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Table 3 The partial correlation between the performance in MWM and hippocampal GDNF-GFRα1 expression in F1 generation

From: Effects of gestational inflammation on age-related cognitive decline and hippocampal Gdnf-GFRα1 levels in F1 and F2 generations of CD-1 Mice

Cognitive parameters

Ages

Groups

GDNF [r (p)]

GFRα1 [r (p)]

Protein

mRNA

Protein

mRNA

Swam distance

3 months

CON

− 0.475 (0.196)

− 0.574 (0.106)

− 0.606 (0.084)

− 0.584 (0.099)

LPS

0.236 (0.542)

− 0.510 (0.161)

0.086 (0.827)

0.665 (0.051)

15 months

CON

− 0.435 (0.242)

− 0.447 (0.228)

− 0.579 (0.103)

− 0.043 (0.912)

LPS

− 0.288 (0.452)

− 0.823 (0.006)**

0.149 (0.702)

0.494 (0.177)

Percentage swam distance in target quadrant

3 months

CON

0.547 (0.127)

0.663 (0.052)

0.772 (0.015)*

0.695 (0.038)*

LPS

0.478 (0.193)

0.084 (0.830)

− 0.359 (0.343)

0.068 (0.863)

15 months

CON

− 0.054 (0.890)

− 0.125 (0.749)

0.012 (0.976)

− 0.016(0.968)

LPS

− 0.583 (0.099)

− 0.034 (0.930)

0.020 (0.960)

0.123 (0.753)

  1. n = 6 per group
  2. *P < 0.05
  3. **P < 0.01. CON mice exposed to saline in utero, LPS mice exposed to inflammation in utero