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BMC Neuroscience

Cellular and molecular mechanisms

Section edited by Maurizio Popoli, Vijiyalaxmi Ravindraneth and Mark Rasenick

This section covers all aspects of cellular and molecular neuroscience. Topics of interest are widespread and include, but are not limited to, neurotransmitters, neuropsychopharmacology, cell signaling, neurophysiology and glial development.

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  1. Content type: Software

    Intracellular calcium is an important ion involved in the regulation and modulation of many neuronal functions. From regulating cell cycle and proliferation to initiating signaling cascades and regulating pres...

    Authors: Elena Artimovich, Russell K. Jackson, Michaela B. C. Kilander, Yu-Chih Lin and Michael W. Nestor

    Citation: BMC Neuroscience 2017 18:72

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  2. Content type: Methodology

    A sensitive, rapid and selective UHPLC–MS/MS method has been developed and validated for the quantification of Nicotine (NT) and Cotinine (CN) using Continine-d 3 as internal standard (...

    Authors: Mohammad A. Kaisar, Raja Reddy Kallem, Ravi K. Sajja, Ali Ehsan Sifat and Luca Cucullo

    Citation: BMC Neuroscience 2017 18:71

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  3. Content type: Research article

    Alzheimer’s disease is characterized by the accumulation of amyloid beta (Aβ) and the formation of neurofibrillary tangles. Aβ is the main constituent of senile plaques and is largely involved in neuronal deat...

    Authors: Yuqin Zhang, Changchun Chen, Yanliu Jiang, Shupei Wang, Xiaoyu Wu and Kai Wang

    Citation: BMC Neuroscience 2017 18:69

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  4. Content type: Research article

    The Na+/K+-ATPases are transmembrane ion pumps important for maintenance of ion gradients across the plasma membrane that serve to support multiple cellular functions, such as membrane potentials, regulation of c...

    Authors: Ditte Gry Ellman, Toke Jost Isaksen, Minna Christiansen Lund, Safinaz Dursun, Martin Wirenfeldt, Louise Helskov Jørgensen, Karin Lykke-Hartmann and Kate Lykke Lambertsen

    Citation: BMC Neuroscience 2017 18:66

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  5. Content type: Research article

    CLCA is a family of metalloproteases that regulate Ca2+-activated Cl fluxes in epithelial tissues. In HEK293 cells, CLCA1 promotes membrane expression of an endogenous Anoctamin 1 (ANO1, also termed TMEM16A)-dep...

    Authors: Casilda V. Mura, Ricardo Delgado, María Graciela Delgado, Diego Restrepo and Juan Bacigalupo

    Citation: BMC Neuroscience 2017 18:61

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  6. Content type: Research article

    The identification of biomarkers that predict susceptibility to major depressive disorder and treatment response to antidepressants is a major challenge. Vortioxetine is a novel multimodal antidepressant that ...

    Authors: Jessica A. Waller, Sara Holm Nygaard, Yan Li, Kristian Gaarn du Jardin, Joseph A. Tamm, Aicha Abdourahman, Betina Elfving, Alan L. Pehrson, Connie Sánchez and Rasmus Wernersson

    Citation: BMC Neuroscience 2017 18:56

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  7. Content type: Methodology article

    CRISPR/Cas9 system is a powerful method to investigate the role of genes by introducing a mutation selectively and efficiently to specific genome positions in cell and animal lines. However, in primary neuron...

    Authors: Hiroto Tsunematsu, Akiko Uyeda, Nobuhiko Yamamoto and Noriyuki Sugo

    Citation: BMC Neuroscience 2017 18:55

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  8. Content type: Review

    In the recent decade, iron oxide nanoparticles (IONPs) have been proposed for several applications in the central nervous system (CNS), including targeting amyloid beta (Aβ) in the arteries, inhibiting the mic...

    Authors: Zahra Yarjanli, Kamran Ghaedi, Abolghasem Esmaeili, Soheila Rahgozar and Ali Zarrabi

    Citation: BMC Neuroscience 2017 18:51

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  9. Content type: Research article

    The GluN2B subunit of the N-methyl-d-aspartate receptor (NMDAr) modulates many physiological processes including learning, memory, and pain. Excessive increase in NMDAr/GluN2B activity has been associated with va...

    Authors: Edwin A. Reyes-Guzman, Nohora Vega-Castro, Edgar A. Reyes-Montaño and Esperanza Recio-Pinto

    Citation: BMC Neuroscience 2017 18:44

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  10. Content type: Research article

    Recent studies have suggested that the activation of mammalian target of rapamycin (mTOR) signaling may be related to antidepressant action. Therefore, the present study evaluated whether antidepressant drugs ...

    Authors: Mi Kyoung Seo, Cheol Min Choi, Roger S. McIntyre, Hye Yeon Cho, Chan Hong Lee, Rodrigo B. Mansur, Yena Lee, Jae-Hon Lee, Young Hoon Kim, Sung Woo Park and Jung Goo Lee

    Citation: BMC Neuroscience 2017 18:39

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  11. Content type: Research article

    The mechanisms of steroids actions in the brain mainly involve the binding and nuclear translocation of specific cytoplasmic receptors. These receptors can act as transcription factors and regulate gene expres...

    Authors: Marcin Piechota, Michał Korostynski, Slawomir Golda, Joanna Ficek, Danuta Jantas, Ziolkowska Barbara and Ryszard Przewlocki

    Citation: BMC Neuroscience 2017 18:37

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  12. Content type: Methodology

    Cation-chloride cotransporters (CCCs) are indispensable for maintaining chloride homeostasis in multiple cell types, but K–Cl cotransporter KCC2 is the only CCC member with an exclusively neuronal expression i...

    Authors: Anastasia Ludwig, Claudio Rivera and Pavel Uvarov

    Citation: BMC Neuroscience 2017 18:23

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  13. Content type: Research article

    Previous studies have indicated that selenium supplementation may be beneficial in neuroprotection against glutamate-induced cell damage, in which mitochondrial dysfunction is considered a major pathogenic fea...

    Authors: Yan-Mei Ma, Gordon Ibeanu, Li-Yao Wang, Jian-Zhong Zhang, Yue Chang, Jian-Da Dong, P. Andy Li and Li Jing

    Citation: BMC Neuroscience 2017 18:15

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  14. Content type: Research Article

    Poly(ADP-ribose) polymerase 1 (PARP-1), which catalyzes poly(ADP-ribosyl)ation of proteins by using NAD+ as a substrate, plays a key role in several nuclear events, including DNA repair, replication, and transcri...

    Authors: Akiko Okuda, Suguru Kurokawa, Masanori Takehashi, Aika Maeda, Katsuya Fukuda, Yukari Kubo, Hyuma Nogusa, Tomoka Takatani-Nakase, Shujiro Okuda, Kunihiro Ueda and Seigo Tanaka

    Citation: BMC Neuroscience 2017 18:14

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  15. Content type: Research article

    Deposition of aggregated amyloid beta (Aβ) protein is hallmark of Alzheimer’s disease, leading to dysfunction and apoptosis of neurons. The isoflavone phytoestrogen compound genistein (Gen) exerts a significan...

    Authors: Fuling You, Qiao Li, Guifang Jin, Yaojie Zheng, Jingrong Chen and Hong Yang

    Citation: BMC Neuroscience 2017 18:12

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  16. Content type: Research Article

    A fundamental feature of early nervous system development is the guidance of axonal projections to their targets in order to assemble neural circuits that control behavior. Spinal commissural neurons are an at...

    Authors: Simon D. Sun, Ashley M. Purdy and Gregory S. Walsh

    Citation: BMC Neuroscience 2016 17:83

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  17. Content type: Research article

    The AP-2 transcription factor APTF-1 is crucially required for developmentally controlled sleep behavior in Caenorhabditis elegans larvae. Its human ortholog, TFAP-2beta, causes Char disease and has also been lin...

    Authors: Mariya M. Kucherenko, Vinodh Ilangovan, Bettina Herzig, Halyna R. Shcherbata and Henrik Bringmann

    Citation: BMC Neuroscience 2016 17:72

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  18. Content type: Research article

    Limited surveys have assessed the performance of 5-hydroxytreptamine receptor 1A and its antagonist WAY-100635 in pharmacological manipulations targeting delirium therapies. The purpose of this paper was to as...

    Authors: Yimin Qiu, Dongmei Chen, Xiaojing Huang, Lina Huang, Liang Tang, Jihong Jiang, Lianhua Chen and Shitong Li

    Citation: BMC Neuroscience 2016 17:66

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  19. Content type: Research article

    Polymorphisms in the gene for phosphatidylinositol binding clathrin assembly protein (PICALM), an endocytic-related protein, are associated with a small, increased risk of developing Alzheimer’s disease (AD), ...

    Authors: Rhian S. Thomas, Alex Henson, Amy Gerrish, Lesley Jones, Julie Williams and Emma J. Kidd

    Citation: BMC Neuroscience 2016 17:50

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