Neurobiology of disease

Section edited by Karsten Ruscher

This section covers the neurobiological aspects of diseases that can affect the brain. Topics of interest include, but are not limited to, neurodegenerative pathophysiology, neurogenesis and experimental brain research. Diseases range across neurodegeneration, demyelinating conditions, ischemia and spinal cord conditions.

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  1. Research article

    Musashi-1 is the candidate of the regulator of hair cell progenitors during inner ear regeneration

    Hair cell loss in the cochlea is caused by ototoxic drugs, aging, and environmental stresses and could potentially lead to devastating pathophysiological effects. In adult mammals, hair cell loss is irreversib...

    Takahiro Wakasaki, Hiroaki Niiro, Siamak Jabbarzadeh-Tabrizi, Mitsuru Ohashi, Takashi Kimitsuki, Takashi Nakagawa, Shizuo Komune and Koichi Akashi

    BMC Neuroscience 2017 18:64

    Published on: 16 August 2017

  2. Research article

    Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma

    Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are ass...

    Ryan L. O’Hare Doig, Wissam Chiha, Marcus K. Giacci, Nathanael J. Yates, Carole A. Bartlett, Nicole M. Smith, Stuart I. Hodgetts, Alan R. Harvey and Melinda Fitzgerald

    BMC Neuroscience 2017 18:62

    Published on: 14 August 2017

  3. Research article

    White matter damage and systemic inflammation in Parkinson’s disease

    Systemic inflammation and white matter (WM) alterations have been noted as effects of Parkinson’s disease (PD). This study sought to evaluate WM integrity in PD patients using diffusion tensor imaging (DTI) an...

    Pi-Ling Chiang, Hsiu-Ling Chen, Cheng-Hsien Lu, Pei-Chin Chen, Meng-Hsiang Chen, I.-Hsiao Yang, Nai-Wen Tsai and Wei-Che Lin

    BMC Neuroscience 2017 18:48

    Published on: 8 June 2017

  4. Research article

    Astaxanthin protects astrocytes against trauma-induced apoptosis through inhibition of NKCC1 expression via the NF-κB signaling pathway

    Astaxanthin (ATX) is a carotenoid pigment with pleiotropic pharmacological properties that is seen as a possible drug for treating cerebral ischemic injury and subarachnoid hemorrhage. Na+–K+–2Cl co-transporter-...

    Mingkun Zhang, Zhenwen Cui, Hua Cui, Yong Wang and Chunlong Zhong

    BMC Neuroscience 2017 18:42

    Published on: 10 May 2017

  5. Research article

    An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator

    Recent rodent and human studies provide evidence in support of the fact that CD157, well known as bone marrow stromal cell antigen-1 (BST-1) and a risk factor in Parkinson’s disease, also meaningfully acts in ...

    Haruhiro Higashida, Mingkun Liang, Toru Yoshihara, Shirin Akther, Azam Fakhrul, Cherepanov Stanislav, Tae-Sik Nam, Uh-Hyun Kim, Satoka Kasai, Tomoko Nishimura, Naila Al Mahmuda, Shigeru Yokoyama, Katsuhiko Ishihara, Maria Gerasimenko, Alla Salmina, Jing Zhong…

    BMC Neuroscience 2017 18:35

    Published on: 24 March 2017

  6. Research article

    Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice

    Synucleinopathies such as Parkinson’s disease or multiple system atrophy are characterized by Lewy bodies in distinct brain areas. These aggregates are mainly formed by α-synuclein inclusions, a protein crucia...

    R. Rabl, C. Breitschaedel, S. Flunkert, S. Duller, D. Amschl, J. Neddens, V. Niederkofler, E. Rockenstein, E. Masliah, H. Roemer and B. Hutter-Paier

    BMC Neuroscience 2017 18:22

    Published on: 31 January 2017

  7. Research article

    TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis

    TDP-43 aggregates accumulate in individuals affected by amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, representing potential diagnostic and therapeutic targets. Using an atomic forc...

    Stephanie M. Williams, Galam Khan, Brent T. Harris, John Ravits and Michael R. Sierks

    BMC Neuroscience 2017 18:20

    Published on: 25 January 2017

  8. Research article

    Brain metabolic pattern analysis using a magnetic resonance spectra classification software in experimental stroke

    Magnetic resonance spectroscopy (MRS) provides non-invasive information about the metabolic pattern of the brain parenchyma in vivo. The SpectraClassifier software performs MRS pattern-recognition by determin...

    Elena Jiménez-Xarrié, Myriam Davila, Ana Paula Candiota, Raquel Delgado-Mederos, Sandra Ortega-Martorell, Margarida Julià-Sapé, Carles Arús and Joan Martí-Fàbregas

    BMC Neuroscience 2017 18:13

    Published on: 13 January 2017

  9. Research Article

    CX3C chemokine receptor 1 deficiency modulates microglia morphology but does not affect lesion size and short-term deficits after experimental stroke

    The fractalkine/CX3C chemokine receptor 1 (CX3CR1) pathway has been identified to play an essential role in the chemotaxis of microglia, leukocyte trafficking and microglia/macrophage recruitment. It has also bee...

    Gerlinde van der Maten, Vivien Henck, Tadeusz Wieloch and Karsten Ruscher

    BMC Neuroscience 2017 18:11

    Published on: 6 January 2017

  10. Research Article

    Investigating potentially salvageable penumbra tissue in an in vivo model of transient ischemic stroke using sodium, diffusion, and perfusion magnetic resonance imaging

    Diffusion magnetic resonance imaging (MRI) is the current-state-of-the-art technique to clinically investigate acute (0–24 h) ischemic stroke tissue. However, reduced apparent diffusion coefficient (ADC)—cons...

    Friedrich Wetterling, Eva Chatzikonstantinou, Laurent Tritschler, Stephen Meairs, Marc Fatar, Lothar R. Schad and Saema Ansar

    BMC Neuroscience 2016 17:82

    Published on: 7 December 2016

  11. Research Article

    Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia

    α-Synuclein (αSYN) has been genetically implicated in familial and sporadic Parkinson’s disease (PD), and is associated with disease susceptibility, progression and pathology. Excess amounts of αSYN are toxic ...

    Tatsunori Maekawa, Toshikuni Sasaoka, Sadahiro Azuma, Takafumi Ichikawa, Heather L. Melrose, Matthew J. Farrer and Fumiya Obata

    BMC Neuroscience 2016 17:77

    Published on: 30 November 2016

  12. Research Article

    CatWalk gait analysis in a rat model of multiple sclerosis

    Myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for multiple sclerosis. The characteristic feature of the MOG-EAE model in Brown...

    Sabine Herold, Prateek Kumar, Klaus Jung, Irina Graf, Henrike Menkhoff, Xenia Schulz, Mathias Bähr and Katharina Hein

    BMC Neuroscience 2016 17:78

    Published on: 30 November 2016

  13. Research article

    Interleukin-1 receptor (IL-1R) mediates epilepsy-induced sleep disruption

    Sleep disruptions are common in epilepsy patients. Our previous study demonstrates that homeostatic factors and circadian rhythm may mediate epilepsy-induced sleep disturbances when epilepsy occurs at differen...

    Tzu-Rung Huang, Shuo-Bin Jou, Yu-Ju Chou, Pei-Lu Yi, Chun-Jen Chen and Fang-Chia Chang

    BMC Neuroscience 2016 17:74

    Published on: 22 November 2016

  14. Review

    mTOR and MAPK: from localized translation control to epilepsy

    Epilepsy is one of the most common neurological diseases characterized by excessive hyperexcitability of neurons. Molecular mechanisms of epilepsy are diverse and not really understood. All in common is the mi...

    Helena F. Pernice, Rico Schieweck, Michael A. Kiebler and Bastian Popper

    BMC Neuroscience 2016 17:73

    Published on: 17 November 2016

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