Table 2 The correlation between the performance in MWM and hippocampal GDNF-GFRα1 expression in F2 generation
Ages | Cognitive parameters | Groups | GDNF [r (p)] | GFRα1 [r (p)] | ||
|---|---|---|---|---|---|---|
Protein | mRNA | Protein | mRNA | |||
3 months | Swimming distance | F2-CON | − 0.247 (0.440) | − 0.453 (0.139) | − 0.047 (0.885) | − 0.423 (0.170) |
Mother-LPS | − 0.392 (0.207) | − 0.387 (0.214) | − 0.378 (0.226) | − 0.166 (0.606) | ||
Father-LPS | − 0.626 (0.029)* | − 0.474 (0.120) | − 0.343 (0.275) | − 0.433 (0.159) | ||
Parents-LPS | − 0.208 (0.517) | − 0.329 (0.296) | − 0.293 (0.356) | − 0.629 (0.029)* | ||
Distance percentage in target quadrant | F2-CON | 0.311 (0.325) | 0.533 (0.075) | 0.159 (0.621) | 0.378 (0.225) | |
Mother-LPS | − 0.166 (0.607) | − 0.159 (0.621) | 0.353 (0.260) | − 0.025 (0.940) | ||
Father-LPS | 0.449 (0.143) | 0.248 (0.438) | 0.568 (0.054) | 0.281 (0.376) | ||
Parents-LPS | 0.302 (0.339) | − 0.051 (0.875) | 0.254 (0.426) | 0.675 (0.016)* | ||
15 months | Swimming distance | F2-CON | − 0.125 (0.700) | − 0.468 (0.125) | − 0.387 (0.214) | − 0.026 (0.936) |
Mother-LPS | 0.008 (0.980) | − 0.468 (0.125) | − 0.249 (0.435) | 0.230 (0.472) | ||
Father-LPS | − 0.705 (0.010)* | − 0.536 (0.072) | − 0.687 (0.014)* | − 0.583 (0.047)* | ||
Parents-LPS | − 0.674 (0.016)* | − 0.802 (0.002)** | − 0.646 (0.023)* | − 0.639 (0.025)* | ||
Distance percentage in target quadrant | F2-CON | − 0.009 (0.978) | − 0.250 (0.433) | − 0.227(0.479) | − 0.038 (0.906) | |
Mother-LPS | 0.246 (0.441) | 0.250 (0.433) | 0.524 (0.081) | 0.501 (0.097) | ||
Father-LPS | 0.791 (0.002)** | 0.831 (0.001)** | 0.831 (0.001)** | 0.939 (0.000)** | ||
Parents-LPS | 0.853 (0.000)** | 0.534 (0.073) | 0.701 (0.011)* | 0.863 (0.000)** | ||