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Neurobiology of disease

Topics of interest include, but are not limited to, neuroinflammation, neurodegenerative pathophysiology, neurodevelopmental disorders, neuropsychiatric disorders, addiction, stroke, ischemia, spinal cord injury, traumatic brain injury (TBI), demyelination and genetic and genomic analysis of diseases of the nervous system.

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  1. Methamphetamine (METH) is one of the most widely abused illicit substances worldwide; unfortunately, its addiction mechanism remains unclear. Based on accumulating evidence, changes in gene expression and chro...

    Authors: Hui Li, Jing-An Chen, Qian-Zhi Ding, Guan-Yi Lu, Ning Wu, Rui-Bin Su, Fei Li and Jin Li

    Citation: BMC Neuroscience 2021 22:24

    Content type: Research article

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  2. Differences of genotypes between male and female have been studied in Parkinson’s disease (PD), but limited research has focused on the comparison between sexes with LRRK2 G2385 variant.

    Authors: Shi-Shuang Cui, Rao Fu, Juan-Juan Du, Yi-Qi Lin, Pei Huang, Chao Gao, Hai-Yan Zhou and Sheng-Di Chen

    Citation: BMC Neuroscience 2021 22:22

    Content type: Research article

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  3. The SCN11A gene, encoded Nav1.9 TTX resistant sodium channels, is a main effector in peripheral inflammation related pain in nociceptive neurons. The role of SCN11A gene in the auditory system has not been well c...

    Authors: Mian Zu, Wei-Wei Guo, Tao Cong, Fei Ji, Shi-Li Zhang, Yue Zhang, Xin Song, Wei Sun, David Z. Z. He, Wei-Guo Shi and Shi-Ming Yang

    Citation: BMC Neuroscience 2021 22:18

    Content type: Research article

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  4. Several studies have shown that glutamate neurotransmission in the nucleus accumbens (NAc) is required for the development of morphine-induced conditional place preference (CPP). In addition, metabotropic glut...

    Authors: Zahra Ebrahimi, Nazanin Kahvandi, Alireza Komaki, Seyed Asaad Karimi, Marzieh Naderishahab and Abdolrahman Sarihi

    Citation: BMC Neuroscience 2021 22:17

    Content type: Research article

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  5. Rupture of intracranial aneurysm (IA) is the main cause of devastating subarachnoid hemorrhage, which urges our understanding of the pathogenesis and regulatory mechanisms of IA. However, the regulatory roles ...

    Authors: Yuan-Bo Pan, Jianan Lu, Biao Yang, Cameron Lenahan, Jianmin Zhang and Anwen Shao

    Citation: BMC Neuroscience 2021 22:15

    Content type: Research article

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  6. Alzheimer’s disease (AD) is characterized by cognitive impairment that eventually develops into dementia. Amyloid-beta (Aβ) accumulation is a widely described hallmark in AD, and has been reported to cause olf...

    Authors: Mara A. Guzmán-Ruiz, Amor Herrera-González, Adriana Jiménez, Alan Candelas-Juárez, Crystal Quiroga-Lozano, Claudia Castillo-Díaz, Erika Orta-Salazar, Diana Organista-Juárez, Sofía Díaz-Cintra and Rosalinda Guevara-Guzmán

    Citation: BMC Neuroscience 2021 22:14

    Content type: Research article

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  7. We previously reported that heat shock protein 27 (HSP27) phosphorylation plays an important role in the activation of glucose-6-phosphate dehydrogenase (G6PD), resulting in the upregulation of the pentose pho...

    Authors: Kazuya Matsuo, Kohkichi Hosoda, Jun Tanaka, Yusuke Yamamoto, Taichiro Imahori, Tomoaki Nakai, Yasuhiro Irino, Masakazu Shinohara, Takashi Sasayama and Eiji Kohmura

    Citation: BMC Neuroscience 2021 22:9

    Content type: Research article

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  8. It has been shown that eosinophils are decreased and monocytes are elevated in patients with acute ischemic stroke (AIS), but the impact of eosinophil-to-monocyte ratio (EMR) on clinical outcomes among AIS pat...

    Authors: Shuhong Yu, Yi Luo, Tan Zhang, Chenrong Huang, Yu Fu, Qiang Zhang, Fangyue Zeng, Hao Huang, Chunyuan Zhang and Zhiliang Guo

    Citation: BMC Neuroscience 2021 22:8

    Content type: Research article

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  9. SYNE1 ataxia is an autosomal recessive hereditary condition, the main characteristic features of which are gait and limb ataxia and cerebellar dysarthria. Reports have revealed that the clinical phenotype of SYNE...

    Authors: Laszlo Szpisjak, Gabor Szaraz, Andras Salamon, Viola L. Nemeth, Noemi Szepfalusi, Gabor Veres, Balint Kincses, Zoltan Maroti, Tibor Kalmar, Malgorzata Rydzanicz, Rafal Ploski, Peter Klivenyi and Denes Zadori

    Citation: BMC Neuroscience 2021 22:7

    Content type: Research article

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    The Correction to this article has been published in BMC Neuroscience 2021 22:16

  10. Neuropathic pain (NeuP) is a complex, debilitating condition of the somatosensory system, where dysregulation between pro- and anti-inflammatory cytokines and chemokines are believed to play a pivotal role. As...

    Authors: Mika Jönsson, Björn Gerdle, Bijar Ghafouri and Emmanuel Bäckryd

    Citation: BMC Neuroscience 2021 22:6

    Content type: Research article

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  11. Status epilepticus (SE) is a life-threatening neurological disorder. The hippocampus, as an important area of the brain that regulates cognitive function, is usually damaged after SE, and cognitive deficits of...

    Authors: Xin-Ming Luo, Jing Zhao, Wen-Yue Wu, Jie Fu, Zheng-Yu Li, Ming Zhang and Jie Lu

    Citation: BMC Neuroscience 2021 22:2

    Content type: Research article

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  12. As a noninvasive perfusion-weighted MRI technique, arterial spin-labeling (ASL) was becoming increasingly used to evaluate cerebral hemodynamics in many studies. The relation between ASL-MRI and crossed cerebe...

    Authors: Juan Wang, Li-Jun Pan, Bin Zhou, Jin-Yan Zu, Yi-Xu Zhao, Yang Li, Wan-Qiu Zhu, Lei Li, Jian-Rong Xu and Zeng-Ai Chen

    Citation: BMC Neuroscience 2020 21:46

    Content type: Research article

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  13. Cardiac arrest (CA) is the most common cause of acute neurologic insult in children. Many survivors have significant neurocognitive deficits at 1 year of recovery. Epoxyeicosatrienoic acids (EETs) are multifun...

    Authors: Caitlin E. O’Brien, Polan T. Santos, Ewa Kulikowicz, Jennifer K. Lee, Raymond C. Koehler and Lee J. Martin

    Citation: BMC Neuroscience 2020 21:43

    Content type: Research article

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  14. Although previous studies have shown that intra-network abnormalities in brain functional networks are correlated with clinical/cognitive impairment in multiple sclerosis (MS), there is little information rega...

    Authors: Lin Wu, Muhua Huang, Fuqing Zhou, Xianjun Zeng and Honghan Gong

    Citation: BMC Neuroscience 2020 21:37

    Content type: Research article

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  15. Frontotemporal dementia (FTD) is the second leading cause of early onset dementia following Alzheimer’s disease. It involves atrophy of the frontal and temporal regions of the brain affecting language, memory,...

    Authors: Lalitha Venkataraman, Ping He, Galam Khan, Brent T. Harris and Michael R. Sierks

    Citation: BMC Neuroscience 2020 21:36

    Content type: Research article

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  16. Alzheimer’s disease (AD) is a progressive neuro-degenerative disease with a major manifestation of dementia. MicroRNAs were reported to regulate the transcript expression in patients with Alzheimer’s disease (...

    Authors: Jin Miao, Jin Jing, Yixiang Shao and Huaichang Sun

    Citation: BMC Neuroscience 2020 21:33

    Content type: Research article

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  17. Parkinson’s disease (PD) is a disease of the central nervous system that progressively affects the motor system. Epidemiological studies have provided evidence that exposure to agriculture-related occupations ...

    Authors: Rodney C. P. Go, Michael J. Corley, G. Webster Ross, Helen Petrovitch, Kamal H. Masaki, Alika K. Maunakea, Qimei He and Maarit I. Tiirikainen

    Citation: BMC Neuroscience 2020 21:31

    Content type: Research article

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  18. Cerebral stroke occurs following ischemic and hemorrhagic lesions in the brain. Survival and recovery of stroke patients depend on the severity of the initial injury but also the therapeutic approaches applied...

    Authors: Ewen Tu, Qiong Chen, Li Tan and Yan Wang

    Citation: BMC Neuroscience 2020 21:24

    Content type: Research article

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  19. Polynitroxylated PEGylated hemoglobin (PNPH, aka SanFlow) possesses superoxide dismutase/catalase mimetic activities that may directly protect the brain from oxidative stress. Stabilization of PNPH with bound ...

    Authors: Soichiro Seno, Jun Wang, Suyi Cao, Manda Saraswati, Sharon Park, Jan Simoni, Li Ma, Bohdan Soltys, Carleton J. C. Hsia, Raymond C. Koehler and Courtney L. Robertson

    Citation: BMC Neuroscience 2020 21:22

    Content type: Research article

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  20. Patients positive for anti-glutamic acid decarboxylase 65 (GAD65) antibodies have attracted increasing attention. Their clinical manifestations are highly heterogeneous and can be comorbid with tumors. Current...

    Authors: Tao-Ran Li, Yu-Di Zhang, Qun Wang, Xiao-Qiu Shao, Zhi-Mei Li and Rui-Juan Lv

    Citation: BMC Neuroscience 2020 21:13

    Content type: Research article

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  21. Medium spiny neurons (MSNs) comprise the main body (95% in mouse) of the dorsal striatum neurons and represent dopaminoceptive GABAergic neurons. The cAMP (cyclic Adenosine MonoPhosphate)—mediated cascade of e...

    Authors: Vladimir N. Babenko, Anna G. Galyamina, Igor B. Rogozin, Dmitry A. Smagin and Natalia N. Kudryavtseva

    Citation: BMC Neuroscience 2020 21:12

    Content type: Research article

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  22. Neuromyelitis optica (NMO) is a demyelinating disease primarily affecting the optic nerves and spinal cord. It is distinguished from other demyelinating conditions by the presence of AQP4-IgG and serum aquapor...

    Authors: Etedal Ahmed AbuElbasher Ibrahim, Fatima Gammer and Alsadig Gassoum

    Citation: BMC Neuroscience 2020 21:9

    Content type: Research article

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  23. Synaptic degeneration and accumulation of amyloid β-peptides (Aβ) are hallmarks of the Alzheimer diseased brain. Aβ is synaptotoxic and produced by sequential cleavage of the amyloid precursor protein (APP) by...

    Authors: Jolanta L. Lundgren, Lina Vandermeulen, Anna Sandebring-Matton, Saheeb Ahmed, Bengt Winblad, Monica Di Luca, Lars O. Tjernberg, Elena Marcello and Susanne Frykman

    Citation: BMC Neuroscience 2020 21:6

    Content type: Research article

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  24. Opioids are the most effective drugs commonly prescribed to treat pain. Due to their addictive nature, opioid pain relievers are now second to marijuana, ahead of cocaine with respect to dependence. Ours and o...

    Authors: Ruping Fan, Lisa M. Schrott, Stephen Snelling, John Felty, Derrel Graham, Patrick L. McGauly, Thomas Arnold and Nadejda L. Korneeva

    Citation: BMC Neuroscience 2020 21:4

    Content type: Research article

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  25. The growing abuse of amphetamine-type stimulants leads to new challenges to human health. A possible addiction mechanism has been proposed by altered functional architecture of the nucleus accumbens (NAc) duri...

    Authors: Yun Wang, Kai-Juan Yan, Chen-Xiao Fan, Xiao-Nian Luo and Yuan Zhou

    Citation: BMC Neuroscience 2019 20:66

    Content type: Research article

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  26. Sodium ion transportation plays a crucial role in the pathogenesis of hypoxic–ischemic brain injury. Amiodarone, a Vaughan-Williams class III antiarrhythmic drug, has been widely used to treat life-threatening...

    Authors: Masakazu Kotoda, Sohei Hishiyama, Tadahiko Ishiyama, Kazuha Mitsui and Takashi Matsukawa

    Citation: BMC Neuroscience 2019 20:62

    Content type: Research article

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  27. Parkinson’s disease (PD) is characterised by dopaminergic cell loss within the substantia nigra pars compacta (SNc) that leads to reduced striatal dopamine content and resulting motor deficits. Identifying new...

    Authors: Edward J. R. Fletcher, Lawrence D. F. Moon and Susan Duty

    Citation: BMC Neuroscience 2019 20:61

    Content type: Research article

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  28. The aim was to examine the impact of lipopolysaccharide-induced systemic inflammation on expression of mRNA for cocaine- and amphetamine-regulated transcript (CART) and the thyrotropin receptor (TSHR) and its ...

    Authors: Jonathan R. Burgos, Britt-Marie Iresjö, Linda Olsson and Ulrika Smedh

    Citation: BMC Neuroscience 2019 20:59

    Content type: Research article

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  29. In animal research, authorities require a classification of anticipated pain levels and a perioperative analgesia protocol prior to approval of the experiments. However, data on this topic is rare and so is th...

    Authors: Irina Staib-Lasarzik, Nadine Nagel, Anne Sebastiani, Eva-Verena Griemert and Serge C. Thal

    Citation: BMC Neuroscience 2019 20:49

    Content type: Research article

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  30. The Pde6brd1 (Rd1) mouse is widely used as a murine model for human retinitis pigmentosa. Understanding the spatio-temporal patterns of cone degeneration is important for evaluating potential treatments. In th...

    Authors: Daniel S. Narayan, Jack Ao, John P. M. Wood, Robert J. Casson and Glyn Chidlow

    Citation: BMC Neuroscience 2019 20:46

    Content type: Research article

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  31. Systemic inflammation is an important risk factor for neurodevelopmental impairments in preterm infants. Premyelinating oligodendrocytes are main building blocks of white matter in preterm infants and vulnerab...

    Authors: Seung Han Shin, Ee-Kyung Kim, Kyung-yup Lee and Han-Suk Kim

    Citation: BMC Neuroscience 2019 20:45

    Content type: Research article

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  32. Distinctive patterns of functional connectivity (FC) abnormalities in neural circuitry has been reported in patients with bipolar depression (BD) and unipolar depression (UD). However, it is unclear that wheth...

    Authors: Chang Liu, Weidan Pu, Guowei Wu, Jie Zhao and Zhimin Xue

    Citation: BMC Neuroscience 2019 20:30

    Content type: Research article

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  33. Mutants which carry mutations in genes encoding mitochondrial ligases MUL1 and PARKIN are convenient Drosophila models of Parkinson’s disease (PD). In several studies it has been shown that in Parkinson’s disease...

    Authors: Bartosz Doktór, Milena Damulewicz and Elżbieta Pyza

    Citation: BMC Neuroscience 2019 20:24

    Content type: Research article

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  34. Patients with Parkinson’s disease (PD) have elevated levels of brain iron, especially in the nigrostriatal dopaminergic system. The purpose of this study was to evaluate the iron deposition in the substantia n...

    Authors: Qiqi Chen, Yiting Chen, Yue Zhang, Furu Wang, Hongchang Yu, Caiyuan Zhang, Zhen Jiang and Weifeng Luo

    Citation: BMC Neuroscience 2019 20:23

    Content type: Research article

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  35. Chronic neuropathic pain is often associated with anxiety, depressive symptoms, and cognitive impairment with relevant impact on patients` health related quality of life. To investigate the influence of a pro-...

    Authors: Franziska Karl, Maria B. Nandini Colaço, Annemarie Schulte, Claudia Sommer and Nurcan Üçeyler

    Citation: BMC Neuroscience 2019 20:16

    Content type: Research article

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  36. Knock-in (KI) mouse models of Alzheimer’s disease (AD) that endogenously overproduce Aβ without non-physiological overexpression of amyloid precursor protein (APP) provide important insights into the pathogeni...

    Authors: Yasufumi Sakakibara, Michiko Sekiya, Takashi Saito, Takaomi C. Saido and Koichi M. Iijima

    Citation: BMC Neuroscience 2019 20:13

    Content type: Research article

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  37. Epidemiologic studies strongly suggest that the pathophysiology of late-onset Alzheimer disease (AD) versus early-onset AD has environmental rather than genetic causes, thus revealing potentially novel therape...

    Authors: Zein Al-Atrache, Danielle B. Lopez, Susan T. Hingley and Denah M. Appelt

    Citation: BMC Neuroscience 2019 20:6

    Content type: Research article

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  38. Accurately assessing promising therapeutic interventions for human diseases depends, in part, on the reproducibility of preclinical disease models. With the development of transgenic mice, the rapid adaptation...

    Authors: Peggy Rentsch, Sandy Stayte, Gary P. Morris and Bryce Vissel

    Citation: BMC Neuroscience 2019 20:5

    Content type: Research article

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  39. Cobalt chloride (CoCl2) induces chemical hypoxia through activation of hypoxia-inducible factor-1 alpha (HIF-1α). Mammalian target of rapamycin (mTOR) is a multifaceted protein capable of regulating cell growth, ...

    Authors: Mary A. Zimmerman, Christan D. Biggers and P. Andy Li

    Citation: BMC Neuroscience 2018 19:82

    Content type: Research article

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  40. Acute subdural hemorrhage (ASDH) is a severe consequence of traumatic brain injury. The occurrence of subdural blood increases the lethality of these patients independent of the amount of blood or elevated int...

    Authors: Tobias J. Krämer, Wasim Sakas, Daniel Jussen, Harald Krenzlin, Oliver Kempski and Beat Alessandri

    Citation: BMC Neuroscience 2018 19:81

    Content type: Research article

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  41. Development of anxiety- and depression-like states under chronic social defeat stress in mice has been shown by many experimental studies. In this article, the differentially expressed Slc25* family genes encodin...

    Authors: Vladimir N. Babenko, Dmitry A. Smagin, Anna G. Galyamina, Irina L. Kovalenko and Natalia N. Kudryavtseva

    Citation: BMC Neuroscience 2018 19:79

    Content type: Research article

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  42. The treatment of Parkinson’s disease is often complicated by levodopa-induced dyskinesia (LID). Nicotinic acetylcholine receptor agonists can alleviate LID in animal models but may be less effective in conditi...

    Authors: Sakari Leino, Samuel Kohtala, Tomi Rantamäki, Sini K. Koski, Saara Rannanpää and Outi Salminen

    Citation: BMC Neuroscience 2018 19:77

    Content type: Research article

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  43. Traumatic brain injury (TBI) is a complex condition and remains a prominent public and medical health issue in individuals of all ages. A rapid increase in extracellular glutamate occurs after TBI, leading to ...

    Authors: Wenbo Wu, Siyi Xu, Jialin Wang, Kuiming Zhang, Mingkun Zhang, Yang Cao, Hongqing Ren, Deyou Zheng and Chunlong Zhong

    Citation: BMC Neuroscience 2018 19:75

    Content type: Research article

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  44. Neurological disorders suggest that the excitotoxicity involves a drastic increase in intracellular Ca2+ concentrations and the formation of reactive oxygen species. The presence of these free radicals may also a...

    Authors: Armando Valenzuela Peraza, David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortiz Herrera, Hugo Juárez Olguín, Miroslava Lindoro Silva, Belén Juárez Tapia and Gerardo Barragán Mejía

    Citation: BMC Neuroscience 2018 19:71

    Content type: Research article

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  45. The clinical significance of anti-neuronal antibodies in patients with psychiatric disorders, but without encephalitis, remains unknown. In patients admitted to acute psychiatric inpatient care we aimed to ide...

    Authors: Morten B. Schou, Sverre Georg Sæther, Ole Kristian Drange, Karoline Krane-Gartiser, Solveig K. Reitan, Arne E. Vaaler and Daniel Kondziella

    Citation: BMC Neuroscience 2018 19:68

    Content type: Research article

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  46. Spinal cord injury (SCI) is one of the leading causes of disability and chronic pain. In SCI-induced pathology, homeostasis of the nitric oxide (NO) metabolome is lost. Major NO metabolites such as S-nitrosogl...

    Authors: Mushfiquddin Khan, Tajinder S. Dhammu, Inderjit Singh and Avtar K. Singh

    Citation: BMC Neuroscience 2018 19:50

    Content type: Research article

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