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Cellular and molecular mechanisms

In this section topics of interest include, but are not limited to, neurotransmitters, neurotransmission, gliotransmission, synaptic transmission, neuropsychopharmacology, cell signaling, neurophysiology, neurogenetics and neurogenomics.

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  1. MCT14 (SLC16A14) is an orphan member of the monocarboxylate transporter (MCT) family, also known as the SLC16 family of secondary active transmembrane transporters. Available expression data for this transport...

    Authors: Sahar Roshanbin, Frida A. Lindberg, Emilia Lekholm, Mikaela M. Eriksson, Emelie Perland, Johan Åhlund, Amanda Raine and Robert Fredriksson

    Citation: BMC Neuroscience 2016 17:43

    Content type: Research article

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  2. Conducting research on the molecular biology, immunology, and physiology of brain tumors (BTs) and primary brain tissues requires the use of viably dissociated single cells. Inadequate methods for tissue diss...

    Authors: Ilan Volovitz, Netanel Shapira, Haim Ezer, Aviv Gafni, Merav Lustgarten, Tal Alter, Idan Ben-Horin, Ori Barzilai, Tal Shahar, Andrew Kanner, Itzhak Fried, Igor Veshchev, Rachel Grossman and Zvi Ram

    Citation: BMC Neuroscience 2016 17:30

    Content type: Methodology article

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  3. To get a broader view of global ischemia-induced cerebral disorders at the metabolic level, a nuclear magnetic resonance-based metabolomic study was performed to evaluate the metabolic profile changes on regio...

    Authors: Tianshu Zhang, Wei Wang, Jin Huang, Xia Liu, Haiyan Zhang and Naixia Zhang

    Citation: BMC Neuroscience 2016 17:25

    Content type: Research article

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  4. Epilepsy is a common neurological disorder characterized by recurrent unprovoked seizures. Seizure-induced TLR4/MYD88 signaling plays a critical role in activating microglia and triggering neuron apoptosis. SA...

    Authors: Qing-Peng Hu and Ding-An Mao

    Citation: BMC Neuroscience 2016 17:22

    Content type: Research article

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  5. The decline of remyelination in chronic multiple sclerosis (MS) is in part attributed to inadequate oligodendrocyte precursor cell (OPC) migration, a process governed by the extracellular matrix (ECM). Elucida...

    Authors: Ryan W. O’Meara, Sarah E. Cummings, John-Paul Michalski and Rashmi Kothary

    Citation: BMC Neuroscience 2016 17:7

    Content type: Methodology article

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  6. Depression is one of the most prevalent mood disorders, and is known to be associated with abnormal functional connectivity in neural networks of the brain. Interestingly, a significant proportion of patients ...

    Authors: Arshi Khalid, Byung Sun Kim, Bo Am Seo, Soon-Tae Lee, Keun-Hwa Jung, Kon Chu, Sang Kun Lee and Daejong Jeon

    Citation: BMC Neuroscience 2016 17:4

    Content type: Research article

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  7. Periventricular leukomalacia (PVL) is the leading cause of neurological disabilities including motor and cognitive deficits in premature infants. Periventricular leukomalacia is characterized by damage to the ...

    Authors: Xiao-Bo Liu, Yan Shen, David E. Pleasure and Wenbin Deng

    Citation: BMC Neuroscience 2016 17:2

    Content type: Research Article

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  8. Hippocampal neurons in the brain polarize to form multiple dendrites and one long axon. The formation of central synapses remains poorly understood. Although several of the intracellular proteins involved in t...

    Authors: Yuriko Inoue, Yuji Kamikubo, Hiromitsu Ezure, Junji Ito, Yu Kato, Hiroshi Moriyama and Naruhito Otsuka

    Citation: BMC Neuroscience 2015 16:92

    Content type: Research article

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  9. Tropomyosin-related kinase A (TRKA) is a nerve growth factor (NGF) receptor that belongs to the tyrosine kinase receptor family. It is critical for the correct development of many types of neurons including pa...

    Authors: Kristi Luberg, Rahel Park, Elina Aleksejeva and Tõnis Timmusk

    Citation: BMC Neuroscience 2015 16:78

    Content type: Research article

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  10. UbcM2 is a ubiquitin-conjugating enzyme with roles in the turnover of damaged and misfolded proteins, cell cycle progression, development, and regulation of the antioxidant transcription factor, Nrf2. Recent s...

    Authors: Chelsea M. Larabee, Constantin Georgescu, Jonathan D. Wren and Scott M. Plafker

    Citation: BMC Neuroscience 2015 16:76

    Content type: Research article

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  11. Accumulation of protein aggregates is the leading cause of cellular dysfunction in neurodegenerative disorders. Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease, Prion disease and motor...

    Authors: Shohreh Majd, John H. Power and Hugh J. M. Grantham

    Citation: BMC Neuroscience 2015 16:69

    Content type: Review

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  12. Alpha (α)-amidation of peptides is a mechanism required for the conversion of prohormones into functional peptide sequences that display biological activities, receptor recognition and signal transduction on t...

    Authors: Benito Antón Palma, Philippe Leff Gelman, Mayra Medecigo Ríos, Juan Carlos Calva Nieves, Rodolfo Acevedo Ortuño, Maura Epifanía Matus Ortega, Jorge Alberto Hernández Calderón, Ricardo Hernández Miramontes, Anabel Flores Zamora and Alberto Salazar Juárez

    Citation: BMC Neuroscience 2015 16:65

    Content type: Research article

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  13. Neurogenesis in the brain of adult mammals occurs throughout life in two locations: the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus in the hippocampus. RNA interf...

    Authors: Filippo M. Cernilogar, Rossella Di Giaimo, Frederick Rehfeld, Silvia Cappello and D. Chichung Lie

    Citation: BMC Neuroscience 2015 16:60

    Content type: Research article

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  14. Oxycodone is an opioid that is prescribed to treat multiple types of pain, especially when other opioids are ineffective. Unfortunately, similar to other opioids, repetitive oxycodone administration has the po...

    Authors: Ruping Fan, Lisa M. Schrott, Stephen Snelling, Julius Ndi, Thomas Arnold and Nadejda L. Korneeva

    Citation: BMC Neuroscience 2015 16:58

    Content type: Research article

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  15. Necroptosis is a type of regulated form of cell death that has been implicated in the pathogenesis of various diseases. Receptor-interacting protein 3 (RIP3), a member of the RIP family of proteins, has been r...

    Authors: Wei Ding, Lei Shang, Ju-Fang Huang, Na Li, Dan Chen, Li-Xiang Xue and Kun Xiong

    Citation: BMC Neuroscience 2015 16:49

    Content type: Research article

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  16. Tobacco smoke (TS) toxicity to the brain microvasculature is still an understudied area till date. NF-E2 related factor (Nrf2) is a key transcription factor responsible for activating the antioxidant response ...

    Authors: Pooja Naik, Ravi K Sajja, Shikha Prasad and Luca Cucullo

    Citation: BMC Neuroscience 2015 16:38

    Content type: Research article

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  17. SLC10A4 belongs to the solute carrier family SLC10 whose founding members are the Na+/taurocholate co-transporting polypeptide (NTCP, SLC10A1) and the apical sodium-dependent bile acid transporter (ASBT, SLC10A2)...

    Authors: Stephanie Schmidt, Marcela Moncada, Simone Burger and Joachim Geyer

    Citation: BMC Neuroscience 2015 16:35

    Content type: Research article

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  18. Inhibitory molecules in the adult central nervous system, including NogoA, impede neural repair by blocking axon outgrowth. The actin-myosin regulatory protein Shroom3 directly interacts with Rho kinase and co...

    Authors: Heather M Dickson, Amanda Wilbur, Ashley A Reinke, Mathew A Young and Anne B Vojtek

    Citation: BMC Neuroscience 2015 16:34

    Content type: Research article

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  19. Assembly and disassembly of microtubules (MTs) is critical for neurite outgrowth and differentiation. Evidence suggests that nerve growth factor (NGF) induces neurite outgrowth from PC12 cells by activating th...

    Authors: Jorge A Sierra-Fonseca, Omar Najera, Jessica Martinez-Jurado, Ellen M Walker, Armando Varela-Ramirez, Arshad M Khan, Manuel Miranda, Nazarius S Lamango and Sukla Roychowdhury

    Citation: BMC Neuroscience 2014 15:132

    Content type: Research article

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  20. Naringenin (NGEN) is a citrus bioflavonoid known to have beneficial health properties; however, the ionic mechanism of its actions remains largely unclear. In this study, we attempted to evaluate the possible ...

    Authors: Hung-Te Hsu, Yu-Ting Tseng, Yi-Ching Lo and Sheng-Nan Wu

    Citation: BMC Neuroscience 2014 15:135

    Content type: Research article

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  21. In order to better understand the effects of social stress on the prefrontal cortex, we investigated gene expression in mice subjected to acute and repeated social encounters of different duration using microa...

    Authors: Adrian M Stankiewicz, Joanna Goscik, Artur H Swiergiel, Alicja Majewska, Marek Wieczorek, Grzegorz R Juszczak and Paweł Lisowski

    Citation: BMC Neuroscience 2014 15:130

    Content type: Research article

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  22. In male birds, influence of the sex steroid hormone testosterone and its estrogenic metabolites on seasonal song behavior has been demonstrated for many species. In contrast, female song was only recently reco...

    Authors: Falk Dittrich, Claudia Ramenda, Doris Grillitsch, Carolina Frankl-Vilches, Meng-Ching Ko, Moritz Hertel, Wolfgang Goymann, Andries ter Maat and Manfred Gahr

    Citation: BMC Neuroscience 2014 15:128

    Content type: Research article

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  23. The novel antidepressant agomelatine, a melatonergic MT1/MT2 agonist combined with 5-HT2c serotonin antagonist properties, showed antidepressant action in preclinical and clinical studies. There is a general agre...

    Authors: Laura Musazzi, Mara Seguini, Alessandra Mallei, Giulia Treccani, Mariagrazia Pelizzari, Paolo Tornese, Giorgio Racagni and Daniela Tardito

    Citation: BMC Neuroscience 2014 15:119

    Content type: Research article

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  24. GABA has important functions in brain plasticity related processes like memory, learning, locomotion and during the development of the nervous system. It is synthesized by the glutamic acid decarboxylase (GAD)...

    Authors: Stefan Trifonov, Yuji Yamashita, Masahiko Kase, Masato Maruyama and Tetsuo Sugimoto

    Citation: BMC Neuroscience 2014 15:114

    Content type: Research article

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  25. ApoER2 and the neurotrophin receptors Trk and p75NTR are expressed in the CNS and regulate key functional aspects of neurons, including development, survival, and neuronal function. It is known that both ApoER2 a...

    Authors: Jorge A Larios, Ignacio Jausoro, Maria-Luisa Benitez, Francisca C Bronfman and Maria-Paz Marzolo

    Citation: BMC Neuroscience 2014 15:108

    Content type: Research article

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  26. In view of the global increase in diabetes, and the fact that recent findings indicate that diabetic neuropathy is more frequently seen in males, it is crucial to evaluate any gender differences in nerve regen...

    Authors: Lena Stenberg and Lars B Dahlin

    Citation: BMC Neuroscience 2014 15:107

    Content type: Research article

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  27. Hypocretins/orexins (Hcrt/Ox) are hypothalamic neuropeptides involved in sleep-wakefulness regulation. Deficiency in Hcrt/Ox neurotransmission results in the sleep disorder narcolepsy, which is characterized b...

    Authors: Esther Del Cid-Pellitero and Miguel Garzón

    Citation: BMC Neuroscience 2014 15:105

    Content type: Research article

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  28. Accumulating evidence suggests that growth hormone (GH) may play a major role in the regulation of postnatal neurogenesis, thus supporting the possibility that it may be also involved in promoting brain repair...

    Authors: Pablo Devesa, Fabienne Agasse, Sara Xapelli, Cristina Almengló, Jesús Devesa, Joao O Malva and Víctor M Arce

    Citation: BMC Neuroscience 2014 15:100

    Content type: Research article

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  29. In physiologic and pathologic conditions of the central nervous system (CNS), astrocytes are a double-edged sword. They not only support neuronal homeostasis but also contribute to increases in neuronal demise...

    Authors: Samin Hong, Mi Ran Son, Kyungeun Yun, Won Taek Lee, Kyung Ah Park and Jong Eun Lee

    Citation: BMC Neuroscience 2014 15:99

    Content type: Research article

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  30. The transcription factor, Sox2, is central to the behaviour of neural stem cells. It is also one of the key embryonic stem cell factors that, when overexpressed can convert somatic cells into induced pluripote...

    Authors: Yu-Ru Liu, Zulfiqar A Laghari, Carolina A Novoa, Jaime Hughes, Jamie RM Webster, Paul E Goodwin, Sally P Wheatley and Paul J Scotting

    Citation: BMC Neuroscience 2014 15:95

    Content type: Research article

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  31. Parkinson’s disease (PD) is the second most common neurodegenerative movement disorder, caused by preferential dopaminergic neuronal cell death in the substantia nigra, a process also influenced by oxidative s...

    Authors: Mohammad-Saeid Jami, Ramavati Pal, Esthelle Hoedt, Thomas A Neubert, Jan Petter Larsen and Simon Geir Møller

    Citation: BMC Neuroscience 2014 15:93

    Content type: Research article

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  32. Spinal root avulsion induces multiple pathophysiological events consisting of altered levels of specific genes and proteins related to inflammation, apoptosis, and oxidative stress, which collectively result i...

    Authors: Ying Tang, Ze-Min Ling, Rao Fu, Ying-Qin Li, Xiao Cheng, Fa-Huan Song, Hao-Xuan Luo and Li-Hua Zhou

    Citation: BMC Neuroscience 2014 15:92

    Content type: Research article

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  33. During the clinical treatment of the brachial plexus root avulsion (BPRA), reimplantation surgery can not completely repair the motor function of the hand because the axonal growth velocity of the spinal moton...

    Authors: Rao Fu, Ying Tang, Ze-Min Ling, Ying-Qin Li, Xiao Cheng, Fa-Huan Song, Li-Hua Zhou and Wutian Wu

    Citation: BMC Neuroscience 2014 15:84

    Content type: Research article

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  34. Mirtazapine, a noradrenergic and specific serotonergic antidepressant (NaSSA), shows multiple pharmacological actions such as inhibiting presynaptic α2 noradrenaline receptor (NAR) and selectively activating 5-hy...

    Authors: Naoto Kadoguchi, Shinji Okabe, Yukio Yamamura, Misaki Shono, Tatsuya Fukano, Akie Tanabe, Hironori Yokoyama and Jiro Kasahara

    Citation: BMC Neuroscience 2014 15:79

    Content type: Research article

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  35. Localization of mRNAs encoding cytoskeletal or signaling proteins to neuronal processes is known to contribute to axon growth, synaptic differentiation and plasticity. In addition, a still increasing spectrum ...

    Authors: Brigitte Pfeiffer-Guglielmi, Benjamin Dombert, Sibylle Jablonka, Vanessa Hausherr, Christoph van Thriel, Nicole Schöbel and Ralf-Peter Jansen

    Citation: BMC Neuroscience 2014 15:70

    Content type: Research article

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  36. Microtubule-associated protein tau (MAPT) is a neuronal protein involved in the pathogenesis of several neurodegenerative diseases including Parkinson’s Disease (PD). Glycogen synthase kinase 3 beta (GSK3B) ca...

    Authors: Lan Yu, Jinsha Huang, Desheng Zhai, Ling Liu, Kexin Guo, Xi Long, Jing Xiong, Zhentao Zhang, Youpei Wang, Ying Zhao, Ping Wu, Dingan Wang, Zhicheng Lin, Jing Wu, Nian Xiong and Tao Wang

    Citation: BMC Neuroscience 2014 15:54

    Content type: Research article

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  37. D-3-aminoisobutyrate, an intermediary product of thymine, is converted to 2-methyl-3-oxopropanoate using pyruvate as an amino acceptor by D-3-aminoisobutyrate-pyruvate aminotransferase (D-AIB AT; EC 2.6.1.40)....

    Authors: Masao Abe, Shinichiro Ochi, Yoko Mori, Kiyohiro Yamazaki, Takashi Ishimaru, Yuta Yoshino, Ryuji Fukuhara, Satoshi Tanimukai, Seiji Matsuda and Shu-ichi Ueno

    Citation: BMC Neuroscience 2014 15:53

    Content type: Research article

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  38. Growing evidence shows that, in vivo, the precursor of Nerve Growth Factor (NGF), proNGF, displays biological activities different from those of its mature NGF counterpart, mediated by distinct, and somewhat comp...

    Authors: Ivan Arisi, Mara D’Onofrio, Rossella Brandi, Francesca Malerba, Francesca Paoletti, Andrea Ennio Storti, Fulvio Florenzano, Luisa Fasulo and Antonino Cattaneo

    Citation: BMC Neuroscience 2014 15:48

    Content type: Research article

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  39. Recent alleged attacks with nerve agent sarin on civilians in Syria indicate their potential threat to both civilian and military population. Acute nerve agent exposure can cause rapid death or leads to multip...

    Authors: Golime RamaRao, Prachiti Afley, Jyothiranjan Acharya and Bijoy Krishna Bhattacharya

    Citation: BMC Neuroscience 2014 15:47

    Content type: Research article

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  40. Because there is little research on the effects of transplanted stem cells on neuronal metabolites in infarct areas, we transplanted human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) into cerebral ...

    Authors: Ye-Ming Guan, Yao Zhu, Xue-Chun Liu, Hai-Li Huang, Zhi-Wei Wang, Bo Liu, You-Zi Zhu and Qing-Song Wang

    Citation: BMC Neuroscience 2014 15:41

    Content type: Research article

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  41. Altered hypothalamo-pituitary-adrenal (HPA) axis activity may be accompanied by a modulation of pain sensitivity. In a model of neuropathic pain (chronic constriction injury, CCI) we investigated the onset and...

    Authors: Glenn-Marie Le Coz, Cathy Fiatte, Fernand Anton and Ulrike Hanesch

    Citation: BMC Neuroscience 2014 15:35

    Content type: Research article

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  42. Exposures to environmental toxins are now thought to contribute to the development of autism spectrum disorder. Propionic acid (PA) found as a metabolic product of gut bacteria has been reported to mimic/media...

    Authors: Mashael Al-Ghamdi, Laila Al-Ayadhi and Afaf El-Ansary

    Citation: BMC Neuroscience 2014 15:34

    Content type: Research article

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  43. Cardiac complications are often developed after subarachnoid hemorrhage (SAH) and may cause sudden death of the patient. There are reports in the literature addressing ischemia modified albumin (IMA) as an ear...

    Authors: Şerefden Açıkgöz, Nurullah Edebali, Figen Barut, Murat Can, İshak Özel Tekin, Çağatay Büyükuysal and Bektaş Açıkgöz

    Citation: BMC Neuroscience 2014 15:33

    Content type: Research article

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  44. DNA methylation has been viewed as the most highly characterized epigenetic mark for genome regulation and development. Postnatal brains appear to exhibit stimulus-induced methylation changes because of factor...

    Authors: Xiaoling Weng, Daizhan Zhou, Fatao Liu, Hong Zhang, Junyi Ye, Zhou Zhang, Di Zhang, Yinan Wang, Liming Tao, Lan Cao, Mengyuan Kan, Ting Wang, Guoyin Feng, Xiaolan Qin, Jihui Sun, Lin He…

    Citation: BMC Neuroscience 2014 15:31

    Content type: Research article

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  45. Signaling pathways outside dopamine D2 receptor antagonism may govern the variable clinical profile of antipsychotic drugs (APD) in schizophrenia. One postulated mechanism causal to APD action may regulate syn...

    Authors: Avril Pereira, Betty Zhang, Peter Malcolm, Anthony Sugiharto-Winarno and Suresh Sundram

    Citation: BMC Neuroscience 2014 15:30

    Content type: Research article

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  46. In recent years, there has been an increased interest in using recombinant adeno-associated viruses (AAV) to make localized genetic manipulations within the rodent brain. Differing serotypes of AAV possess div...

    Authors: Roopashri Holehonnur, Jonathan A Luong, Dushyant Chaturvedi, Anthony Ho, Srihari K Lella, Matthew P Hosek and Jonathan E Ploski

    Citation: BMC Neuroscience 2014 15:28

    Content type: Research article

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