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Cellular and molecular mechanisms

Section edited by Maurizio Popoli, Vijiyalaxmi Ravindraneth and Mark Rasenick

This section covers all aspects of cellular and molecular neuroscience. Topics of interest are widespread and include, but are not limited to, neurotransmitters, neuropsychopharmacology, cell signaling, neurophysiology and glial development.

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  1. Content type: Research article

    Previous studies have indicated that selenium supplementation may be beneficial in neuroprotection against glutamate-induced cell damage, in which mitochondrial dysfunction is considered a major pathogenic fea...

    Authors: Yan-Mei Ma, Gordon Ibeanu, Li-Yao Wang, Jian-Zhong Zhang, Yue Chang, Jian-Da Dong, P. Andy Li and Li Jing

    Citation: BMC Neuroscience 2017 18:15

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  2. Content type: Research Article

    Poly(ADP-ribose) polymerase 1 (PARP-1), which catalyzes poly(ADP-ribosyl)ation of proteins by using NAD+ as a substrate, plays a key role in several nuclear events, including DNA repair, replication, and transcri...

    Authors: Akiko Okuda, Suguru Kurokawa, Masanori Takehashi, Aika Maeda, Katsuya Fukuda, Yukari Kubo, Hyuma Nogusa, Tomoka Takatani-Nakase, Shujiro Okuda, Kunihiro Ueda and Seigo Tanaka

    Citation: BMC Neuroscience 2017 18:14

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  3. Content type: Research article

    Deposition of aggregated amyloid beta (Aβ) protein is hallmark of Alzheimer’s disease, leading to dysfunction and apoptosis of neurons. The isoflavone phytoestrogen compound genistein (Gen) exerts a significan...

    Authors: Fuling You, Qiao Li, Guifang Jin, Yaojie Zheng, Jingrong Chen and Hong Yang

    Citation: BMC Neuroscience 2017 18:12

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  4. Content type: Research Article

    A fundamental feature of early nervous system development is the guidance of axonal projections to their targets in order to assemble neural circuits that control behavior. Spinal commissural neurons are an at...

    Authors: Simon D. Sun, Ashley M. Purdy and Gregory S. Walsh

    Citation: BMC Neuroscience 2016 17:83

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  5. Content type: Research article

    The AP-2 transcription factor APTF-1 is crucially required for developmentally controlled sleep behavior in Caenorhabditis elegans larvae. Its human ortholog, TFAP-2beta, causes Char disease and has also been lin...

    Authors: Mariya M. Kucherenko, Vinodh Ilangovan, Bettina Herzig, Halyna R. Shcherbata and Henrik Bringmann

    Citation: BMC Neuroscience 2016 17:72

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  6. Content type: Research article

    Limited surveys have assessed the performance of 5-hydroxytreptamine receptor 1A and its antagonist WAY-100635 in pharmacological manipulations targeting delirium therapies. The purpose of this paper was to as...

    Authors: Yimin Qiu, Dongmei Chen, Xiaojing Huang, Lina Huang, Liang Tang, Jihong Jiang, Lianhua Chen and Shitong Li

    Citation: BMC Neuroscience 2016 17:66

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  7. Content type: Research article

    Polymorphisms in the gene for phosphatidylinositol binding clathrin assembly protein (PICALM), an endocytic-related protein, are associated with a small, increased risk of developing Alzheimer’s disease (AD), ...

    Authors: Rhian S. Thomas, Alex Henson, Amy Gerrish, Lesley Jones, Julie Williams and Emma J. Kidd

    Citation: BMC Neuroscience 2016 17:50

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  8. Content type: Research article

    MCT14 (SLC16A14) is an orphan member of the monocarboxylate transporter (MCT) family, also known as the SLC16 family of secondary active transmembrane transporters. Available expression data for this transport...

    Authors: Sahar Roshanbin, Frida A. Lindberg, Emilia Lekholm, Mikaela M. Eriksson, Emelie Perland, Johan Åhlund, Amanda Raine and Robert Fredriksson

    Citation: BMC Neuroscience 2016 17:43

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  9. Content type: Methodology article

    Conducting research on the molecular biology, immunology, and physiology of brain tumors (BTs) and primary brain tissues requires the use of viably dissociated single cells. Inadequate methods for tissue diss...

    Authors: Ilan Volovitz, Netanel Shapira, Haim Ezer, Aviv Gafni, Merav Lustgarten, Tal Alter, Idan Ben-Horin, Ori Barzilai, Tal Shahar, Andrew Kanner, Itzhak Fried, Igor Veshchev, Rachel Grossman and Zvi Ram

    Citation: BMC Neuroscience 2016 17:30

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  10. Content type: Research article

    To get a broader view of global ischemia-induced cerebral disorders at the metabolic level, a nuclear magnetic resonance-based metabolomic study was performed to evaluate the metabolic profile changes on regio...

    Authors: Tianshu Zhang, Wei Wang, Jin Huang, Xia Liu, Haiyan Zhang and Naixia Zhang

    Citation: BMC Neuroscience 2016 17:25

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  11. Content type: Research article

    Epilepsy is a common neurological disorder characterized by recurrent unprovoked seizures. Seizure-induced TLR4/MYD88 signaling plays a critical role in activating microglia and triggering neuron apoptosis. SA...

    Authors: Qing-Peng Hu and Ding-An Mao

    Citation: BMC Neuroscience 2016 17:22

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  12. Content type: Methodology article

    The decline of remyelination in chronic multiple sclerosis (MS) is in part attributed to inadequate oligodendrocyte precursor cell (OPC) migration, a process governed by the extracellular matrix (ECM). Elucida...

    Authors: Ryan W. O’Meara, Sarah E. Cummings, John-Paul Michalski and Rashmi Kothary

    Citation: BMC Neuroscience 2016 17:7

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  13. Content type: Research article

    Depression is one of the most prevalent mood disorders, and is known to be associated with abnormal functional connectivity in neural networks of the brain. Interestingly, a significant proportion of patients ...

    Authors: Arshi Khalid, Byung Sun Kim, Bo Am Seo, Soon-Tae Lee, Keun-Hwa Jung, Kon Chu, Sang Kun Lee and Daejong Jeon

    Citation: BMC Neuroscience 2016 17:4

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  14. Content type: Research Article

    Periventricular leukomalacia (PVL) is the leading cause of neurological disabilities including motor and cognitive deficits in premature infants. Periventricular leukomalacia is characterized by damage to the ...

    Authors: Xiao-Bo Liu, Yan Shen, David E. Pleasure and Wenbin Deng

    Citation: BMC Neuroscience 2016 17:2

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  15. Content type: Research article

    Hippocampal neurons in the brain polarize to form multiple dendrites and one long axon. The formation of central synapses remains poorly understood. Although several of the intracellular proteins involved in t...

    Authors: Yuriko Inoue, Yuji Kamikubo, Hiromitsu Ezure, Junji Ito, Yu Kato, Hiroshi Moriyama and Naruhito Otsuka

    Citation: BMC Neuroscience 2015 16:92

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  16. Content type: Research article

    Tropomyosin-related kinase A (TRKA) is a nerve growth factor (NGF) receptor that belongs to the tyrosine kinase receptor family. It is critical for the correct development of many types of neurons including pa...

    Authors: Kristi Luberg, Rahel Park, Elina Aleksejeva and Tõnis Timmusk

    Citation: BMC Neuroscience 2015 16:78

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  17. Content type: Research article

    UbcM2 is a ubiquitin-conjugating enzyme with roles in the turnover of damaged and misfolded proteins, cell cycle progression, development, and regulation of the antioxidant transcription factor, Nrf2. Recent s...

    Authors: Chelsea M. Larabee, Constantin Georgescu, Jonathan D. Wren and Scott M. Plafker

    Citation: BMC Neuroscience 2015 16:76

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