Skip to content


Cellular and molecular mechanisms

Section edited by Maurizio Popoli, Vijiyalaxmi Ravindraneth and Mark Rasenick

This section covers all aspects of cellular and molecular neuroscience. Topics of interest are widespread and include, but are not limited to, neurotransmitters, neuropsychopharmacology, cell signaling, neurophysiology and glial development.

Page 2 of 4

  1. Content type: Research article

    Oxycodone is an opioid that is prescribed to treat multiple types of pain, especially when other opioids are ineffective. Unfortunately, similar to other opioids, repetitive oxycodone administration has the po...

    Authors: Ruping Fan, Lisa M. Schrott, Stephen Snelling, Julius Ndi, Thomas Arnold and Nadejda L. Korneeva

    Citation: BMC Neuroscience 2015 16:58

    Published on:

  2. Content type: Research article

    Necroptosis is a type of regulated form of cell death that has been implicated in the pathogenesis of various diseases. Receptor-interacting protein 3 (RIP3), a member of the RIP family of proteins, has been r...

    Authors: Wei Ding, Lei Shang, Ju-Fang Huang, Na Li, Dan Chen, Li-Xiang Xue and Kun Xiong

    Citation: BMC Neuroscience 2015 16:49

    Published on:

  3. Content type: Research article

    Tobacco smoke (TS) toxicity to the brain microvasculature is still an understudied area till date. NF-E2 related factor (Nrf2) is a key transcription factor responsible for activating the antioxidant response ...

    Authors: Pooja Naik, Ravi K Sajja, Shikha Prasad and Luca Cucullo

    Citation: BMC Neuroscience 2015 16:38

    Published on:

  4. Content type: Research article

    SLC10A4 belongs to the solute carrier family SLC10 whose founding members are the Na+/taurocholate co-transporting polypeptide (NTCP, SLC10A1) and the apical sodium-dependent bile acid transporter (ASBT, SLC10A2)...

    Authors: Stephanie Schmidt, Marcela Moncada, Simone Burger and Joachim Geyer

    Citation: BMC Neuroscience 2015 16:35

    Published on:

  5. Content type: Research article

    Inhibitory molecules in the adult central nervous system, including NogoA, impede neural repair by blocking axon outgrowth. The actin-myosin regulatory protein Shroom3 directly interacts with Rho kinase and co...

    Authors: Heather M Dickson, Amanda Wilbur, Ashley A Reinke, Mathew A Young and Anne B Vojtek

    Citation: BMC Neuroscience 2015 16:34

    Published on:

  6. Content type: Research article

    Assembly and disassembly of microtubules (MTs) is critical for neurite outgrowth and differentiation. Evidence suggests that nerve growth factor (NGF) induces neurite outgrowth from PC12 cells by activating th...

    Authors: Jorge A Sierra-Fonseca, Omar Najera, Jessica Martinez-Jurado, Ellen M Walker, Armando Varela-Ramirez, Arshad M Khan, Manuel Miranda, Nazarius S Lamango and Sukla Roychowdhury

    Citation: BMC Neuroscience 2014 15:132

    Published on:

  7. Content type: Research article

    Naringenin (NGEN) is a citrus bioflavonoid known to have beneficial health properties; however, the ionic mechanism of its actions remains largely unclear. In this study, we attempted to evaluate the possible ...

    Authors: Hung-Te Hsu, Yu-Ting Tseng, Yi-Ching Lo and Sheng-Nan Wu

    Citation: BMC Neuroscience 2014 15:135

    Published on:

  8. Content type: Research article

    In order to better understand the effects of social stress on the prefrontal cortex, we investigated gene expression in mice subjected to acute and repeated social encounters of different duration using microa...

    Authors: Adrian M Stankiewicz, Joanna Goscik, Artur H Swiergiel, Alicja Majewska, Marek Wieczorek, Grzegorz R Juszczak and Paweł Lisowski

    Citation: BMC Neuroscience 2014 15:130

    Published on:

  9. Content type: Research article

    In male birds, influence of the sex steroid hormone testosterone and its estrogenic metabolites on seasonal song behavior has been demonstrated for many species. In contrast, female song was only recently reco...

    Authors: Falk Dittrich, Claudia Ramenda, Doris Grillitsch, Carolina Frankl-Vilches, Meng-Ching Ko, Moritz Hertel, Wolfgang Goymann, Andries ter Maat and Manfred Gahr

    Citation: BMC Neuroscience 2014 15:128

    Published on:

  10. Content type: Research article

    The novel antidepressant agomelatine, a melatonergic MT1/MT2 agonist combined with 5-HT2c serotonin antagonist properties, showed antidepressant action in preclinical and clinical studies. There is a general agre...

    Authors: Laura Musazzi, Mara Seguini, Alessandra Mallei, Giulia Treccani, Mariagrazia Pelizzari, Paolo Tornese, Giorgio Racagni and Daniela Tardito

    Citation: BMC Neuroscience 2014 15:119

    Published on:

  11. Content type: Research article

    GABA has important functions in brain plasticity related processes like memory, learning, locomotion and during the development of the nervous system. It is synthesized by the glutamic acid decarboxylase (GAD)...

    Authors: Stefan Trifonov, Yuji Yamashita, Masahiko Kase, Masato Maruyama and Tetsuo Sugimoto

    Citation: BMC Neuroscience 2014 15:114

    Published on:

  12. Content type: Research article

    ApoER2 and the neurotrophin receptors Trk and p75NTR are expressed in the CNS and regulate key functional aspects of neurons, including development, survival, and neuronal function. It is known that both ApoER2 a...

    Authors: Jorge A Larios, Ignacio Jausoro, Maria-Luisa Benitez, Francisca C Bronfman and Maria-Paz Marzolo

    Citation: BMC Neuroscience 2014 15:108

    Published on:

  13. Content type: Research article

    In view of the global increase in diabetes, and the fact that recent findings indicate that diabetic neuropathy is more frequently seen in males, it is crucial to evaluate any gender differences in nerve regen...

    Authors: Lena Stenberg and Lars B Dahlin

    Citation: BMC Neuroscience 2014 15:107

    Published on:

  14. Content type: Research article

    Hypocretins/orexins (Hcrt/Ox) are hypothalamic neuropeptides involved in sleep-wakefulness regulation. Deficiency in Hcrt/Ox neurotransmission results in the sleep disorder narcolepsy, which is characterized b...

    Authors: Esther Del Cid-Pellitero and Miguel Garzón

    Citation: BMC Neuroscience 2014 15:105

    Published on:

  15. Content type: Research article

    In physiologic and pathologic conditions of the central nervous system (CNS), astrocytes are a double-edged sword. They not only support neuronal homeostasis but also contribute to increases in neuronal demise...

    Authors: Samin Hong, Mi Ran Son, Kyungeun Yun, Won Taek Lee, Kyung Ah Park and Jong Eun Lee

    Citation: BMC Neuroscience 2014 15:99

    Published on:

  16. Content type: Research article

    Accumulating evidence suggests that growth hormone (GH) may play a major role in the regulation of postnatal neurogenesis, thus supporting the possibility that it may be also involved in promoting brain repair...

    Authors: Pablo Devesa, Fabienne Agasse, Sara Xapelli, Cristina Almengló, Jesús Devesa, Joao O Malva and Víctor M Arce

    Citation: BMC Neuroscience 2014 15:100

    Published on:

  17. Content type: Research article

    The transcription factor, Sox2, is central to the behaviour of neural stem cells. It is also one of the key embryonic stem cell factors that, when overexpressed can convert somatic cells into induced pluripote...

    Authors: Yu-Ru Liu, Zulfiqar A Laghari, Carolina A Novoa, Jaime Hughes, Jamie RM Webster, Paul E Goodwin, Sally P Wheatley and Paul J Scotting

    Citation: BMC Neuroscience 2014 15:95

    Published on:

  18. Content type: Research article

    Parkinson’s disease (PD) is the second most common neurodegenerative movement disorder, caused by preferential dopaminergic neuronal cell death in the substantia nigra, a process also influenced by oxidative s...

    Authors: Mohammad-Saeid Jami, Ramavati Pal, Esthelle Hoedt, Thomas A Neubert, Jan Petter Larsen and Simon Geir Møller

    Citation: BMC Neuroscience 2014 15:93

    Published on:

  19. Content type: Research article

    Spinal root avulsion induces multiple pathophysiological events consisting of altered levels of specific genes and proteins related to inflammation, apoptosis, and oxidative stress, which collectively result i...

    Authors: Ying Tang, Ze-Min Ling, Rao Fu, Ying-Qin Li, Xiao Cheng, Fa-Huan Song, Hao-Xuan Luo and Li-Hua Zhou

    Citation: BMC Neuroscience 2014 15:92

    Published on:

  20. Content type: Research article

    During the clinical treatment of the brachial plexus root avulsion (BPRA), reimplantation surgery can not completely repair the motor function of the hand because the axonal growth velocity of the spinal moton...

    Authors: Rao Fu, Ying Tang, Ze-Min Ling, Ying-Qin Li, Xiao Cheng, Fa-Huan Song, Li-Hua Zhou and Wutian Wu

    Citation: BMC Neuroscience 2014 15:84

    Published on:

  21. Content type: Research article

    Mirtazapine, a noradrenergic and specific serotonergic antidepressant (NaSSA), shows multiple pharmacological actions such as inhibiting presynaptic α2 noradrenaline receptor (NAR) and selectively activating 5-hy...

    Authors: Naoto Kadoguchi, Shinji Okabe, Yukio Yamamura, Misaki Shono, Tatsuya Fukano, Akie Tanabe, Hironori Yokoyama and Jiro Kasahara

    Citation: BMC Neuroscience 2014 15:79

    Published on:

  22. Content type: Research article

    Localization of mRNAs encoding cytoskeletal or signaling proteins to neuronal processes is known to contribute to axon growth, synaptic differentiation and plasticity. In addition, a still increasing spectrum ...

    Authors: Brigitte Pfeiffer-Guglielmi, Benjamin Dombert, Sibylle Jablonka, Vanessa Hausherr, Christoph van Thriel, Nicole Schöbel and Ralf-Peter Jansen

    Citation: BMC Neuroscience 2014 15:70

    Published on:

  23. Content type: Research article

    Microtubule-associated protein tau (MAPT) is a neuronal protein involved in the pathogenesis of several neurodegenerative diseases including Parkinson’s Disease (PD). Glycogen synthase kinase 3 beta (GSK3B) ca...

    Authors: Lan Yu, Jinsha Huang, Desheng Zhai, Ling Liu, Kexin Guo, Xi Long, Jing Xiong, Zhentao Zhang, Youpei Wang, Ying Zhao, Ping Wu, Dingan Wang, Zhicheng Lin, Jing Wu, Nian Xiong and Tao Wang

    Citation: BMC Neuroscience 2014 15:54

    Published on:

  24. Content type: Research article

    D-3-aminoisobutyrate, an intermediary product of thymine, is converted to 2-methyl-3-oxopropanoate using pyruvate as an amino acceptor by D-3-aminoisobutyrate-pyruvate aminotransferase (D-AIB AT; EC

    Authors: Masao Abe, Shinichiro Ochi, Yoko Mori, Kiyohiro Yamazaki, Takashi Ishimaru, Yuta Yoshino, Ryuji Fukuhara, Satoshi Tanimukai, Seiji Matsuda and Shu-ichi Ueno

    Citation: BMC Neuroscience 2014 15:53

    Published on:

  25. Content type: Research article

    Growing evidence shows that, in vivo, the precursor of Nerve Growth Factor (NGF), proNGF, displays biological activities different from those of its mature NGF counterpart, mediated by distinct, and somewhat comp...

    Authors: Ivan Arisi, Mara D’Onofrio, Rossella Brandi, Francesca Malerba, Francesca Paoletti, Andrea Ennio Storti, Fulvio Florenzano, Luisa Fasulo and Antonino Cattaneo

    Citation: BMC Neuroscience 2014 15:48

    Published on:

  26. Content type: Research article

    Recent alleged attacks with nerve agent sarin on civilians in Syria indicate their potential threat to both civilian and military population. Acute nerve agent exposure can cause rapid death or leads to multip...

    Authors: Golime RamaRao, Prachiti Afley, Jyothiranjan Acharya and Bijoy Krishna Bhattacharya

    Citation: BMC Neuroscience 2014 15:47

    Published on:

  27. Content type: Research article

    Because there is little research on the effects of transplanted stem cells on neuronal metabolites in infarct areas, we transplanted human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) into cerebral ...

    Authors: Ye-Ming Guan, Yao Zhu, Xue-Chun Liu, Hai-Li Huang, Zhi-Wei Wang, Bo Liu, You-Zi Zhu and Qing-Song Wang

    Citation: BMC Neuroscience 2014 15:41

    Published on:

  28. Content type: Research article

    Altered hypothalamo-pituitary-adrenal (HPA) axis activity may be accompanied by a modulation of pain sensitivity. In a model of neuropathic pain (chronic constriction injury, CCI) we investigated the onset and...

    Authors: Glenn-Marie Le Coz, Cathy Fiatte, Fernand Anton and Ulrike Hanesch

    Citation: BMC Neuroscience 2014 15:35

    Published on:

  29. Content type: Research article

    Exposures to environmental toxins are now thought to contribute to the development of autism spectrum disorder. Propionic acid (PA) found as a metabolic product of gut bacteria has been reported to mimic/media...

    Authors: Mashael Al-Ghamdi, Laila Al-Ayadhi and Afaf El-Ansary

    Citation: BMC Neuroscience 2014 15:34

    Published on:

  30. Content type: Research article

    Cardiac complications are often developed after subarachnoid hemorrhage (SAH) and may cause sudden death of the patient. There are reports in the literature addressing ischemia modified albumin (IMA) as an ear...

    Authors: Şerefden Açıkgöz, Nurullah Edebali, Figen Barut, Murat Can, İshak Özel Tekin, Çağatay Büyükuysal and Bektaş Açıkgöz

    Citation: BMC Neuroscience 2014 15:33

    Published on:

  31. Content type: Research article

    DNA methylation has been viewed as the most highly characterized epigenetic mark for genome regulation and development. Postnatal brains appear to exhibit stimulus-induced methylation changes because of factor...

    Authors: Xiaoling Weng, Daizhan Zhou, Fatao Liu, Hong Zhang, Junyi Ye, Zhou Zhang, Di Zhang, Yinan Wang, Liming Tao, Lan Cao, Mengyuan Kan, Ting Wang, Guoyin Feng, Xiaolan Qin, Jihui Sun, Lin He…

    Citation: BMC Neuroscience 2014 15:31

    Published on:

  32. Content type: Research article

    Signaling pathways outside dopamine D2 receptor antagonism may govern the variable clinical profile of antipsychotic drugs (APD) in schizophrenia. One postulated mechanism causal to APD action may regulate syn...

    Authors: Avril Pereira, Betty Zhang, Peter Malcolm, Anthony Sugiharto-Winarno and Suresh Sundram

    Citation: BMC Neuroscience 2014 15:30

    Published on:

  33. Content type: Research article

    In recent years, there has been an increased interest in using recombinant adeno-associated viruses (AAV) to make localized genetic manipulations within the rodent brain. Differing serotypes of AAV possess div...

    Authors: Roopashri Holehonnur, Jonathan A Luong, Dushyant Chaturvedi, Anthony Ho, Srihari K Lella, Matthew P Hosek and Jonathan E Ploski

    Citation: BMC Neuroscience 2014 15:28

    Published on:

  34. Content type: Research article

    In mammals, Eag K+ channels (KV10) are exclusively expressed in the brain and comprise two isoforms: Eag1 (KV10.1) and Eag2 (KV10.2). Despite their wide presence in various regions of the brain, the functional ro...

    Authors: Chao-Chin Chuang, Guey-Mei Jow, Huei-Min Lin, Yu-Han Weng, Jui-Hsiang Hu, Yi-Jheng Peng, Yi-Chih Chiu, Mei-Miao Chiu and Chung-Jiuan Jeng

    Citation: BMC Neuroscience 2014 15:23

    Published on:

  35. Content type: Research article

    The properties of Ca2+ signaling mediated by purinergic receptors are intrinsically linked with functional activity of astrocytes. At present little is known concerning Ca2+-dependent purinergic responses in adul...

    Authors: Sadayuki Hashioka, Yun Fan Wang, Jonathan P Little, Hyun B Choi, Andis Klegeris, Patrick L McGeer and James G McLarnon

    Citation: BMC Neuroscience 2014 15:18

    Published on:

  36. Content type: Research article

    The mother-child relationship is the most fundamental social bond in mammals, and previous studies indicate that the medial preoptic area (MPOA) contributes to this increase in sociability. It is possible that...

    Authors: Terri M Driessen, Brian E Eisinger, Changjiu Zhao, Sharon A Stevenson, Michael C Saul and Stephen C Gammie

    Citation: BMC Neuroscience 2014 15:11

    Published on:

  37. Content type: Research article

    Olig1 and Olig2, encoding closely related basic helix-loop-helix transcription factors, were originally identified in screens for glial-specific genes. Olig1 and Olig2 are both expressed in restricted parts of th...

    Authors: Joana Paes de Faria, Nicoletta Kessaris, Paul Andrew, William D Richardson and Huiliang Li

    Citation: BMC Neuroscience 2014 15:12

    Published on:

  38. Content type: Research article

    Intracellular calcium signaling regulates a variety of cellular and physiological processes. The inositol 1,4,5 trisphosphate receptor (IP3R) is a ligand gated calcium channel present on the membranes of endoplas...

    Authors: Manivannan Subramanian, Siddharth Jayakumar, Shlesha Richhariya and Gaiti Hasan

    Citation: BMC Neuroscience 2013 14:157

    Published on:

  39. Content type: Research article

    Synergistic multi-ligand treatments that can induce neuronal differentiation offer valuable strategies to regulate and modulate neurite outgrowth. Whereas the signaling pathways mediating single ligand-induced...

    Authors: Kok Huei Seow, Lihan Zhou, Gregory Stephanopoulos and Heng-Phon Too

    Citation: BMC Neuroscience 2013 14:153

    Published on:

  40. Content type: Research article

    The effects of chronic treatment with tricyclic antidepressant (desipramine, DMI) on the hippocampal transcriptome in mice displaying high and low swim stress-induced analgesia (HA and LA lines) were studied. ...

    Authors: Pawel Lisowski, Grzegorz R Juszczak, Joanna Goscik, Adrian M Stankiewicz, Marek Wieczorek, Lech Zwierzchowski and Artur H Swiergiel

    Citation: BMC Neuroscience 2013 14:144

    Published on:

  41. Content type: Research article

    Dopamine (DA) can produce divergent effects at different time scales. DA has opposing immediate and long-term effects on the transient potassium current (IA) within neurons of the pyloric network, in the Panuliru...

    Authors: Edmund W Rodgers, Wulf-Dieter Krenz, Xiaoyue Jiang, Lingjun Li and Deborah J Baro

    Citation: BMC Neuroscience 2013 14:143

    Published on:

  42. Content type: Research article

    The hypothalamic paraventricular nucleus (PVN) is an important site in the regulation of the autonomic nervous system. Specifically, PVN neurons projecting to the rostral ventrolateral medulla (PVN-RVLM) play ...

    Authors: Seul Ki Lee, Pan Dong Ryu and So Yeong Lee

    Citation: BMC Neuroscience 2013 14:134

    Published on:

  43. Content type: Methodology article

    In terms of vesicular recycling, synaptic efficiency is a key determinant of the fidelity of synaptic transmission. The ability of a presynaptic terminal to reuse its vesicular content is thought to be a signa...

    Authors: Jorge Ramírez-Franco, Beatris Alonso, David Bartolomé-Martín, José Sánchez-Prieto and Magdalena Torres

    Citation: BMC Neuroscience 2013 14:127

    Published on:

  44. Content type: Research article

    Group II metabotropic glutamate receptors (mGlu2 and mGlu3, encoded by Grm2 and Grm3) have been the focus of attention as treatment targets for a number of psychiatric conditions. Double knockout mice lacking mGl...

    Authors: Tracy A Lane, Thomas Boerner, David M Bannerman, James NC Kew, Elizabeth M Tunbridge, Trevor Sharp and Paul J Harrison

    Citation: BMC Neuroscience 2013 14:102

    Published on:

  45. Content type: Research article

    Myelinated axons are organized into distinct subcellular and molecular regions. Without proper organization, electrical nerve conduction is delayed, resulting in detrimental physiological outcomes. One such re...

    Authors: James A Green, Jun Yang, M’hamed Grati, Bechara Kachar and Manzoor A Bhat

    Citation: BMC Neuroscience 2013 14:96

    Published on:

  46. Content type: Research article

    Drugs targeting insomnia ideally promote sleep throughout the night, maintain normal sleep architecture, and are devoid of residual effects associated with morning sedation. These features of an ideal compound...

    Authors: Anthony L Gotter, Christopher J Winrow, Joseph Brunner, Susan L Garson, Steven V Fox, Jacquelyn Binns, Charles M Harrell, Donghui Cui, Ka Lai Yee, Mark Stiteler, Joanne Stevens, Alan Savitz, Pamela L Tannenbaum, Spencer J Tye, Terrence McDonald, Leon Yao…

    Citation: BMC Neuroscience 2013 14:90

    Published on: