions using the intensity of neighbouring n...

    Authors: Stefano Magon, Laura Gaetano, M Mallar Chakravarty, Jason P Lerch, Yvonne Naegelin, Christoph Stippich, Ludwig Kappos, Ernst-Wilhelm Radue and Till Sprenger

    Citation: BMC Neuroscience 2014 15:106

    Content type: Methodology article

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  28. The causes of dural arteriovenous fistula have not been clearly defined. The aim of this study was to investigate the mechanism of dural arteriovenous fistula formation induced by high intracranial venous pres...

    Authors: Shou-Sen Wang, Chang-Hua Li, Xiao-Jun Zhang and Ru-Mi Wang

    Citation: BMC Neuroscience 2014 15:101

    Content type: Research article

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  29. Neuropsychiatric affection involving extrapyramidal symptoms is a frequent component of Wilson’s disease (WD). WD is caused by a genetic defect of the copper (Cu) efflux pump ATPase7B. Mouse strains with natur...

    Authors: Sorina Georgiana Boaru, Uta Merle, Ricarda Uerlings, Astrid Zimmermann, Sabine Weiskirchen, Andreas Matusch, Wolfgang Stremmel and Ralf Weiskirchen

    Citation: BMC Neuroscience 2014 15:98

    Content type: Research article

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  30. Alzheimer’s Disease (AD) and Fronto temporal lobar dementia (FTLD) are common causes of dementia in the aging population for which limited therapeutical options are available. These disorders are associated wi...

    Authors: Edward Rockenstein, Kiren Ubhi, Margarita Trejo, Michael Mante, Christina Patrick, Anthony Adame, Philipp Novak, Marion Jech, Edith Doppler, Herbert Moessler and Eliezer Masliah

    Citation: BMC Neuroscience 2014 15:90

    Content type: Research article

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  31. The neuronal cytoplasmic localization of SET, an inhibitor of the phosphatase 2A (PP2A), results in tau hyperphosphorylation in the brains of Alzheimer patients through mechanisms that are still not well defined.

    Authors: Stéphanie Chasseigneaux, Christine Clamagirand, Léa Huguet, Lucie Gorisse-Hussonnois, Christiane Rose and Bernadette Allinquant

    Citation: BMC Neuroscience 2014 15:82

    Content type: Research article

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  32. Hirano bodies are actin-rich paracrystalline inclusions found in brains of patients with Alzheimer’s disease (AD), frontotemporal dementia (FTD), and in normal aged individuals. Although studies of post-mortem...

    Authors: William Spears, Matthew Furgerson, John Michael Sweetnam, Parker Evans, Marla Gearing, Marcus Fechheimer and Ruth Furukawa

    Citation: BMC Neuroscience 2014 15:74

    Content type: Research article

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  33. Recent evidence has suggested that Alzheimer’s disease (AD)-associated neuronal loss may occur via the caspase-independent route of programmed cell death (PCD) in addition to caspase-dependent mechanisms. Howe...

    Authors: Wenfeng Yu, Mathilde Bonnet, Mark Farso, Keran Ma, Jean-Guy Chabot, Elisabeth Martin, Alicia Torriglia, Zhizhong Guan, JoAnne McLaurin, Rémi Quirion and Slavica Krantic

    Citation: BMC Neuroscience 2014 15:73

    Content type: Research article

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  34. α-Synuclein (α-syn) plays a central role in the pathogenesis of synucleinopathies, a group of neurodegenerative disorders that includes Parkinson disease, dementia with Lewy bodies and multiple system atrophy....

    Authors: Suzana Aulić, Tran Thanh Nhat Le, Fabio Moda, Saïda Abounit, Stefania Corvaglia, Loredana Casalis, Stefano Gustincich, Chiara Zurzolo, Fabrizio Tagliavini and Giuseppe Legname

    Citation: BMC Neuroscience 2014 15:69

    Content type: Research article

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  35. Genomic reprogramming is thought to be, at least in part, responsible for the protective effect of brain preconditioning. Unraveling mechanisms of this endogenous neuroprotection, activated by preconditioning,...

    Authors: Kimberly EM Cox-Limpens, Johan SH Vles, Daniel LA van den Hove, Luc JI Zimmermann and Antonio WD Gavilanes

    Citation: BMC Neuroscience 2014 15:67

    Content type: Research article

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  36. Glucocorticoid released by stressful stimuli elicits various stress responses. Acute treatment with a single dose of corticosterone (CORT; predominant glucocorticoid of rats) alone has previously been shown to...

    Authors: Hyejin Kim, Jee Hyun Yi, Kyuhyun Choi, Seokheon Hong, Ki Soon Shin and Shin Jung Kang

    Citation: BMC Neuroscience 2014 15:65

    Content type: Research article

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  37. RIP3 (Receptor-interacting protein 3) pathway was mainly described as the molecular mechanism of necroptosis (programmed necrosis). But recently, non-RIP3 pathways were found to mediate necroptosis. We deliber...

    Authors: Lei Shang, Ju-Fang Huang, Wei Ding, Shuang Chen, Li-Xiang Xue, Ruo-Fei Ma and Kun Xiong

    Citation: BMC Neuroscience 2014 15:63

    Content type: Research article

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  38. Adolescence is a developmental stage vulnerable to alcohol drinking-related problems and the onset of alcoholism. Hypothalamus is a key brain region for food and water intake regulation, and is one of the alco...

    Authors: Hong Zou, Ke Wang, Yang Gao, Huaiguang Song, Qinglian Xie, Meilei Jin, Guoping Zhao, Huasheng Xiao and Lei Yu

    Citation: BMC Neuroscience 2014 15:61

    Content type: Research article

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  39. Following the onset of focal ischemic stroke, the brain experiences a series of alterations including infarct evolvement, cellular proliferation in the penumbra, and behavioral deficits. However, systematic st...

    Authors: Hailong Li, Nannan Zhang, Hsin-Yun Lin, Yang Yu, Quan-Yu Cai, Lixin Ma and Shinghua Ding

    Citation: BMC Neuroscience 2014 15:58

    Content type: Research article

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  40. Reactive oxygen species (ROS) are essential for normal physiological functioning of the brain. However, uncompensated increase in ROS levels may results in oxidative stress. Phospholipase A2 (PLA2) is one of the ...

    Authors: Emily Beaulieu, Julie Ioffe, Shawn N Watson, Petra M Hermann and Willem C Wildering

    Citation: BMC Neuroscience 2014 15:56

    Content type: Research article

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  41. Both active and passive tobacco smoke (TS) potentially impair the vascular endothelial function in a causative and dose-dependent manner, largely related to the content of reactive oxygen species (ROS), nicoti...

    Authors: Pooja Naik, Neel Fofaria, Shikha Prasad, Ravi K Sajja, Babette Weksler, Pierre-Olivier Couraud, Ignacio A Romero and Luca Cucullo

    Citation: BMC Neuroscience 2014 15:51

    Content type: Research article

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  42. Microglia are resident mononuclear phagocytes of the brain that become activated in response to insults including neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and prion disease. ...

    Authors: Julia Grizenkova, Shaheen Akhtar, Sebastian Brandner, John Collinge and Sarah E Lloyd

    Citation: BMC Neuroscience 2014 15:44

    Content type: Research article

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  43. Bone morphogenic proteins (BMPs) promote the survival of neurons, suggesting a therapeutic application of BMPs in the treatment of acute and chronic neurodegenerative disorders. However, the application of rec...

    Authors: Ann-Marie Heinonen, Mahbubur Rahman, Godwin Dogbevia, Hannah Jakobi, Stefan Wölfl, Rolf Sprengel and Markus Schwaninger

    Citation: BMC Neuroscience 2014 15:38

    Content type: Research article

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  44. Extraneuronal levels of the neurotransmitter glutamate in brain rise during aging. This is thought to lead to synaptic dysfunction and neuronal injury or death. To study the effects of glutamate hyperactivity ...

    Authors: Xinkun Wang, Nilam D Patel, Dongwei Hui, Ranu Pal, Mohamed M Hafez, Mohamed M Sayed-Ahmed, Abdulaziz A Al-Yahya and Elias K Michaelis

    Citation: BMC Neuroscience 2014 15:37

    Content type: Research article

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  45. Nicotine is rapidly absorbed from cigarette smoke and therefore induces a number of chronic illnesses with the widespread use of tobacco products. Studies have shown a few cerebral metabolites modified by nico...

    Authors: Hongyu Li, Bo Chen, Xue Shao, Zhengtao Hu, Yi Deng, Ruiming Zhu, Yan Li, Baolai Zhang, Jing Hou, Changman Du, Qian Zhao, Dengqi Fu, Qian Bu, Yinglan Zhao and Xiaobo Cen

    Citation: BMC Neuroscience 2014 15:32

    Content type: Research article

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  46. To explore the neuroprotective effect and optimize the therapeutic dose and time window of picroside II by orthogonal test and the expression of myelin basic protein (MBP) in cerebral ischemic injury in rats. ...

    Authors: Li Zhao, Yunliang Guo, Xiaojun Ji and Meizeng Zhang

    Citation: BMC Neuroscience 2014 15:25

    Content type: Research article

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