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BMC Neuroscience

Cellular and molecular mechanisms

Section edited by Maurizio Popoli, Vijiyalaxmi Ravindraneth and Mark Rasenick

This section covers all aspects of cellular and molecular neuroscience. Topics of interest are widespread and include, but are not limited to, neurotransmitters, neuropsychopharmacology, cell signaling, neurophysiology and glial development.

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  1. Content type: Research article

    Polymorphisms in the gene for phosphatidylinositol binding clathrin assembly protein (PICALM), an endocytic-related protein, are associated with a small, increased risk of developing Alzheimer’s disease (AD), ...

    Authors: Rhian S. Thomas, Alex Henson, Amy Gerrish, Lesley Jones, Julie Williams and Emma J. Kidd

    Citation: BMC Neuroscience 2016 17:50

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  2. Content type: Research article

    MCT14 (SLC16A14) is an orphan member of the monocarboxylate transporter (MCT) family, also known as the SLC16 family of secondary active transmembrane transporters. Available expression data for this transport...

    Authors: Sahar Roshanbin, Frida A. Lindberg, Emilia Lekholm, Mikaela M. Eriksson, Emelie Perland, Johan Åhlund, Amanda Raine and Robert Fredriksson

    Citation: BMC Neuroscience 2016 17:43

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  3. Content type: Methodology article

    Conducting research on the molecular biology, immunology, and physiology of brain tumors (BTs) and primary brain tissues requires the use of viably dissociated single cells. Inadequate methods for tissue diss...

    Authors: Ilan Volovitz, Netanel Shapira, Haim Ezer, Aviv Gafni, Merav Lustgarten, Tal Alter, Idan Ben-Horin, Ori Barzilai, Tal Shahar, Andrew Kanner, Itzhak Fried, Igor Veshchev, Rachel Grossman and Zvi Ram

    Citation: BMC Neuroscience 2016 17:30

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  4. Content type: Research article

    To get a broader view of global ischemia-induced cerebral disorders at the metabolic level, a nuclear magnetic resonance-based metabolomic study was performed to evaluate the metabolic profile changes on regio...

    Authors: Tianshu Zhang, Wei Wang, Jin Huang, Xia Liu, Haiyan Zhang and Naixia Zhang

    Citation: BMC Neuroscience 2016 17:25

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  5. Content type: Research article

    Epilepsy is a common neurological disorder characterized by recurrent unprovoked seizures. Seizure-induced TLR4/MYD88 signaling plays a critical role in activating microglia and triggering neuron apoptosis. SA...

    Authors: Qing-Peng Hu and Ding-An Mao

    Citation: BMC Neuroscience 2016 17:22

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  6. Content type: Methodology article

    The decline of remyelination in chronic multiple sclerosis (MS) is in part attributed to inadequate oligodendrocyte precursor cell (OPC) migration, a process governed by the extracellular matrix (ECM). Elucida...

    Authors: Ryan W. O’Meara, Sarah E. Cummings, John-Paul Michalski and Rashmi Kothary

    Citation: BMC Neuroscience 2016 17:7

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  7. Content type: Research article

    Depression is one of the most prevalent mood disorders, and is known to be associated with abnormal functional connectivity in neural networks of the brain. Interestingly, a significant proportion of patients ...

    Authors: Arshi Khalid, Byung Sun Kim, Bo Am Seo, Soon-Tae Lee, Keun-Hwa Jung, Kon Chu, Sang Kun Lee and Daejong Jeon

    Citation: BMC Neuroscience 2016 17:4

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  8. Content type: Research Article

    Periventricular leukomalacia (PVL) is the leading cause of neurological disabilities including motor and cognitive deficits in premature infants. Periventricular leukomalacia is characterized by damage to the ...

    Authors: Xiao-Bo Liu, Yan Shen, David E. Pleasure and Wenbin Deng

    Citation: BMC Neuroscience 2016 17:2

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  9. Content type: Research article

    Hippocampal neurons in the brain polarize to form multiple dendrites and one long axon. The formation of central synapses remains poorly understood. Although several of the intracellular proteins involved in t...

    Authors: Yuriko Inoue, Yuji Kamikubo, Hiromitsu Ezure, Junji Ito, Yu Kato, Hiroshi Moriyama and Naruhito Otsuka

    Citation: BMC Neuroscience 2015 16:92

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  10. Content type: Research article

    Tropomyosin-related kinase A (TRKA) is a nerve growth factor (NGF) receptor that belongs to the tyrosine kinase receptor family. It is critical for the correct development of many types of neurons including pa...

    Authors: Kristi Luberg, Rahel Park, Elina Aleksejeva and Tõnis Timmusk

    Citation: BMC Neuroscience 2015 16:78

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  11. Content type: Research article

    UbcM2 is a ubiquitin-conjugating enzyme with roles in the turnover of damaged and misfolded proteins, cell cycle progression, development, and regulation of the antioxidant transcription factor, Nrf2. Recent s...

    Authors: Chelsea M. Larabee, Constantin Georgescu, Jonathan D. Wren and Scott M. Plafker

    Citation: BMC Neuroscience 2015 16:76

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  12. Content type: Review

    Accumulation of protein aggregates is the leading cause of cellular dysfunction in neurodegenerative disorders. Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease, Prion disease and motor...

    Authors: Shohreh Majd, John H. Power and Hugh J. M. Grantham

    Citation: BMC Neuroscience 2015 16:69

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  13. Content type: Research article

    Alpha (α)-amidation of peptides is a mechanism required for the conversion of prohormones into functional peptide sequences that display biological activities, receptor recognition and signal transduction on t...

    Authors: Benito Antón Palma, Philippe Leff Gelman, Mayra Medecigo Ríos, Juan Carlos Calva Nieves, Rodolfo Acevedo Ortuño, Maura Epifanía Matus Ortega, Jorge Alberto Hernández Calderón, Ricardo Hernández Miramontes, Anabel Flores Zamora and Alberto Salazar Juárez

    Citation: BMC Neuroscience 2015 16:65

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  14. Content type: Research article

    Neurogenesis in the brain of adult mammals occurs throughout life in two locations: the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus in the hippocampus. RNA interf...

    Authors: Filippo M. Cernilogar, Rossella Di Giaimo, Frederick Rehfeld, Silvia Cappello and D. Chichung Lie

    Citation: BMC Neuroscience 2015 16:60

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  15. Content type: Research article

    Oxycodone is an opioid that is prescribed to treat multiple types of pain, especially when other opioids are ineffective. Unfortunately, similar to other opioids, repetitive oxycodone administration has the po...

    Authors: Ruping Fan, Lisa M. Schrott, Stephen Snelling, Julius Ndi, Thomas Arnold and Nadejda L. Korneeva

    Citation: BMC Neuroscience 2015 16:58

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  16. Content type: Research article

    Necroptosis is a type of regulated form of cell death that has been implicated in the pathogenesis of various diseases. Receptor-interacting protein 3 (RIP3), a member of the RIP family of proteins, has been r...

    Authors: Wei Ding, Lei Shang, Ju-Fang Huang, Na Li, Dan Chen, Li-Xiang Xue and Kun Xiong

    Citation: BMC Neuroscience 2015 16:49

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  17. Content type: Research article

    Tobacco smoke (TS) toxicity to the brain microvasculature is still an understudied area till date. NF-E2 related factor (Nrf2) is a key transcription factor responsible for activating the antioxidant response ...

    Authors: Pooja Naik, Ravi K Sajja, Shikha Prasad and Luca Cucullo

    Citation: BMC Neuroscience 2015 16:38

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  18. Content type: Research article

    SLC10A4 belongs to the solute carrier family SLC10 whose founding members are the Na+/taurocholate co-transporting polypeptide (NTCP, SLC10A1) and the apical sodium-dependent bile acid transporter (ASBT, SLC10A2)...

    Authors: Stephanie Schmidt, Marcela Moncada, Simone Burger and Joachim Geyer

    Citation: BMC Neuroscience 2015 16:35

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