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Section edited by Karsten Ruscher
This section covers the neurobiological aspects of diseases that can affect the brain. Topics of interest include, but are not limited to, neurodegenerative pathophysiology, neurogenesis and experimental brain research. Diseases range across neurodegeneration, demyelinating conditions, ischemia and spinal cord conditions.
Research article
Hair cell loss in the cochlea is caused by ototoxic drugs, aging, and environmental stresses and could potentially lead to devastating pathophysiological effects. In adult mammals, hair cell loss is irreversib...
BMC Neuroscience 2017 18:64
Published on: 16 August 2017
Research article
Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are ass...
BMC Neuroscience 2017 18:62
Published on: 14 August 2017
Research article
In Duchenne muscular dystrophy (DMD), the loss of the dystrophin component of the dystrophin-glycoprotein complex (DGC) compromises plasma membrane integrity in skeletal muscle, resulting in extensive muscle d...
BMC Neuroscience 2017 18:63
Published on: 14 August 2017
Research article
Sesamin is a well-known antioxidant extracted from sesame seeds that exhibits various curative effects. The present study investigated whether sesamin would protect neuroblastoma SH-SY5Y cells against mechanic...
BMC Neuroscience 2017 18:57
Published on: 7 August 2017
Research article
Systemic inflammation and white matter (WM) alterations have been noted as effects of Parkinson’s disease (PD). This study sought to evaluate WM integrity in PD patients using diffusion tensor imaging (DTI) an...
BMC Neuroscience 2017 18:48
Published on: 8 June 2017
Research article
Sirtuins (SIRTs) are NAD+ dependent lysine deacetylases which are conserved from bacteria to humans and have been associated with longevity and lifespan extension. SIRT1, the best studied mammalian SIRT is invol...
BMC Neuroscience 2017 18:46
Published on: 2 June 2017
Research article
Mice lacking Kalirin-7 (Kal7KO), a Rho GDP/GTP exchange factor, self-administer cocaine at a higher rate than wildtype mice, and show an exaggerated locomotor response to experimenter-administered cocaine. Kal7, ...
BMC Neuroscience 2017 18:45
Published on: 23 May 2017
Research article
Astaxanthin (ATX) is a carotenoid pigment with pleiotropic pharmacological properties that is seen as a possible drug for treating cerebral ischemic injury and subarachnoid hemorrhage. Na+–K+–2Cl− co-transporter-...
BMC Neuroscience 2017 18:42
Published on: 10 May 2017
Research article
Recent rodent and human studies provide evidence in support of the fact that CD157, well known as bone marrow stromal cell antigen-1 (BST-1) and a risk factor in Parkinson’s disease, also meaningfully acts in ...
BMC Neuroscience 2017 18:35
Published on: 24 March 2017
Research article
The possibility of using deep brain stimulation (DBS) for memory enhancement has recently been reported, but the precise underlying mechanisms of its effects remain unknown. Our previous study suggested that s...
BMC Neuroscience 2017 18:29
Published on: 7 March 2017
Research article
Synucleinopathies such as Parkinson’s disease or multiple system atrophy are characterized by Lewy bodies in distinct brain areas. These aggregates are mainly formed by α-synuclein inclusions, a protein crucia...
BMC Neuroscience 2017 18:22
Published on: 31 January 2017
Research article
TDP-43 aggregates accumulate in individuals affected by amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, representing potential diagnostic and therapeutic targets. Using an atomic forc...
BMC Neuroscience 2017 18:20
Published on: 25 January 2017
Research article
Magnetic resonance spectroscopy (MRS) provides non-invasive information about the metabolic pattern of the brain parenchyma in vivo. The SpectraClassifier software performs MRS pattern-recognition by determin...
BMC Neuroscience 2017 18:13
Published on: 13 January 2017
Research Article
The fractalkine/CX3C chemokine receptor 1 (CX3CR1) pathway has been identified to play an essential role in the chemotaxis of microglia, leukocyte trafficking and microglia/macrophage recruitment. It has also bee...
BMC Neuroscience 2017 18:11
Published on: 6 January 2017
Research article
Ultraviolet B irradiation confers strong resistance against experimental autoimmune encephalomyelitis, a model of multiple sclerosis. This protection by ultraviolet B is independent of vitamin D production but...
BMC Neuroscience 2017 18:8
Published on: 5 January 2017
Research Article
Diffusion magnetic resonance imaging (MRI) is the current-state-of-the-art technique to clinically investigate acute (0–24 h) ischemic stroke tissue. However, reduced apparent diffusion coefficient (ADC)—cons...
BMC Neuroscience 2016 17:82
Published on: 7 December 2016
Research Article
α-Synuclein (αSYN) has been genetically implicated in familial and sporadic Parkinson’s disease (PD), and is associated with disease susceptibility, progression and pathology. Excess amounts of αSYN are toxic ...
BMC Neuroscience 2016 17:77
Published on: 30 November 2016
Research Article
Myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for multiple sclerosis. The characteristic feature of the MOG-EAE model in Brown...
BMC Neuroscience 2016 17:78
Published on: 30 November 2016
Research article
Sleep disruptions are common in epilepsy patients. Our previous study demonstrates that homeostatic factors and circadian rhythm may mediate epilepsy-induced sleep disturbances when epilepsy occurs at differen...
BMC Neuroscience 2016 17:74
Published on: 22 November 2016
Review
Epilepsy is one of the most common neurological diseases characterized by excessive hyperexcitability of neurons. Molecular mechanisms of epilepsy are diverse and not really understood. All in common is the mi...
BMC Neuroscience 2016 17:73
Published on: 17 November 2016
