Table 1 The correlation between the performance in MWM and hippocampal GDNF-GFRα1 expression in F1 generation
Ages | Cognitive parameters | Groups | GDNF [r (p)] | GFRα1 [r (p)] | ||
|---|---|---|---|---|---|---|
Protein | mRNA | Protein | mRNA | |||
3 months | Swam distance | CON | − 0.482 (0.112) | − 0.572 (0.052) | − 0.388 (0.212) | − 0.342 (0.276) |
LPS | 0.088 (0.785) | − 0.401 (0.196) | − 0.159 (0.621) | − 0.389 (0.211) | ||
Percentage swam distance in target quadrant | CON | 0.450 (0.143) | 0.536 (0.072) | 0.500 (0.098) | 0.507 (0.093) | |
LPS | 0.400 (0.197) | 0.364 (0.245) | 0.245 (0.444) | 0.439 (0.153) | ||
15 months | Swam distance | CON | − 0.519 (0.084) | − 0.554 (0.062) | − 0.524 (0.080) | − 0.290 (0.361) |
LPS | − 0.893 (0.000)** | − 0.788 (0.002)** | − 0.702 (0.011)* | − 0.788 (0.002)** | ||
Percentage swam distance in target quadrant | CON | 0.099 (0.760) | 0.146 (0.652) | 0.230 (0.472) | 0.167 (0.604) | |
LPS | 0.666 (0.018)* | 0.799 (0.002)** | 0.709 (0.010)** | 0.776 (0.003)** | ||