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Fig. 5 | BMC Neuroscience

Fig. 5

From: Effects of HDAC inhibitors on neuroblastoma SH-SY5Y cell differentiation into mature neurons via the Wnt signaling pathway

Fig. 5

Noncanonical Wnt signaling for neuronal differentiation with HDAC inhibitors. HDAC inhibitors activate Wnt4, Wnt5α, Wnt 11, and the Fzd receptor. Fzd activates Dvl and stimulates the Wnt/Ca2+ or Wnt/JNK pathway. In the Wnt/Ca2+ pathway, activated Dvl promotes Ca2+, which stimulates PKC. In the Wnt/JNK pathway, activated Dvl promotes phosphorylated ERK and phosphorylated JNK. Finally, c-Jun, a transcription factor, binds to DNA and promotes neuronal differentiation. Here, we demonstrate that Wnt4/5α/11 can modulate Dvl/PKC signaling and the Dvl/p-ERK/p-JNK pathway for neuronal differentiation following HDAC inhibition. Orange color indicates the signaling observed in this study

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