Cognition and behavior: in vitro or in vivo brain repair

Section edited by Anthony Kline

This section covers topics in the field of brain repair in both human and animal models. Topics of interest include, but are not limited to, neurotrauma and repair, neuropharmacology, pathophysiology, and rehabilitation.

  1. Research article

    Normobaric hypoxia overnight impairs cognitive reaction time

    Impaired reaction time in patients suffering from hypoxia during sleep, caused by sleep breathing disorders, is a well-described phenomenon. High altitude sleep is known to induce periodic breathing with centr...

    Stephan Pramsohler, Stefan Wimmer, Martin Kopp, Hannes Gatterer, Martin Faulhaber, Martin Burtscher and Nikolaus Cristoph Netzer

    BMC Neuroscience 2017 18:43

    Published on: 15 May 2017

  2. Research article

    The GLP-1 receptor agonists exendin-4 and liraglutide alleviate oxidative stress and cognitive and micturition deficits induced by middle cerebral artery occlusion in diabetic mice

    Glucagon-like peptide 1 (GLP-1) analogs protect a variety of cell types against oxidative damage and vascular and neuronal injury via binding to GLP-1 receptors. This study aimed to investigate the effects of ...

    Ping-Chia Li, Li-Fen Liu, Ming-Jia Jou and Hao-Kuang Wang

    BMC Neuroscience 2016 17:37

    Published on: 13 June 2016

  3. Research article

    Reduced task-related functional connectivity during a set-shifting task in unmedicated early-stage Parkinson’s disease patients

    Patients with Parkinson’s disease (PD) often suffer from cognitive impairments, including set-shifting deficits, in addition to the characteristic motor symptoms. It is hypothesized that the striatal dopamine ...

    Corine C. de Bondt, Niels J. H. M. Gerrits, Dick J. Veltman, Henk W. Berendse, Odile A. van den Heuvel and Ysbrand D. van der Werf

    BMC Neuroscience 2016 17:20

    Published on: 18 May 2016

  4. Research article

    Astaxanthin ameliorates prenatal LPS-exposed behavioral deficits and oxidative stress in adult offspring

    Prenatal maternal lipopolysaccharide (LPS) exposure leads to behavioral deficits such as depression, anxiety, and schizophrenia in the adult lives. LPS-exposure resulted in the production of cytokines and oxid...

    Md. Mamun Al-Amin, Rabeya Sultana, Sharmin Sultana, Md. Mahbubur Rahman and Hasan Mahmud Reza

    BMC Neuroscience 2016 17:11

    Published on: 8 February 2016

  5. Research article

    Re-engineering a neuroprotective, clinical drug as a procognitive agent with high in vivo potency and with GABAA potentiating activity for use in dementia

    Synaptic dysfunction is a key event in pathogenesis of neurodegenerative diseases such as Alzheimer’s disease (AD) where synapse loss pathologically correlates with cognitive decline and dementia. Although evi...

    Jia Luo, Sue H. Lee, Lawren VandeVrede, Zhihui Qin, Sujeewa Piyankarage, Ehsan Tavassoli, Rezene T. Asghodom, Manel Ben Aissa, Mauro Fà, Ottavio Arancio, Lan Yue, David R. Pepperberg and Gregory R. J. Thatcher

    BMC Neuroscience 2015 16:67

    Published on: 19 October 2015

  6. Research article

    Impaired trial-by-trial adjustment of cognitive control in obsessive compulsive disorder improves after deep repetitive transcranial magnetic stimulation

    Adaptive decision making requires the adjustment of behaviour following an error. Some theories suggest that repetitive thoughts and behaviours in obsessive compulsive disorder (OCD) are driven by malfunctioni...

    Mandana Modirrousta, Benjamin P. Meek, Jitender Sareen and Murray W. Enns

    BMC Neuroscience 2015 16:63

    Published on: 9 October 2015

  7. Research article

    Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus

    Latrunculin A microperfusion of the hippocampus induces acute epileptic seizures and long-term biochemical changes leading to spontaneous seizures. This study tested the effect of eslicarbazepine acetate (ESL)...

    Germán Sierra-Paredes, Ana I Loureiro, Lyndon C Wright, Germán Sierra-Marcuño and Patrício Soares-da-Silva

    BMC Neuroscience 2014 15:134

    Published on: 20 December 2014

  8. Research article

    Long-lasting anxiolytic effect of neural precursor cells freshly prepared but not neurosphere-derived cell transplantation in newborn rats

    The GABAergic system plays an important role in modulating levels of anxiety. When transplanted into the brain, precursor cells from the medial ganglionic eminence (MGE) have the ability to differentiate into ...

    Simone Amaro Alves Romariz, Daisyléa de Souza Paiva, Maria Fernanda Valente, Gabriela Filoso Barnabé, Roberto Frussa-Filho, Regina Cláudia Barbosa-Silva, Maria Elisa Calcagnotto and Beatriz Monteiro Longo

    BMC Neuroscience 2014 15:94

    Published on: 2 August 2014

  9. Research article

    Changes in motor cortex excitability associated with temporal repetitive transcranial magnetic stimulation in tinnitus: hints for cross-modal plasticity?

    Motor cortex excitability was found to be changed after repetitive transcranial magnetic stimulation (rTMS) of the temporal cortex highlighting the occurrence of cross-modal plasticity in non-invasive brain st...

    Martin Schecklmann, Michael Landgrebe, Tobias Kleinjung, Elmar Frank, Philipp G Sand, Rainer Rupprecht, Peter Eichhammer, Göran Hajak and Berthold Langguth

    BMC Neuroscience 2014 15:71

    Published on: 4 June 2014

  10. Research article

    The effects of different doses of estradiol (E2) on cerebral ischemia in an in vitro model of oxygen and glucose deprivation and reperfusion and in a rat model of middle carotid artery occlusion

    Because neuroprotective effects of estrogen remain controversial, we aimed to investigate the effect of different doses of estradiol (E2) on cerebral ischemia using both in vivo and in vitro experiments.

    Yu-Long Ma, Pei Qin, Yan Li, Lan Shen, Shi-Quan Wang, Hai-Long Dong, Wu-Gang Hou and Li-Ze Xiong

    BMC Neuroscience 2013 14:118

    Published on: 9 October 2013

  11. Research article

    Evidence for inflammation-mediated memory dysfunction in gastropods: putative PLA2and COX inhibitors abolish long-term memory failure induced by systemic immune challenges

    Previous studies associate lipid peroxidation with long-term memory (LTM) failure in a gastropod model (Lymnaea stagnalis) of associative learning and memory. This process involves activation of Phospholipase A2 ...

    Petra M Hermann, Deborah Park, Emily Beaulieu and Willem C Wildering

    BMC Neuroscience 2013 14:83

    Published on: 6 August 2013

  12. Research article

    Enriched environment and masticatory activity rehabilitation recover spatial memory decline in aged mice

    To measure the impact of masticatory reduction on learning and memory, previous studies have produced experimental masticatory reduction by modified diet or molar removal. Here we induced spatial learning impa...

    Fabíola de Carvalho Chaves de Siqueira Mendes, Marina Negrão Frota de Almeida, André Pinheiro Gurgel Felício, Ana Carla Fadel, Diego de Jesus Silva, Thaíssa Gomes Borralho, Rodrigo Perez da Silva, João Bento-Torres, Pedro Fernando da Costa Vasconcelos, Victor Hugh Perry, Edson Marcos Leal Soares Ramos, Cristovam Wanderley Picanço-Diniz and Marcia Consentino Kronka Sosthenes

    BMC Neuroscience 2013 14:63

    Published on: 28 June 2013

  13. Research article

    Cortical mapping of the infraspinatus muscle in healthy individuals

    While cortical representations of intrinsic hand muscles have been extensively studied in healthy individuals, little is known about the representation of proximal upper limb muscles. Improving our understandi...

    Suzy Ngomo, Catherine Mercier and Jean-Sébastien Roy

    BMC Neuroscience 2013 14:52

    Published on: 24 April 2013

  14. Research article

    Etanercept attenuates traumatic brain injury in rats by reducing early microglial expression of tumor necrosis factor-α

    Tumor necrosis factor-alpha (TNF-α) is elevated early in injured brain after traumatic brain injury (TBI), in humans and in animals. Etanercept (a TNF-α antagonist with anti-inflammatory effects) attenuates TB...

    Chung-Ching Chio, Chin-Hong Chang, Che-Chuan Wang, Chong-Un Cheong, Chien-Ming Chao, Bor-Chih Cheng, Chung-Zhing Yang and Ching-Ping Chang

    BMC Neuroscience 2013 14:33

    Published on: 15 March 2013

  15. Research article

    Acupuncture regulates the glucose metabolism in cerebral functional regions in chronic stage ischemic stroke patients—a PET-CT cerebral functional imaging study

    Acupuncture has been applied to aid in the recovery of post-stroke patients, but its mechanism is unclear. This study aims to analyze the relationship between acupuncture and glucose metabolism in cerebral fun...

    Yong Huang, Chunzhi Tang, Shuxia Wang, Yangjia Lu, Wei Shen, Junjun Yang, Junqi Chen, Renyong Lin, Shaoyang Cui, Huiling Xiao, Shanshan Qu, Xinsheng Lai and Baoci Shan

    BMC Neuroscience 2012 13:75

    Published on: 27 June 2012