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Anatomy, development, plasticity and repair

This section covers all aspects of brain anatomy, development, plasticity and repair in human, cellular, organoid and animal models. Topics of interest include, but are not limited to, neural development, glial development, neural activity, synapse formation, stem cells, plasticity, neurotrauma and repair, neuropharmacology, pathophysiology, and regeneration and genetics and genomics of neural development and function.

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  1. Hepatic encephalopathy (HE) is a reversible neuropsychiatric syndrome associated with acute and chronic liver diseases. It includes a number of neuropsychiatric disturbances including impaired motor activity a...

    Authors: Jeng-Rung Chen, Bing-Ning Wang, Guo-Fang Tseng, Yueh-Jan Wang, Yong-San Huang and Tsyr-Jiuan Wang

    Citation: BMC Neuroscience 2014 15:15

    Content type: Research article

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  2. The neurotrophin Nerve Growth factor (NGF) is known to influence the phenotype of mature nociceptors, for example by altering synthesis of neuropeptides, and changes in NGF levels have been implicated in the p...

    Authors: Laura J Evans, Alison R Loescher, Fiona M Boissonade, Simon A Whawell, Peter P Robinson and David Andrew

    Citation: BMC Neuroscience 2014 15:1

    Content type: Research article

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  3. Transplantation of olfactory ensheathing cells (OEC) and Schwann cells (SC) is a promising therapeutic strategy to promote axonal growth and remyelination after spinal cord injury. Previous studies mainly focu...

    Authors: Frank Roloff, Susanne Ziege, Wolfgang Baumgärtner, Konstantin Wewetzer and Gerd Bicker

    Citation: BMC Neuroscience 2013 14:141

    Content type: Research article

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  4. IGFBP-4 has been considered as a factor involving in development of the central nervous system (CNS), but its role needs to be further clarified. In present study, the localization of IGFBP-4 expression in the...

    Authors: Xiaohua Jiang, Junpeng Zhao, Lili Ju, Yujun Liu, Beibei Wang, Xifeng Zou, Changlei Xu and Quanyuan Xu

    Citation: BMC Neuroscience 2013 14:132

    Content type: Research article

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  5. The neural stem cells discovered in the adult ciliary epithelium (CE) in higher vertebrates have emerged as an accessible source of retinal progenitors; these cells can self-renew and possess retinal potential...

    Authors: Carolina Beltrame Del Debbio, Xu Peng, Huangui Xiong and Iqbal Ahmad

    Citation: BMC Neuroscience 2013 14:130

    Content type: Research article

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  6. The efficient derivation of mature (Hb9+) motor neurons from embryonic stem cells is a sought-after goal in the understanding, and potential treatment, of motor neuron diseases. Conditions that promote the rob...

    Authors: Yiota A Christou, Kyoji Ohyama, Marysia Placzek, Peter N Monk and Pamela J Shaw

    Citation: BMC Neuroscience 2013 14:126

    Content type: Research article

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  7. Irradiation with light wavelengths from the far red (FR) to the near infrared (NIR) spectrum (600 nm -1000 nm) has been shown to have beneficial effects in several disease models. In this study, we aim to exam...

    Authors: Rizalyn Albarracin, Riccardo Natoli, Matthew Rutar, Krisztina Valter and Jan Provis

    Citation: BMC Neuroscience 2013 14:125

    Content type: Research article

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  8. Idiopathic cervical dystonia is characterized by involuntary spasms, tremors or jerks. It is not restricted to a disturbance in the basal ganglia system because non-conventional voxel-based MRI morphometry (VB...

    Authors: Tino Prell, Thomas Peschel, Bernadette Köhler, Martin H Bokemeyer, Reinhard Dengler, Albrecht Günther and Julian Grosskreutz

    Citation: BMC Neuroscience 2013 14:123

    Content type: Research article

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  9. Microglia possess an elevated grade of plasticity, undergoing several structural changes based on their location and state of activation. The first step towards the comprehension of microglia’s biology and fun...

    Authors: Susanna Amadio, Adele De Ninno, Cinzia Montilli, Luca Businaro, Annamaria Gerardino and Cinzia Volonté

    Citation: BMC Neuroscience 2013 14:121

    Content type: Research article

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  10. There is growing evidence that inflammatory processes of activated microglia could play an important role in the progression of nerve cell damage in neurodegenerative disorders such as Parkinson’s disease and ...

    Authors: Dae-Yong Song, Ha-Nul Yu, Chae-Ri Park, Jin-Sook Lee, Ji-Yong Lee, Byung-Gu Park, Ran-Sook Woo, Jung-Tae Han, Byung-Pil Cho and Tai-Kyoung Baik

    Citation: BMC Neuroscience 2013 14:112

    Content type: Research article

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  11. Aging is typically accompanied by memory decline and changes in hippocampal function. Among these changes is a decline in the activity of the dentate gyrus (DG) during behavior. Lasting memory, however, is tho...

    Authors: Ali Gheidi, Erin Azzopardi, Allison A Adams and Diano F Marrone

    Citation: BMC Neuroscience 2013 14:100

    Content type: Research article

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  12. The neocortex is a highly specialised and complex brain structure, involved in numerous tasks, ranging from processing and interpretation of somatosensory information, to control of motor functions. The normal...

    Authors: Kari M Ersland, Bjarte Håvik, Johanne Egge Rinholm, Vidar Gundersen, Christine Stansberg and Vidar M Steen

    Citation: BMC Neuroscience 2013 14:68

    Content type: Research article

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  13. Psychological conditions affect pain responses in the human anterior cingulate cortex (ACC) according to brain imaging analysis. The rodent prefrontal cortex (PFC) including cingulate areas is also related to ...

    Authors: Shoichi Sogabe, Yuki Yagasaki, Kitaro Onozawa and Yoriko Kawakami

    Citation: BMC Neuroscience 2013 14:65

    Content type: Research article

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  14. Fetal asphyctic (FA) preconditioning is effective in attenuating brain damage incurred by a subsequent perinatal asphyctic insult. Unraveling mechanisms of this endogenous neuroprotection, activated by FA prec...

    Authors: Kimberly EM Cox-Limpens, Johan SH Vles, Jana Schlechter, Luc JI Zimmermann, Eveline Strackx and Antonio WD Gavilanes

    Citation: BMC Neuroscience 2013 14:61

    Content type: Research article

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  15. Previous studies have suggested that the axon guidance proteins Slit1 and Slit2 co-operate to establish the optic chiasm in its correct position at the ventral diencephalic midline. This is based on the observ...

    Authors: Matthew Down, David A Willshaw, Thomas Pratt and David J Price

    Citation: BMC Neuroscience 2013 14:9

    Content type: Research article

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  16. The role of the endothelial cell (EC) in blood flow regulation within the central nervous system has been little studied. Here, we explored EC participation in morphological changes of the anterior hypothalami...

    Authors: Albertina Cortés-Sol, Miguel Lara-Garcia, Mayvi Alvarado, Robyn Hudson, Pere Berbel and Pablo Pacheco

    Citation: BMC Neuroscience 2013 14:7

    Content type: Research article

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  17. The rd1 mouse retina is a well-studied model of retinal degeneration where rod photoreceptors undergo cell death beginning at postnatal day (P) 10 until P21. This period coincides with photoreceptor terminal diff...

    Authors: Virginia M Dickison, Angela M Richmond, Ameair Abu Irqeba, Joshua G Martak, Sean CE Hoge, Matthew J Brooks, Mohammed I Othman, Ritu Khanna, Alan J Mears, Adnan Y Chowdhury, Anand Swaroop and Judith Mosinger Ogilvie

    Citation: BMC Neuroscience 2012 13:152

    Content type: Research article

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  18. Trigeminal nerve is a major source of the sensory input of the face, and trigeminal neuropathology models have been reported in rodents with injury to branches of the maxillary or mandibular division of the tr...

    Authors: Ning Guo, Xiyao Gu, Jun Zhao, Guoping Zhao, Meilei Jin, Hong Zou, Yuqiu Zhang, Zhiqi Zhao, Gang Jason Jin and Lei Yu

    Citation: BMC Neuroscience 2012 13:150

    Content type: Research article

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  19. Successful delivery of compounds to the brain and retina is a challenge in the development of therapeutic drugs and imaging agents. This challenge arises because internalization of compounds into the brain and...

    Authors: Kohei Watanabe, Yuhei Nishimura, Tsuyoshi Nomoto, Noriko Umemoto, Zi Zhang, Beibei Zhang, Junya Kuroyanagi, Yasuhito Shimada, Taichi Shintou, Mie Okano, Takeshi Miyazaki, Takeshi Imamura and Toshio Tanaka

    Citation: BMC Neuroscience 2012 13:101

    Content type: Methodology article

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  20. During development neural crest derived Schwann Cell (SC) precursors migrate to nerve trunks and populate nascent nerves. Axonal ensheathment by SC is a prerequisite for normal nerve function and the integrity...

    Authors: Stephan Heermann, Björn Spittau, Katalin Zajzon, Markus H Schwab and Kerstin Krieglstein

    Citation: BMC Neuroscience 2012 13:92

    Content type: Research article

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  21. Members of the proteolipid protein family, including the four-transmembrane glycoprotein M6a, are involved in neuronal plasticity in mammals. Results from our group previously demonstrated that M6, the only pr...

    Authors: María Paula Zappia, Guillermo Bernabo, Silvia C Billi, Alberto C Frasch, María Fernanda Ceriani and Marcela Adriana Brocco

    Citation: BMC Neuroscience 2012 13:78

    Content type: Research article

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  22. Originating from a marine ancestor, the myriapods most likely invaded land independently of the hexapods. As these two evolutionary lineages conquered land in parallel but separately, we are interested in comp...

    Authors: Andy Sombke, Elisabeth Lipke, Matthes Kenning, Carsten HG Müller, Bill S Hansson and Steffen Harzsch

    Citation: BMC Neuroscience 2012 13:1

    Content type: Research article

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  23. Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, known as statins, are commonly used as cholesterol-lowering drugs. During the past decade, evidence has emerged that statins also have neuroprotec...

    Authors: Yves Brand, Cristian Setz, Soledad Levano, Alwin Listyo, Eduardo Chavez, Kwang Pak, Michael Sung, Vesna Radojevic, Allen F Ryan and Daniel Bodmer

    Citation: BMC Neuroscience 2011 12:114

    Content type: Research article

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  24. Activation of amoeboid microglial cells (AMC) and its related inflammatory response have been linked to the periventricular white matter damage after hypoxia in neonatal brain. Hypoxia increases free ATP in th...

    Authors: Fan Li, Lei Wang, Ji-Wei Li, Min Gong, Liang He, Rui Feng, Zhen Dai and Shu-Qing Li

    Citation: BMC Neuroscience 2011 12:111

    Content type: Research article

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  25. The Dystrophin Glycoprotein Complex (DGC) is a large multi-component complex that is well known for its function in muscle tissue. When the main components of the DGC, Dystrophin (Dys) and Dystroglycan (Dg) ar...

    Authors: April K Marrone, Mariya M Kucherenko, Valentyna M Rishko and Halyna R Shcherbata

    Citation: BMC Neuroscience 2011 12:93

    Content type: Research article

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  26. Unlike mammals, teleost fishes are capable of regenerating sensory inner ear hair cells that have been lost following acoustic or ototoxic trauma. Previous work indicated that immediately following sound expos...

    Authors: Julie B Schuck, Huifang Sun, W Todd Penberthy, Nigel GF Cooper, Xiaohong Li and Michael E Smith

    Citation: BMC Neuroscience 2011 12:88

    Content type: Research article

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  27. Synaptic burst activation feeds back as a short-term depression of release probability at hippocampal CA3-CA1 synapses. This short-term synaptic plasticity requires functional astrocytes and it affects both th...

    Authors: My S Andersson and Eric Hanse

    Citation: BMC Neuroscience 2011 12:87

    Content type: Research article

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  28. In cat visual cortex, critical period neuronal plasticity is minimal until approximately 3 postnatal weeks, peaks at 5 weeks, gradually declines to low levels at 20 weeks, and disappears by 1 year of age. Dark...

    Authors: Cui Bo Yang, Yu Ting Zheng, Paul J Kiser and George D Mower

    Citation: BMC Neuroscience 2011 12:70

    Content type: Research article

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  29. It is difficult to repair nerve if proximal stump is unavailable or autogenous nerve grafts are insufficient for reconstructing extensive nerve damage. Therefore, alternative methods have been developed, inclu...

    Authors: Petr Dubový, Otakar Raška, Ilona Klusáková, Lubomír Stejskal, Pavel Čelakovský and Pavel Haninec

    Citation: BMC Neuroscience 2011 12:58

    Content type: Research article

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  30. Insect neuropeptides are involved in diverse physiological functions and can be released as neurotransmitters or neuromodulators acting within the central nervous system, and as circulating neurohormones in in...

    Authors: Hsiao-Ling Lu and Patricia V Pietrantonio

    Citation: BMC Neuroscience 2011 12:57

    Content type: Research article

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  31. Oxidative stress and large amounts of nitric oxide (NO) have been implicated in the pathophysiology of neuronal injury and neurodegenerative disease. Recent studies have shown that (-)-epigallocatechin gallate...

    Authors: I-Hua Wei, Hui-Chin Tu, Chih-Chia Huang, Mang-Hung Tsai, Chi-Yu Tseng and Jeng-Yung Shieh

    Citation: BMC Neuroscience 2011 12:52

    Content type: Research article

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  32. Histone deacetylases (HDACs) are enzymes that modulate gene expression and cellular processes by deacetylating histones and non-histone proteins. While small molecule inhibitors of HDAC activity (HDACi) are us...

    Authors: Qiong Zhou, Clifton L Dalgard, Christopher Wynder and Martin L Doughty

    Citation: BMC Neuroscience 2011 12:50

    Content type: Research article

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  33. Mutations in the LGI1 gene predispose to a rare, hereditary form of temporal epilepsy. Currently, little is known about the temporal and spatial expression pattern of Lgi1 during normal embryogenesis and so to...

    Authors: Jeane Silva, Guanghu Wang and John K Cowell

    Citation: BMC Neuroscience 2011 12:43

    Content type: Research article

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  34. The vertebrate peripheral nervous system contains sensory neurons that arise from ectodermal placodes. Placodal cells ingress to move inside the head to form sensory neurons of the cranial ganglia. To date, ho...

    Authors: Celia E Shiau, Raman M Das and Kate G Storey

    Citation: BMC Neuroscience 2011 12:37

    Content type: Methodology article

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  35. Enkephalins are endogenous opiates that are assumed to modulate nociceptive information by mediating synaptic transmission in the central nervous system, including the spinal dorsal horn.

    Authors: Teruyuki Fukushima, Masayuki Tsuda, Takefumi Kofuji and Yuuichi Hori

    Citation: BMC Neuroscience 2011 12:36

    Content type: Research article

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  36. The sphingolipids galactosylceramide (GalCer) and sulfatide are major myelin components and are thought to play important roles in myelin function. The importance of GalCer and sulfatide has been validated usi...

    Authors: Marion Meixner, Julia Jungnickel, Claudia Grothe, Volkmar Gieselmann and Matthias Eckhardt

    Citation: BMC Neuroscience 2011 12:22

    Content type: Research article

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  37. Disabled-1 (Dab1) is an adaptor protein that is essential for the intracellular transduction of Reelin signaling, which regulates the migration and differentiation of postmitotic neurons during brain developme...

    Authors: Huan Long, Hans H Bock, Ting Lei, Xuejun Chai, Jihong Yuan, Joachim Herz, Michael Frotscher and Zaiqing Yang

    Citation: BMC Neuroscience 2011 12:17

    Content type: Research article

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  38. The Na+,K+-ATPase plays an important role for ion homeostasis in virtually all mammalian cells, including neurons. Despite this, there is as yet little known about the isoform specific distribution in neurons.

    Authors: Hans Blom, Daniel Rönnlund, Lena Scott, Zuzana Spicarova, Jerker Widengren, Alexander Bondar, Anita Aperia and Hjalmar Brismar

    Citation: BMC Neuroscience 2011 12:16

    Content type: Research article

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  39. Extracellular-signal regulated kinase (ERK1/2) is activated by nerve damage and its activation precedes survival and proliferation of Schwann cells. In contrast, activation of caspase 3, a cysteine protease, i...

    Authors: Yoshifumi Tsuda, Martin Kanje and Lars B Dahlin

    Citation: BMC Neuroscience 2011 12:12

    Content type: Research article

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  40. The mammalian suprachiasmatic nucleus (SCN), located in the ventral hypothalamus, is a major regulator of circadian rhythms in mammals and birds. However, the role of the SCN in lower vertebrates remains poorl...

    Authors: Ramil R Noche, Po-Nien Lu, Lauren Goldstein-Kral, Eric Glasgow and Jennifer O Liang

    Citation: BMC Neuroscience 2011 12:7

    Content type: Research article

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  41. According to several lines of evidence, the great expansion observed in the primate prefrontal cortex (PfC) was accompanied by the emergence of new cortical areas during phylogenetic development. As a conseque...

    Authors: Roelf J Cruz-Rizzolo, Miguel AX De Lima, Edilson Ervolino, José A de Oliveira and Claudio A Casatti

    Citation: BMC Neuroscience 2011 12:6

    Content type: Research article

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  42. Previously we have found that cannabinoid treatment of zebra finches during sensorimotor stages of vocal development alters song patterns produced in adulthood. Such persistently altered behavior must be attri...

    Authors: Ken Soderstrom, Justin L Poklis and Aron H Lichtman

    Citation: BMC Neuroscience 2011 12:3

    Content type: Research article

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  43. Lack of appropriate tools and techniques to study fate and functional integration of newly generated neurons has so far hindered understanding of neurogenesis' relevance under physiological and pathological co...

    Authors: Jingzhong Zhang, Florian Giesert, Karina Kloos, Daniela M Vogt Weisenhorn, Ludwig Aigner, Wolfgang Wurst and Sebastien Couillard-Despres

    Citation: BMC Neuroscience 2010 11:158

    Content type: Research article

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  44. Hypertonic saline and mannitol are commonly used in the treatment of cerebral edema and elevated intracranial pressure (ICP) at present. In this connection, 10% hypertonic saline (HS) alleviates cerebral edema...

    Authors: Hong-Ke Zeng, Qiao-Sheng Wang, Yi-Yu Deng, Wen-Qiang Jiang, Ming Fang, Chun-Bo Chen and Xin Jiang

    Citation: BMC Neuroscience 2010 11:153

    Content type: Research article

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