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Anatomy, development, plasticity and repair

Section edited by Charanjit Kaur

This section is dedicated to covering brain anatomy, development, plasticity and repair. Topics of interest include, but are not limited to, neurodevelopment, neural activity, synapse formation, stem cells, blood flow in the brain and neurobehavioural genetics.

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  1. Content type: Research article

    Previously, we have shown that transgenic cells bearing the GDNF gene with deleted pre- and pro-regions (mGDNF) can release transgenic GDNF. The medium conditioned by transgenic cells with mGDNF induced axonal...

    Authors: A. Revishchin, L. Moiseenko, N. Kust, N. Bazhenova, P. Teslia, D. Panteleev, V. Kovalzon and G. Pavlova

    Citation: BMC Neuroscience 2016 17:34

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  2. Content type: Research article

    A major area of unmet need is the development of strategies to restore neuronal network systems and to recover brain function in patients with neurological disease. The use of cell-based therapies remains an a...

    Authors: Jaime Belkind-Gerson, Ryo Hotta, Michael Whalen, Naema Nayyar, Nandor Nagy, Lily Cheng, Aaron Zuckerman, Allan M. Goldstein and Jorg Dietrich

    Citation: BMC Neuroscience 2016 17:5

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  3. Content type: Research article

    Nerve growth factor (NGF) is known not only as a major factor for neuronal plasticity but also as a pain stimulator. Although there have been several trials with NGF for its application in the regeneration or ...

    Authors: Joo-Yeon Kang, Dae Young Yoo, Kwon-Young Lee, Wooseok Im, Manho Kim, Jung Hoon Choi, Hwa-Young Youn, Sae Hoon Kim, In Koo Hwang and Jin-Young Chung

    Citation: BMC Neuroscience 2016 17:1

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  4. Content type: Research article

    WDR81 (WD repeat-containing protein 81) is associated with cerebellar ataxia, mental retardation and disequilibrium syndrome (CAMRQ2, [MIM 610185]). Human and mouse studies suggest tha...

    Authors: Fusun Doldur-Balli, Mehmet Neset Ozel, Suleyman Gulsuner, Ayse B. Tekinay, Tayfun Ozcelik, Ozlen Konu and Michelle M. Adams

    Citation: BMC Neuroscience 2015 16:96

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  5. Content type: Research article

    Scutellarin, an anti-inflammatory agent, effectively suppressed microglia activation in rats with middle cerebral artery occlusion (MCAO). Robust microglia activation, acute in onset, was followed by astroglio...

    Authors: Ming Fang, Yun Yuan, Parakalan Rangarajan, Jia Lu, Yajun Wu, Huadong Wang, Chunyun Wu and Eng-Ang Ling

    Citation: BMC Neuroscience 2015 16:84

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  6. Content type: Research Article

    It is well documented that the nitric oxide (NO) might be directly involved in brain response to hypobaric hypoxia, and could contribute to memory deficiencies. Recent studies have shown that melatonin could a...

    Authors: Chih-Chia Huang, Chia-Jou Lai, Mang-Hung Tsai, Ya-Chieh Wu, Kuang-Ti Chen, Ming-Jia Jou, Pin-I Fu, Ching-Hsiang Wu and I-Hua Wei

    Citation: BMC Neuroscience 2015 16:61

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  7. Content type: Research article

    The transplantation of bone marrow stromal cells (MSCs) has proved to ameliorate ischemic brain injury in animals, but most transplanted MSCs undergo apoptosis in the ischemic penumbra, greatly compromising th...

    Authors: Yi-Xian Zhang, Ming-Zhou Yuan, Lin Cheng, Long-Zai Lin, Hou-Wei Du, Rong-Hua Chen and Nan Liu

    Citation: BMC Neuroscience 2015 16:56

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  8. Content type: Research article

    While the tripartite brain of arthropods is believed to have evolved by a fusion of initially separate ganglia, the evolutionary origin of the bipartite brain of onychophorans—one of the closest arthropod rela...

    Authors: Christine Martin and Georg Mayer

    Citation: BMC Neuroscience 2015 16:53

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  9. Content type: Research article

    GABAA receptor-mediated neurotransmission is greatly influenced by cation-chloride cotransporter activity during developmental stages. In embryonic neurons Na–K–2Cl (NKCC1) cotransporters mediate active chloride ...

    Authors: Joelle N Chabwine, Karel Talavera, Ludo Van Den Bosch and Geert Callewaert

    Citation: BMC Neuroscience 2015 16:41

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  10. Content type: Research article

    Axons from the visceral motor neurons (vMNs) project from nuclei in the hindbrain to innervate autonomic ganglia and branchial arch-derived muscles. Although much is known about the events that govern specific...

    Authors: Jessica M Rosin, Deborah M Kurrasch and John Cobb

    Citation: BMC Neuroscience 2015 16:39

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  11. Content type: Research article

    Niemann-Pick type C1 (NPC1) disease is an inherited lysosomal storage disease caused by mutation of the Npc1 gene, resulting in a progressive accumulation of unesterified cholesterol and glycolipids in lysosomes ...

    Authors: Xin Yan, Lucy Ma, Marina Hovakimyan, Jan Lukas, Andreas Wree, Marcus Frank, Rudolf Guthoff, Arndt Rolfs, Martin Witt and Jiankai Luo

    Citation: BMC Neuroscience 2014 15:126

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  12. Content type: Research article

    In response to cerebral ischemia, activated microglia release excessive inflammatory mediators which contribute to neuronal damage. Therefore, inhibition of microglial over-activation could be a therapeutic st...

    Authors: Yun Yuan, Hao Zha, Parakalan Rangarajan, Eng-Ang Ling and Chunyun Wu

    Citation: BMC Neuroscience 2014 15:125

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  13. Content type: Research article

    There has been increasing interest recently in the plasticity of mesenchymal stem cells (MSCs) and their potential to differentiate into neural lineages. To unravel the roles and effects of different growth fa...

    Authors: Tee Jong Huat, Amir Ali Khan, Soumya Pati, Zulkifli Mustafa, Jafri Malin Abdullah and Hasnan Jaafar

    Citation: BMC Neuroscience 2014 15:91

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  14. Content type: Research article

    Understanding the underlying causes of nicotine addiction will require a multidisciplinary approach examining the key molecular, cellular and neuronal circuit functional changes that drive escalating levels of...

    Authors: Anthony Renda and Raad Nashmi

    Citation: BMC Neuroscience 2014 15:89

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  15. Content type: Research article

    The boundary cap is a transient group of neural crest-derived cells located at the presumptive dorsal root transitional zone (DRTZ) when sensory axons enter the spinal cord during development. Later, these cel...

    Authors: Carl Trolle, Niclas Konig, Ninnie Abrahamsson, Svitlana Vasylovska and Elena N Kozlova

    Citation: BMC Neuroscience 2014 15:60

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  16. Content type: Research article

    Myelination is a very complex process that requires the cross talk between various neural cell types. Previously, using cytosolic or membrane associated GFP tagged neurospheres, we followed the interaction of ...

    Authors: Kalliopi Ioannidou, Kurt I Anderson, David Strachan, Julia M Edgar and Susan C Barnett

    Citation: BMC Neuroscience 2014 15:59

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  17. Content type: Research article

    Norbin is a neuron-specific, cytosolic protein that interacts with the metabotropic glutamate receptor 5 (mGluR5) and has a profound impact on mGluR5 signaling. Yet, little is known about its synaptic distribu...

    Authors: Linda Westin, Matthias Reuss, Maria Lindskog, Anita Aperia and Hjalmar Brismar

    Citation: BMC Neuroscience 2014 15:45

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  18. Content type: Research article

    Epidermal growth factor receptor substrate 8 (Eps8) is a multifunctional protein that regulates actin cytoskeleton dynamics and architecture through its barbed-end capping and bundling activities. In cultured ...

    Authors: Chiung-Chun Huang, Yun-Shen Lin, Cheng-Che Lee and Kuei-Sen Hsu

    Citation: BMC Neuroscience 2014 15:26

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