Anatomy, development, plasticity and repair

Section edited by Charanjit Kaur

This section is dedicated to covering brain anatomy, development, plasticity and repair. Topics of interest include, but are not limited to, neurodevelopment, neural activity, synapse formation, stem cells, blood flow in the brain and neurobehavioural genetics.

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  1. Research article

    Regeneration of long-distance peripheral nerve defects after delayed reconstruction in healthy and diabetic rats is supported by immunomodulatory chitosan nerve guides

    Delayed reconstruction of transection or laceration injuries of peripheral nerves is inflicted by a reduced regeneration capacity. Diabetic conditions, more frequently encountered in clinical practice, are kno...

    Lena Stenberg, Maria Stößel, Giulia Ronchi, Stefano Geuna, Yaobin Yin, Susanne Mommert, Lisa Mårtensson, Jennifer Metzen, Claudia Grothe, Lars B. Dahlin and Kirsten Haastert-Talini

    BMC Neuroscience 2017 18:53

    Published on: 18 July 2017

  2. Research article

    Hypertonic saline attenuates expression of Notch signaling and proinflammatory mediators in activated microglia in experimentally induced cerebral ischemia and hypoxic BV-2 microglia

    Ischemic stroke is a major disease that threatens human health in ageing population. Increasing evidence has shown that neuroinflammatory mediators play crucial roles in the pathophysiology of cerebral ischemi...

    Wen-Xin Zeng, Yong-Li Han, Gao-Feng Zhu, Lin-Qiang Huang, Yi-Yu Deng, Qiao-Sheng Wang, Wen-Qiang Jiang, Miao-Yun Wen, Qian-Peng Han, Di Xie and Hong-Ke Zeng

    BMC Neuroscience 2017 18:32

    Published on: 14 March 2017

  3. Research article

    Effect of skilled reaching training and enriched environment on generation of oligodendrocytes in the adult sensorimotor cortex and corpus callosum

    Increased motor activity or social interactions through enriched environment are strong stimulators of grey and white matter plasticity in the adult rodent brain. In the present study we evaluated whether spe...

    Silke Keiner, Fanny Niv, Susanne Neumann, Tanja Steinbach, Christian Schmeer, Katrin Hornung, Yvonne Schlenker, Martin Förster, Otto W. Witte and Christoph Redecker

    BMC Neuroscience 2017 18:31

    Published on: 9 March 2017

  4. Research article

    Effect of Spp1 on nerve degeneration and regeneration after rat sciatic nerve injury

    Wallerian degeneration (WD) in injured peripheral nerves is associated with a large number of up- or down-regulated genes, but the effects of these changes are poorly understood. In our previous studies, we re...

    Xingyu Liu, Yuhua Sun, Huaiqin Li, Yuting Li, Meiyuan Li, Ying Yuan, Shusen Cui and Dengbing Yao

    BMC Neuroscience 2017 18:30

    Published on: 7 March 2017

  5. Research article

    Immunization with neural derived peptides plus scar removal induces a permissive microenvironment, and improves locomotor recovery after chronic spinal cord injury

    Immunization with neural derived peptides (INDP) as well as scar removal—separately—have shown to induce morphological and functional improvement after spinal cord injury (SCI). In the present study, we compar...

    Roxana Rodríguez-Barrera, Adrián Flores-Romero, Ana María Fernández-Presas, Elisa García-Vences, Raúl Silva-García, Mina Konigsberg, Liliana Blancas-Espinoza, Vinnitsa Buzoianu-Anguiano, Karla Soria-Zavala, Paola Suárez-Meade and Antonio Ibarra

    BMC Neuroscience 2017 18:7

    Published on: 5 January 2017

  6. Research Article

    Bone morphogenetic protein-2-mediated pain and inflammation in a rat model of posterolateral arthrodesis

    Bone morphogenetic protein-2 (BMP-2) is a pleiotropic, secreted molecule with diverse effects. The potent ability of BMP-2 to stimulate bone growth prompted its widespread clinical use for arthrodesis (spine f...

    Kendall Mitchell, Jill P. Shah, Clifton L. Dalgard, Lyubov V. Tsytsikova, Ashley C. Tipton, Anton E. Dmitriev and Aviva J. Symes

    BMC Neuroscience 2016 17:80

    Published on: 1 December 2016

  7. Research article

    Hypertonic saline alleviates experimentally induced cerebral oedema through suppression of vascular endothelial growth factor and its receptor VEGFR2 expression in astrocytes

    Cerebral oedema is closely related to the permeability of blood–brain barrier, vascular endothelial growth factor (VEGF) and its receptor vascular endothelial growth factor receptor 2 (VEGFR2) all of which are...

    Linqiang Huang, Wei Cao, Yiyu Deng, Gaofeng Zhu, Yongli Han and Hongke Zeng

    BMC Neuroscience 2016 17:64

    Published on: 13 October 2016

  8. Research article

    Col1a1+ perivascular cells in the brain are a source of retinoic acid following stroke

    Perivascular stromal cells (PSCs) are a recently identified cell type that comprises a small percentage of the platelet derived growth factor receptor-β+ cells within the CNS perivascular space. PSCs are activ...

    Kathleen K. Kelly, Amber M. MacPherson, Himmat Grewal, Frank Strnad, Jace W. Jones, Jianshi Yu, Keely Pierzchalski, Maureen A. Kane, Paco S. Herson and Julie A. Siegenthaler

    BMC Neuroscience 2016 17:49

    Published on: 15 July 2016

  9. Research article

    Effects of striatal transplantation of cells transfected with GDNF gene without pre- and pro-regions in mouse model of Parkinson’s disease

    Previously, we have shown that transgenic cells bearing the GDNF gene with deleted pre- and pro-regions (mGDNF) can release transgenic GDNF. The medium conditioned by transgenic cells with mGDNF induced axonal...

    A. Revishchin, L. Moiseenko, N. Kust, N. Bazhenova, P. Teslia, D. Panteleev, V. Kovalzon and G. Pavlova

    BMC Neuroscience 2016 17:34

    Published on: 10 June 2016

  10. Research article

    Developmental interneuron subtype deficits after targeted loss of Arx

    Aristaless-related homeobox (ARX) is a paired-like homeodomain transcription factor that functions primarily as a transcriptional repressor and has been implicated in neocortical interneuron specification and mig...

    Eric D. Marsh, MacLean Pancoast Nasrallah, Caroline Walsh, Kaitlin A. Murray, C. Nicole Sunnen, Almedia McCoy and Jeffrey A. Golden

    BMC Neuroscience 2016 17:35

    Published on: 10 June 2016

  11. Research article

    Engraftment of enteric neural progenitor cells into the injured adult brain

    A major area of unmet need is the development of strategies to restore neuronal network systems and to recover brain function in patients with neurological disease. The use of cell-based therapies remains an a...

    Jaime Belkind-Gerson, Ryo Hotta, Michael Whalen, Naema Nayyar, Nandor Nagy, Lily Cheng, Aaron Zuckerman, Allan M. Goldstein and Jorg Dietrich

    BMC Neuroscience 2016 17:5

    Published on: 25 January 2016

  12. Research article

    SP, CGRP changes in pyridoxine induced neuropathic dogs with nerve growth factor gene therapy

    Nerve growth factor (NGF) is known not only as a major factor for neuronal plasticity but also as a pain stimulator. Although there have been several trials with NGF for its application in the regeneration or ...

    Joo-Yeon Kang, Dae Young Yoo, Kwon-Young Lee, Wooseok Im, Manho Kim, Jung Hoon Choi, Hwa-Young Youn, Sae Hoon Kim, In Koo Hwang and Jin-Young Chung

    BMC Neuroscience 2016 17:1

    Published on: 5 January 2016

  13. Research article

    Characterization of a novel zebrafish (Danio rerio) gene, wdr81, associated with cerebellar ataxia, mental retardation and dysequilibrium syndrome (CAMRQ)

    WDR81 (WD repeat-containing protein 81) is associated with cerebellar ataxia, mental retardation and disequilibrium syndrome (CAMRQ2, [MIM 610185]). Human and mouse studies suggest tha...

    Fusun Doldur-Balli, Mehmet Neset Ozel, Suleyman Gulsuner, Ayse B. Tekinay, Tayfun Ozcelik, Ozlen Konu and Michelle M. Adams

    BMC Neuroscience 2015 16:96

    Published on: 23 December 2015

  14. Research article

    Scutellarin regulates microglia-mediated TNC1 astrocytic reaction and astrogliosis in cerebral ischemia in the adult rats

    Scutellarin, an anti-inflammatory agent, effectively suppressed microglia activation in rats with middle cerebral artery occlusion (MCAO). Robust microglia activation, acute in onset, was followed by astroglio...

    Ming Fang, Yun Yuan, Parakalan Rangarajan, Jia Lu, Yajun Wu, Huadong Wang, Chunyun Wu and Eng-Ang Ling

    BMC Neuroscience 2015 16:84

    Published on: 25 November 2015

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