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Cognition and behavior: in vitro or in vivo brain repair

Section edited by Anthony Kline

This section covers topics in the field of brain repair in both human and animal models. Topics of interest include, but are not limited to, neurotrauma and repair, neuropharmacology, pathophysiology, and rehabilitation.

  1. We aimed to study the role of amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR) glutamate receptor 2 (GluR2) subunit trafficking, and activity changes in short-term neuroprotection provided b...

    Authors: Chenxu Wang, Ying Wei, Yuan Yuan, Yonghao Yu, Keliang Xie, Beibei Dong, Yuan Shi and Guolin Wang

    Citation: BMC Neuroscience 2019 20:51

    Content type: Research article

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  2. Oxidative stress and neuroinflammation are central pathogenic mechanisms common to many neurological diseases. Isoliquiritigenin (ISL) is a flavonoid in licorice with multiple pharmacological properties, inclu...

    Authors: Xiaobo Zhu, Jiankun Liu, Shaojie Chen, Jiang Xue, Shanying Huang, Yibiao Wang and Ou Chen

    Citation: BMC Neuroscience 2019 20:41

    Content type: Research article

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  3. Transcranial direct current stimulation (tDCS) is a noninvasive neural control technology that has become a research hotspot. To facilitate further research of tDCS, the biosafety of 500 μA cathodal tDCS, a co...

    Authors: Keying Zhang, Ling Guo, Junping Zhang, Guangzhou An, Yan Zhou, Jiajin Lin, Junling Xing, Mai Lu and Guirong Ding

    Citation: BMC Neuroscience 2019 20:40

    Content type: Research article

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  4. Recently, the use of traditional Chinese medicine (TCM) has become more generally accepted, including by the Food and Drug Administration. To expand the use of TCM worldwide, it is important to study the molec...

    Authors: Jinyuan Yan, Zhongshan Yang, Ninghui Zhao, Zhiwei Li and Xia Cao

    Citation: BMC Neuroscience 2019 20:31

    Content type: Research article

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  5. The electroencephalogram (EEG) is a widely used laboratory technique in rodent models of epilepsy, traumatic brain injury (TBI), and other neurological diseases accompanied by seizures. Obtaining prolonged con...

    Authors: Yasser Medlej, Rita Asdikian, Lara Wadi, Houssein Salah, Laura Dosh, Rabih Hashash, Nabil Karnib, Mohammad Medlej, Hala Darwish, Firas Kobeissy and Makram Obeid

    Citation: BMC Neuroscience 2019 20:8

    Content type: Methodology article

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  6. Our published data have indicated that the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) provides beneficial effects by attenuating neuronal damage induced by interleukin-1β (IL-1β), and up-re...

    Authors: YiLong Dong, KangJing Pu, WenJing Duan, HuiCheng Chen, LiXing Chen and YanMei Wang

    Citation: BMC Neuroscience 2018 19:52

    Content type: Research article

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  7. Impaired reaction time in patients suffering from hypoxia during sleep, caused by sleep breathing disorders, is a well-described phenomenon. High altitude sleep is known to induce periodic breathing with centr...

    Authors: Stephan Pramsohler, Stefan Wimmer, Martin Kopp, Hannes Gatterer, Martin Faulhaber, Martin Burtscher and Nikolaus Cristoph Netzer

    Citation: BMC Neuroscience 2017 18:43

    Content type: Research article

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  8. Glucagon-like peptide 1 (GLP-1) analogs protect a variety of cell types against oxidative damage and vascular and neuronal injury via binding to GLP-1 receptors. This study aimed to investigate the effects of ...

    Authors: Ping-Chia Li, Li-Fen Liu, Ming-Jia Jou and Hao-Kuang Wang

    Citation: BMC Neuroscience 2016 17:37

    Content type: Research article

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  9. Patients with Parkinson’s disease (PD) often suffer from cognitive impairments, including set-shifting deficits, in addition to the characteristic motor symptoms. It is hypothesized that the striatal dopamine ...

    Authors: Corine C. de Bondt, Niels J. H. M. Gerrits, Dick J. Veltman, Henk W. Berendse, Odile A. van den Heuvel and Ysbrand D. van der Werf

    Citation: BMC Neuroscience 2016 17:20

    Content type: Research article

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  10. Prenatal maternal lipopolysaccharide (LPS) exposure leads to behavioral deficits such as depression, anxiety, and schizophrenia in the adult lives. LPS-exposure resulted in the production of cytokines and oxid...

    Authors: Md. Mamun Al-Amin, Rabeya Sultana, Sharmin Sultana, Md. Mahbubur Rahman and Hasan Mahmud Reza

    Citation: BMC Neuroscience 2016 17:11

    Content type: Research article

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  11. Synaptic dysfunction is a key event in pathogenesis of neurodegenerative diseases such as Alzheimer’s disease (AD) where synapse loss pathologically correlates with cognitive decline and dementia. Although evi...

    Authors: Jia Luo, Sue H. Lee, Lawren VandeVrede, Zhihui Qin, Sujeewa Piyankarage, Ehsan Tavassoli, Rezene T. Asghodom, Manel Ben Aissa, Mauro Fà, Ottavio Arancio, Lan Yue, David R. Pepperberg and Gregory R. J. Thatcher

    Citation: BMC Neuroscience 2015 16:67

    Content type: Research article

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  12. Adaptive decision making requires the adjustment of behaviour following an error. Some theories suggest that repetitive thoughts and behaviours in obsessive compulsive disorder (OCD) are driven by malfunctioni...

    Authors: Mandana Modirrousta, Benjamin P. Meek, Jitender Sareen and Murray W. Enns

    Citation: BMC Neuroscience 2015 16:63

    Content type: Research article

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  13. Latrunculin A microperfusion of the hippocampus induces acute epileptic seizures and long-term biochemical changes leading to spontaneous seizures. This study tested the effect of eslicarbazepine acetate (ESL)...

    Authors: Germán Sierra-Paredes, Ana I Loureiro, Lyndon C Wright, Germán Sierra-Marcuño and Patrício Soares-da-Silva

    Citation: BMC Neuroscience 2014 15:134

    Content type: Research article

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  14. Progesterone is neuroprotective in numerous preclinical CNS injury models including cerebral ischaemia. The aim of this study was two-fold; firstly, we aimed to determine whether progesterone delivery via osmo...

    Authors: Raymond Wong, Claire L Gibson, David A Kendall and Philip MW Bath

    Citation: BMC Neuroscience 2014 15:131

    Content type: Research article

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  15. The GABAergic system plays an important role in modulating levels of anxiety. When transplanted into the brain, precursor cells from the medial ganglionic eminence (MGE) have the ability to differentiate into ...

    Authors: Simone Amaro Alves Romariz, Daisyléa de Souza Paiva, Maria Fernanda Valente, Gabriela Filoso Barnabé, Roberto Frussa-Filho, Regina Cláudia Barbosa-Silva, Maria Elisa Calcagnotto and Beatriz Monteiro Longo

    Citation: BMC Neuroscience 2014 15:94

    Content type: Research article

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  16. Motor cortex excitability was found to be changed after repetitive transcranial magnetic stimulation (rTMS) of the temporal cortex highlighting the occurrence of cross-modal plasticity in non-invasive brain st...

    Authors: Martin Schecklmann, Michael Landgrebe, Tobias Kleinjung, Elmar Frank, Philipp G Sand, Rainer Rupprecht, Peter Eichhammer, Göran Hajak and Berthold Langguth

    Citation: BMC Neuroscience 2014 15:71

    Content type: Research article

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  17. Because neuroprotective effects of estrogen remain controversial, we aimed to investigate the effect of different doses of estradiol (E2) on cerebral ischemia using both in vivo and in vitro experiments.

    Authors: Yu-Long Ma, Pei Qin, Yan Li, Lan Shen, Shi-Quan Wang, Hai-Long Dong, Wu-Gang Hou and Li-Ze Xiong

    Citation: BMC Neuroscience 2013 14:118

    Content type: Research article

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  18. Some neurodegenerative diseases, such as Alzheimer and Parkinson, present an olfactory impairment in early stages, and sometimes even before the clinical symptoms begin. In this study, we assess the role of CA...

    Authors: Carlos Bernal-Mondragón, Selva Rivas-Arancibia, Keith M Kendrick and Rosalinda Guevara-Guzmán

    Citation: BMC Neuroscience 2013 14:104

    Content type: Research article

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  19. Previous studies associate lipid peroxidation with long-term memory (LTM) failure in a gastropod model (Lymnaea stagnalis) of associative learning and memory. This process involves activation of Phospholipase A2 ...

    Authors: Petra M Hermann, Deborah Park, Emily Beaulieu and Willem C Wildering

    Citation: BMC Neuroscience 2013 14:83

    Content type: Research article

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  20. To measure the impact of masticatory reduction on learning and memory, previous studies have produced experimental masticatory reduction by modified diet or molar removal. Here we induced spatial learning impa...

    Authors: Fabíola de Carvalho Chaves de Siqueira Mendes, Marina Negrão Frota de Almeida, André Pinheiro Gurgel Felício, Ana Carla Fadel, Diego de Jesus Silva, Thaíssa Gomes Borralho, Rodrigo Perez da Silva, João Bento-Torres, Pedro Fernando da Costa Vasconcelos, Victor Hugh Perry, Edson Marcos Leal Soares Ramos, Cristovam Wanderley Picanço-Diniz and Marcia Consentino Kronka Sosthenes

    Citation: BMC Neuroscience 2013 14:63

    Content type: Research article

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  21. While cortical representations of intrinsic hand muscles have been extensively studied in healthy individuals, little is known about the representation of proximal upper limb muscles. Improving our understandi...

    Authors: Suzy Ngomo, Catherine Mercier and Jean-Sébastien Roy

    Citation: BMC Neuroscience 2013 14:52

    Content type: Research article

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  22. Tumor necrosis factor-alpha (TNF-α) is elevated early in injured brain after traumatic brain injury (TBI), in humans and in animals. Etanercept (a TNF-α antagonist with anti-inflammatory effects) attenuates TB...

    Authors: Chung-Ching Chio, Chin-Hong Chang, Che-Chuan Wang, Chong-Un Cheong, Chien-Ming Chao, Bor-Chih Cheng, Chung-Zhing Yang and Ching-Ping Chang

    Citation: BMC Neuroscience 2013 14:33

    Content type: Research article

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  23. Acupuncture has been applied to aid in the recovery of post-stroke patients, but its mechanism is unclear. This study aims to analyze the relationship between acupuncture and glucose metabolism in cerebral fun...

    Authors: Yong Huang, Chunzhi Tang, Shuxia Wang, Yangjia Lu, Wei Shen, Junjun Yang, Junqi Chen, Renyong Lin, Shaoyang Cui, Huiling Xiao, Shanshan Qu, Xinsheng Lai and Baoci Shan

    Citation: BMC Neuroscience 2012 13:75

    Content type: Research article

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