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Fig. 6 | BMC Neuroscience

Fig. 6

From: KDM4A, involved in the inflammatory and oxidative stress caused by traumatic brain injury-hemorrhagic shock, partly through the regulation of the microglia M1 polarization

Fig. 6

The simple scheme indicated that TBI + HS resulted in enhanced microglia M1 polarization. KDM4A was upregulated in response to TBI + HS and microglia were among the cell types showing the increased level of KDM4A. Inhibition of KDM4A alleviated the inflammation and oxidative stress, which was related with microglia activation. Accordingly, our findings indicated that the important role of KDM4A in TBI + HS induced inflammatory response and oxidative stress was at least partially realized through microglia M1 polarization

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BMC Neuroscience

ISSN: 1471-2202

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