Fig. 5

A–F Lateral ventricle volume was significantly higher in DE50-MD dogs compared with WT. Representative T2-weighted transverse magnetic resonance images of the brain of a 28mo WT dog and 28mo DE50-MD dog shows comparatively larger lateral ventricles (indicated by white arrows) in the DE50-MD dog (C,D). (A,C: at the level of the caudal aspect of the third ventricle. B, D: at the level of the caudal colliculi). Both the left (E) and right (F) lateral ventricles were larger in volume in DE50-MD dogs compared with WT (*p < 0.05). G, H) T1W images revealed reduced regional gray matter in DE50-MD dogs compared with WT. G) Cerebral cortical gray matter transverse area at the level of the interthalamic adhesion and H) at the level of the rostral colliculi of the midbrain was significantly decreased in DE50-MD dogs compared with WT (*p < 0.05). Individual data, mean and standard deviation shown