Table 4 The partial correlation between the performance in MWM and hippocampal GDNF-GFRα1 expression in F2 generation
Cognitive parameters | Ages | Groups | GDNF [r (p)] | GFRα1 [r (p)] | ||
|---|---|---|---|---|---|---|
Protein | mRNA | Protein | mRNA | |||
Swam distance | 3 months | F2-CON | − 0.273 (0.477) | − 0.502 (0.169) | − 0.498 (0.173) | − 0.562 (0.115) |
Mother-LPS | 0.206 (0.594) | 0.061 (0.876) | − 0.029 (0.940) | 0.278 (0.468) | ||
Father-LPS | − 0.612 (0.080) | − 0.444 (0.232) | − 0.560 (0.117) | − 0.441 (0.234) | ||
Parents-LPS | 0.112 (0.773) | − 0.289 (0.450) | − 0.062 (0.874) | − 0.424 (0.256) | ||
15 months | F2-CON | − 0.135 (0.729) | − 0.335 (0.377) | − 0.346 (0.362) | 0.110 (0.778) | |
Mother-LPS | − 0.631 (0.068) | − 0.645 (0.061) | − 0.586 (0.098) | −0.043 (0.913) | ||
Father-LPS | − 0.020 (0.959) | − 0.345 (0.363) | − 0.353 (0.352) | −0.377 (0.318) | ||
Parents-LPS | − 0.336 (0.377) | − 0.688 (0.041)* | − 0.436 (0.241) | −0.421 (0.259) | ||
Percentage swam distance in target quadrant | 3 months | F2-CON | 0.242 (0.530) | 0.563 (0.115) | 0.519 (0.152) | 0.535 (0.138) |
Mother-LPS | 0.392 (0.297) | 0.611 (0.080) | 0.470 (0.202) | 0.452 (0.222) | ||
Father-LPS | − 0.315 (0.409) | − 0.040 (0.918) | 0.274 (0.475) | 0.055 (0.889) | ||
Parents-LPS | 0.157 (0.687) | − 0.090 (0.817) | 0.265 (0.491) | 0.320 (0.401) | ||
15 months | F2-CON | 0.198 (0.610) | 0.324 (0.395) | 0.164 (0.673) | 0.465 (0.207) | |
Mother-LPS | − 0.073 (0.851) | 0.092 (0.814) | 0.428 (0.250) | 0.705 (0.034)* | ||
Father-LPS | 0.220 (0.570) | 0.547 (0.127) | 0.472 (0.199) | 0.722 (0.028)* | ||
Parents-LPS | 0.349 (0.358) | 0.503 (0.167) | 0.724 (0.028)* | 0.901 (0.001)** | ||