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Cellular and molecular mechanisms

In this section topics of interest include, but are not limited to, neurotransmitters, neurotransmission, gliotransmission, synaptic transmission, neuropsychopharmacology, cell signaling, neurophysiology, neurogenetics and neurogenomics.

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  1. In mammals, Eag K+ channels (KV10) are exclusively expressed in the brain and comprise two isoforms: Eag1 (KV10.1) and Eag2 (KV10.2). Despite their wide presence in various regions of the brain, the functional ro...

    Authors: Chao-Chin Chuang, Guey-Mei Jow, Huei-Min Lin, Yu-Han Weng, Jui-Hsiang Hu, Yi-Jheng Peng, Yi-Chih Chiu, Mei-Miao Chiu and Chung-Jiuan Jeng

    Citation: BMC Neuroscience 2014 15:23

    Content type: Research article

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  2. The properties of Ca2+ signaling mediated by purinergic receptors are intrinsically linked with functional activity of astrocytes. At present little is known concerning Ca2+-dependent purinergic responses in adul...

    Authors: Sadayuki Hashioka, Yun Fan Wang, Jonathan P Little, Hyun B Choi, Andis Klegeris, Patrick L McGeer and James G McLarnon

    Citation: BMC Neuroscience 2014 15:18

    Content type: Research article

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  3. Olig1 and Olig2, encoding closely related basic helix-loop-helix transcription factors, were originally identified in screens for glial-specific genes. Olig1 and Olig2 are both expressed in restricted parts of th...

    Authors: Joana Paes de Faria, Nicoletta Kessaris, Paul Andrew, William D Richardson and Huiliang Li

    Citation: BMC Neuroscience 2014 15:12

    Content type: Research article

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  4. The mother-child relationship is the most fundamental social bond in mammals, and previous studies indicate that the medial preoptic area (MPOA) contributes to this increase in sociability. It is possible that...

    Authors: Terri M Driessen, Brian E Eisinger, Changjiu Zhao, Sharon A Stevenson, Michael C Saul and Stephen C Gammie

    Citation: BMC Neuroscience 2014 15:11

    Content type: Research article

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  5. Intracellular calcium signaling regulates a variety of cellular and physiological processes. The inositol 1,4,5 trisphosphate receptor (IP3R) is a ligand gated calcium channel present on the membranes of endoplas...

    Authors: Manivannan Subramanian, Siddharth Jayakumar, Shlesha Richhariya and Gaiti Hasan

    Citation: BMC Neuroscience 2013 14:157

    Content type: Research article

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  6. Synergistic multi-ligand treatments that can induce neuronal differentiation offer valuable strategies to regulate and modulate neurite outgrowth. Whereas the signaling pathways mediating single ligand-induced...

    Authors: Kok Huei Seow, Lihan Zhou, Gregory Stephanopoulos and Heng-Phon Too

    Citation: BMC Neuroscience 2013 14:153

    Content type: Research article

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  7. The effects of chronic treatment with tricyclic antidepressant (desipramine, DMI) on the hippocampal transcriptome in mice displaying high and low swim stress-induced analgesia (HA and LA lines) were studied. ...

    Authors: Pawel Lisowski, Grzegorz R Juszczak, Joanna Goscik, Adrian M Stankiewicz, Marek Wieczorek, Lech Zwierzchowski and Artur H Swiergiel

    Citation: BMC Neuroscience 2013 14:144

    Content type: Research article

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  8. Dopamine (DA) can produce divergent effects at different time scales. DA has opposing immediate and long-term effects on the transient potassium current (IA) within neurons of the pyloric network, in the Panuliru...

    Authors: Edmund W Rodgers, Wulf-Dieter Krenz, Xiaoyue Jiang, Lingjun Li and Deborah J Baro

    Citation: BMC Neuroscience 2013 14:143

    Content type: Research article

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  9. The hypothalamic paraventricular nucleus (PVN) is an important site in the regulation of the autonomic nervous system. Specifically, PVN neurons projecting to the rostral ventrolateral medulla (PVN-RVLM) play ...

    Authors: Seul Ki Lee, Pan Dong Ryu and So Yeong Lee

    Citation: BMC Neuroscience 2013 14:134

    Content type: Research article

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  10. In terms of vesicular recycling, synaptic efficiency is a key determinant of the fidelity of synaptic transmission. The ability of a presynaptic terminal to reuse its vesicular content is thought to be a signa...

    Authors: Jorge Ramírez-Franco, Beatris Alonso, David Bartolomé-Martín, José Sánchez-Prieto and Magdalena Torres

    Citation: BMC Neuroscience 2013 14:127

    Content type: Methodology article

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  11. Group II metabotropic glutamate receptors (mGlu2 and mGlu3, encoded by Grm2 and Grm3) have been the focus of attention as treatment targets for a number of psychiatric conditions. Double knockout mice lacking mGl...

    Authors: Tracy A Lane, Thomas Boerner, David M Bannerman, James NC Kew, Elizabeth M Tunbridge, Trevor Sharp and Paul J Harrison

    Citation: BMC Neuroscience 2013 14:102

    Content type: Research article

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  12. Myelinated axons are organized into distinct subcellular and molecular regions. Without proper organization, electrical nerve conduction is delayed, resulting in detrimental physiological outcomes. One such re...

    Authors: James A Green, Jun Yang, M’hamed Grati, Bechara Kachar and Manzoor A Bhat

    Citation: BMC Neuroscience 2013 14:96

    Content type: Research article

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  13. Drugs targeting insomnia ideally promote sleep throughout the night, maintain normal sleep architecture, and are devoid of residual effects associated with morning sedation. These features of an ideal compound...

    Authors: Anthony L Gotter, Christopher J Winrow, Joseph Brunner, Susan L Garson, Steven V Fox, Jacquelyn Binns, Charles M Harrell, Donghui Cui, Ka Lai Yee, Mark Stiteler, Joanne Stevens, Alan Savitz, Pamela L Tannenbaum, Spencer J Tye, Terrence McDonald, Leon Yao…

    Citation: BMC Neuroscience 2013 14:90

    Content type: Research article

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  14. Huntington’s Disease (HD) is a progressive neurodegenerative disorder caused by an expansion in the polyglutamine (polyQ) region of the Huntingtin (HTT) gene. The clinical features of HD are characterized by cogn...

    Authors: Jannet Kocerha, Yuhong Liu, David Willoughby, Kumaravel Chidamparam, Joseph Benito, Kate Nelson, Yan Xu, Tim Chi, Heidi Engelhardt, Sean Moran, Shang-Hsun Yang, Shi-Hua Li, Xiao-Jiang Li, Katherine Larkin, Adam Neumann, Heather Banta…

    Citation: BMC Neuroscience 2013 14:88

    Content type: Research article

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  15. Drp1 is the primary protein responsible for mitochondrial fission. Perturbations of mitochondrial morphology and increased fission are seen in neurodegeneration. While Drp1 degradation induced by Parkin overex...

    Authors: Phillip R Purnell and Howard S Fox

    Citation: BMC Neuroscience 2013 14:86

    Content type: Research article

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  16. Propagating waves of excitation have been observed extensively in the neocortex, during both spontaneous and sensory-evoked activity, and they play a critical role in spatially organizing information processin...

    Authors: Tim Wanger, Kentaroh Takagaki (高垣堅太郎), Michael T Lippert, Jürgen Goldschmidt and Frank W Ohl

    Citation: BMC Neuroscience 2013 14:78

    Content type: Research article

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  17. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces Parkinson’s disease (PD)-like neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) via its oxidized product, 1-meth...

    Authors: Yan Chen, Ying-yin Ni, Jie Liu, Jia-wei Lu, Fang Wang, Xiao-lin Wu, Ming-min Gu, Zhen-yu Lu, Zhu-gang Wang and Zhi-hua Ren

    Citation: BMC Neuroscience 2013 14:76

    Content type: Research article

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  18. Growing compelling evidence from clinical and preclinical studies has demonstrated the primary role of alterations of glutamatergic transmission in cortical and limbic areas in the pathophysiology of mood diso...

    Authors: Marco Milanese, Daniela Tardito, Laura Musazzi, Giulia Treccani, Alessandra Mallei, Tiziana Bonifacino, Cecilia Gabriel, Elisabeth Mocaer, Giorgio Racagni, Maurizio Popoli and Giambattista Bonanno

    Citation: BMC Neuroscience 2013 14:75

    Content type: Research article

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  19. We have previously reported evidence of cell proliferation and increased neurogenesis in rat organotypic hippocampal slice cultures (OHSC) after a transient excitotoxic injury to the hippocampal CA1 area induc...

    Authors: Anabel Pérez-Gómez and R Andrew Tasker

    Citation: BMC Neuroscience 2013 14:72

    Content type: Research article

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  20. Previous work showed differences in the polysynaptic activation of GABAergic synapses during corticostriatal suprathreshold responses in direct and indirect striatal projection neurons (dSPNs and iSPNs). Here,...

    Authors: Bianca J Vizcarra-Chacón, Mario A Arias-García, Maria B Pérez-Ramírez, Edén Flores-Barrera, Dagoberto Tapia, Rene Drucker-Colin, José Bargas and Elvira Galarraga

    Citation: BMC Neuroscience 2013 14:60

    Content type: Research article

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  21. Modelling the blood-CNS barriers of the brain and spinal cord in vitro continues to provide a considerable challenge for research studying the passage of large and small molecules in and out of the central nervou...

    Authors: P Marc D Watson, Judy C Paterson, George Thom, Ulrika Ginman, Stefan Lundquist and Carl I Webster

    Citation: BMC Neuroscience 2013 14:59

    Content type: Methodology article

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  22. The mechanisms that underlie autophagy in cerebral ischemia remain poorly defined. Myeloid cell leukemia-1 (Mcl1), an anti-apoptotic member of the Bcl-2 family of proteins, regulates the balance between autoph...

    Authors: Chen Xingyong, Sun Xicui, Su Huanxing, Ou Jingsong, Huang Yi, Zhang Xu, Huang Ruxun and Pei Zhong

    Citation: BMC Neuroscience 2013 14:56

    Content type: Research article

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  23. The vesicular B0AT3 transporter (SLC6A17), one of the members of the SLC6 family, is a transporter for neutral amino acids and is exclusively expressed in brain. Here we provide a comprehensive expression profile...

    Authors: Maria GA Hägglund, Sofie V Hellsten, Sonchita Bagchi, Anna Ljungdahl, Victor CO Nilsson, Sonja Winnergren, Olga Stephansson, Juris Rumaks, Simons Svirskis, Vija Klusa, Helgi B Schiöth and Robert Fredriksson

    Citation: BMC Neuroscience 2013 14:54

    Content type: Research article

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  24. Immortalized neuronal cell lines can be induced to differentiate into more mature neurons by adding specific compounds or growth factors to the culture medium. This property makes neuronal cell lines attractiv...

    Authors: Devon Andres, Brian M Keyser, John Petrali, Betty Benton, Kyle S Hubbard, Patrick M McNutt and Radharaman Ray

    Citation: BMC Neuroscience 2013 14:49

    Content type: Research article

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  25. The ability to recreate an optimal cellular microenvironment is critical to understand neuronal behavior and functionality in vitro. An organized neural extracellular matrix (nECM) promotes neural cell adhesion, ...

    Authors: Patricia García-Parra, Marcos Maroto, Fabio Cavaliere, Neia Naldaiz-Gastesi, José Iñaki Álava, Antonio G García, Adolfo López de Munain and Ander Izeta

    Citation: BMC Neuroscience 2013 14:48

    Content type: Methodology article

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  26. Recent work has shown that the chaperone resistant to inhibitors of acetylcholinesterase (RIC-3) is critical for the folding, maturation and functional expression of a variety of neuronal nicotinic acetylcholine ...

    Authors: Alejandro Dau, Pragya Komal, Mimi Truong, Geoff Morris, Gareth Evans and Raad Nashmi

    Citation: BMC Neuroscience 2013 14:47

    Content type: Research article

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  27. Cortical cultures grown long-term on multi-electrode arrays (MEAs) are frequently and extensively used as models of cortical networks in studies of neuronal firing activity, neuropharmacology, toxicology and m...

    Authors: Mark W Hammond, Dimitris Xydas, Julia H Downes, Giovanna Bucci, Victor Becerra, Kevin Warwick, Andrew Constanti, Slawomir J Nasuto and Benjamin J Whalley

    Citation: BMC Neuroscience 2013 14:38

    Content type: Research article

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  28. Recently, we and others proposed plasticity-related gene 3 (PRG3) as a novel molecule in neuritogenesis based on PRG3 overexpression experiments in neuronal and non-neuronal cell lines. However, direct informa...

    Authors: Tanja Velmans, Arne Battefeld, Beate Geist, Anna Soriguera Farrés, Ulf Strauss and Anja U Bräuer

    Citation: BMC Neuroscience 2013 14:36

    Content type: Research article

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  29. Chronic administration of Aluminum is proposed as an environmental factor that may affect several enzymes and other biomolecules related to neurotoxicity and Alzheimer's disease (AD). APE1 a multifunctional pr...

    Authors: Amira Zaky, Bassma Mohammad, Marie Moftah, Kamal M Kandeel and Ahmad R Bassiouny

    Citation: BMC Neuroscience 2013 14:26

    Content type: Research article

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  30. A large number of invertebrate models, including the snail Helix, emerged as particularly suitable tools for investigating the formation of synapses and the specificity of neuronal connectivity. Helix neurons can...

    Authors: Paolo Massobrio, Carlo NG Giachello, Mirella Ghirardi and Sergio Martinoia

    Citation: BMC Neuroscience 2013 14:22

    Content type: Research article

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  31. Somatosensory nerve fibres arising from cell bodies within the trigeminal ganglia (TG) in the head and from a string of dorsal root ganglia (DRG) located lateral to the spinal cord convey endogenous and enviro...

    Authors: Ine Vandewauw, Grzegorz Owsianik and Thomas Voets

    Citation: BMC Neuroscience 2013 14:21

    Content type: Research article

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  32. Vertebrate pheromones are known to prime the endocrine system, especially the hypothalamic-pituitary-gonadal (HPG) axis. However, no known pheromone molecule has been shown to modulate directly the synthesis o...

    Authors: Yu-Wen Chung-Davidson, Huiyong Wang, Michael J Siefkes, Mara B Bryan, Hong Wu, Nicholas S Johnson and Weiming Li

    Citation: BMC Neuroscience 2013 14:11

    Content type: Research article

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  33. Antisense oligonucleotide (AON)-mediated exon skipping is a powerful tool to manipulate gene expression. In the present study we investigated the potential of exon skipping by local injection in the central nu...

    Authors: Ioannis Zalachoras, Gwendolynn Grootaers, Lisa TCM van Weert, Yves Aubert, Suzanne R de Kreij, Nicole A Datson, Willeke MC van Roon-Mom, Annemieke Aartsma-Rus and Onno C Meijer

    Citation: BMC Neuroscience 2013 14:5

    Content type: Methodology article

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  34. The inactivation of c-Jun N-terminal kinase (JNK) is associated with anti-apoptotic and anti-inflammatory effects in cerebral ischemia, which can be induced by an imbalance between upstream phosphatases and ki...

    Authors: JianXi Zhu, Wei Shen, Li Gao, Hao Gu, ShuTong Shen, Yi Wang, HuiWen Wu and Jun Guo

    Citation: BMC Neuroscience 2013 14:1

    Content type: Research article

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  35. β-amyloid (Aβ) accumulation is described as a hallmark of Alzheimer’s disease (AD). Aβ perturbs a number of synaptic components including nicotinic acetylcholine receptors containing α7 subunits (α7-nAChRs), w...

    Authors: Qiang Liu, Yao Huang, Jianxin Shen, Scott Steffensen and Jie Wu

    Citation: BMC Neuroscience 2012 13:155

    Content type: Research article

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  36. There are two widely used transient middle cerebral artery occlusion (MCAO) methods, which differ in the use of unilateral or bilateral carotid artery reperfusion (UNICAR and BICAR). Of the two methods, UNICAR...

    Authors: Jian-Ren Liu, Ulf R Jensen-Kondering, Jia-Jun Zhou, Fen Sun, Xiao-Yan Feng, Xiao-Lei Shen, Günther Deuschl, Olav Jansen, Thomas Herdegen, Johannes Meyne, Yi Zhao and Christoph Eschenfelder

    Citation: BMC Neuroscience 2012 13:154

    Content type: Research article

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  37. Reactive gliosis had been implicated in injury and recovery patterns associated with hydrocephalus. Our aim is to determine the efficacy of minocycline, an antibiotic known for its anti-inflammatory properties...

    Authors: Hao Xu, Guowei Tan, Shaolin Zhang, Hongwei Zhu, Feng Liu, Caiquan Huang, Feifei Zhang and Zhanxiang Wang

    Citation: BMC Neuroscience 2012 13:148

    Content type: Research article

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  38. Enhanced activity of trigeminal ganglion neurons is thought to underlie neuronal sensitization facilitating the onset of chronic pain attacks, including migraine. Recurrent headache attacks might establish a c...

    Authors: Alessia Franceschini, Asha Nair, Tanja Bele, Arn MJM van den Maagdenberg, Andrea Nistri and Elsa Fabbretti

    Citation: BMC Neuroscience 2012 13:143

    Content type: Research article

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  39. Spinal cord metastatic lesions affect a high number of cancer patients usually resulting in spinal cord compression syndrome. A major obstacle in the research of spinal metastatic disease is the lack of a simp...

    Authors: Zion Zibly, Cody D Schlaff, Ira Gordon, Jeeva Munasinghe and Kevin A Camphausen

    Citation: BMC Neuroscience 2012 13:137

    Content type: Research article

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  40. Parkinson’s disease is characterized by a continuous loss of neurons within the substantia nigra (SN) leading to a depletion of dopamine. Within the adult SN as a non-neurogenic region, cells with mainly oligo...

    Authors: Philipp Klaissle, Anne Lesemann, Petra Huehnchen, Andreas Hermann, Alexander Storch and Barbara Steiner

    Citation: BMC Neuroscience 2012 13:132

    Content type: Research article

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  41. The generation of action potential is required for stimulus-evoked neurotransmitter release in most neurons. Although various voltage-gated ion channels are involved in action potential production, the initiat...

    Authors: Jinxu Liu, Huiyin Tu, Dongze Zhang, Hong Zheng and Yu-Long Li

    Citation: BMC Neuroscience 2012 13:129

    Content type: Research article

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  42. Recently, there has been a strong emphasis on identifying an in vitro model for neurotoxicity research that combines the biological relevance of primary neurons with the scalability, reproducibility and genetic t...

    Authors: Kyle S Hubbard, Ian M Gut, Megan E Lyman, Kaylie M Tuznik, Mariano T Mesngon and Patrick M McNutt

    Citation: BMC Neuroscience 2012 13:127

    Content type: Methodology article

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  43. Psychological stress, particularly in chronic form, can lead to mood and cognitive dysfunction and is a major risk factor in the development of depressive states. How stress affects the brain to cause psychopa...

    Authors: Rafael A Barreto, Frederick Rohan Walker, Peter R Dunkley, Trevor A Day and Doug W Smith

    Citation: BMC Neuroscience 2012 13:125

    Content type: Research article

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  44. Diva ( d eath i nducer binding to v Bcl-2 and A paf-1)/BclB is a Bcl-2 family member, which is known for its function in apoptosis. Diva/BclB has been shown to interact with NDPKB/Nm23H2, which is involved in cel...

    Authors: Jasmin Qian Ru Lim, Jia Lu and Bei Ping He

    Citation: BMC Neuroscience 2012 13:123

    Content type: Research article

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  45. Iodine deficiency and iodine excess are both associated with adverse health consequences. Iodine deficiency during pregnancy leads to insufficient maternal thyroid hormone, subsequently causing irreversible ad...

    Authors: Le Zhang, Weiping Teng, Yuhui Liu, Jing Li, Jinyuan Mao, Chenling Fan, Hong Wang, Hongmei Zhang and Zhongyan Shan

    Citation: BMC Neuroscience 2012 13:121

    Content type: Research article

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  46. Glucocorticoids, secreted by the adrenals in response to stress, profoundly affect structure and plasticity of neurons. Glucocorticoid action in neurons is mediated by glucocorticoid receptors (GR) that operat...

    Authors: J Annelies E Polman, Jennifer E Welten, Danny S Bosch, Robert T de Jonge, Judit Balog, Silvère M van der Maarel, E Ronald de Kloet and Nicole A Datson

    Citation: BMC Neuroscience 2012 13:118

    Content type: Research article

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