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Neurobiology of disease

Section edited by Karsten Ruscher

This section covers the neurobiological aspects of diseases that can affect the brain. Topics of interest include, but are not limited to, neuroinflammation, neurodegenerative pathophysiology, neurogenesis and experimental brain research. Diseases range across neurodegeneration, demyelinating conditions, addiction, psychiatric conditions, stroke and spinal cord conditions.

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  1. Content type: Research article

    Tick-borne encephalitis (TBE) is the main tick-borne viral infection in Eurasia. Its manifestations range from inapparent infections and fevers with complete recovery to debilitating or fatal encephalitis. Th...

    Authors: Martin Palus, Yahya Sohrabi, Karl W. Broman, Hynek Strnad, Matyáš Šíma, Daniel Růžek, Valeriya Volkova, Martina Slapničková, Jarmila Vojtíšková, Lucie Mrázková, Jiří Salát and Marie Lipoldová

    Citation: BMC Neuroscience 2018 19:39

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  2. Content type: Research article

    Post-traumatic stress disorder (PTSD) is an important psychological disease that can develop following the physical experience or witnessing of traumatic events. The psychopathological response to traumatic st...

    Authors: Bombi Lee, Insop Shim, Hyejung Lee and Dae-Hyun Hahm

    Citation: BMC Neuroscience 2018 19:38

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  3. Content type: Research article

    High-frequency transcutaneous neuromuscular electrical nerve stimulation (TENS) is currently used for the administration of electrical current in denervated muscle to alleviate muscle atrophy and enhance moto...

    Authors: Hong-Lin Su, Chien-Yi Chiang, Zong-Han Lu, Fu-Chou Cheng, Chun-Jung Chen, Meei-Ling Sheu, Jason Sheehan and Hung-Chuan Pan

    Citation: BMC Neuroscience 2018 19:37

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  4. Content type: Research article

    Cholinergic hypothesis has been advanced as an etiology of Alzheimer disease (AD) on the basis of the presynaptic deficit found in the diseased brains, and cholinesterase inhibitors (ChEIs) are the treatment o...

    Authors: Yu San Chang, Yu Hsuan Wu, Chin Jen Wang, Shu Hui Tang and Hsiang Lan Chen

    Citation: BMC Neuroscience 2018 19:36

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  5. Content type: Research article

    Exposure to electromagnetic fields can affect human health, damaging tissues and cell homeostasis. Stress modulates neuronal responses and composition of brain lipids. The aim of this study was to evaluate the...

    Authors: Jesús Martínez-Sámano, Alan Flores-Poblano, Leticia Verdugo-Díaz, Marco Antonio Juárez-Oropeza and Patricia V. Torres-Durán

    Citation: BMC Neuroscience 2018 19:31

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  6. Content type: Research article

    The progressive neurodegenerative disorder multiple system atrophy (MSA) is characterized by α-synuclein-positive (oligodendro-) glial cytoplasmic inclusions (GCIs). A connection between the abnormal accumulat...

    Authors: Lisa Fellner, Edith Buchinger, Dominik Brueck, Regina Irschick, Gregor K. Wenning and Nadia Stefanova

    Citation: BMC Neuroscience 2018 19:32

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  7. Content type: Research article

    Studies have suggested the supplementation of Zinc and Linoleic acid in the management of neurodegenerative disorders but none has investigated the combined effects. Little is known about the neuroprotective e...

    Authors: Ngala Elvis Mbiydzenyuy, Herbert Izo Ninsiima, Miriela Betancourt Valladares and Constant Anatole Pieme

    Citation: BMC Neuroscience 2018 19:29

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  8. Content type: Research article

    To investigated distinct manifestations of Sjögren’s syndrome (SS) patients with neurological complications and the potential risk factors associated with neurological complications in SS, and to produce a dis...

    Authors: Wenjing Ye, Siyan Chen, Xinshi Huang, Wei Qin, Ting Zhang, Xiaofang Zhu, Xiaochun Zhu, Chongxiang Lin and Xiaobing Wang

    Citation: BMC Neuroscience 2018 19:26

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  9. Content type: Research article

    Stroke is among the leading causes of death and disability. Although intense research efforts have provided promising treatment options in animals, most clinical trials in humans have failed and the therapeuti...

    Authors: Edvin Ingberg, Hua Dock, Elvar Theodorsson, Annette Theodorsson and Jakob O. Ström

    Citation: BMC Neuroscience 2018 19:24

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  10. Content type: Research article

    Apoptotic changes after cerebral hemorrhage in brain samples of humans have been found. Caspase-cleaved cytokeratin (CCCK)-18 could be detected in the bloodstream during apoptosis. Higher circulating CCCK-18 l...

    Authors: Leonardo Lorente, María M. Martín, Antonia Pérez-Cejas, Luis Ramos, Mónica Argueso, Jordi Solé-Violán, Juan J. Cáceres, Alejandro Jiménez and Victor García-Marín

    Citation: BMC Neuroscience 2018 19:23

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  11. Content type: Research article

    Stroke is a leading cause of death and disability worldwide, yet there are limited treatments available. Intranasal administration is a novel non-invasive strategy to deliver cell therapy into the brain. Cell...

    Authors: Monica J. Chau, Todd C. Deveau, Xiaohuan Gu, Yo Sup Kim, Yun Xu, Shan Ping Yu and Ling Wei

    Citation: BMC Neuroscience 2018 19:20

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  12. Content type: Methodology article

    Amyotrophic lateral sclerosis (ALS) is a clinically and histopathologically heterogeneous neurodegenerative disorder, in which therapy is hindered by the rapid progression of disease and lack of biomarkers. Ma...

    Authors: Menuka Pallebage-Gamarallage, Sean Foxley, Ricarda A. L. Menke, Istvan N. Huszar, Mark Jenkinson, Benjamin C. Tendler, Chaoyue Wang, Saad Jbabdi, Martin R. Turner, Karla L. Miller and Olaf Ansorge

    Citation: BMC Neuroscience 2018 19:11

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  13. Content type: Research article

    Labor subjects the fetus to an hypoxic episode and concomitant adrenomodullary catecholamine surge that may provide protection against the hypoxic insult. The beta1-adrenergic agonist dobutamine protects again...

    Authors: Tina Markus, David Ley, Stefan R. Hansson, Tadeusz Wieloch and Karsten Ruscher

    Citation: BMC Neuroscience 2018 19:9

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  14. Content type: Research article

    Neuroinflammation and the presence of amyloid beta protein (Aβ) and neurofibrillary tangles are key pathologies in Alzheimer’s disease (AD). As a potent anti-amyloid and anti-inflammatory natural polyphenol, c...

    Authors: Panchanan Maiti, Leela Paladugu and Gary L. Dunbar

    Citation: BMC Neuroscience 2018 19:7

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  15. Content type: Methodology article

    Brain pericytes ensheathe the endothelium and contribute to formation and maintenance of the blood–brain-barrier. Additionally, pericytes are involved in several aspects of the CNS immune response including sc...

    Authors: Justin Rustenhoven, Leon C. Smyth, Deidre Jansson, Patrick Schweder, Miranda Aalderink, Emma L. Scotter, Edward W. Mee, Richard L. M. Faull, Thomas I.-H. Park and Mike Dragunow

    Citation: BMC Neuroscience 2018 19:6

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  16. Content type: Research article

    The recent Zika virus (ZIKV) outbreak has linked ZIKV with microcephaly and other central nervous system pathologies in humans. Astrocytes are among the first cells to respond to ZIKV infection in the brain an...

    Authors: Michal Stefanik, Petra Formanova, Tomas Bily, Marie Vancova, Ludek Eyer, Martin Palus, Jiri Salat, Carla Torres Braconi, Paolo M. de A. Zanotto, Ernest A. Gould and Daniel Ruzek

    Citation: BMC Neuroscience 2018 19:5

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  17. Content type: Research article

    Real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR) is a critical tool for evaluating the levels of mRNA transcribed from genes. Reliable RT-qPCR results largely depend on normaliz...

    Authors: Yingbo Kang, Zhuomin Wu, De Cai and Binger Lu

    Citation: BMC Neuroscience 2018 19:3

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  18. Content type: Research article

    Alzheimer’s disease (AD) is characterized by the deposition of amyloid-β (Aβ) in brain parenchyma and cerebral blood vessels as cerebral amyloid angiopathy (CAA). Clusterin, a chaperon protein associated with ...

    Authors: Xue-Mei Qi, Cheng Wang, Xing-Kun Chu, Gen Li and Jian-Fang Ma

    Citation: BMC Neuroscience 2018 19:2

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  19. Content type: Research article

    Activated microglia interact with astrocytes and neuronal cells to induce neuroinflammation, which can contribute to the pathogenesis and progression of Alzheimer’s and Parkinson’s disease. To identify the mos...

    Authors: Lalita Subedi, Oh Wook Kwon, Chaeho Pak, Goeun Lee, Kangwoo Lee, Hakwon Kim and Sun Yeou Kim

    Citation: BMC Neuroscience 2017 18:82

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  20. Content type: Research article

    Obesity induced brain inflammation is associated with cognitive disorders. We aimed to investigate the influence of vitamin D on hypothalamus and hippocampus inflammatory response in high-fat diet induced obes...

    Authors: Mahdieh Abbasalizad Farhangi, Mehran Mesgari-Abbasi, Ghazaleh Nameni, Ghazaleh Hajiluian and Parviz Shahabi

    Citation: BMC Neuroscience 2017 18:81

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