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Cellular and molecular mechanisms

Section edited by Maurizio Popoli, Vijiyalaxmi Ravindraneth and Mark Rasenick

This section covers all aspects of cellular and molecular neuroscience. Topics of interest are widespread and include, but are not limited to, neurotransmitters, neuropsychopharmacology, cell signaling, neurophysiology and glial development.

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  1. Content type: Research article

    Minocycline is a lipophilic tetracycline of increasing appeal in neuroscience as it inhibits microglial activation, a mechanism involved in numerous neuropsychiatric disorders. Own data point towards retinoid-...

    Authors: Vera Clemens, Francesca Regen, Nathalie Le Bret, Isabella Heuser and Julian Hellmann-Regen

    Citation: BMC Neuroscience 2018 19:58

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  2. Content type: Research article

    The long-term effects of psychotropic drugs are associated with the reversal of disease-related alterations through the reorganization and normalization of neuronal connections. Molecular factors that trigger ...

    Authors: Magdalena Zygmunt, Dżesika Hoinkis, Jacek Hajto, Marcin Piechota, Bożena Skupień-Rabian, Urszula Jankowska, Sylwia Kędracka-Krok, Jan Rodriguez Parkitna and Michał Korostyński

    Citation: BMC Neuroscience 2018 19:55

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  3. Content type: Review

    Adipose tissue is a dynamic organ with different effects on the body. Many of these effects are mediated by leptin, a hormone strongly involved in regulation of feeding and energy metabolism. It has an importa...

    Authors: Laura Mora-Muñoz, Alejandro Guerrero-Naranjo, Elisa Angélica Rodríguez-Jimenez, Claudio Alberto Mastronardi and Alberto Velez-van-Meerbeke

    Citation: BMC Neuroscience 2018 19:51

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  4. Content type: Research article

    The amino acid taurine (2-Aminoethanesulfonic acid) modulates inhibitory neurotransmitter receptors. This study aimed to determine if the dual action of taurine on GABAC-ρ1R relates to its structure. To address t...

    Authors: Lenin David Ochoa-de la Paz, Martin González-Andrade, Herminia Pasantes-Morales, Rodrigo Franco, Rubén Zamora-Alvarado, Edgar Zenteno, Hugo Quiroz-Mercado, Roberto Gonzales-Salinas and Rosario Gulias-Cañizo

    Citation: BMC Neuroscience 2018 19:47

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  5. Content type: Research article

    Light exposure induces oxidative stress, which contributes to ocular diseases of aging. Blue light provides a model for light-induced oxidative stress, lipid peroxidation and retinal degeneration in Drosophila me...

    Authors: Hana Hall, Jingqun Ma, Sudhanshu Shekhar, Walter D. Leon-Salas and Vikki M. Weake

    Citation: BMC Neuroscience 2018 19:43

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  6. Content type: Research article

    Striatal fast-spiking interneurons (FSI) are a subset of GABAergic cells that express calcium-binding protein parvalbumin (PV). They provide feed-forward inhibition to striatal projection neurons (SPNs), recei...

    Authors: Ernesto Alberto Rendón-Ochoa, Teresa Hernández-Flores, Victor Hugo Avilés-Rosas, Verónica Alejandra Cáceres-Chávez, Mariana Duhne, Antonio Laville, Dagoberto Tapia, Elvira Galarraga and José Bargas

    Citation: BMC Neuroscience 2018 19:42

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  7. Content type: Research article

    Many neuropsychiatric disorders develop in early life. Although the mechanisms involved have not been elucidated, it is possible that functional abnormalities of parvalbumin-positive interneurons (PV neurons) ...

    Authors: Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Shozo Aoki and Takeshi Ishihara

    Citation: BMC Neuroscience 2018 19:41

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  8. Content type: Research article

    Accumulation of the α-synuclein (α-syn) protein is a hallmark of a group of brain disorders collectively known as synucleinopathies. The mechanisms responsible for α-syn accumulation are not well understood. S...

    Authors: Jared Schommer, Gurdeep Marwarha, Trevor Schommer, Travis Flick, Jonah Lund and Othman Ghribi

    Citation: BMC Neuroscience 2018 19:17

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  9. Content type: Research article

    Chronic opioid therapy for non-malignant pain conditions has significantly increased over the last 15 years. Recently, the correlation between opioid analgesics and alternations in brain structure, such as leu...

    Authors: Ruping Fan, Lisa M. Schrott, Thomas Arnold, Stephen Snelling, Meghana Rao, Derrel Graham, Angela Cornelius and Nadejda L. Korneeva

    Citation: BMC Neuroscience 2018 19:15

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  10. Content type: Research article

    Sleep deprivation impairs learning, causes stress, and can lead to death. Notch and JNK-1 pathways impact C. elegans sleep in complex ways; these have been hypothesized to involve compensatory sleep. C. elegans D...

    Authors: Heather L. Bennett, Yulia Khoruzhik, Dustin Hayden, Huiyan Huang, Jarred Sanders, Melissa B. Walsh, David Biron and Anne C. Hart

    Citation: BMC Neuroscience 2018 19:10

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  11. Content type: Software

    Intracellular calcium is an important ion involved in the regulation and modulation of many neuronal functions. From regulating cell cycle and proliferation to initiating signaling cascades and regulating pres...

    Authors: Elena Artimovich, Russell K. Jackson, Michaela B. C. Kilander, Yu-Chih Lin and Michael W. Nestor

    Citation: BMC Neuroscience 2017 18:72

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  12. Content type: Methodology

    A sensitive, rapid and selective UHPLC–MS/MS method has been developed and validated for the quantification of Nicotine (NT) and Cotinine (CN) using Continine-d 3 as internal standard (...

    Authors: Mohammad A. Kaisar, Raja Reddy Kallem, Ravi K. Sajja, Ali Ehsan Sifat and Luca Cucullo

    Citation: BMC Neuroscience 2017 18:71

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  13. Content type: Research article

    Alzheimer’s disease is characterized by the accumulation of amyloid beta (Aβ) and the formation of neurofibrillary tangles. Aβ is the main constituent of senile plaques and is largely involved in neuronal deat...

    Authors: Yuqin Zhang, Changchun Chen, Yanliu Jiang, Shupei Wang, Xiaoyu Wu and Kai Wang

    Citation: BMC Neuroscience 2017 18:69

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  14. Content type: Research article

    The Na+/K+-ATPases are transmembrane ion pumps important for maintenance of ion gradients across the plasma membrane that serve to support multiple cellular functions, such as membrane potentials, regulation of c...

    Authors: Ditte Gry Ellman, Toke Jost Isaksen, Minna Christiansen Lund, Safinaz Dursun, Martin Wirenfeldt, Louise Helskov Jørgensen, Karin Lykke-Hartmann and Kate Lykke Lambertsen

    Citation: BMC Neuroscience 2017 18:66

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  15. Content type: Research article

    CLCA is a family of metalloproteases that regulate Ca2+-activated Cl fluxes in epithelial tissues. In HEK293 cells, CLCA1 promotes membrane expression of an endogenous Anoctamin 1 (ANO1, also termed TMEM16A)-dep...

    Authors: Casilda V. Mura, Ricardo Delgado, María Graciela Delgado, Diego Restrepo and Juan Bacigalupo

    Citation: BMC Neuroscience 2017 18:61

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  16. Content type: Research article

    The identification of biomarkers that predict susceptibility to major depressive disorder and treatment response to antidepressants is a major challenge. Vortioxetine is a novel multimodal antidepressant that ...

    Authors: Jessica A. Waller, Sara Holm Nygaard, Yan Li, Kristian Gaarn du Jardin, Joseph A. Tamm, Aicha Abdourahman, Betina Elfving, Alan L. Pehrson, Connie Sánchez and Rasmus Wernersson

    Citation: BMC Neuroscience 2017 18:56

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  17. Content type: Methodology article

    CRISPR/Cas9 system is a powerful method to investigate the role of genes by introducing a mutation selectively and efficiently to specific genome positions in cell and animal lines. However, in primary neuron...

    Authors: Hiroto Tsunematsu, Akiko Uyeda, Nobuhiko Yamamoto and Noriyuki Sugo

    Citation: BMC Neuroscience 2017 18:55

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  18. Content type: Review

    In the recent decade, iron oxide nanoparticles (IONPs) have been proposed for several applications in the central nervous system (CNS), including targeting amyloid beta (Aβ) in the arteries, inhibiting the mic...

    Authors: Zahra Yarjanli, Kamran Ghaedi, Abolghasem Esmaeili, Soheila Rahgozar and Ali Zarrabi

    Citation: BMC Neuroscience 2017 18:51

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  19. Content type: Research article

    The GluN2B subunit of the N-methyl-d-aspartate receptor (NMDAr) modulates many physiological processes including learning, memory, and pain. Excessive increase in NMDAr/GluN2B activity has been associated with va...

    Authors: Edwin A. Reyes-Guzman, Nohora Vega-Castro, Edgar A. Reyes-Montaño and Esperanza Recio-Pinto

    Citation: BMC Neuroscience 2017 18:44

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  20. Content type: Research article

    Recent studies have suggested that the activation of mammalian target of rapamycin (mTOR) signaling may be related to antidepressant action. Therefore, the present study evaluated whether antidepressant drugs ...

    Authors: Mi Kyoung Seo, Cheol Min Choi, Roger S. McIntyre, Hye Yeon Cho, Chan Hong Lee, Rodrigo B. Mansur, Yena Lee, Jae-Hon Lee, Young Hoon Kim, Sung Woo Park and Jung Goo Lee

    Citation: BMC Neuroscience 2017 18:39

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  21. Content type: Research article

    The mechanisms of steroids actions in the brain mainly involve the binding and nuclear translocation of specific cytoplasmic receptors. These receptors can act as transcription factors and regulate gene expres...

    Authors: Marcin Piechota, Michał Korostynski, Slawomir Golda, Joanna Ficek, Danuta Jantas, Ziolkowska Barbara and Ryszard Przewlocki

    Citation: BMC Neuroscience 2017 18:37

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  22. Content type: Methodology

    Cation-chloride cotransporters (CCCs) are indispensable for maintaining chloride homeostasis in multiple cell types, but K–Cl cotransporter KCC2 is the only CCC member with an exclusively neuronal expression i...

    Authors: Anastasia Ludwig, Claudio Rivera and Pavel Uvarov

    Citation: BMC Neuroscience 2017 18:23

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  23. Content type: Research article

    Previous studies have indicated that selenium supplementation may be beneficial in neuroprotection against glutamate-induced cell damage, in which mitochondrial dysfunction is considered a major pathogenic fea...

    Authors: Yan-Mei Ma, Gordon Ibeanu, Li-Yao Wang, Jian-Zhong Zhang, Yue Chang, Jian-Da Dong, P. Andy Li and Li Jing

    Citation: BMC Neuroscience 2017 18:15

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  24. Content type: Research Article

    Poly(ADP-ribose) polymerase 1 (PARP-1), which catalyzes poly(ADP-ribosyl)ation of proteins by using NAD+ as a substrate, plays a key role in several nuclear events, including DNA repair, replication, and transcri...

    Authors: Akiko Okuda, Suguru Kurokawa, Masanori Takehashi, Aika Maeda, Katsuya Fukuda, Yukari Kubo, Hyuma Nogusa, Tomoka Takatani-Nakase, Shujiro Okuda, Kunihiro Ueda and Seigo Tanaka

    Citation: BMC Neuroscience 2017 18:14

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  25. Content type: Research article

    Deposition of aggregated amyloid beta (Aβ) protein is hallmark of Alzheimer’s disease, leading to dysfunction and apoptosis of neurons. The isoflavone phytoestrogen compound genistein (Gen) exerts a significan...

    Authors: Fuling You, Qiao Li, Guifang Jin, Yaojie Zheng, Jingrong Chen and Hong Yang

    Citation: BMC Neuroscience 2017 18:12

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  26. Content type: Research Article

    A fundamental feature of early nervous system development is the guidance of axonal projections to their targets in order to assemble neural circuits that control behavior. Spinal commissural neurons are an at...

    Authors: Simon D. Sun, Ashley M. Purdy and Gregory S. Walsh

    Citation: BMC Neuroscience 2016 17:83

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  27. Content type: Research article

    The AP-2 transcription factor APTF-1 is crucially required for developmentally controlled sleep behavior in Caenorhabditis elegans larvae. Its human ortholog, TFAP-2beta, causes Char disease and has also been lin...

    Authors: Mariya M. Kucherenko, Vinodh Ilangovan, Bettina Herzig, Halyna R. Shcherbata and Henrik Bringmann

    Citation: BMC Neuroscience 2016 17:72

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  28. Content type: Research article

    Limited surveys have assessed the performance of 5-hydroxytreptamine receptor 1A and its antagonist WAY-100635 in pharmacological manipulations targeting delirium therapies. The purpose of this paper was to as...

    Authors: Yimin Qiu, Dongmei Chen, Xiaojing Huang, Lina Huang, Liang Tang, Jihong Jiang, Lianhua Chen and Shitong Li

    Citation: BMC Neuroscience 2016 17:66

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  29. Content type: Research article

    Polymorphisms in the gene for phosphatidylinositol binding clathrin assembly protein (PICALM), an endocytic-related protein, are associated with a small, increased risk of developing Alzheimer’s disease (AD), ...

    Authors: Rhian S. Thomas, Alex Henson, Amy Gerrish, Lesley Jones, Julie Williams and Emma J. Kidd

    Citation: BMC Neuroscience 2016 17:50

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  30. Content type: Research article

    MCT14 (SLC16A14) is an orphan member of the monocarboxylate transporter (MCT) family, also known as the SLC16 family of secondary active transmembrane transporters. Available expression data for this transport...

    Authors: Sahar Roshanbin, Frida A. Lindberg, Emilia Lekholm, Mikaela M. Eriksson, Emelie Perland, Johan Åhlund, Amanda Raine and Robert Fredriksson

    Citation: BMC Neuroscience 2016 17:43

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  31. Content type: Methodology article

    Conducting research on the molecular biology, immunology, and physiology of brain tumors (BTs) and primary brain tissues requires the use of viably dissociated single cells. Inadequate methods for tissue diss...

    Authors: Ilan Volovitz, Netanel Shapira, Haim Ezer, Aviv Gafni, Merav Lustgarten, Tal Alter, Idan Ben-Horin, Ori Barzilai, Tal Shahar, Andrew Kanner, Itzhak Fried, Igor Veshchev, Rachel Grossman and Zvi Ram

    Citation: BMC Neuroscience 2016 17:30

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  32. Content type: Research article

    To get a broader view of global ischemia-induced cerebral disorders at the metabolic level, a nuclear magnetic resonance-based metabolomic study was performed to evaluate the metabolic profile changes on regio...

    Authors: Tianshu Zhang, Wei Wang, Jin Huang, Xia Liu, Haiyan Zhang and Naixia Zhang

    Citation: BMC Neuroscience 2016 17:25

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  33. Content type: Research article

    Epilepsy is a common neurological disorder characterized by recurrent unprovoked seizures. Seizure-induced TLR4/MYD88 signaling plays a critical role in activating microglia and triggering neuron apoptosis. SA...

    Authors: Qing-Peng Hu and Ding-An Mao

    Citation: BMC Neuroscience 2016 17:22

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  34. Content type: Methodology article

    The decline of remyelination in chronic multiple sclerosis (MS) is in part attributed to inadequate oligodendrocyte precursor cell (OPC) migration, a process governed by the extracellular matrix (ECM). Elucida...

    Authors: Ryan W. O’Meara, Sarah E. Cummings, John-Paul Michalski and Rashmi Kothary

    Citation: BMC Neuroscience 2016 17:7

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  35. Content type: Research article

    Depression is one of the most prevalent mood disorders, and is known to be associated with abnormal functional connectivity in neural networks of the brain. Interestingly, a significant proportion of patients ...

    Authors: Arshi Khalid, Byung Sun Kim, Bo Am Seo, Soon-Tae Lee, Keun-Hwa Jung, Kon Chu, Sang Kun Lee and Daejong Jeon

    Citation: BMC Neuroscience 2016 17:4

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  36. Content type: Research Article

    Periventricular leukomalacia (PVL) is the leading cause of neurological disabilities including motor and cognitive deficits in premature infants. Periventricular leukomalacia is characterized by damage to the ...

    Authors: Xiao-Bo Liu, Yan Shen, David E. Pleasure and Wenbin Deng

    Citation: BMC Neuroscience 2016 17:2

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  37. Content type: Research article

    Hippocampal neurons in the brain polarize to form multiple dendrites and one long axon. The formation of central synapses remains poorly understood. Although several of the intracellular proteins involved in t...

    Authors: Yuriko Inoue, Yuji Kamikubo, Hiromitsu Ezure, Junji Ito, Yu Kato, Hiroshi Moriyama and Naruhito Otsuka

    Citation: BMC Neuroscience 2015 16:92

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  38. Content type: Research article

    Tropomyosin-related kinase A (TRKA) is a nerve growth factor (NGF) receptor that belongs to the tyrosine kinase receptor family. It is critical for the correct development of many types of neurons including pa...

    Authors: Kristi Luberg, Rahel Park, Elina Aleksejeva and Tõnis Timmusk

    Citation: BMC Neuroscience 2015 16:78

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  39. Content type: Research article

    UbcM2 is a ubiquitin-conjugating enzyme with roles in the turnover of damaged and misfolded proteins, cell cycle progression, development, and regulation of the antioxidant transcription factor, Nrf2. Recent s...

    Authors: Chelsea M. Larabee, Constantin Georgescu, Jonathan D. Wren and Scott M. Plafker

    Citation: BMC Neuroscience 2015 16:76

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  40. Content type: Review

    Accumulation of protein aggregates is the leading cause of cellular dysfunction in neurodegenerative disorders. Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease, Prion disease and motor...

    Authors: Shohreh Majd, John H. Power and Hugh J. M. Grantham

    Citation: BMC Neuroscience 2015 16:69

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  41. Content type: Research article

    Alpha (α)-amidation of peptides is a mechanism required for the conversion of prohormones into functional peptide sequences that display biological activities, receptor recognition and signal transduction on t...

    Authors: Benito Antón Palma, Philippe Leff Gelman, Mayra Medecigo Ríos, Juan Carlos Calva Nieves, Rodolfo Acevedo Ortuño, Maura Epifanía Matus Ortega, Jorge Alberto Hernández Calderón, Ricardo Hernández Miramontes, Anabel Flores Zamora and Alberto Salazar Juárez

    Citation: BMC Neuroscience 2015 16:65

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  42. Content type: Research article

    Neurogenesis in the brain of adult mammals occurs throughout life in two locations: the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus in the hippocampus. RNA interf...

    Authors: Filippo M. Cernilogar, Rossella Di Giaimo, Frederick Rehfeld, Silvia Cappello and D. Chichung Lie

    Citation: BMC Neuroscience 2015 16:60

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  43. Content type: Research article

    Oxycodone is an opioid that is prescribed to treat multiple types of pain, especially when other opioids are ineffective. Unfortunately, similar to other opioids, repetitive oxycodone administration has the po...

    Authors: Ruping Fan, Lisa M. Schrott, Stephen Snelling, Julius Ndi, Thomas Arnold and Nadejda L. Korneeva

    Citation: BMC Neuroscience 2015 16:58

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  44. Content type: Research article

    Necroptosis is a type of regulated form of cell death that has been implicated in the pathogenesis of various diseases. Receptor-interacting protein 3 (RIP3), a member of the RIP family of proteins, has been r...

    Authors: Wei Ding, Lei Shang, Ju-Fang Huang, Na Li, Dan Chen, Li-Xiang Xue and Kun Xiong

    Citation: BMC Neuroscience 2015 16:49

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