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BMC Neuroscience

Neurobiology of disease

Section edited by Karsten Ruscher

This section covers the neurobiological aspects of diseases that can affect the brain. Topics of interest include, but are not limited to, neuroinflammation, neurodegenerative pathophysiology, neurogenesis and experimental brain research. Diseases range across neurodegeneration, demyelinating conditions, addiction, psychiatric conditions, stroke and spinal cord conditions.

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  1. Content type: Research article

    The possibility of using deep brain stimulation (DBS) for memory enhancement has recently been reported, but the precise underlying mechanisms of its effects remain unknown. Our previous study suggested that s...

    Authors: Da Un Jeong, Jihyeon Lee, Won Seok Chang and Jin Woo Chang

    Citation: BMC Neuroscience 2017 18:29

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  2. Content type: Research article

    Synucleinopathies such as Parkinson’s disease or multiple system atrophy are characterized by Lewy bodies in distinct brain areas. These aggregates are mainly formed by α-synuclein inclusions, a protein crucia...

    Authors: R. Rabl, C. Breitschaedel, S. Flunkert, S. Duller, D. Amschl, J. Neddens, V. Niederkofler, E. Rockenstein, E. Masliah, H. Roemer and B. Hutter-Paier

    Citation: BMC Neuroscience 2017 18:22

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  3. Content type: Research article

    TDP-43 aggregates accumulate in individuals affected by amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, representing potential diagnostic and therapeutic targets. Using an atomic forc...

    Authors: Stephanie M. Williams, Galam Khan, Brent T. Harris, John Ravits and Michael R. Sierks

    Citation: BMC Neuroscience 2017 18:20

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  4. Content type: Research article

    Magnetic resonance spectroscopy (MRS) provides non-invasive information about the metabolic pattern of the brain parenchyma in vivo. The SpectraClassifier software performs MRS pattern-recognition by determin...

    Authors: Elena Jiménez-Xarrié, Myriam Davila, Ana Paula Candiota, Raquel Delgado-Mederos, Sandra Ortega-Martorell, Margarida Julià-Sapé, Carles Arús and Joan Martí-Fàbregas

    Citation: BMC Neuroscience 2017 18:13

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  5. Content type: Research Article

    The fractalkine/CX3C chemokine receptor 1 (CX3CR1) pathway has been identified to play an essential role in the chemotaxis of microglia, leukocyte trafficking and microglia/macrophage recruitment. It has also bee...

    Authors: Gerlinde van der Maten, Vivien Henck, Tadeusz Wieloch and Karsten Ruscher

    Citation: BMC Neuroscience 2017 18:11

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  6. Content type: Research article

    Ultraviolet B irradiation confers strong resistance against experimental autoimmune encephalomyelitis, a model of multiple sclerosis. This protection by ultraviolet B is independent of vitamin D production but...

    Authors: Amy A. Irving, Steven J. Marling, Lori A. Plum and Hector F. DeLuca

    Citation: BMC Neuroscience 2017 18:8

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  7. Content type: Research Article

    Diffusion magnetic resonance imaging (MRI) is the current-state-of-the-art technique to clinically investigate acute (0–24 h) ischemic stroke tissue. However, reduced apparent diffusion coefficient (ADC)—cons...

    Authors: Friedrich Wetterling, Eva Chatzikonstantinou, Laurent Tritschler, Stephen Meairs, Marc Fatar, Lothar R. Schad and Saema Ansar

    Citation: BMC Neuroscience 2016 17:82

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  8. Content type: Research Article

    α-Synuclein (αSYN) has been genetically implicated in familial and sporadic Parkinson’s disease (PD), and is associated with disease susceptibility, progression and pathology. Excess amounts of αSYN are toxic ...

    Authors: Tatsunori Maekawa, Toshikuni Sasaoka, Sadahiro Azuma, Takafumi Ichikawa, Heather L. Melrose, Matthew J. Farrer and Fumiya Obata

    Citation: BMC Neuroscience 2016 17:77

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  9. Content type: Research Article

    Myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for multiple sclerosis. The characteristic feature of the MOG-EAE model in Brown...

    Authors: Sabine Herold, Prateek Kumar, Klaus Jung, Irina Graf, Henrike Menkhoff, Xenia Schulz, Mathias Bähr and Katharina Hein

    Citation: BMC Neuroscience 2016 17:78

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  10. Content type: Research article

    Sleep disruptions are common in epilepsy patients. Our previous study demonstrates that homeostatic factors and circadian rhythm may mediate epilepsy-induced sleep disturbances when epilepsy occurs at differen...

    Authors: Tzu-Rung Huang, Shuo-Bin Jou, Yu-Ju Chou, Pei-Lu Yi, Chun-Jen Chen and Fang-Chia Chang

    Citation: BMC Neuroscience 2016 17:74

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  11. Content type: Review

    Epilepsy is one of the most common neurological diseases characterized by excessive hyperexcitability of neurons. Molecular mechanisms of epilepsy are diverse and not really understood. All in common is the mi...

    Authors: Helena F. Pernice, Rico Schieweck, Michael A. Kiebler and Bastian Popper

    Citation: BMC Neuroscience 2016 17:73

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  12. Content type: Methodology article

    Cone photoreceptors are specialised sensory retinal neurons responsible for photopic vision, colour perception and visual acuity. Retinal degenerative diseases are a heterogeneous group of eye diseases in whic...

    Authors: Antonino Glaviano, Andrew J. Smith, Alfonso Blanco, Sarah McLoughlin, Maria L. Cederlund, Theresa Heffernan, Beata Sapetto-Rebow, Yolanda Alvarez, Jun Yin and Breandán N. Kennedy

    Citation: BMC Neuroscience 2016 17:71

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  13. Content type: Research article

    Fused in sarcoma (FUS) is an RNA-binding protein associated with the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. ALS manifests in patients as a progres...

    Authors: Kasey L. Jackson, Hemangini A. Dhaibar, Robert D. Dayton, Sergio G. Cananzi, William G. Mayhan, Edward Glasscock and Ronald L. Klein

    Citation: BMC Neuroscience 2016 17:69

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  14. Content type: Research article

    There is evidence that experimentally elicited auditory illusions in the general population index risk for psychotic symptoms. As little is known about underlying cortical mechanisms of auditory illusions, an ...

    Authors: E. Schepers, L. Bodar, J. van Os and R. Lousberg

    Citation: BMC Neuroscience 2016 17:65

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  15. Content type: Research article

    Bilateral adrenalectomy has been shown to damage the hippocampal neurons. Although the effects of long-term adrenalectomy have been studied extensively there are few publications on the effects of short-term a...

    Authors: Naserddine Hamadi, Azimullah Sheikh, Nather Madjid, Loai Lubbad, Naheed Amir, Safa Al-Deen Saudi Shehab, Fatima Khelifi-Touhami and Abdu Adem

    Citation: BMC Neuroscience 2016 17:61

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  16. Content type: Research article

    Astaxanthin is a carotenoid pigment that possesses potent antioxidative, anti-inflammatory, antitumor, and immunomodulatory activities. Previous studies have demonstrated that astaxanthin displays potential ne...

    Authors: Mingkun Zhang, Zhenwen Cui, Hua Cui, Yang Cao, Yong Wang and Chunlong Zhong

    Citation: BMC Neuroscience 2016 17:60

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  17. Content type: Research article

    Parkinson disease (PD) is a movement disorder affecting 1 % of people over the age of 60. The etiology of the disease is unknown; however, accumulating evidence suggests that mitochondrial defects, oxidative s...

    Authors: Hayate Javed, Sheikh Azimullah, Salema B. Abul Khair, Shreesh Ojha and M. Emdadul Haque

    Citation: BMC Neuroscience 2016 17:58

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  18. Content type: Research article

    Recurrent convulsions can cause irreversible astrocyte death, impede neuron regeneration, and further aggravate brain damage. MicroRNAs have been revealed as players in the progression of numerous diseases inc...

    Authors: Liqun Liu, Lingjuan Liu, Jiayun Shi, Menglin Tan, Jie Xiong, Xingfang Li, Qingpeng Hu, Zhuwen Yi and Ding’an Mao

    Citation: BMC Neuroscience 2016 17:56

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  19. Content type: Research article

    Amyloid-beta (Aβ) accumulation is a hallmark of Alzheimer’s disease (AD) that can lead to neuronal dysfunction and apoptosis. Tumor necrosis factor, alpha-induced protein 1 (TNFAIP1) is an apoptotic protein th...

    Authors: Ning Liu, Zhanyang Yu, Yu Xun, Miaomiao Li, Xiaoning Peng, Ye Xiao, Xiang Hu, Yi Sun, Manjun Yang, Shiquan Gan, Shishan Yuan, Xiaoying Wang, Shuanglin Xiang and Jian Zhang

    Citation: BMC Neuroscience 2016 17:51

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